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BIO 344Cell and Molecular Biology
Course description :
Organization and function of biological molecules, cell diversity, cell structure
and function, and cell interaction .
Prerequisites:BIO 181, CHM 152, BIO 220 or BIO 205
Lectures: Tuesday and Thursday; 9:35 a.m. – 10:50 p.m. room 265 Biology
building
Office Hours
• Monday 12-1
• Thursday 11-12
• By appointment
• Walk-in
• Molecular Biology of the Cell, 2002, 4th or 5th edition. Alberts, Johnson, Lewis, Raff, Roberts and Walter.Garland Science, New York, NY.
BOOK (required)
Exams:
• There will be three exams and a final.
• The final will cover all material from the class.
• You may elect to not take the final if you are happy with the grades on your exams
Grading: if you don’t take the final
• Exam I 33 %Exam II 33 %Exam III 33 %
• A = 90-100B = 80-89.999C = 70-79.999D= 60-69.999
Grading: if do take the final
• Exam I 20 %Exam II 20 %Exam III 20 %Final 40%
• A = 90-100B = 80-89.999C = 70-79.999D= 60-69.999
If the final exam lowers your overall grade it will not be counted in calculating your final
grade. Thus you can’t lose by taking the final.
Makeup tests
• You will need to make special arrangements with me if you want to take the test at another time. You will need a valid excuse such as a medical emergency or religious holiday. Arrangements must be made prior to the exam.
Attendance
• Attendance for this class is not required. However, because most questions will come directly from the lectures, the probability of receiving a decent grade without attendance is very small. Recognize that the book is very difficult and part of the book will not be on the exam
Brief preview of lectures
chapter 10 – 13, 15-19
Membrane structure
Membrane Transport
Protein sorting
Vesicular transport
Cell to cell communication
Cytoskeleton
Cell Cycle and Cell Death
Cell Division
Cell Junctions and Adhesion
The response of blood platelets to injury
Platelets prior to activation
Ca2+ and diacylglycerol activate protein kinase C
Actin filament dynamics and platelet activation
in
Actin filament dynamics and platelet activation
Activated platelet with large spread lamellipodium
Activated platelet after contraction
Chapter 10
Membrane Structure
4.7 – Part 1
figure 04-07a.jpg
1
Eukaryotic Cell
The plasma membrane is a lipid bi-layer
2
2-dimensional model of plasma membrane
3-dimensional model of plasma membrane
Phosphatidylcholine
3
Phosphatidylcholine
4
Phosphatidylcholine
Polar molecule dissolved in water
Arrangement of water molecules is barely disturbed5
Non-polar molecule dissolved in water
Arrangement of water molecules strongly disturbed
Shape of lipid determines packing of lipid molecules
Shape of lipid determines packing of lipid molecules
Figure 10-11a Molecular Biology of the Cell (© Garland Science 2008)
Formation of sphere is energetically favorable
Figure 10-9a Molecular Biology of the Cell (© Garland Science 2008)
Figure 10-9b Molecular Biology of the Cell (© Garland Science 2008)
Figure 10-11b Molecular Biology of the Cell (© Garland Science 2008)
Figure 10-11 Molecular Biology of the Cell (© Garland Science 2008)
Figure 10-12 Molecular Biology of the Cell (© Garland Science 2008)
Effect of cis double bonds on membranes
Figure 10-13 Molecular Biology of the Cell (© Garland Science 2008)
1:1 phosphotidylcholine and sphingomyelin
1:1:1 phosphotidylcholine and sphingomyelin and cholesterol
Figure 10-14b Molecular Biology of the Cell (© Garland Science 2008)
Figure 10-14a Molecular Biology of the Cell (© Garland Science 2008)
DVD clip 36
6,7
Cholesterol
9
Cholesterol
Cholesterol
Cholesterol in lipid bilayer
DVD Clip 37
10
Lipid composition varies among different cell types
11
