The Functional Genomics Center Zurich (FGCZ) is a joint research and training facility of the ETH Zurich and the University of Zurich. Biological systems at the level of tissues, organs, and increasingly single cells, are investigated via the identification and quantitation of nucleic acids, proteins, metabolites, and even chemical modifications of bio -mole cules. This is enabled by the use of high-end techno-logies that range from high-throughput or single molecule sequencing to multidimensional mass spectrometry.

Genomics I Proteomics I Metabolomics I Bioinformatics

The Functional Genomics Center Zurich (FGCZ) is a joint research and training facility of the ETH Zurich and the University of Zurich. Biological systems at the level of tissues, organs, and increasingly single cells, are investigated via the identification and quantitation of nucleic acids, proteins,

mole cules. This is enabled by the use of high-end techno-logies that range from high-throughput or single molecule

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Functional Genomics Center Zurich

ResearchTrainingEducation

Collaboration

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Whether an established, robust pipeline or a customized implementation of advanced models and algorithms – we run them all

Bioinformatics

Scan the QR code to see our large spectrum of bioinformatics applications

bioinformatics@fgcz.ethz.ch

At the FGCZ we provide the know-how and the resources to handle and evaluate the different types of Omics data. We transfer our knowledge to the user community in the form of courses and lectures as well as in direct collaborations with individual research groups.

We develop, run and maintain software for the management, processing, and statistical as well as functional analysis of Omics data. We provide bioinformatics support at three levels:– We grant our users access to software and provide support

in the analysis of the project specific data.– We offer training on general data analysis strategies and

teach their application using our software infrastructure.– We develop and implement algorithms for dedicated data

handling and data analysis, either as a general support effort that benefits all projects, or as specific support for individual user projects in a collaborative approach.

How to reach us

Support modes

There are three ways of interacting with the FGCZ: – Service: If you are planning to leverage some of the state-of-

the-art technologies at the FGCZ but you do not need physical access to our center (i.e. you will deliver or ship your samples), then you probably want to order a service for a fee.

– User Lab: Do you need access to the FGCZ labs to work on-site together with our team? Consult us about the User lab access mode and our support and training possibilities.

– Collaboration: In case you have new and challenging techniques or ideas that you would like to test or productively implement together with the FGCZ, please contact us for a discussion of collaboration options.

University of Zurich, Irchel CampusBuilding Y32, H FloorWinterthurerstrasse 1908057 Zürich

www.fgcz.ch

Fotos: zVg, Artur Marciniec, berya113, fotolia.com

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Benefit from the revolution of next generation sequencing technologies

Use the latest technologies and expertise to explore the complex world of proteins

Investigate metabolite and lipid profiles and determine molecular interactions

Applications of genomics and transcriptomics include the analysis of function and structure of well-annotated to newly characterised organisms, DNA modifications, gene expression, and many more. Next-generation sequencing (NGS) technologies enable us to tackle these applications faster and more precisely than ever before, revolutionizing research in biology and biomedicine. The FGCZ is strongly committed to continue its investments in cutting edge high throughput and single molecule sequencing technolo-gies including the accompanying bioinformatics and data analysis know-how and infrastructures.

The on-site availability of the latest generation of NGS allows to flexibly combine the different technologies within or between projects. Thus, opens up possibilities that ensure suitable analytical strategies tailored to the needs of a research project.

Proteomics aims to elucidate the entire content of proteins in cells, organs or organisms, including protein abundances, protein modifications and protein-protein interactions. Challenges arise from the overall protein content that differs between organs or cell types, and it changes over time and in response to physiological conditions. Specific proteins exist in multiple splice variants, vary in abundance, and almost all proteins carry post-translational modifications (PTMs). The rapid development of new instrumen-tation and data analysis tools have made mass spectrometry (MS)-based proteomics the currently best-suited technology to study complex molecular and cellular processes in cells and organisms.

Thanks to its state-of-the-art technologies, the FGCZ can support you at every step of analysis of your protein and proteome sample.

Metabolomics and lipidomics investigate the composition and the dynamics of metabolites and lipids in relation to genetic differences and environmental conditions. At the FGCZ a set of mass spectrometry-based standard protocols enable the broad coverage of metabolites and lipids in a wide range of biological samples. Classification based on profiles, search for biomarkers or the quantification of selected compounds can be supported.

Biophysics at the FGCZ uses advanced physical methods and principles to study biological systems at the molecular level down to single molecules. Applying a range of technologies from surface plasmon resonance (SPR) to single-molecule real-time technology (SMRT), enables us to determine molecular interactions and perform kinetics studies of a large variety of biomolecules.

Proteomics and protein analysis applications Metabolomics, Lipidomics and Biophysics applications

Scan the QR code to see our large spectrum of proteomics and protein analysis applications.

Scan the QR code to see our large spectrumof metabolomicsand biophysics applications

metabolomics@fgcz.ethz.chproteomics@fgcz.ethz.ch

Genomics and Transcriptomics applications

Scan the QR code to see our large spectrum of genomics and transcriptomics applications

sequencing@fgcz.ethz.ch

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