bioinformatics semester 8th

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    Yashwantrao

    Chava

    n

    Maharashtra

    Open

    Univers

    ity

    M.Sc.

    inBio-Informatics

    SyllabuS

    Yashwantrao ChavanMaharashtra

    Open UniversityDnyangangotri, Near Gangapur Dam,

    Nashik 422 222, IndiaPhone: 0253-223!4, 223!5, 2234!3

    "a#: 2234!3$ 223!%&mai': s(te(h)y(mou*(om

    +esite: http:$$*y(mou*(om$

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    Contents .harts and /a'es *************************************************************************************************************3

    * io-In1o rmati(s Programme tru(ture .harts **************************************************************3

    *2 io-In1o rmati(s Programmes Detai' s ***************************************************************************4

    *3 ioin1ormati(s .ourse Detai' s **************************************************************************************4

    *4 .ourse Distriution .hart ********************************************************************************************52 y''aus ***************************************************************************************************************************%

    2* emester 0 ****************************************************************************************************************%

    200, .678* 9'' ights eser;ed*Price: Indian s 200$- or 8< 50$- on'y* "ree Don'oad o1 Internet =ersion*Last Update: aturday, >une 2!, 200?Printed By:Publisher: egistrar, .678, Nashik 422 222, India*

    Bio-Informatics Proramme Curriculum Pae 2of 14

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    ! Charts an" #ables

    !.! Bio-Informatics Proramme Structure Charts

    !.!.! $or O"" %umbere" SemestersMandatoryCS Month

    September October November ecember !anuary

    OddNumberedSemester

    Course 14 CP" #heory

    Course

    Course 24 CP" #heory

    Course

    Course $4 CP" #heory

    Course

    Course 44 CP" # heory

    Course

    Course %4 CP" Practical or

    Pro&ect'(or) Course

    0I0:

    asi( io'ogy

    I02:.ommuni(ation

    ki''s

    I03:6athemati(s

    I04:&n;ironmenta'

    (ien(e

    I05:@a, .ourse

    03

    I03:asi(

    io(hemistry

    I032:Genera'

    6i(ro,io'ogy-I

    I033:Physio'ogy

    I034:6eta,o'ism

    I035:@a, .ourse

    05I05:asi(s o1

    ioin1ormati(s

    I052:.omputer

    Programming-I

    I053:

    D6-I

    I054:Introdu(tion to

    6o'e(u'arGeneti(s

    I055:

    @a .ourse

    0!

    00!:.on(epts in

    .omputing andasi(s o1

    ioin1ormati(s

    I0!2:io'ogi(a'.hemistry

    I0!3:tatisti(a'/e(hniAues

    I0!4:tru(tura' io'ogy

    I0!5:@a .ourse

    0?I0?:

    io(hemistry o16etao'ism

    0?0?2:eAuen(e-asedioin1ormati(s

    9pproa(hes

    I0?3:Programming

    @anguages ando1tarte /oo's

    inioin1ormati(s-I

    I0?4:Programming

    @anguages ando1tarte /oo's inioin1ormati(s-II

    I0?5:@a .ourse

    !.!.& $or 'ven %umbere" Semesters

    MandatoryCS Month

    March *pril May !une !uly

    +venNumberedSemester

    Course 14 CP" #heory

    Course

    Course 24 CP" #heory

    Course

    Course $4 CP" #heory

    Course

    Course 44 CP" #heory

    Course

    Course %4 CP" Practical or

    Pro&ect'(or) Course

    02I02:

    asi( tatisti(sI022:

    asi( .hemistryI023:

    9pp'ied Physi(s

    I024:Programming

    .on(epts

    I025:@a, .ourse

    04I04:

    .e'' io'ogy-II042:

    asi( ios(ien(es

    I043:iophysi(a'

    /e(hniAues-I

    I044:6o'e(u'ar io'ogy-I

    I045:@a, .ourse

    0%

    I0%:.omputationa'

    6o'e(u'ario'ogy

    I0%2:.omputer

    Programming-II

    I0%3:D6-II

    I0%4:.e'' io'ogy,Geneti(s B

    Immuno'ogy

    I0%5@a .ourse

    0

    I0:Genomi(s

    Dataases and9pp'i(ations

    I02:Geneti(

    In1ormation"'o and

    Pro(essing

    I03:Programming in

    Per'

    I04:Protein tru(ture

    Predi(tion and6o'e(u'ar6ode'ing

    I05@a (ourse

    0I0:Geneti(

    &ngineering

    I02:Geneti(s and

    Genomi(s

    I03:Dataase

    6anagementystems

    I04:esear(h

    6ethodo'ogy

    I05ProCe(t

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    !.& Bio-Informatics Prorammes (etails

    SN Pro,ramme -or certi.ication" student must con.irm tospeci.ied certi.ication eli,ibility criteria and.oll o/in, courses spec i.i ed .or therespective pro,ramme must be success.ullycompleted

    Post'0raduate e,ree Pro,ramme

    6*(* io-In1ormati(sE 9'' 20 (ourses at semester 0! to 0

    0raduate e,ree Pro,ramme

    *(* io-In1ormati(sE 9'' 30 (ourses at semester 0 to 0%

    !.) Bioinformatics Course (etails

    .P: .redit Points

    ./: .ounse'ing ession /ime/: e'1-tudy /ime.at: .ourse .ategory 1rom the e'o:

    : asi( (ien(e em 0-02E

    D: Dis(ip'ine asi( em 03-04E D.: Dis(ip'ine .ore em 05-0%E

    .: pe(ia'iFation .ourses em 0!0E/ype: .ourse /ype 1rom the e'o: /: /heory

    P: Pra(ti(a' P: eminar or ProCe(t-+ork

    SN Semester Course

    Code Name CP CS# SS# Mar)s Cat #ype

    !

    I0 asi( io'ogy 4 40 20 00 /

    2 I02 .ommuni(ation ki'' 4 40 20 00 /

    3 I03 6athemati(s 4 40 20 00 /

    4 I04 &n;ironmenta' (ien(e 4 40 20 00 /

    5 I05 @a .ourse 4 0 20 00 P

    %

    &

    I02 asi( tatisti(s 4 40 20 00 /

    ! I022 asi( .hemistry 4 40 20 00 /

    I023 9pp'ied Physi(s 4 40 20 00 /

    ? I024 Programming .on(epts 4 40 20 00 /

    0 I025 @a .ourse 4 0 20 00 P

    )

    I03 asi( io(hemistry 4 40 20 00 D /

    2 I032 Genera' 6i(roio'ogy-I 4 40 20 00 D /

    3 I033 Physio'ogy 4 40 20 00 D /

    4 I034 6etao'ism 4 40 20 00 D /

    5 I035 @a .ourse 4 0 20 00 D P

    %

    *

    I04 .e'' io'ogy-I 4 40 20 00 D /

    ! I042 asi( ios(ien(es 4 40 20 00 D /

    I043 iophysi(a' /e(hniAues-I 4 40 20 00 D /

    ? I044 6o'e(u'ar io'ogy-I 4 40 20 00 D /20 I045 @a .ourse 4 0 20 00 D P

    2

    +

    I05 asi(s o1 ioin1ormati(s 4 40 20 00 D. /

    22 I052 .omputer Programming - I 4 40 20 00 D. /

    23 I053 D6 - I 4 40 20 00 D. /

    24 I054 Introdu(tion to 6o'e(u'ar Geneti(s 4 40 20 00 D. /

    25 I055 @a .ourse 4 0 20 00 D. P

    2% , I0% .omputationa' 6o'e(u'ar io'ogy 4 40 20 00 D. /2! I0%2 .omputer Programming - II 4 40 20 00 D. /

    2 I0%3 D6 - II 4 40 20 00 D. /

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    SN Semester Course

    Code Name CP CS# SS# Mar)s Cat #ype

    2? I0%4 .e'' io'ogy, Geneti(s BImmuno'ogy

    4 40 20 00 D. /

    30 I0%5 @a .ourse 4 0 20 00 D. P

    2%

    00! .on(epts in .omputing and asi(s

    o1 ioin1ormati(s

    4 40 20 00 . /

    2! I0!2 io'ogi(a' .hemistry 4 40 20 00 . /

    2 I0!3 tatisti(a' /e(hniAues 4 40 20 00 . /

    2? I0!4 tru(tura' io'ogy 4 40 20 00 . /

    30 I0!5 @a .ourse 4 0 20 00 . P

    2%

    I0 Genomi(s Dataases B 9pp'i(ations 4 40 20 00 . /

    2! I02 Geneti( In1ormation "'o andPro(essing

    4 40 20 00 . /

    2 I03 Programming in Per' 4 40 20 00 . /

    2? I04 Protein tru(ture Predi(tion B6o'e(u'ar 6ode''ing

    4 40 20 00 . /

    30 I05 @a .ourse 4 0 20 00 . P

    2%

    /

    I0? io(hemistry o1 6etao'ism 4 40 20 00 . /

    2! 0?0?2 eAuen(e-ased ioin1ormati(s9pproa(hes

    4 40 20 00 . /

    2 I0?3 Programming @anguages ando1tarte /oo's in ioin1ormati(s-I

    4 40 20 00 . /

    2? I0?4 Programming @anguages ando1tarte /oo's in ioin1ormati(s-II

    4 40 20 00 . /

    30 I0?5 @a .ourse 4 0 20 00 . P

    2%

    !0

    I0 Geneti( &ngineering 4 40 20 00 . /

    2! I02 Geneti(s and Genomi(s 4 40 20 00 . /

    2 I03 Dataase 6nagement ystems 4 40 20 00 . /

    2? I04 esear(h 6ethodo'ogy 4 40 20 00 . /

    30 I05 ProCe(t 4 0 20 00 . P

    !.* Course (istribution Chart

    !.*.! 1s per Course Cateory

    SN Course Cate,ory No o.Courses

    CreditPoints

    o. CreditPoints

    Counselin,ours

    o.Counselin,

    ours

    : asi( (ien(e 0 40 20H 40 20H

    2 D: Dis(ip'ine asi( 0 40 20H 40 20H

    3 D.: Dis(ip'ine .ore 0 40 20H 40 20H

    4 .: pe(ia'iFation .ourses 20 0 40H ?%0 40H

    % #otal %3 233 133 2433 133

    !.*.& 1s per Course #ype

    SN Course #ype No o.Courses

    CreditPoints

    o. CreditPoints

    Counselin,ours

    o.Counselin,

    ours

    /: /heoreti(a' 40 %0 0H %00 %!H

    2 : ki'' ased P and P+E 0 40 20H 00 33H

    $ #otal %3 233 133 2433 133

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    & Syllabus

    &.! Semester 0

    &.!.! SBI0!

    Code Course Name Pro, Sem CP CS# SS# Mar)s #ype Cat

    I0 Genomi(s Dataases B 9pp'i(ations I 4 40 20 00 / .

    Course Prereuisites:

    asi( kno'edge aout io'ogi(a'dataases

    Course Ob&ectives: 91ter su((ess1u' (omp'etion o1 this(ourse, student shou'd e a'e to

    8nderstand the ro'e o1 ioin1ormati(s in thegenome seAuen(ing, assem'y, annotation andpost genomi( ana'yses 1or gene identi1i(ation,s tru(tura ' and 1un(t iona ' e 'u(idation o 1genomes, drug target identi1i(ation et(*

    5emar)s6

    UN Name o. Unit CP CS# +valuation Pattern rosing Genomi( esour(es 0

    9 B @9 in &nd amE and 5 6.sin e'1-/estE i'' e asked on these units*

    2 Data 6ining /oo's 2 0 9 B @9 in &nd amE and 5 6.sin e'1-/estE i'' e asked on these units*

    3 @inking Genotype to Phenotype 3 0 9 B @9 in &nd amE and 5 6.sin e'1-/estE i'' e asked on these units*

    4 9pp'i(ations o1 Genome Data 4 0 9 B @9 in &nd amE and 5 6.sin e'1-/estE i'' e asked on these units*

    UN etai l Sy llabus o. the Un it

    Bro/sin, 0enomic 5esources6

    Genome 9ssem'y o;er;ie

    e'ated data resour(es &/, /, G, E et(*

    Genomi( dataases at &I and N.I

    Genomi( dataases 1or human, mouse, yeast and other mode' organisms

    Genomi( dataases 1or p'ant, mi(roia', parasite and ;ira' genomes

    .ha''enges in de;e'opment o1 genomi( dataases B resour(es

    2 ata Minin, #ools6

    asi( 9spe(ts o1 Genome 9nnotation

    rosing genomi( data using &nsem' &IE and 6ap =ieer N.IE

    Predi(tion o1 7"s and GenesJ Gene 6ode'ing,

    Gene predi(tion a'gorithms 1or prokaryotes B eukaryotes

    Predi(tion o1 igna' seAuen(es Promoters, Primers, sp'i(e sites, 8/s et(*E, 7perons

    3 Lin)in, 0enotype to Phenotype6

    uman B mouse genome: 76I6 dataase

    Identi1i(ation o1 Disease Genes

    @inking human genome data, 76I6 dataase and NP dataases

    uerying genomi( data 1or ;arious diseases

    Identi1i(ation o1 homo'ogous genes: 7rtho'ogs B Para'ogs

    @inking genomi( data in the (onte#t o1 metao'i( pathays

    4 *pplications o. 0enome ata6

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    Genome ased drug design

    Genome ased ;a((ine design

    6i(roarray ana'ysis B too's

    Proteomi(s ana'ysis B too's

    tru(tura' genomi(s

    "un(tiona' genomi(s

    Boo) Code #it le"*uthor"8SBN o. Ori,inal +dition

    etails o.Chapters and Sections8ncluded in Syllabus

    +dition9ear

    Publisher"Price"Order 8t ere

    #e:t Boo)s

    I0-/ Prin(ip'es o1 Genome9na'ysis 9nd Genomi(s 3rd&d*E y Primrose, ** B/yman, *6*

    In('uded:

    ('uded:'a(ke' ' Pu'ish ing

    .ompany, 2003*

    I0-/2 /he Genome

    am * =erma

    IN -5%0-043-2*

    =.

    5e.erence Boo)s

    I0- Genome mapping andseAuen(ing y IanDunham,

    oriFon, IN-

    ?4%-50-%*

    Bio-Informatics Proramme Curriculum Pae ;of 14

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    &.!.& SBI0&

    Code Course Name Pro, Sem CP CS# SS# Mar)s #ype Cat

    I02 Geneti ( In1ormation "'o andPro(essing

    I 4 40 20 00 / .

    Course Prereuisites: Kno'edge o1 geneti( materia' in

    prokaryotes and eukaryotes

    Course Ob&ectives: 91ter su((ess1u' (omp'etion o1 this(ourse, student shou'd e a'e to

    8nderstand (on(epts in gene organiFation,trans(ription, trans'ation and gene regu'ation

    9ppre(iate iote(hno'ogi(a' imp'i(ations o1re(ent de;e'opments in ('oning and genomeseAuen(ing

    5emar)s6

    UN Name o. Unit CP CS# +valuation Pattern

    Gene pression 0

    9 B @9 in &nd amE and 5 6.sin e'1-/estE i'' e asked on these units*

    2 Genes and &nFymes2 0

    9 B @9 in &nd amE and 5 6.sin e'1-/estE i'' e asked on these units*

    3 Genes N9 and Proteins3 0

    9 B @9 in &nd amE and 5 6.sin e'1-/estE i'' e asked on these units*

    4 Gene pression and 6ethods o19na'ysis

    4 0 9 B @9 in &nd amE and 5 6.sin e'1-/estE i'' e asked on these units*

    UN etail Syllabus o. the Unit

    0ene +:pression6Prokaryoti( gene e#pression, operons positi;e B negati;e regu'ation, sigma1a(tors* Initiation, e'ongation and termination o1 trans(ription temp'ate B enFyme properties

    2 0enes and +n

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    &.!.) SBI0)

    Code Course Name Pro, Sem CP CS# SS# Mar)s #ype Cat

    I03 Programming in Per' I 4 40 20 00 / .

    Course Prereuisites:

    Kno'edge o 1 I052, I053,I0%2

    Course Ob&ectives: 91ter su((ess1u' (omp'etion o1 this

    (ourse, student shou'd e a'e to 8nderstand organisation o1 io'ogi(a' data in

    dataases and parse data 1or pro(essing

    5emar)s6

    UN Name o. Unit CP CS# +valuation Pattern

    Per' Introdu(tion B Data /ypes 0 9 B @9 in &nd amE and 5 6.sin e'1-/estE i'' e asked on these units*

    2 .ontro' tru(tures B egu'ar

    pressions2 0

    9 B @9 in &nd amE and 5 6.sin e'1-/estE i'' e asked on these units*

    3 "ormats 3 0 9 B @9 in &nd amE and 5 6.sin e'1-/estE i'' e asked on these units*

    4 ystem, Netork B D6 using Per' 4 0 9 B @9 in &nd amE and 5 6.s

    in e'1-/estE i'' e asked on these units*

    UN etail Syllabus o. the Unit

    Perl 8ntroduction > ata #ypes6

    Introdu(tion B 7;er;ie:

    +hat is Per'M +hy use Per' in ioin1ormati(sM istory o1 Per', 9;ai'ai'ity, upport, asi(

    .on(epts

    (a'ar Data: +hat Is (a'ar DataM, Numers, trings, (a'ar 7perators, (a'ar =aria'es, (a'ar

    7perators and "un(tions

    9rrays and @ist Data: +hat Is a @ist or 9rrayM @itera' epresentation, =aria'es, 9rray 7perators

    and "un(tions, (a'ar and @ist .onte#t

    2 Control Structures > 5e,ular +:pressions6

    .ontro' tru(tures: tatement 'o(ks

    ashes: +hat Is a ashM ash =aria'es, @itera' epresentation o1 a ash, ash "un(tions, ash

    'i(es* asi( I$7

    egu'ar pressions: .on(epts 9out egu'ar pressions, imp'e 8ses o1 egu'ar pressions,

    Patterns, 6ore on t he 6at(hing 7perator, ustitutions, /he sp'it and Coin "un(tions

    uroutines: ystem and 8ser "un(tions, /he 'o(a' 7perator, =aria'e-'ength Parameter @ists,

    Notes on @e#i(a' =aria'es

    6is(e''aneous .ontro' tru(tures:

    "i'ehand'es and "i'e /ests: +hat Is a "i'ehand'eM 7pening and .'osing a "i'ehand'e, 8sing

    Pathnames and "i'enames, 9 'ight Di;ersion: die, 8sing "i'ehand'es, /he -# "i'e /ests, /he stat

    "un(tion

    3 -ormats6

    +hat Is a "ormatM De1ining a "ormat, In;oking a "ormat

    Dire(tory 9((ess: 6o;ing 9round the Dire(tory /ree, G'oing, Dire(tory and'es, 7pening and

    .'osing a Dire(tory and'e, eading a Dire(tory and'e

    "i'e and Dire(tory 6anipu'ation

    Pro(ess 6anagement: 8sing system and e#e(, 8sing a(kAuotes,

    7ther Data /rans1ormation: "inding a ustring, tra(ting and ep'a(ing a ustring

    "ormatting Data: orting, /rans'iteration

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    4 System" Net/or) > BM usin, Perl6

    ystem In1ormation: Getting 8ser and 6a(hine In1ormation, Pa(king and 8npa(king inary Data

    Getting Netork In1ormation

    Dataase 6anipu'ation: D6 Dataases and D6 ashes, 7pening and .'osing D6 ashes,

    "i#ed-@ength andom-9((ess Dataases, =aria'e-@ength /e#tE Dataases, +in32 Dataase

    Inter1a(es

    .GI Programming: /he .GI*pm 6odu'e, our .GI Program in .onte#t, imp'est .GI Program,Passing Parameters ;ia .GI, Per' and the +e

    7Ce(t oriented per': Introdu(tion to modu'es, .reating 7Ce(ts

    ioper': Introdu(tion, Insta''ation pro(edures, 9r(hite(ture, 8ses o1 ioper'

    Boo) Code #it le"*uthor"8SBN o. Ori,inal +dition

    etails o.Chapters and Sections8ncluded in Syllabus

    +dition9ear

    Publisher"Price"Order 8t ere

    #e:t Boo)s

    I03-/ eginning Per' 1or

    ioin1ormati(s

    >ames /isda'',

    In('uded:

    ('uded:

    7-ei''y

    I03-/2 De;e'oping ioin1ormati(s.omputer ki''s

    .ynthia Gias, Per

    >ame(k,

    7-ei''y

    I03-/3 Programming the Per' DI

    9'' igator Des(artes, / im

    un(e,

    7-ei''y

    5e.erence Boo)s

    I03- 9d;an(ed Per' Programming

    riram rini;asan

    7-ei''y

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    &.!.* SBI0*

    Code Course Name Pro, Sem CP CS# SS# Mar)s #ype Cat

    I04 Protein t ru(ture Pred i(t ion B

    6o'e(u'ar 6ode'ing

    I 4 40 20 00 / .

    Course Prereuisites:

    Kno'edge o1 I05, I0! BI0!4

    Course Ob&ectives: 91ter su((ess1u' (omp'etion o1 this(ourse, student shou'd e a'e to

    8nderstand ing the ' e;e 's o1 st ru(tureorganiFation o1 ma(romo'e(u'es and re'atedmethods o1 stru(ture determination

    8nderstand and use ;arious methods o1 2D and3D stru(ture predi(tion

    8nderstand t he inte ra(tion eteenma(romo'e(u'es

    5emar)s6

    UN Name o. Unit CP CS# +valuation Pattern

    Protein Puri.ication 0

    9 B @9 in &nd amE and 5 6.sin e'1-/estE i'' e asked on these units*

    2 @ua litative and @uanti tative+valuation o. Protein

    2 0 9 B @9 in &nd amE and 5 6.sin e'1-/estE i'' e asked on these units*

    3 +:plorin, proteins3 0

    9 B @9 in &nd amE and 5 6.sin e'1-/estE i'' e asked on these units*

    4 Prediction o. Protein Structure4 0

    9 B @9 in &nd amE and 5 6.sin e'1-/estE i'' e asked on these units*

    UN etail Syllabus o. the Unit

    Protein Puri.ication6

    asi(s o1 protein puri1i(ation, di11erentia' (entri1ugation, sa'ting out, dia'ysis, ge' 1i'tration and

    ion e#(hange (hromatography, a11inity (hromatography, P@., ge' e'e(trophoresis, isoe'e(tri(

    1o(using, to dimensiona' e'e(trophoresis*

    2 @ualitative and @uantitative +valuation o. Protein6

    8'tra(entri1ugation, 6ass spe(tros(opy 69@/DI-/7", peptide mass 1 ingerprinting, eman

    degradation, protein seAuen(ing, automated soi'd phase peptide synthesis, N6r spe(tros(opy*

    3 +:plorin, proteins6

    Dataases:, ND B ..D

    .a'(u'ation o1 (on1ormationa' energy 1or io-ma(romo'e(u'es

    6o'e(u'ar 6e(hani(s B 6o'e(u'ar Dynami(s o1 7'igopeptides, Proteins, Nu('eotides and sma''

    6o'e(u'es

    6e(hani(s and dynami(s o1 io-ma(romo'e(u'es

    imu'ation o1 mo'e(u'ar me(hani(s and dynami(s

    imu'ations o1 "ree &nergy (hanges

    "or(e 1ie'ds

    6o'e(u'ar intera(tions o1

    Protein Protein

    Protein DN9

    Protein (arohydrate

    DN9 sma'' mo'e(u'es et(*

    4 Prediction o. Protein Structure6

    Predi(tion o1 e(ondary tru(ture using .hou B "asman, G7 series, PD, P6 et(*

    Bio-Informatics Proramme Curriculum Pae 11of 14

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    6etaser;ers

    /ertiary stru(tures o1 Proteins using homo'ogy mode'ing

    &;a'uation o1 stru(ture using Pro(he(k, ProsaII et(*

    Dataases B ser;ers 1or mode'ing

    9pproa(hes ased on Neura'J netorks, geneti( a'gorithms B ma(hine 'earning methods

    "o'd re(ognition, threading

    6ethods to predi(t three dimensiona' stru(tures o1 nu('ei( a(ids, rN9

    .9P, ."9P e#periments

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    I04-/ Proteins: tru(ture 9nd

    6o'e(u'ar Properties

    .reighton, /*&*

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    Ne ork* +* *"reeman and .ompany,??3*

    I04-/2 Protein "o'ding,*

    .reighton,/*

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    I04-/3 Protein stru(ture

    p red i(t ion: a pra(t i(a'

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    I04-/4 6o'e(u'ar mode''ing:

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    Bio-Informatics Proramme Curriculum Pae 12of 14

  • 8/10/2019 bioinformatics semester 8th

    13/14

    &.!.+ SBI0+

    Code Course Name Pro, Sem CP CS# SS# Mar)s #ype Cat

    I05 @a* .ourse I 4 0 20 00 P .

    Course Prereuisites:

    Kno'edge o1 'ist a'' 4 (ourses in thissem

    Course Ob&ectives: 91ter su((ess1u' (omp'etion o1 this

    (ourse, student shou'd e a'e to Per1orm pra(t i(a' re'ated to Genomi(

    dataases, tru(tura' ioin1ormati(s, GI"P andPer'*

    Special Note:tudy .enters shou'd (ondu(t any 23 activitiesout o1 tota' 24 a(ti;ities gi;en in the'ist* tudents are e#pe(ted to per1orm a'' a(ti;ities mentioned in ea(h e#periment and maintain the up-to-date Courna' and get (erti1ied 1rom the 'a instru(tor*

    UN etail Syllabus o. the Unit

    rosing Genomi( dataases using 6ap=ieer B ensem', ;ieing geneti(, 'inkage maps 1or

    human and other mode' organisms*

    2 rosing uman genome data, 76I6, NP dataases to understand geneti( and metao'i(

    disorders at 'east 2 ea(h

    3 rosing genomi( resour(es 1or p'ant, yeast genomes

    4 rosing resour(es 1or mi(roia' and ;ira' genomes

    5 6ining genomi( data to identi1y genomi( 1eatures: (odon usage, repeats, re;ersa's,

    omo'ogous regions, operon stru(tures, synteni( regions, horiFonta' gene trans1er

    % Gene predi(tion a'gorithms 1or Prokaryotes at 'east 2E

    ! Gene predi(tion a'gorithms 1or &ukaryotes at 'east 2E

    tru(tura' dataases: re;ise pd, nd, ((sd,

    ? &;a'uation o1 3D stru(ture o1 proteins:

    Pro(he(k, ama(handran p'ot, ProsaII p'ot

    0 p'ore: Deri;ed dataases o1 stru(tures: DP, "P, .9/ B .7P

    Predi(tion o1 se(ondary stru(tures o1 proteins: at 'east 3 methods 1or 3 proteins

    2 Predi(tion o1 /ertiary stru(ture 1o proteins: iss6ode' and 6ode''er

    3 p'oring metaser;ers 1or 2D and 3D stru(ture predi(tion

    .a'(u'ation o1 6.. B rmsd

    4 Identi1ying 1o'd o1 proteins

    8se o1 threading ser;ers: Phyre et(

    5 &nergy minimisation B geometry optimiFation 1or proteins B peptides

    % 8sing ser;ers 1or 1un(tion annotations: &;o'utionary tra(e method et(*

    ! Per' assignments: !-24

    "inding restri(tion ites in gi;en nu('eotide seAuen(e

    "inding GI numer 1or a Gi;en 9((ession Numer

    ? "inding restri(tion ites in gi;en nu('eotide seAuen(e

    20 eading "eature ta'e and e#tra(tion o1 seAuen(e position and 1eature in1ormation 1or

    ioma(romo'e(u'es*

    2 .on;ersion o1 seAuen(e 1ormats

    22 Parsing PD 1i'e to popu'ate ta'es in a dataase

    23 "inding 6o'e(u'ar eight gi;en the 6o'e(u'ar 1ormu'ae* : .%27%

    24 6aking Phy'ogeneti( tree o1 gi;en seAuen(es y using .'usta'+ and P@IP

    Bio-Informatics Proramme Curriculum Pae 1$of 14

  • 8/10/2019 bioinformatics semester 8th

    14/14

    Boo) Code #it le"*uthor"8SBN o. Ori,inal +dition

    etails o.Chapters and Sections8ncluded in Syllabus

    +dition9ear

    Publisher"Price"Order 8t ere

    #e:t Boo)s

    I05-/ ioin1ormati(s9 eginners Guide

    .'a;erie, Notredame

    In('uded:

    ('uded:

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    I05-/2 Programming the Per' DIy 9''igator Des(artes, /imun(e,

    7-ei''y*

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    I05- ioin1ormati(s.**=* 6ur thy

    ima'aya Pu'ish ingouse

    Bio-Informatics Proramme Curriculum Pae 14of 14