Bio Breakthroughs - Harvard Apparatus

PA G E 1Harvard Apparatus • Bio-Breakthroughs www.harvardapparatus.com • 508.893.8999

MRI imaging techniques in animal researchare growing rapidly, and the need to infusedyes, drugs and nutrients at the MRI site isrequired. Harvard Apparatus is introducing apump made of mostly non-magnetic materials that works wellwithin three feet of the magnet. This pump has very high accura-cy ±0.35 and ±0.05 precision at a broad flow rate range from0.0001 µl/hr to 220.82 ml/min. The pump has a separate controlunit at the pump site and a remote full control unit that can reachas far as 60 ft away from the pump if necessary.

The new 2004 Harvard Apparatus catalog has many otherMRI compatible products: ventilators, catheters, clamps,stands and supports. If you have questions or require otherMRI compatible products e-mail:

[email protected] or visit our new website: www.harvardapparatus.com

See page vi in the 2004 Harvard Apparatus Full Line Catalog.

MRI Compatible Syringe Pump

What’s NEW In Innovative Products For Bioresearch...Enh a n c i n g Yo u r B i o r e s e a r c h

508.893.8999 • www.harvardapparatus.com Since 1901Volume 1, Ser ies 101

Breakthroughs

This 5x and 10x magnification system can be operatedfrom batteries or an electrical outlet.

Can be linked to a computer to store images or view data.See page D40 in the 2004 Harvard Apparatus Full Line Catalog

Electronic Magnification Glasses-Advanced Visualizations

This advanced workstation is a total tool to studying lipidbilayer mechanisms. It has been designed to make these difficult experiments easy to run, and provide you with thehighest quality data from your experiments.See page H6 in the 2004 Harvard Apparatus Full Line Catalog

The Planar Lipid Bilayer Workstation

Biotelemetry System forEEG, EMG, EOG or PSG in Small Rodents

This system is a low noise, 2-channel wireless data systemused to monitor physiological parameters on animals thatweigh 100 grams or more. Parameters include: electroen-cephalogram; electromyogram; electrocardiogram; elec-trooculogram or polysomnography. Submicrovolt noise levelis excellent for EEG.

This unit allows the animal to be untethered with a rangeof up to 50 feet. This unit also allows for monitoring of animals during activities such as in a treadmill, metaboliccage or roto-rod.

This capability opens new areas of research on real-time monitoring of unrestrained animals in their natural environments.See page I101 in the 2004 Harvard Apparatus Full Line Catalog

For single or 96 simultaneous experiments: Protein and protein binding assays; receptor binding assays; ligand binding assays; protein and protein-DNA interactions. Membranes come in three molecularweight membrane cut off sizes: 5K, 10K and 25K. The singles handle volumes from 25 to 75 µl and the 96 well version 50 –200 µl.

The 96 well version works with three rotators: single, dual or 8 plate.There are many more equilibrium dialysis products from Harvard Apparatus.See pages N38 to N44 in the 2004 Harvard Apparatus Full Line Catalog

Equilibrium Dialysis For Binding Studies

The stronghold MRI Series… An entirefamily of non magnetic clamps and stands towork near your MRI.See pages O22-O27 in the 2004 Harvard Apparatus Full Line Catalog

MRI Compatible Clamps & Stands

w w w . h a r v a r d a p p a r a t u s . c o m

Your most comprehensive source for Specialty Bioresearch Products.

For your FREE Bioresearch Catalog:

Call 800-272-2775 or visit us on the web at

www.harvardapparatus.com for your FREE copy

H A R VA R D A P PA R AT U S L A U N C H E S N E W W E B S I T E

PA G E 2

What’s NEW In Innovative Products For Bioresearch...508.893.8999 • www.harvardapparatus.com Since 1901Volume 1, Ser ies 101

BreakthroughsEnh a n c i n g Yo u r B i o r e s e a r c h

Harvard Apparatus • Bio-Breakthroughs www.harvardapparatus.com • 508.893.8999

High Performance UssingChambers for Large & Micro Samples

Portable Capnographs & Pulse Oximeters

Inspira–Advanced SafetyVentilator (ASV): Ventilate from Mice to Cats

Small Animal Portable AnalyzerThat’s Easy to Use

This easy to usediagnostic meterrequires 1 to 80 µl ofblood and 2 minutes toget results dependingon the test. It measuresmany parametersincluding blood gasand glucose with highaccuracy and precision.

This advanced unitis so easy to use andfast that you no longerhave to wait for theresults you need imme-diately. Each cartridgecontains only the test

you need done, so it is economical to use. Each cartridge hasits own calibration standards and all reagents necessary forthe analysis.

The I-STAT® portable analyzer is the most advanced analyzer making it simple to operate and resulting in the high-est quality analysis.See page F52 in the 2004 Harvard Apparatus Full Line Catalog

Harvard Apparatus isthe leader in animal ventilation with a broadfamily of ventilation andanesthesia products forsmall and large animals.The Inspira is the mostadvanced and versatileventilator.

Capable of ventilat-ing mice to cats (15g to10kg). Adjustable I:E ratio 1:4 to 4:1), two models - constantvolume and volume/pressure and many other advanced fea-tures: sigh breath, assist mode, PEEP.See pages F4 to F6 the 2004 Harvard Apparatus Full Line Catalog

These capnographs provide spot readings of End Tidal CO2,CO2 waveform and sample at a rate of 120ml/min.

Pulse oximeters: SpO2, faster pulse rate up to 450 bpm, temper-ature, pulse strength, respiration rate, alarms all in one unit.See pages F43 to F48 and F53 in the 2004 Harvard Apparatus Full Line Catalog.

1. Fill the cartridgewith 3 drops offresh whole blood

2. Insert cartridge in i-STAT® Analyzer

3. Critical results in less than 2 minutes forimmediate therapy decisions

Celite ACT

Glucose

Creatinine

Sodium

Potassium

Hematocrit

Hemoglobin

pH

PCO2

PO2

Bicarbonate

Total CO2

Base Excess

O2 Saturation

Lactate

Chloride

Urea Nitrogen

Ionized Calcium

Anion Gap

6 Vertical Chamber System with Gas Manifold and Heating Block

The vertical diffusionchamber system is usedfor transport studies onboth filter grown cellmonolayers and surgi-cally excised tissue sec-tions. The vertical diffu-sion chamber systemconsists of six diffusionchambers, a 12-channelgas manifold and a heat block. Fourteen general types of vertical chambers are currently available: one for use withcells grown on Snapwell™ membrane supports and the othersfor use with tissue. The model RC-50 Imaging Chamber is fortransepithelial studies. It is a low profile, horizontally mounted Ussing Chamber incorporating special features forusing confocal imaging.See page M167 in the 2004 Harvard Apparatus Full Line Catalog

RC-50

11 Models to

Choose From!

This Basic Table TopAnesthesia Machine is anextremely compact, (L x Wx H): 8 x 8 x 13 inches,making it ideal for locations where space islimited. Four models areavailable that differ onlyby the type of flowmetersupplied.See pages E13 in the 2004 Harvard Apparatus FullLine Catalog.

Rugged, Space Efficient TableTop Anesthesia Machine

(Vaporizer not included)

The small size and dual calipers of this gauge is ideal formeasuring ears, toes and fat deposits. Range 12 mm or 25 mm,resolution 0.01 mm. Battery operated.See pages C18 in the 2004 Harvard Apparatus Full Line Catalog

Accurate, Easy-To-Use ThicknessGauge for Animals

The Warner Catalog has thousands of products for your Upright, Inverted, Confocal,AFM or any microscope from any manufacturer.

Use Warner Products to:

• Keep Cells Alive During Analysis

• Study Their Physiology

• Perform Cellular Injections

Live Cell Imaging ProductsCELL

BIOLOGY

Available Chemistries

Call 800-272-2775for a FREE Warner Cell Biology Catalog!

Call 800-599-4203 for Technical Supportwww.warneronl ine.com




Food and Liquid Consumption System

Nitric Oxide, Rugged Probe Measurement System

New Trends In Ex Vivo & In SituIsolated Organ Perfusion

Pneumotach Air FlowTransducers (Very Low Flow) Metabolic Monitoring System for

Treadmill & Activity Monitor

This Metabolic Monitoring System is ideal for measure-ment of oxygen consumption and carbon dioxide production inlab animals. It uses open circuit calorimetry technique. It isvery flexible: the size of the animal is immaterial. The data canbe analyzed by the statistical packages.

The system comes with windows based software. The com-bination of the Metabolic Monitor and Activity MonitoringSystem permits measurement of metabolic rate and animallocomotor activity simultaneously, thus allowing this correla-tion to be calculated. The metabolic monitoring system workswell with the motorized air tight treadmill for mice and rats.See pages G4 to G5 for the Metabolic Monitoring System.

This Food and Liquid Consumption System is designed toprovide nutrition researchers with the ability to preciselymonitor food and liquid consumption of laboratory animalsover time. In contrast to other systems, this system monitorsconsumption directly by weighing the reservoir continuously.See pages G6 and G7 in the 2004 Harvard Apparatus Full Line Catalog

The TSD137 series pneumotachs can perform a variety ofsmall animal pulmonary measurements relating to air flow,lung volume and expired gas analysis. Each TSD137 transduc-er type consists of a low flow pneumotach head coupled to aprecision, highly sensitive, differential pressure transducer.See page I129 in the 2004 Harvard Apparatus Full Line Catalog

Single Channel inNO-T System

Dual Channel inNO-T System

This Nitric Oxide System is the most technologicallyadvanced nitric oxide electrochemical detection system on themarket today.

Using the latest state of the art combination NO sensordesign, the ‘amiNO’ series of nitric oxide sensors increases thesensitivity of electrochemical nitric oxide measurement by upto 100 times that of any existing electrochemical sensor on the market today.See pages M2 to M5 in the 2004 Harvard Apparatus Full Line Catalog

Organ Perfusion Systems are available for both in situ andex vivo organ perfusion and include setups for heart, lung,kidney, liver, intestine and mesentery. Most include the ability to perfuse under constant flow or constant pressurewith a simple turn of a knob. Parameter and system specificelectrodes and transducers extend the versatility and function-ality of each system. The UP-100 and PS-1 organ perfusionsystems are: compact in size; have a single setup for pressureor constant flow; easy-to-insert custom cannulae; optimizedtemperature control and applications expertise form HugoSachs Elektronik, the leaders in perfusion systems.See pages K5 to K8 in the 2004 Harvard Apparatus Full Line Catalog

Harvard Apparatus introduces these new 96-Well and 384-Well Filter Plates which bring speed and high throughputto sample filtration on a microliter to milliliter scale. Themembrane-bottom individual sample wells or chambers haveseparate high-strength single or dual filter membranes to provide rapid filtration rates and to eliminate leakage or cross-talk between adjacent wells.See pages N23 to N24 in the 2004 Harvard Apparatus Full Line Catalog

96 & 384 Well Economical Filter Plates

Now setting up andreproducing settings onstereotaxic manipulatorsis easy, accurate andreproducible with theadvent of electronic sensors on each axis of themanipulator bars. Measurements are accurate to 10 microns inall three directions, and the easy to read display is program-mable to a resolution of 1 to 10 microns. Other versions ofdigital control are available with computers that allow you toeasily change the approach angle automatically calculatingthe new coordinates of the target structure.

This reduces the need for extensive calculations and therisk of error.See pages L29 and L32 in the 2004 Harvard Apparatus Full Line Catalog

Autocalculation of TargetStructure & Digital Readout For Stereotaxic Instruments

Call 800-272-2775for technical or ordering assistance

www.harvardapparatus.com

LIVER KIDNEY

INTESTINE

PERFUSIONS

• Compact size...single set-up for constant pressure or constant flow

• Only commercial in situ organ perfusionsystem available

• Easy-to-insert custom cannulae:– Occlusion Protection– With or Without Pressure Monitoring Port– Pressure Measurement at the Source

Hugo Sachs Elektronik (a Harvard Apparatus Company)

Introduces the UP-100 and PS-1 Organ Perfusion Systems

• Optimized temperature control

• Applicationsexpertise from the leaders in perfusion systems

• Fully instrumented turnkey systems

New Trends In Ex Vivo & In Situ Isolated Organ Perfusion

PA G E 4




The PLI–100 Pico-Injector and PDMI Open PerfusionMicro-Incubator are two important tools for cellular research.

The PLI-100 Pico-Injector reliably delivers a wide range ofvolumes through micropipettes by applying a regulated pres-sure for a digitally set period of time. Compressed gas allowsthe user to deliver desired volumes from femtoliters to micro-liters while simultaneously holding a cell.

Whether you need to do large injections into capillaries orvery small injections into mammalian nuclei, the PLI-100 iswell suited for your experiment. Researchers say:

“The PLI-100 is very robust, in constant use in our lab.”“Most importantly, the PLI-100 valves prevent cytosol and yolk backflow into my pipette after oocyte injection.”“It’s very easy to control.”“The PLI-100 is heavily used on a daily basis, and worksgreat.”“I like the fact that I can use the PLI-100 with TTL pulses.”The PDMI-2 operates equally well under static or perfused

conditions. When operated with perfusion, the micro-incuba-tor’s unique design places flexible tubes carrying inflowing per-fusate in contact with a temperature regulated Peltier heat pumpdriven plate, thus heating or cooling the incoming fluid to acommand temperature. The PDMI-2 also provides gas flowover the top of the chamber for pH control and improved tem-perature uniformity. A Teflon™ well is provided with anAg/AgCl electrode at its base to allow for the formation of a saltbridge when making low noise electrophysiological recordings.

• Heats and cools : ~5° to 50°C• Maintains required cell environment for hours:

— pH O2, and temperature• Peltier heat pump• Flexible chamber option

See pages M71 and M87 in the 2004 Harvard Apparatus Full Line Catalog

Ultra-Micro SpinColumn™

Handles volumes from 10 µl to25 µl, see page N18 in the 2004 Harvard Apparatus

Full Line Catalog

Macro SpinColumn™

Handles volumes from 75 µl to150 µl, see pages N20 and N21 in the 2004 Harvard Apparatus

Full Line Catalog

96-Well SpinColumn™

High Throughput sample prep applications, handles volumes from25 µl to 100 µl, see page N22 inthe 2004 Harvard Apparatus Full

Line Catalog

Micro SpinColumn™

Handles volumes from 25 µl to 75 µl, see page N19 in the 2004 Harvard Apparatus

Full Line Catalog

Gel FiltrationG-10G-25G-50G-100P-2 *P-6 *Hydrophobic (non-polar)C18C8C4

Hydrophilic(polar)SilicaCyanoAminoHydrophilicIon ExchangeStrong AnionWeak AnionStrong CationWeak Cation

Misc.CelluloseDetergentRemovalIMAC **

Spin columns are ease-to-use, disposable sample clean-updevices.

Spin Columns are used for: DNA, protein and peptide purification, small molecule, carbohydrate, salt and radiolabel removal, affinity separation, buffer exchange. The product line has single, disposable, and 96-well configu-rations. This Harvard family of spin columns has the broadestrange of sizes and selectivities of packings of any samplepreparation products.

Available Packing Materials

The Leading Cell Injectors &Heating Cooling Micro-Incubators

The 1 µl to 5 µl Ultra-Micro DispoDIALYZER is a uniquedisposable DIALYZER for the dialysis of very small samples.The entire dialysis unit, installed with different MWCO mem-branes, is small enough so that dialysis can be carried out in amicrocentrifuge tube. Sample recovery is quick and easy withalmost 100% of the sample recovered after only a short cen-trifugation step.

• Removal of detergents• Concentration of samples• Purification of proteins, DNA and RNA

See page N34 in the 2004 Harvard Apparatus Full Line Catalog

Largest Family of Spin Columns,Sample Sizes & Chemistries

1 to 5 µl Dialysis Sample Preparation

See pages N17 to N22 in the 2004 Harvard Apparatus Full Line Catalog

PDMI-2 Micro-Incubator Typical Setup

PLI-100 Pico-Injector

This bidirectionalmicro processor con-trolled Rota-Rod formice features a frontpanel with a large,very readable back-light display. Thepanel can be orientedto select the mostcomfortable anglefor the operator andto avoid glare.

This Mouse RotaRod has two operat-ing modes. The

Constant Speed Mode – the angular speed (RPM) is preset bythe operator in the range between 4 and 50 rotations per minute.

The Accelerating Speed Mode - the operator presets boththe duration and the steepness of the ramp, e.g., 4 minutes topass from 4 to 40 RPM, 5 minutes to pass from 6 to 30 RPM.See page G13 in the 2004 Harvard Apparatus Full Line Catalog

Accelerating 5-Lane Rota-Rod Treadmill for Mice



Advanced SamplePreparation Products

Vertical Equilibrium Dialysis

96-Well Format

Single Format

Dialysis and Chromatographic Technologies for micro and macro sample clean-up

Amika (a Harvard Apparatus Company)• Equilibrium Dialysis for Binding Studies

– Single sample and 96-well format • Dialysis

– Single sample and 96-well format– Broad selection of molecular weight cutoffs

• Chromatographic Columns– Single sample and 96-well format– Broad selection of column chemistries

Dialysis Buffer Chamber

Membrane

SampleChamber

Continous Flow Dialyzer

SAMPLE

PREPARATION

This Syringe Pump is ideal for when you have small sam-ple volumes to infuse/withdraw. The Microject Plus fromHarvard Apparatus was created for Stereotaxic injectionswhere the amount of material injected is very small or expen-sive. You can mount this pump directly on a stereotaxicmanipulator, eliminating the need for long, small bore tubing.The syringe is positioned directly at the injection site. Thisnew, powerful pump is capable of delivering up to 3 poundsof force to a gas tight syringe.

• Infuse / Withdraw• RS232• End of Run Visual Alarm• 2x the power of other small remote pumps

Please call for details.

The Microject Plus …




CoA

FAD

BIOTIN

FOLIC ACID

This 10-Syringe Feeding System is a convenient and versatile system to feed multiple animals simultaneously,making it ideal for multiple animal feeding studies or otherapplications which require precise parallel pumping. Thestandard syringe rack can hold up to 10 syringes ranging insize from 50cc to 140cc. You can use plastic or glass syringes.The broad performance characteristics of the Feeding Systemmake it ideal for small drug or large volume nutritional variables on large animal populations.See page A32 in the 2004 Harvard Apparatus Full Line Catalog

CPK ATOMIC models are the most accurate atomic models available. They are sold in kits, individual pieces oralready constructed molecules. They are the best way toexamine new drugs or model compounds.See pages P2 to P18 in the 2004 Harvard Apparatus Full Line Catalog.

Study exercise physiology in mice and rats with this quietand compact unit for exercising. Airtight chambers are avail-able for VO2/VCO2 studies.See page G15 in the 2004 Harvard Apparatus Full Line Catalog

For investigating the tone of small blood vessels under theeffect of vascular substances. This unit is warm and moist andhas electrical field stimulation capabilities.See page K9 in the 2004 Harvard Apparatus Full Line Catalog

10 Syringe Feeding Station

Isolated Perfused Rat Mesenteric Bed

CPK–The Most Authentic Atomic Models

Treadmill for Mice and RatsMotorized Air Tight Treadmill

48 samples from one or two microdialysis probes can becollected and refrigerated at 4˚C. Handles volumes from 5 µl to 200 µl. Also great for LC fraction collection.See page L28 in the 2004 Harvard Apparatus Full Line Catalog

Now the PHD 22/2000 Series and the Physio 22 syringepumps have virtually no electrical noise emitted so that theycan be used in close proximity to sensitive sensors withoutcausing any noise interferences. This feature is ideal for cellphysiology experiments.See pages A12 to A13 in the 2004 Harvard Apparatus Full Line Catalog.Refrigerated Fraction Collector

For Microdialysis

Low EF Syringe Pumps ForPerfusing Near SensitivePhysiological Sensors

PHD 22/2000Infusion Only with Standard2-Syringe Rack

PHD 22/2000 Infuse/Withdraw with 6/10Multi-Rack

PHD 22/2000 Programmable withStandard 2-Syringe Rack

This chamber is particularly useful with transgenic mice andis suitable for use in barrier facilities. It features an advanceddesign for accurate and efficient collection of urine and fecesthat are totally separated. This unit can be gas sterilized and isconstructed of high impact resistant acrylic materials.See page C11 in the 2004 Harvard Apparatus Full Line Catalog

Mouse Metabolic Chamber withHigh Collection Efficiencies

Ideal Wireless Micro-DrillThis rechargeable drill is

ideal for research applicationsthat require surgical burrs andtrephines. It is lightweight and the chargelasts for up to 8 hours.See page L42 in the2004 Harvard ApparatusFull Line Catalog



• Can dispense up to 1,400 ml using ten 140 ml syringes

• ±0.5% Accuracy±0.05% Reproducibility

• Two year warranty

• Advanced built-in programmingcapability or PC compatible

• Flow rates from: 1.5 µl/hr to 112.0 ml/min

• Provides 433 pounds of force

• Applications:– Injecting into

High Pressure Reaction Vessels

– Multiple SimultaneousAnimal Feeding Station

– Accurate Delivery of Coatings

– HPLC Delivery System

– Remote Operation in Hazardous Environments

...For Your Most Demanding Applications

High Pressure Syringe PumpSYRINGE

PUMPS

PA G E 6




Remote monitoring allows you to monitor your equipmentwhile it is unattended. This Harvard Apparatus unit can monitor 24/7 and if it senses a problem it will automaticallye-mail, telephone, or fax you anywhere in the world.See page A22 in the 2004 Harvard Apparatus Full Line Catalog.

For lymphatic, vascular or blood collection circuit accesswith minimum worry of thrombogenecity common inintravascular devices.See page B33 in the 2004 Harvard Apparatus Full Line Catalog

Reduce animal trauma and cost with flexible, disposable,plastic feeding tubes.See page B27 in the 2004 Harvard Apparatus Full Line Catalog

Long Term, No Leaching,Heparin Coated Catheters

Plastic Feeding Tubes Reduce theRisk of Perforation

24/7 Sentry…To Monitor YourEquipment That is Unattended

Ideal for mice, newborns and small ani-mals, this easy to use economical tattooingsystem uses sterilized needles to reduce

infection.See page C29 in the 2004 Harvard Apparatus

Full Line Catalog

The newly developed MiniVent Model 845 Ventilator is aquiet, compact and light weight ventilator. While it wasdesigned specifically for mice, the MiniVent can be used forany animal (e.g. birds and perinatal rats) which requires tidalvolumes in the range of 30 to 350 µl and respiratory rates of60 to 400 breaths per minute.See page F8 in the 2004 Harvard Apparatus Full Line Catalog

Artificial cerebrospinal fluid (aCSF) is commonly usedwhen sampling brain interstitial fluid. This solution closelymatches the electrolyte concentrations of CSF. It is preparedfrom high purity water and analytical grade reagents. It ismicrofiltered and sterile. Final Ion Concentrations (in mM):Na 150; K 3.0; Ca 1.4; Mg 0.8; P 1.0; Cl 155. Supplied as apackage of six 25 ml vials.See page L44 in the 2004 Harvard Apparatus Full Line Catalog

If you are performing cardiovascular work, this is thepump for you. It truly simulates the pumping action of theheart. It features silicone rubber-covered heart-type ballvalves and smooth flow paths which minimize hemolysis.The pumping head is easy to take apart and reassemble andcan be sterilized.See page A37 in the 2004 Harvard Apparatus Full Line Catalog

L a b V I E W ™

Driver for HarvardApparatus PHD22/2000 and model11 syringe pumps is built using the popular LabVIEW™

programming application from National Instruments. Controlmany pumps, write special applications or integrate into existing applications.See page A21 in the 2004 Harvard Apparatus Full Line Catalog

The Pump 11 Pico Plus can be programmed in microliters,nanoliters and/or picoliters directly. Two syringes, I/W goodfor microdialysis, cell injection or reaction vessel delivery.RS232 or foot pedal control. Flow range 3.3pl/min to 0.8788ml/min.See page A9 in the 2004 Harvard Apparatus Full Line Catalog

This professional quality trimmer is super convenient andsuitable for all your small animal fur removal needs. The pow-erful yet quiet rotary motor runs at 6,000 rpm and does notrequire a spray coolant. This trimmer offers convenient cord orcordless operation to provide constant trimming power so youwill always have a fully charged trimmer ready for use.See page C20 in the 2004 Harvard Apparatus Full Line Catalog

This cannula is designed for insertion in the very smallvessels of mice or rats. OD 0.4mm (0.016in) x ID 0.2mm(0.008in).See page B36 in the 2004 Harvard Apparatus Full Line Catalog

Mini & Micro Ventilator forSmall to Very Small Animals

Lab View Drivers - Take Controlof Your Syringe Pumps

Artificial Cerebral Spinal Fluid

Picoliter Syringe Pump

Micro-Cannula

Hot Bead Dry Sterilizer

Mini Cordless Small Animal Fur Trimmer

Pulsatile Blood Pump

Micro-Tattooing System

This compact unitprovides a quick andeasy way to sterilize sur-gical instruments. Thestainless steel, centralwell is filled with dryglass beads that are heat-ed to 500°F. Simplyinsert an instrument intothe beads and, within 15seconds, the submergedportion of the instrumentis sterilized. It’s thateasy! This unit is sup-plied ready to use.Replacement glass beads

are available separately. This product is a must for any labo-ratory doing small animal surgery.See page E30 in the 2004 Harvard Apparatus Full Line Catalog.




OS-250 Overflow/Spill Sensor

The days of struggling with tedious cuvettes limiting thenumber of samples and cell types tested are about to change.The Methods Optimization Systems, MOS 25 & MOS 96,allow you to boost your productivity by optimizing your conditions and increasing your yields and viability. Once youuse the MOS 25 system you will never want to go back tousing a traditional cuvette.See page M55 in the 2004 Harvard Apparatus Full Line Catalog

MOS 25 & MOS 96 Multi-WellAdvanced Electroporation Systems

Test 1 to 8 animals simultaneously with interchangableanimal platforms for mice and rats. Control unit with built incontroller, PDA or PC. Capable of measuring conditioned ani-mals at about 100/day.See page J8 and J12 in the 2004 Harvard Apparatus Full Line Catalog

Research Grade NIBP on Rats & Mice (Non-Invasive Blood Pressure)

Taking the rectal or vascular temperature of neonatal mice,spectrometer cuvettes etc., is easy with the 0.23 mm (0.009 in)Teflon™ coated probe.

This highly flexible probe is autoclavable or gas steriliz-able. The small mass of these probes allows for extremely fastreading times with time constants as low as 0.005 seconds.

These micro probes work with the controller above tomeasure temperatures with an accuracy of 0.1˚C with auto cor-rection compensating for ambient temperatures from 0 to 50˚C.See page D16 in the 2004 Harvard Apparatus Full Line Catalog

Microprobes, 0.23 mm (0.009 in),for Temperature Measurement

Knives for Microsurgery

Circular Knife Tip

Beaver™ Needle Blade

Stiletto Tip

Ideal for small animal surgery. These ultra sharp smalltools with advanced ergonomic design enhance your ability todo surgery without distortion on small animals. Seven stylesavailable.See page E13 in the 2004 Harvard Apparatus Full Line Catalog

2.25 mm.6 mm

These advanced illumination systems provides 36,000 luxof bright white light. The working distance of 34 inches guar-antees bright images of your treatment area. This illuminationsystem clips onto the Leather Padded Headband and is ultralight (only 28g) and comfortable to wear. The advancedGalilean system binocular magnifier provides sharp images.See pages D38-D39 in the 2004 Harvard Apparatus Full Line Catalog

Advanced Magnification withFiber Optics Illumination Systems& Headband

The OS-250 Overflow/Spill Sensor from WarnerInstruments provides a simple and effective method fordetecting leaks and spills around sensitive equipment (suchas microscopes). The integrated, switched power controllercan be used to rapidly turn off all pumps and perfusionsytems in the event of a spill. When assembled, the OS-250can respond to as few as 3 drops of liquid. Liquids detectedinclude: nanopure H2O, normal saline, ETOH, MeOH, acetone, hexane, chloroform, decane, DMSO and others.Please call for details or visit our website and type“Spill Detection” in the search box.

Your most comprehensive source for Specialty Bioresearch Products.

For your FREE Bioresearch Catalog:

Call 800-272-2775 or visit us on the web at

www.harvardapparatus.com for your FREE copy

w w w . h a r v a r d a p p a r a t u s . c o mH A R VA R D A P PA R AT U S L A U N C H E S N E W W E B S I T E

PA G E 8




Contac t In format ion

1

3 4 5

7

98

10

13

11 12

6

2

15

18

2120

17

22

23

19

16

14

Across1. Increasing _______ will speed

up dialysis.

2. A group of geese in the air isa(n) _______.

6. The smallest dog is a(n) _______.

7. In Beer’s law A= _______.

8. The pig is the _______ smartestanimal.

12. The oldest breed of dog is _______.

13. The square root of 400 is _______.

14. Spin columns go in a(n) _______.

16. A giraffes _______ is 50 cm (20 in) long.

18. (C2H5)2O is the chemical forumlafor _______.

19. Canis latrans is the scientificname for an _______.

20. What you take when you cuff arats tail _______.

22. The animal with the largest eyesis an _______.

23. Movement of molecules thru semipermiable membrane is called _______.

Down1. C13C.CO2H

2. The fastest flying bird is the

spine-tailed _______.

3. A group of geese on the ground

is a(n) _______.

4. Elephants have _______ teeth.

5. _______ are the only animals

with flaps around their ears.

8. House flies live for _______ days.

9. A substance which yields readilyto any force which tends to alter itsshape is a(n) _______.

10. _______ is what you call changing

the liquid surrounding a cell.

11. An ostrich can run up to _______

km/h (43 mph).

12. A(n) _______ pump is the most

accurate and pulseless.

15. There are 6,000 _______ of reptiles.

17. Fish and insects have no _______.

21. pH of 1 represents an _______.

Harvard Apparatus S.A.R.L. – France

6 avenue des AndesMiniparc Bat. 891952 Les Ulis Cedex, France

Phone: (33) 1 64 46 00 85 Fax: (33) 1 64 46 94 38E-Mail: [email protected]

Hugo Sachs Elektronik – Germany

Harvard Apparatus GmbHGruenstrasse 1D-79232 March – Hugstetten, Germany

Phone: (49) 7665.9200.0 Fax: (49) 7665.9200.90E-Mail: [email protected]: www.hugo-sachs.de

Take-In Incorporated – Japan

Kyosu Bldg. 3-31-11 AmanumaSuginami,Tokyo 167-0032, Japan

Phone: 81.3.3597.1911 Fax: 81.3.5833.5596E-Mail: [email protected]

Harvard Apparatus – USA

84 October Hill Road Holliston, MA 01746, USA

Phone: 508.893.8999 Toll-Free: 800.272.2775 Fax: 508.429.5732E-Mail: [email protected] Web: www.harvardapparatus.com

Harvard Apparatus Ltd. – United Kingdom

Fircroft WayEdenbridge, Kent TN8 6HE, United Kingdom

Phone: (44) 1732 864001Fax: (44) 1732 863356E-Mail: [email protected]: www.harvardapparatus.co.uk

Harvard Apparatus – Canada

6010 Vanden AbeeleSaint-Laurent, Quebec H4S 1R9, Canada

Phone: 514.335.0792 Toll-Free: 800.361.1905 Fax: 514.335.3482Toll-Free Fax: 800.335.0792 E-Mail: [email protected]: www.harvardapparatus.ca

For answers go to:

www.harvardapparatus .com

Documents

Bio Breakthroughs - Harvard Apparatus