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BIOL 300

Pathophysiology

Christopher Westerkamp,

Ph.D.

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We are here on earth to fart around.Don't let anyone tell you anydifferent.

Kurt Vonnegut

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2005 leading causes of

Diseases of heart

Malignant neoplasms Cerebrovascular diseases

Chronic lower respiratory diseases

Accidents

Diabetes mellitus

Alzheimers disease

Influenza and pneumonia Kidney disease

Se ticemia

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Obesity Trends* Among U.S. AdultsBRFSS, 1985

(*BMI 30, or ~ 30 lbs. overweight for 5 4 person)

No Data

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Obesity Trends* Among U.S. AdultsBRFSS, 1986

(*BMI 30, or ~ 30 lbs. overweight for 5 4 person)

No Data

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Obesity Trends* Among U.S. AdultsBRFSS, 1987

(*BMI 30, or ~ 30 lbs. overweight for 5 4

person)

No Data

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Obesity Trends* Among U.S. AdultsBRFSS, 1988

(*BMI 30, or ~ 30 lbs. overweight for 5 4 person)

No Data

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Obesity Trends* Among U.S. AdultsBRFSS, 1989

(*BMI 30, or ~ 30 lbs. overweight for 5 4 person)

No Data

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Obesity Trends* Among U.S. AdultsBRFSS, 1990

(*BMI 30, or ~ 30 lbs. overweight for 5 4 person)

No Data

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Obesity Trends* Among U.S. AdultsBRFSS, 1991

(*BMI 30, or ~ 30 lbs. overweight for 5 4 person)

No Data

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Obesity Trends* Among U.S. AdultsBRFSS, 1992

(*BMI 30, or ~ 30 lbs. overweight for 5 4 person)

No Data

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Obesity Trends* Among U.S. AdultsBRFSS, 1993

(*BMI 30, or ~ 30 lbs. overweight for 5 4 person)

No Data

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Obesity Trends* Among U.S. AdultsBRFSS, 1994

(*BMI 30, or ~ 30 lbs. overweight for 5 4 person)

No Data

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Obesity Trends* Among U.S. AdultsBRFSS, 1995

(*BMI 30, or ~ 30 lbs. overweight for 5 4 person)

No Data

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Obesity Trends* Among U.S. AdultsBRFSS, 1997

(*BMI 30, or ~ 30 lbs. overweight for 5 4 person)

No Data

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Obesity Trends* Among U.S. AdultsBRFSS, 1998

(*BMI 30, or ~ 30 lbs. overweight for 5 4 person)

No Data

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Obesity Trends* Among U.S. AdultsBRFSS, 1999

(*BMI 30, or ~ 30 lbs. overweight for 5 4 person)

No Data

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Obesity Trends* Among U.S. AdultsBRFSS, 2000

(*BMI 30, or ~ 30 lbs. overweight for 5 4 person)

No Data

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Obesity Trends* Among U.S. AdultsBRFSS, 2001

(*BMI 30, or ~ 30 lbs. overweight for 5 4 person)

No Data

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(*BMI 30, or ~ 30 lbs. overweight for 5 4 person)

Obesity Trends* Among U.S. AdultsBRFSS, 2002

No Data

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Obesity Trends* Among U.S. AdultsBRFSS, 2003

(*BMI 30, or ~ 30 lbs. overweight for 5 4 person)

No Data

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Obesity Trends* Among U.S. AdultsBRFSS, 2004

(*BMI 30, or ~ 30 lbs. overweight for 5 4 person)

No Data

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Obesity Trends* Among U.S. AdultsBRFSS, 2005

(*BMI 30, or ~ 30 lbs. overweight for 5 4 person)

No Data

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Obesity Trends* Among U.S. AdultsBRFSS, 2006

(*BMI 30, or ~ 30 lbs. overweight for 5 4 person)

No Data

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CV Disease Prevalence

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Pathology

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Pathology

Investigation of structural

alterations in cells, tissues,and organs used to identifydisease

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Pathology

Investigation of structural

alterations in cells, tissues,and organs used to identifydisease

Patho h siolo

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Pathology

Study of the traits, causes,

and effects of disease Pathophysiology

Study of the underlyingchanges in functionresultin from disease or

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Etiology

Study of disease causation

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Etiology

Study of disease causation

Also used to refer to causeof disease

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Etiology

Study of disease causation

Also used to refer to causeof disease

Idiopathic no knowncause

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Etiology

Study of disease causation

Also used to refer to causeof disease

Idiopathic no knowncause

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3 categories of etiology

Genetic

Congenitalacquired

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Pathogenesis

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Pathogenesis

Pattern of development of a

disease

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Pathogenesis

Cell dysfunction > tissuedysfunction > organ

dysfunction

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Pathogenesis

What are the biochemicalchanges in an injured cell?

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Pathogenesis

What distinguishes reversiblefrom irreversible damage?

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Clinical Manifestations

Signs and symptoms of adisease

Signs

Symptoms

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Clinical Manifestations

Signs and symptoms of adisease

Signs: objective alterationsthat can be observed andmeasured

Symptoms: subjectiveexperiences reported by a

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What is a disease?

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What is a disease?

What is normal?

How do we define normal?

How do we define disease?

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Molly is a 75 year old womanwho lives alone. For 2 days,

she had a fever and chills andstayed mostly in bed. Onrising to go to the bathroom,she felt dizzy, fainted and fellto the floor.

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Molly is a 75 year old womanwho lives alone. For 2 days,

she had a fever and chills andstayed mostly in bed. Onrising to go to the bathroom,she felt dizzy, fainted and fellto the floor.

Orthostatic hypotension

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What would be the normalresponse of blood pressure tostanding?

What happened to her heart

rate before fainting? Why didshe faint?

How did fainting and fallinghelp establish homeostasis?