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8/13/2019 Bioinformatics Oppertunity
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(insight in to the IT Companies)K.P.Mishra (Director, URC Allahabad )
Brijesh Singh Yadav(Senior Research Associate &Head Bioinformatics Research)United Research Center, UIT Campus Allahabad,
E-mail: [email protected]
Career in Bioinformatics
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What is Bioinformatics? Bioinformatics is the application of
computer technology and statistics to
the management of biological
information.
In the past decade bioinformatics has
become an integral component of
research and development in biologicalsciences.
The need for bioinformatics stems from
a fundamental change that is taking
place in biology.
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Bioinformatics Is aMerging of Disciplines
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Core of BioinformaticsTDQAAFDTNIVTLTRFVMEQGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVTEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLV
sequence 3D structure protein functions
Properties and evolution of genes, genomes, proteins, metabolicpathways in cells
Use of this knowledge for prediction, modelling, and design
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Need ofbioinformatics
Data growth is exponential
Difficult to understand life without BI
Detection of new diseases
BI tools allow to save expr. Expend.
Rational Drug design
Computer-aided vaccine design
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Need of bioinformatics
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Need of bioinformaticso t
Handle the
growth of
information.
Knowledgediscovery.
Globalizing
theresearch.
Data
visualizatio
n.
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Need of bioinformaticso t
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BIOINFORMATICSDEVELOPMENTS IN INDIA Department of Biotechnology created in 1986
Bioinformatics programme started ever since
Biotechnology Information System Network (BTISnet) in 1987.
BTISnet today has 65 institutions and universities. Emphasis on infrastructure creation and human resource
development.
Biotechnology in India has greatly benefited from the capacity
building in Bioinformatics Dedicated virtual private network connecting the major centres
sharing of data as well as computing resources.
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Bioinformatics Facilitiesin India
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Two forms of initiatives are in operationalTwo forms of initiatives are in operationalTwo forms of initiatives are in operational
Two forms of initiatives are in operational
Short-Term Training
Nationwide trainingsand workshops
Presently around 100organised per year in
seven defined areas
More than 10000trainedso far
Long-Term Training
Advanced DiplomaCoursesin five universities
M.Sc., M.Tech., Ph.D.courses
in Bioinformatics
Educational Activities ofIndia in Bioinformatics
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Integration ofBioinformaticsBiotechnology Collaborative effort
RFP (Request for Proposals) in
following areas: Parasitic diseases
Agro-biotech
Herbal medicine
BioPhara Development
Clinical Data management
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In-house softwaredevelopment1. GeneScan, GenEvolve, PROCOR
2. PLHOST
3. APSSP (Protein structureprediction), MHCBN
4. PCR: s/w for setting PCR reactions5. LOOPSEARCH, CONFPLOT
6. VirGen, CE, AVIS
7. Micro array analysis (Avadis),Genome annotation (Acuris),
Oligonucleotide probe design(Sarani)
8. BioSuite
JNU, DelhiIGIB, DelhiIMTECH, ChandigarhDevi Ahilya
UniversityBose Institute,
KolkattaUniversity of Pune,
Pune
Strand Genomics,BangaloreTCS, Hyderabad
These efforts needs to be strengthened withHuman resource development
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Bioinformatics Market
Global Bio-Informatics Market 1.2bn In 2004Overall Market Size Projected to reach USD 1.7 bnby 2006Indian Bioinformatics Market has touched USD22Million in 2004Indian Bioinformatics is growing at the rate of40% per annum
(Source: CII)
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Market share of differentSegments of Bioinformatics Genomic 50%
Proteomics 20%
Chemoinformatics 19% Pharmacogenomics 15%
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Advantages for India Strong IT capabilities
R & D strength in Modern biology
Highly trained manpower inbiotechnology and Bioinformatics
Rich Biodiversity
Diverse ethnic population
Strong Biotechnology Infrastructure Wide Networking of Institutions and
Scientists.
Industrial enterprise.
HHBIO
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The Role of IT inBioinformatics
1. Electronic Data Capture2. Data Mining3. Data Warehousing
4. Data Visualization5. Customized Software
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Indian IT Companies Indian IT companies such as Tata Consultancy
Services (TCS), Cognizant Technologies,Infosys, Wipro, and Satyam have already set up
their bioinformatics divisions.
TCS, for instance, is entering the bio-informaticsmarket with its indigenously developedcomputing platforms and applications within this
year. The company is nurturing a 40-memberteam that is working on developing bio-informatics software solutions.
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Indian IT CompaniesCont.. A database application, specially created for the
bioinformatics segment is in the pipeline. TCS is alsolooking at developing bio-informatics softwareapplications in collaboration with biotech and pharma
companies.
Satyam's Center of Excellence has identified Data
warehousing and Datamining as a key initiative area inthe field of bio-informatics since the field is an emergingdomain where data warehousing and dataminingtechniques and concepts are used extensively fordeciphering complex patterns and to correlate and
analyze the vast volumes of data generated.
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Indian Pharma Companies Pharmaceutical companies too, are making
moves into the bioinformatics arena. GVKBiosciences, Dr. Reddy's Laboratories, Biocon,
Astra Zeneca, Ranbaxy, Biological E, andNicholas Piramal are some of the names thathave either opted for the joint venture route orhave tied up with start-up companies.
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people required by aIndustries Computer Programmer, who develop
software tool and application for
biotechnology and life science
companies.A good Programmerhaving knowledge ofHTML, XMLSAS-CGICGI between web and
databaseBuild HTML page tointerfaceKnow DNA analysisprograms
Understand:Basic MolecularBiologyHow a networkworksHow databasesare structured
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People required by aIndustries cont.. People with a background in life sciences
who are the end user of such programs andpackages and they use these tools to
translate the information into tangibleproducts such as new molecules, drugs,enzymes etc.
They can conduct their R&D program moreeffectively if they are cross-trained in
computing skills. They can also be business analysts for life
science companies.
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Skills needed for the Desing of Experiments Using Bioinformatics
Systems
Administration/Networking
2%
General Computer Sciences
7%
Artificial Intelligence
3%Advanced algorithms
Data Structures
8%
Biochemistry
10%
Biophysics
6%
Structural Biology
7%
Genetics
11%
Molecular Biology
12%
Evolution
7%
Statistics
12%
Mathematics
6%
Computational Chemistry
6%
Software Engineer ing
3%
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What Is a Bioinformatics
Company Like? Consists of Biologists, Computer Scientists,Mathematicians and Marketing people.
Bioinformatics companies should expect
revenues in a few million dollars only. Only those companies who are able to adapt
and innovate will survive.
A great deal of competition exists in the field.
For any new company offering bioinformaticsservices or products, proof of concept, will beessential. This means that a nascent companywill need to demonstrate its ability beforegetting business.
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Areas of opportunity in India Bioinformatics
Vaccines, dignostics and therapeutics
Biomedical devices, instruments and
sensors Bioartificial organs using tissue
engineering and stem cells
Clinical trial and contract research
Agriculuture
disease and pest resistant,drought and salinity tolerant seeds and
plants
Biofertilisers and Biopesticides
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Job opportunities inBioinformatics Postgraduates and,Doctorates
Bachelordegrees / 3year diplomaholders 3) Degree
with one yearcourse incomputers
Qualification Experience Job Title
Formal Training andunderstanding marketrequirement ofBioinformatics
Sound knowledge inMolecular Biology andprogramming
Good typing speed,Knowledge in molecularBiology and computerapplication
Group leaders /Sr. Executives /Scientists/Faculties
System AnalystTechnical Asst./Programmer /
COs / DEOs
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Major Research Areas inBioinformaticsResearch Activities [%]
Gene Analysis
Prot. Struc. Pred.
Prot Design & Folding
Macr. Modelling
Evol. Biol.
Struc-Func Studies
Mech. of Dis.
Data Mining Stud
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Business Opportunities in BI Software development
Web servers development
Train manpower in Field of BI
Database management
Rational Drug design
Develop Diagnostic kits
Assist user in Vaccine development Consultant to Biotech Companies
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Outsourcing Model inTechnology BusinessesOutsourcing has developed as an
important concept in today'sbusiness.
1) Focus on core strength - theopportunity cost of adding a newsegment of services to an existing
business is high. Companies preferto not diverge from their focus on theircore competencies, and staycompetitive.
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Outsourcing cont. 5) Improve service delivery to
customersthe company can dictateto the outsourcing partner the
timelines it is required to meet. 6) Reduce cost and timethe time
spent otherwise on planning anddevelopment is saved and better
utilized to managing the existingresources.
7) Expand service portfoliocompanies can extend their serviceswithout having to invest on building inhouse capabilities
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Outsourcing Inspite of a tremendous increase in
demand, the US educational stream hasnot significantly increased the
production of scientific workforce. As a result cost of research has gone
higher.
Many companies are realizing that they
can get their research done abroad, atcheaper cost, without any compromisein quality.
In clinical trials for example, GSK
(Glaxo smith Kline) has announced thatit will shift 30% of its clinical trials to
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The Ultimate Goals of Bioinformatics is
to:Implement LaboratoryInformation Management
Systems
14%
Design experiments using
bioinformatics
9%
Provide training and
assistance in the use of
bioinformatics software
tools
10%
Use existing software for
bioinform atics analyses
10%
Discover new insights or
hypotheses in molecular
genetics or evolutionary
processes
10%Research new
technologies (algorithms,
principles, models,
databases) to ascertain
their potential for
bioinform atic analysis
11%
Develop software for
bioinformatics applications
12%
Implement web-interfaces
for bioinformatics
applications/data bases
12%
Create & maintain
laboratory research
databases
12%
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Bioinformatics Jobs searchengines Medzilla(Biotech,Medical,etc job listings)
BioSpace (job listings)
BioView (job listings)
Bio online Carrier Center Symbios Career Service
(Biotech,MedDevice,Pharm )
Genomics ,Bioinformatics and
Biocomputing Jumping pills Biotech jobs
NEE-HOW Bioresource Finder jobs
JobsScience
http://www.bhrc.ca/
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