BCAA a-KADH

New Node

G. synthase(-P) (RDS)allosteric (+)

4-epimerase

P/H+ CoT

Glyceral.3-P

F-2,6-BPase (P)

Citrate, AMP, F-6-P

GLUT-2

Glucose

Glucose

Glucose-6-P

P

Glucokinase

Fructose-6-P

Glc-6-P isomerase

F-1,6-BP

PPP

F-1,6-BPase

F-2,6-BP

F-2,6-BP, AMP

DHA-Ptriose isomerase

1,3-BPG

NADHGlyceral.3-P DH

3-PG

PG kinase

2,3-BPGATP

ATP

PG mutase

2-PG

PEP

Enolase

Pyruvate LactateLDH

Pyruvate

OAA

Acetyl-CoA

Citrate

Isocitrate

aconitase

a-KG

Succinyl-CoA

Succinate

Fumarate

Malate

citrate synthase

CO2

ATP

Acetyl-CoA, NADH, ATP, FA's

Arsenic, B1 def.

ATP, NADH, succinyl-CoA

ATP

Pyruvate kinase

NADH

Insulin

3 x NADH

1 x FADH2

1 x GTP isocitrate DH

CO2a-KG DH

malate DH

succinate DH

succinyl-CoA DH

NADH, succinyl-CoA, ATP, GTP

Malate OAA

NADH

Glucose-1-PPhosphoglucomutase

UDP-Glc

Glycogen Branching enzyme

Limit dextrinsdebranching enzyme

Glycogenin-(a-1,4)-Glc

Glycogenin

UTP

PPi

ATP

6-phosphoglucono-2-lactone

2 x NADPH

6-phosphogluconolactone

6-phosphogluconate DH

transald/ket's

Glc-6-P DH (RDS)

NADPH, Low [NADP+] lactonase

2 x NADP+

Glutathione reductase

GS-SG

2 GSH

Gt perox/cat.e

2 x H2O

H2O2

Acetyl-CoA

PCOOHase (Biotin)

GTP

PEPCK

P

Glc-6-Pase

Insulin, Citrate Malonyl-CoA

Citrate

Acetyl-CoA

citrate lyase

Ca2+, ADP, AMP, CoASH, PyruvatePDH(-P)

Biotin/B1(TPP/PPi)/B2(Riboflavin)/B3(Niacin)/B5(Pantoth.)/Lipoate

Aspartate

Transaminase (AST)

GLUT-3GLUT-1

GLUT-4

Ser

b2-R Glucagon-R

Epinephrine

GPCR

AC

cAMP

PKA

G.Phosphorylase kinase

G.Phosphorylase kinase (P)

P

PUDP

PFK-1

PKC

6-phosphogluconateRibulose-5-P

Ribose-5-P

Phosphopentose isomerasetransald/ket's

Galactose

Galactose-1-P

P

Galactokinasegalactose-1-P uridyl transferase

UDP-Gal

GLUT-5

Fructose

Fructose

Fructose-1-P

P

Fructokinase

Aldolase B

GlyceraldehydeATP

triose kinase

SorbitolNADH

sorbitol DHNADP+

aldose reductase

ATP

CoASH

NAD+

CO2

NADPH

Malic enzyme

ATP

CO2

Acetyl-CoA Carboxylase(-P)[inactive]

Acetyl-CoA Carboxylase, Biotin

Glucagon, Epinephrine,AMP, Palmitate

NADPHFatty Acid Synthase[Condense,Reduce,Dehydrate,Reduce]

CPT 1

CPT 2

Palmitate (16:0 C)

thiolase

cytosolic malate DH

"SREBP" ->

3 x Acetyl-CoA HMG-CoAHMG-CoA synthase

Mevalonate

Isoprene (5C)

Squalene (30C)

Cholesterol

cyclase enzymes

2 x NADPHHMG-CoA reductase

!! ATP

FA-CoA

Carnitine FA-Carnitine

CoASH

FA-CarnitineFatty-Acyl CoACoA

Carnitine

Carnitine:AcylcarnitineTranslocase

FA

CoAATP

Fatty acyl-CoA synthetase

FA(Short/Med Ch)

FA(Long Ch)

FATP/CD36

FA

"Beta Oxidation"1. DH

2. Hydratase

3. DH

4. Thiolase

repeat

FADH2

NADH

CoASHProprionyl-CoA

Odd-Chain FA?

Succinyl-CoA

[isomerase: 3,4cis -> 2,3trans]

unsat?[reductase: for conj dbl bonds]

FA-Albumin

FA(Very Long Ch)

peroxisomaldegradation

Alanine

Glycerol-3-P

Glycerol-3-P DH

GlycerolATP

glycerol kinase

cAMP-depkinaseP

PLC

DAG IP3

Ca2+

Ca2+/Calmodulin

phosphorylase kinase

G.phosphorylase "b"

Glycogen phosphorylase "a"(-P)

P

G.synthase [inactive]

Calmodulin-dep kinase

PFK-2

2 x Acetyl-CoA

Acetoacetyl-CoA

HMG-CoA [mitochondrial]

HMG-CoA Synthase (RDS)

HMG-CoA [cytosolic]

Acetoacetate

1 x Acetyl-CoAHMG-CoA lyase

D-b-hydroxybutyrate

NADH

D-b-hydroxybutyrate Acetoacetate

D-b-h.b. DH

D-b-hydroxybutyrate

Acetoacetate

Acetoacetyl-CoA

2 x Acetyl-CoA

CoASHThiolase

Succinyl-CoA

Succinate

CoASH

Succinyl-CoAce

Acetone

a-KG

Glutamate

ALT

AlaninePyruvate GDH

Glucose

Glutamate a-KG

ALTAmino Acida-Ketoacid

NH4+

OTC

Carbamoyl-P

Ornithine

Citrulline

Citrulline

Argininosuccinate

Arginine

Fumarate

argininosuccinase Urea

arginase

Aspartate

argininosuccinatesynthetase

NAGCPS 1

Urea

Met

SAM

ATP

SAM synthase

Homocysteine

Cysteine

THF, B12

Alanine

Tyr

Homogentistic acid

Fumaryl-acetoacetylhydroxylase

Phe

Phe hydroxylase, BH4

Fumarate

Homogentistic acidoxidase

IleTrp

isovaleryl-CoA

Leu

isobutyryl-CoA

Val

?

Glutamine

Glutamine Glutaminase

GDH2 x NH4+