Bios Life Slim - Doctors Packet

www.unicity.net 1201 North 800 East Orem, Utah 84097 P: 801.226.2600 F: 801.714.1100

As Chairman and CEO of Unicity International, the Bios Life Company, I am delighted you are researching our company and our business opportunity. Bios Life gives you and your patients a safe and natural treatment option for obesity, diabetes, and cardiovascular disease that you will not find anywhere else. You can incorporate it into your office practice, or conduct it as a separate home based business. At Unicity we are well aware of the importance of having excellent clinical trials based on sound research protocols for any product recommendations that you might offer to your patients. I am confident you will find the research that stands behind our Bios Life products quite compelling. I look forward to you joining the thousands of medical professionals recommending our products that are making life better for hundreds of thousands of people around the world. Best Regards,

Stewart F. Hughes Chairman and CEO

INGREDIENTS NUTRIENTS AMOUNTPER SERVING

MECHANISMOF ACTION

BiosphereFiber™

Unicity 7X™

Bios CardioMatrix™

Phytosterols

Policosanol

ChrysanthemumMorifolium

Bios VitaminComplex™

Guar GumGum ArabicLocust BeanCitrus PectinOat FiberMaltodextrinBeta Glucans

4 grams A patented blend of 5 highly soluble fibers combined with mineral carbonate that quickly forms a fiber matrix in the digestive tract. -Reduces appetite and absorption of fat-Glucose is moderated by delayed absorptionand decreased glycemic index ofcarbohydrates allowing for fat burning.-Bile acid is sequestered and decreases cholesterol levels.-Beta Glucans are a key factor in immune health.

Proprietary blend of plantderived polysaccharides

Flavor - Orange juice powderwith Citric acid and sucralose

Helps restore the brains sensitivity to Leptin*This decreases appetite and cravings andincreases metabolism which is key to FAT LOSS

*Leptin is a hormone produced by fat cells which helps regulate appetite and metabolism. On average lowers LDL 31%, raises HDL 29% andlowers triglycerides 40%. Lowering LDL facilitates fat burning.

Soy Bean ExtractSunflower Extract

Sugar Cane Extract

Chrysanthemum Extract

Beta CaroteneVitamin C (ascorbic acid)Vitamin E (d-alpha-tocopheryl)

1 gram per serving*

6 mg

12.5 mg

Blocks food-based cholesterol from being absorbed into the bloodstream by blocking the cholesterol transport mechanisms in the intestinal tract.

*Foods containing at least .65g per dose of phytosterols (plant sterol esters), taken twice a day with meals for a total daily intake of 1.3g may reduce the risk of heart disease associated with high cholesterol levels and are recommended by the NCEP guidelinesLowers LDL by inhibiting HMG-CoA reductase without the unwanted side effects of statin medications.Reduces LDL oxidation and platelet aggregation.Activates an enzyme called 7-alpha hydroxylase that removes LDL cholesterol and converts it into bile acids.

750 IU 15%45 mg 75%20 IU 67%

Antioxidants that help prevent Lipid and LDL oxidation and strengthen the immune system

Chromium polynicotinate 100 mcg 84%

60 mg 6%

2.33 mg 16%3 mcg 5%

Enhances effectiveness of insulin--reduces blood glucose levels

Calcium Carbonate Provides for gel like matrix formation in the digestive tract which delays absorption of food, especially carbohydrates.

Vitamin B complex B1 Thiamin B2 Riboflavin B3 Niacin B6 Pyridoxine B7 Biotin B9 Folate B12 Cyanocobolamin

2 mg 134% 2 mg 118%26 mcg 130%7 mg 350%20 mcg 7%220 mcg 55%25 mcg 417%

Powerful B complex that helps breakdown nutrients into energy.

Biotin helps metabolism and use of free fatty acids for energy

Zinc GluconateSelenium

Essential for cellular health

May inhibit LDL oxidation

Product Information SummaryBIOS LIFE SLIM

U.S. Leading Causes of Death, 2003

Card

iova

scul

ar D

isea

se

Canc

er Acci

dent

s

Alzh

eim

er’s

Dis

ease

0

300,000

600,000

900,000

1,200,000

1,500,000Since the early 20th century, Cardiovascular Disease has been the leading cause of death and claims more lives each year than the next three leading causes of death combined.

American Heart Association: Heart Disease and Stroke Statistics, 2006 Update.

The High Cholesterol/Cardiovascular Disease Connection

One of the most simple and effective ways to determine the general health of your cardiovascular system is to have your cholesterol level checked on a regular basis. Why is this important? Because health offi cials estimate that roughly 50 percent of all adults have unhealthy levels of cholesterol and 42 million adults have dangerously high levels—and you could be one of them without even knowing. Lower your cholesterol level, and you’ll lower your risk of cardiovascular disease.

Bios Life Complete™ Lowers High Cholesterol Levels 4 Different Ways — Naturally! Bios Life Complete is the only supplement that combines all four of the known approaches to lowering harmful cholesterol. This proprietary comprehensive approach:

Helps to Block Re-absorption of Cholesterol in the Intestinal TractAs food enters the intestinal tract, bile acids are needed to break down fat. The liver uses the cholesterol that’s already in the body to produce these bile acids. As Bios Life Complete enters the intestinal tract, the proprietary fi ber matrix forms a gel which traps the bile acids (thus, trapping the cholesterol) making them unavailable for re-absorption into the body. This reduces the overall amount of cholesterol in the body. With this approach alone, Bios Life2 has helped millions of people worldwide to lower their cholesterol.

Helps to Block Absorption of Cholesterol Which Comes Directly From FoodPhytosterols have a chemical structure similar to that of cholesterol. However, unlike cholesterol derived from animal sources—which absorbs easily and raises the body’s own cholesterol levels—phytosterols are present only at very low levels in the body because they are diffi cult to absorb.

In fact, phytosterols so closely resemble cholesterol that they can actually block food-based cholesterol from being absorbed into the bloodstream by blocking the cholesterol transport mechanisms in the intestinal tract. The result is that both phytosterols and dietary cholesterol end up excreted in waste matter, which can reduce the overall cholesterol levels in the body.

Foods containing at least .65g per dose of phytosterols (plant sterol esters), taken twice a day with meals for a total daily intake of 1.3g may reduce the risk of heart disease associated with high cholesterol levels. A serving of Bios Life Complete contains .67g of phytosterols.

Reduces the Cholesterol Produced by the LiverThe liver manufactures cholesterol and secretes it into the blood. An important enzyme in this production process is HMG-CoA reductase. This enzyme can be blocked by certain chemicals—such as those found in statin drugs. Unlike synthetic statins, Unicity utilizes the most effective natural component called policosanol, which has the same effect.

Enhances Enzymatic Breakdown and Removal of LDL CholesterolChrysanthemum morifolium has been used for centuries by Chinese medicine and has just recently been proven to stimulate the enzymes associated with cholesterol breakdown. In fact, it was Unicity’s research network that uncovered and developed this proprietary discovery!

1

23

4

1

2

3

4Choose Bios Life™ Complete. The only clinically proven, patented, natural

alternative to statin drugs to effectively reduce cholesterol.

How Bios Life™ Complete Can Lower Your Cholesterol and Add Years to Your Life

©2009 Bios Life Franchise Owners Manual 02/09

Bios Life® is a series of world-class products developed to attack the world’s number one health concern — obesity. Obesity is the leading cause of increased risks for cardiovascular disease (the world’s number one killer), and diabetes. Becoming familiar with the benefits of Bios Life, what it is and how it works, will help you build a strong customer base and expand your Bios Life Franchise.

Although some of this information may be technical, please continue your study and supplement this guide with available resources.

What is Bios Life®?Bios Life is a vitamin-rich fiber based supplement. Not all the products in the Bios Life family are the same. However, they do share common ingredients, namely the base of a Biosphere Fiber and a Bios Vitamin Complex. The differences in the products are the result of the natural progression of our learning and research of new ingredients that improve the effectiveness of the products in combating health issues. We will refer to the nutrients in Bios Life Slim™ since it represents the cutting edge of our research and contains all of the possible nutrients used in the Bios Life family of products. Bios Life Slim consists of the Biosphere Fiber, several proprietary ingredients called Unicity 7X, the Bios Cardio matrix and a Bios Vitamin Complex. We will discuss what each one of these elements is and what they do.

Biosphere FiberA major part of Bios Life is naturally occurring fiber. Fiber is a normal plant component. It is an important part of the skin of an apple, for example, or the bark of a tree. Fibers are carbohydrates which are not absorbed into the blood stream. They can’t be digested because the digestive system lacks the enzymes to break them down. As a result fiber moves through the digestive system without influencing what’s going on inside the body.

The Role of FiberThere are two kinds of fiber - soluble and insoluble. Referring again to the apple, the skin contains mostly insoluble fiber, whereas the flesh of the apple contains pectin, a soluble fiber. Whether fiber is soluble or insoluble determines its biological effect.

Insoluble fiber is known for its digestive benefits. It helps to bulk the feces and can serve as food for friendly bacteria, thereby improving the immune system. It also “scrubs” out the inside of the intestinal tract, resulting in a cleansing of the digestive tract.

Soluble fiber, on the other hand, dissolves in the stomach and becomes a thick, gel-like substance. It is the same thing that happens if Bios Life is left to stand in a glass of water for a period of time, only much more quickly.

Fiber’s Role In Cholesterol ManagementOne of the roles that the Biosphere Fiber plays is to reduce cholesterol through a mechanism called Bile Acid Sequestration. The function of this mechanism is to trap and eliminate cholesterol in bile acid. This, in fact, means that Bios Life is able to trap (sequester) bile acids in the gastrointestinal tract.

How Does It Work? Bile acids are molecules that the body produces to digest fat from the diet. They are made by the liver using cholesterol as a building block. Once the bile acids are formed, they are transported to the gall bladder, where the mixture of acids, cholesterol, and other molecules are concentrated into bile.

Fat entering the gut triggers the gall bladder to excrete bile into the GI tract, where it aids in the digestion of fat. Once the fat is digested, the body efficiently recycles the bile acids. The bile acids are reabsorbed into the blood stream and broken down into their various components so that they can be reused. The cholesterol that is used for this process originates from the total amount of cholesterol in the body,

CHAPTER 13

BIOS LIFE PRODUCT TRAINING

13.1


and after re-absorption, the total concentration of cholesterol in the body stays the same. That explains why bile-mediated normal fat digestion does not alter the cholesterol concentration in the system.

When Bios Life Slim™ is consumed prior to a meal, the fiber from the Biosphere Fiber has time to form the gel in the GI tract before the food arrives. Once the fat in the food arrives, the normal digestive signaling occurs and bile is released into the gut. The bile acids help to digest the fat. However, instead of being reabsorbed in the blood stream for breakdown and later use, the fiber gel traps the bile acids along with the cholesterol, blocking its re-absorption. The bile acids no longer return to the blood stream but are excreted in the feces. The recycling mechanism is thus interrupted. In order for new bile acid to be synthesized, cholesterol from the body’s stored supply will need to be used, thus reducing the total amount of cholesterol in the body.

Another positive benefit from use of the Biosphere Fiber is to inhibit the synthesis of new cholesterol. Fiber is fermented in the colon by bacteria to yield short-chain fatty acids such as acetates, propionates, and butyrates. Overall these fatty acids inhibit the synthesis of cholesterol by the liver.

The cholesterol-lowering effect of fiber is so well established that the Food and Drug Administration allows the use of a health claim in relation to the reduction of the risk of heart disease by a product if the product contains a meaningful amount of soluble fiber. This is unique, since the FDA only allows these kinds of health claims for a limited number of dietary ingredients.

Fiber has been researched in many clinical trials all over the world. Unicity performed a clinical trial with Bios Life® at the prestigious Cleveland Clinic. This study was published in the journal Metabolism. The results from the Cleveland Clinic study showed that the Bios Life fiber matrix was able to reduce LDL (low-density lipoprotein) or bad cholesterol, and increase HDL (high-density lipoprotein) or good cholesterol, by significant amounts. The study also showed that Bios Life improved two other risk factors for heart disease: APOB (Apolipoprotein B) and Homocysteine levels. (Refer to chapter 15 for more information).

Fiber’s Role In The Management of Blood Glucose; Good News for Diabetics and Pre-diabeticsFiber moderates blood sugar levels. Consuming fiber will lower blood sugar levels and increase the amount of time it takes for glucose to be absorbed in the digestive tract. Glucose is the main source of energy for the body. When food, comprised of carbohydrates, is consumed, it is broken down into glucose, after which the body converts it into adenosine triphosphate, commonly known as ATP or energy for the body.

All good things should be consumed in moderation, and carbohydrates are no exception. The body has an elaborate signaling system to ensure that blood sugar levels don’t get too high or too low. If the blood sugar level rises in the body, the pancreas, sensing this rise, releases the hormone insulin. Insulin’s role is to help facilitate the cells in the body to absorb glucose from the bloodstream. If the blood sugar levels drop too low, then the body sends a hunger signal to eat.

Unfortunately the main staples of the traditional American Diet are processed foods, refined sugar and flour. A negative result of excess consumption is that blood sugar levels in the body rise much faster than if a diet consists of whole grains, fruits, and vegetables. If repeated frequently enough, a sudden spike of sugar in the blood will cause the pancreas to work overtime to produce insulin. An unintended consequence of the hard work of the pancreas is overshooting the amount of insulin the body actually needs. An excess of insulin in the bloodstream causes the body’s blood sugar levels to drop rapidly. At that point the body signals to the brain that it is hungry and needs to eat. This cycle repeats until the body no longer recognizes the signaling network and becomes insensitive to insulin. The pancreas, which is overworked to begin with, quits producing insulin, and the result is the disease called diabetes.

The Biosphere Fiber in Bios Life Slim moderates blood glucose levels through two mechanisms. The first involves the gel-like matrix the fiber creates in the gut. This matrix interacts with the food, delaying its absorption. The matrix drags the food along, and every so often a bit of the food escapes and is absorbed in the digestive tract. This is particularly true for carbohydrates.

13.2


By delaying the breakdown of carbohydrates, blood glucose levels do not reach extreme levels, relieving stress on the pancreas and allowing it to more accurately produce the correct amount of insulin needed to facilitate glucose absorption. In general, the same amount of glucose is absorbed. What has changed is the time it takes to absorb it.

The second mechanism in which Biosphere Fiber moderates blood glucose levels is by changing the glycemic index of food. This is tied into the first mechanism. Some foods generate a high level of blood glucose while others elicit a lower level of blood glucose in the body. The difference is generally based on the amount of carbohydrates that a specific food contains and how available those carbohydrates are to the body. This effect is measured by what is called the glycemic index of foods. The glycemic index describes the glucose effect a food has within the body. The higher the glycemic index of a food, the greater the impact that food will have on glucose values and the rise of glucose in the blood.

Remember that the soluble fibers in Biosphere Fiber will create a gel-like matrix in the gut. When food enters the digestive tract, this matrix will begin to interact with it and will create a coating around the food. This protects the food from digestive enzymes and will delay the breakdown of the food into glucose. As with the first mechanism, the interaction of the gel-matrix with food reduces the overall level of blood glucose levels and spreads out glucose absorption over a longer period of time.

Past research confirms the results of fiber supplementation on blood glucose levels. The Unicity Science team has presented multiple abstracts at scientific conferences with data they have collected. This includes conferences conducted by the American Heart Association and the American Diabetes Association. The results show decreases in fasting glucose levels but primarily in the post-prandial (after a meal) glucose levels. This resulted in an average reduction in A1c values of 0.9%. This is very similar to the improvement seen by adding a prescription diabetes oral medication. Another result of the studies was a decrease in triglyceride levels, a result that is crucial to converting bodies into fat-burning machines as we will discuss later in this chapter.

What is Biosphere Fiber?Biosphere Fiber contains five different highly soluble fibers: pectin, guar gum, gum acacia, locust bean gum, and oat fiber. Gum is a scientific term for soluble fiber. These fiber sources have been specifically selected for their cholesterol lowering potential. What is also singular is that calcium carbonate is added to this fiber mixture. The calcium carbonate is not there for its nutritional value but for the gel formation. Upon contact with the acidic environment of the stomach, the calcium carbonate starts to release carbon dioxide, and this bubbling disperses the fiber quickly through the gastric fluid. The fiber matrix is therefore formed quickly and efficiently. The manufacturing process and blend of ingredients are trade secrets of Unicity International and therefore, proprietary.

The American Heart Association advises people to consume 25 – 30 grams of fiber per day for proper nutrition and to promote heart health. The average person only consumes about 12 grams per day, so there is a large gap. A single serving of Bios Life Slim™ provides 4 grams of fiber. Consuming Bios Life Slim can help fill this gap.

Unicity 7XOne of the research discoveries found in Bios Life Slim is the combination of ingredients in our Unicity 7X. This patent-pending, proprietary blend of ingredients contains plant-derived polysaccharides, citric acid, calcium carbonate, and a pinch of orange flavoring. Unicity 7X represents Unicity’s most cutting edge research added to the Bios Life® family of products. The primary constituent of Unicity 7X is the proprietary blend of plant-derived polysaccharides. It’s this constituent that helps facilitate slimming or fat burning. This blend of plant-derived polysaccharides helps restore the body’s hormonal signaling involved in energy metabolism. Recent studies have shown that by consuming these plant-derived polysaccharides, the body is able to restore the brain’s sensitivity to a signal (in this case the hormone leptin) that was previously turned off or ignored.

13.3


Bios Cardio MatrixAnother constituent of Bios Life Slim™ is the Bios Cardio Matrix. This matrix is comprised of the following ingredients: phytosterols, policosanol from sugar cane, and an extract from Chrysathemum morifolium, an herb. This group of ingredients derives its name from the function it performs, namely to improve cholesterol levels thereby reducing the risk of cardiovascular disease. These ingredients are unique and have different modes of action, yet they work synergistically to accomplish their task.

Lowering Cholesterol Through PhytosterolsThe Bios Cardio Matrix uses three mechanisms to improve cholesterol levels. The first mechanism is to utilize plant phytosterols to prevent the body from absorbing cholesterol from food. A phytosterol is a naturally occurring chemical found in plants. Technically speaking, phytosterols are cholesterol analogs, which mean they have similar functions but different origins.

Scientists estimate that 25 percent of the total cholesterol present in the body is derived from food. Cholesterol is present in many foods—particularly fatty foods. Therefore, it makes sense that in order to lower the total cholesterol, the amount of cholesterol ingested from food should be reduced.

Meet the Cholesterol Transportation Department After eating, food eventually arrives in the small intestine,which is the place in the body where most food components are absorbed into the blood stream. The body has special transport systems embedded in the inner layers of the intestinal tissue that look for various and specific ingredients found in food. One of the ingredients this system looks for is cholesterol—after all, cholesterol is necessary to build new cells, insulate nerves, and produce hormones.

Channel Proteins—All Brawn, No Brains This cholesterol transport function is performed by proteins called channel proteins. Once channel proteins recognize cholesterol in the gut, the cholesterol is transported by the channel proteins across the intestinal barrier where the cholesterol can be absorbed into the bloodstream. Even though channel proteins are efficient workers, they can be fooled into spending their time transporting what

they “think” is real cholesterol. Meanwhile, the real cholesterol they should be transporting is passed through the intestines and out of the body, fooling these proteins is the job of the phytosterols in the Bios Cardio Matrix.

How Do Phytosterols Work?Cholesterol is an important molecule serving as a vital constituent of cell membranes and a precursor to various bio-molecules. Phytosterols serve similar functions in plants.

Cholesterol and phytosterols are so similar that they only differ in one way on the chemical structure—a small difference that has large consequences. The body will not absorb phytosterols as it would absorb cholesterol.

In fact, phytosterols are so similar to cholesterol that if they’re present in the gut along with cholesterol, channel proteins can’t tell the difference between the two. As a result, some of the phytosterols are picked up by the channel proteins instead of cholesterol, which allows the cholesterol to be passed out of the body and not absorbed into the bloodstream.

In order to position the phytosterols in the small intestine before the cholesterol from the food arrives, we recommend Bios Life Slim be consumed immediately before or with your meals.

There have been many studies done in relation to the cholesterol-lowering potential of phytosterols. Many of these studies were performed by manufacturers of phytosterol-enriched margarine spread. Typically the studies show a reduction of LDL (bad cholesterol) in the 5 to 20 percent range over periods of eight weeks to one year.

Decrease Cholesterol Manufactured by the Liver The second mechanism of the Bios Cardio Matrix utilizes policosanol derived from sugar cane to naturally decrease the amount of cholesterol manufactured by the liver.

Cholesterol can be brought to its proper levels using several different approaches because cholesterol has many functions in the body. Every function involves its own biochemical reactions, and each one of those is, in principle, a target for intervention.

The most common approach used to lower

13.4


cholesterol is called HMG-CoA reductase inhibition, or, in other words, decreasing the amount of cholesterol manufactured by the liver. This is the approach that prescription statin medications use.

Cholesterol is synthesized from small building blocks in the body using a long chain of biochemical reactions. In total, more than 20 steps are used to construct the cholesterol molecule. Glucose (sugar) or palmitate (a fatty acid) can be used as the source molecule that is used to generate cholesterol. Every individual building step of the molecule is mediated by enzymes. These are large protein molecules that serve to facilitate the biochemical steps.

If the cholesterol synthesis process is compared to an automobile factory line, the workers and robots are the enzymes that bring the different building blocks together. Since the construction line is a linear process, if only one worker is not working or working slowly, the whole line decreases in speed. This is the idea behind HMG-CoA reductase inhibition.

Inhibiting the HMG-CoA Reductase Enzyme HMG-CoA reductase is one of the enzymes involved in cholesterol synthesis. This abbreviation stands for 3-hydroxy-3-methylglutaryl CoEnzyme A reductase. This enzyme converts HMG-CoA to mevalonate, which is one of the steps in the production chain. This enzyme can be inhibited (slowed down) by many components. The most well-known of these are the statin molecules.

Statin molecules can slow down HMG-CoA by binding to it. This binding results in a structural change of the enzyme so that it is no longer active in the production chain. Disabling enough of this enzyme throughout the body will reduce the total amount of cholesterol produced.

Policosanol Inhibits HMG-CoA Reductase Naturally Similar to statin molecules, a specific phytonutrient called policosanol has been shown to inhibit HMG-CoA. Scientists have spent years establishing the cholesterol lowering properties of the policosanol molecule. This molecule is actually a mixture of a couple of different alcohol molecules whose structure is unique in the sense that it also interferes with the effectiveness of HMG-CoA reductase. It is, in fact, a natural statin and like a statin medication, is also highly effective.

Many studies have been performed with this molecule in dosages comparable to statin dosages, from 5 mg to 40 mg per day. LDL is typically reduced by 20 - 25% in a 12 week period. However, unlike statin medications, the use of policosanol is effective without producing unwanted side effects. If policosanol works identically to statins, why doesn’t it cause the same potential side effects? Side effects are not caused by the positive results that the statins have on the enzyme but rather from the aftereffects on other body tissues such as the liver. Consequently, the liver has to filter the statin molecules once the molecules have finished their job. Policosanol does not produce these negative side effects.

Bios Life Slim™ contains 6 mg per serving of pure policosanol. The benefits of this mechanism do not rely on taking the product before meals, as stated with the other mechanisms. Policosanol works throughout the day because cholesterol synthesis occurs continuously. Therefore, if Bios Life Slim is not taken before a meal, it can still be taken after or at any time during the day, yielding positive results.

Policosanol has another beneficial side-effect for the cardiovascular system. Research has shown that it also reduces LDL-oxidation and platelet aggregation. LDL can be oxidized by free radicals, leading to an even greater build-up of atherosclerosis. Slowing this down obviously has an extra benefit in addition to the mere lowering of LDL. Platelet aggregation is the process that may lead to blood clots, which in turn can reduce the blood flow in the body. Policosanol will help the body naturally keep the blood fluid at healthy levels and reduce the risk of clotting.

Boost the Enzymatic Breakdown and Removal of Cholesterol The third mechanism of Bios Cardio Matrix utilizes a water extract of Chrysanthemum morifolium to boost the enzymatic breakdown and removal of cholesterol from the body.

Cholesterol’s Bad ReputationCholesterol has had a lot of bad press over the years. But, the fact is the body needs cholesterol.

1. Cholesterol is a major building block for many of the hormones in the body. For

13.5


example, both the estrogen and testosterone hormones begin with cholesterol as a starting molecule.

2. Another important function of cholesterol is to build and maintain cell membranes. Cholesterol floats in the fatty phospholipids that comprise cell walls and maintains the structural integrity of cells.

3. Cholesterol is a fundamental building block for bile acids. The body needs cholesterol—the problem is that too much cholesterol is a health risk.

Manufacturing the Chemicals Needed to Survive The body is like a high-tech chemical manufacturing facility. It is continually building, tearing down, eliminating or storing the chemicals it needs in order to survive. Bile acid is one of these chemicals that the body continually manufactures and then tears down. Bile acids are biological molecules used to digest fat from the diet. They are made by the liver using cholesterol as a building block.

One of the bile acids is called cholic acid. The first step the body takes to make cholic acid is to convert cholesterol into what’s called 7-alpha-hydroxycholesterol. What facilitates this transformation is an enzyme called 7-alpha hydroxylase.

Now imagine being able to give those 7-alphahydroxylase enzymes an energy drink that makes them work twice as hard. As a result, more cholesterol is taken from the body’s storage and converted into cholic acid—thus reducing the total amount of cholesterol in the body. That’s exactly what the extract from Chrysanthemum does.

Meet the Proprietary Discovery The Unicity Research and Development Team discovered that a water extract of Chrysanthemum morifolium energizes the enzyme 7-alpha hydroxylase. Chrysanthemum morifolium is not a new herbal extract. It has been known for centuries that this flower has healthy benefits when it is consumed as a tea. Particularly in parts of Asia, this flower tea is consumed for the benefits to the eyes and the immune system. In fact, this discovery is the foundation of one of the patents on Bios Life®—

making it the only supplement available that possesses this cholesterol-lowering mechanism.

Bios Vitamin ComplexOver the past few years, clinical studies have removed all doubt—Bios Life is perhaps the most effective all-natural supplement for improving cholesterol levels, lowering triglyceride and blood sugar levels, in the prevention of cardiovascular disease, heart disease, and diabetes. For complete details regarding these studies, refer to chapter 15 of this manual.

The Bios Vitamin Complex found in Bios Life consists of the following ingredients: calcium carbonate, vitamin A (beta-carotene),vitamin C (ascorbic acid), vitamin E (d-alpha-tocopherols), vitamin B1 (thiamine), vitamin B2 (riboflavin), vitamin B3 (niacin), vitamin B6 (pyridoxine HCl), vitamin B12 (cyanocobalamin), biotin, folate, chromium , selenium, and zinc. Bios Life Slim’s primary function isn’t to be a vitamin supplement but to help burn fat.

With fat burning as the ultimate goal, we have selected vitamins and minerals that will help achieve this goal. For example Niacin, Riboflavin, Biotin, Cyanocobalamin, Folic Acid, and Thiamine HCl provide a powerful vitamin B complex. These vitamins are essential for:

• The breakdown of carbohydrates into glucose (this provides energy for the body)

• The breakdown of fats and proteins (which aids the normal functioning of the nervous system)

Another example is the addition of the mineral chromium. Chromium is believed to enhance the effectiveness of insulin. Supplemental chromium reduces blood glucose levels. Many researchers believe that supplementary chromium could be very useful for diabetics, especially those with Type 2 Diabetes.

The vitamins and minerals selected to be part of the Bios Vitamin Complex all play a synergistic role in helping the body produce energy more efficiently, protecting the cardiovascular system from oxidative damage and aids in the management of blood glucose levels.

13.6

©2009 Bios Life Franchise Owners Manual 02/09 13.7

How Does Bios Life Slim™ Work?Now that we have discussed what is in Bios Life Slim, let’s talk about how these nutrients come together and work to convert the body from a fat-storing machine to a fat-burning machine. Bios Life Slim helps the body burn fat in the following six processes:

1. Reduces Appetite. Bios Life Slim curbs the appetite by creating a feeling of satiety or fullness. Scientists have known for years that fiber increases satiety or, in other words, fiber makes you feel fuller quicker. As we have previously mentioned, the Biosphere Fiber creates a gel-like matrix in the gut. This gel-like matrix takes up physical space that would normally be occupied by food.

2. Blocks the Absorption of Fat. Bios Life Slim absorbs fat by binding to fatty molecules, prohibiting the absorption of cholesterol into the blood stream. This is one of the ways in which Bios Life Slim is able to lower cholesterol to healthy levels. By removing fat from our bodies, we reduce the amount of fat our bodies need to break down or store.

3. Creates “Fat Burning Zones”. Bios Life Slim utilizes its fat stores for energy production. We have dubbed these periods as “fat-burning zones.” The main reason this occurs is because Bios Life Slim moderates blood glucose levels. The Biosphere Fiber in Bios Life Slim helps keep glucose levels from spiking too high as well as from dropping too low. This in turn requires less insulin and helps curb the urge to snack. This will help curb urges to snack. Once the body has metabolized insulin, it can utilize its own fat storage for energy production. This is one of the steps crucial to converting the body into a fat burning machine.

4. Reduces Leptin Resistance. Bios Life Slim reduces leptin resistance. Leptin is the signaling hormone between fat cells and the brain. The brain stops craving food when it senses an adequate amount of leptin. This communication helps the brain control the appetite by helping to restore proper hormone signaling to the brain by reducing insulin levels in the body. When insulin levels are high, this communication

blocks the release of leptin from the cells, and as a result, fat accumulates. Maintaining high levels of insulin in the body results in a lack of leptin signaling to the brain which can cause the brain to “stop hearing” the leptin signal. This situation is called leptin resistance and is a significant factor in obesity and weight gain. Bios Life Slim breaks this cycle by moderating blood glucose levels which in turn moderate insulin levels. By taking Bios Life Slim regularly and lowering the level of insulin in the body, the leptin signaling between the fat cells and the brain is reestablished. This may help reduce cravings and appetite leading to fat burn and weight loss.

5. Lowers Triglycerides. In relation to number two, Bios Life Slim lowers blood fat levels, known as triglycerides. Recent studies have shown how triglycerides inhibit leptin from crossing the blood brain barrier, preventing the signal from ever reaching the brain. By reducing triglyceride levels, we are removing one obstacle from allowing leptin to get into the brain. The brain can’t ever react to the message if the message is blocked at the door way. Regular use of Bios Life Slim reduces the triglyceride levels, thus enabling leptin to cross into the brain.

6. Improve Cholesterol Levels. The final benefit of Bios Life Slim is its ability to manage lipid profiles and help bring cholesterol levels to a healthy range. We have already discussed how efficient Bios Life Slim is in reducing total cholesterol and LDL-cholesterol levels. However, we are just discovering how this is important not only for cardiovascular health but in fat burning. A recent study has shown how LDL-cholesterol acts as a signal from the liver to fat cells, inhibiting lipolysis (the process of breaking down fats). By reducing LDL-cholesterol, Bios Life Slim removes an important obstacle in converting the body into a fat-burning machine. Regular consumption of Bios Life Slim will reduce total cholesterol levels but more importantly, will reduce LDL-cholesterol levels.

Through the combination and synergy of these six processes, Bios Life Slim helps the body become a fat-burning machine. There simply isn’t another supplement on the market like it.

©2009 Bios Life Franchise Owners Manual 02/09 13.8

Accelerate the Fat LossA couple of questions undoubtedly asked are, “How can I accelerate the fat loss process?” or, “What can I do to help Bios Life Slim™, slim me down?” The research and development team at Unicity has done the research for you. By incorporating the following five steps, you can experience quicker fat loss for yourself as well as teach others how to accelerate their fat loss:

• Start the day off right by jumpstarting your metabolism with a high protein breakfast. Studies have shown that a high protein breakfast leads to a longer feeling of fullness and the consumption of smaller meals throughout the day.

• Take Bios Life Slim daily along with three healthy, well balanced meals. Research has shown that people who eat three meals a day are less likely to overeat and keep off long-term weight.

• Use the 4-4-12 rule to space your meals. For example, allow (4) four hours between breakfast and lunch, (4) four hours between lunch and dinner, and (12) twelve hours between dinner and breakfast. Give your body time in between meals to metabolize the insulin produced as a result of eating. A general rule of thumb is that on average insulin will drop to low levels in two hours. Spacing your meals every four hours ensures that your body will enter a period where you use fat stores for energy production previously referred to as the fat burning zone. The key to entering the fat-burning zone is to avoid snacking which will increase glucose levels and insulin levels to spike. The presence of insulin blocks the body’s ability to access the fat stores for energy.

• Decrease the glycemic index of your meals. Change what you eat by eating more fruits and vegetables and fewer carbohydrates. If you are going to eat carbs, eat whole grains and avoid refined foods.

• Increase your level of activity. Look for ways to exercise or to simply increase the amount of walking you do. Use the stairs instead of the elevator. Walk to work or walk during your

lunch break. Walking is a great activity that promotes the use of fat-burning for energy.

Bios Life Slim is a singular supplement that is designed to help burn fat and improve overall health. By taking Bios Life Slim with meals, your body will return to its natural fat-burning mode. Your next meal and every meal after that will be much more enjoyable by knowing that with Bios Life Slim you’re improving what may be the biggest factors in determining how you look, how you feel, and in determining the quality and length of your life.

Unicity is committed to producing high quality products. Time, energy and money are invested to ensure each and every product is safe, effective and easy to consume. The Research and Development team at Unicity collaborates with various research institutions to insure quality and effectiveness. The results of these collaborations are available to you and can be accessed in Chapter 15.

Unicity InternationalTHE MAKE LIFE BETTER COMPANY1201 NORTH 800 EASTOREM, UT 84097

Direct Inquiries to:

(801) [email protected] of Unicity International are distributed throughindependent distributors.

BIO-C™ OTC[bıo se]

DESCRIPTIONBio-C™ is a vitamin C nutritional supplement.Bio-C™ is a yellow, water-soluble, crystalline powderpressed into a tablet. Each Bio-C™ tablet consists of a pro-prietary blend of ascorbyl palmitate, calcium ascorbate, as-corbic acid, magnesium ascorbate and 75 mg of citrus biofla-vonoids. In addition to the active ingredients, each 803 mgtablets contains dextrose, microcrystalline cellulose, silicondioxide, magnesium stearate, and stearic acid.

BENEFITS AND RESEARCHVitamin C (ascorbic acid) is a water-soluble vitamin that isused in the body to form cartilage, collagen, muscles andblood vessels. Vitamin C is a potent antioxidant that canprotect small molecules such as proteins, carbohydrates,nucleic acids and lipids from damage caused by free radicalsthat are generated through the course of normal metabo-lism or through exposure to external toxins and pollutants(e.g. ultraviolet radiation from the sun or smoking). VitaminC can also regenerate other antioxidants like vitamin E. Ad-ditionally, vitamin C is required for the synthesis of carni-tine, a molecule involved in the transport of fats across themitochondrial membrane, as well as the synthesis of norep-inephrine, a neurotransmitter.*

USAGETake one tablet morning and night with a meal.

SAFETY AND WARNINGSBio-C™ is well tolerated. Some gastrointestinal discomfortmay be experienced as with any dietary supplement.

HOW SUPPLIEDAvailable in tablets.

REFERENCESCarr, AC and Frei B. (1999), American Journal of ClinicalNutrition 96: 1086-1107.Jacob, RA and Sotoudeh G. (2002), Nutrition in ClinicalCare 5: 66-74.Deruelle F, Baron B. (2008), Journal of Alternative andComplementary Medicine 14:1291-1298.Levine M, Rumsey SC, Daruwala R, Park JB, Wang Y.(1999), The Journal of the American Medical Association281: 1415-1423.* THESE STATEMENTS HAVE NOT BEEN EVALUATEDBY THE FOOD AND DRUG ADMINISTRATION. THISPRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT,CURE, OR PREVENT ANY DISEASE.

BIOS LIFE® C OTC[bı-os lıf se]Advanced Fiber and Nutrient Drink

DESCRIPTIONBios Life® C is a fiber-based, vitamin-rich nutritional sup-plement. Bios Life® C contains a blend of soluble and insol-uble fibers, phytosterols, policosanol, an extract of Chrysan-themum morifolium, vitamins, and minerals that whencombined with a healthy diet and exercise may lower totalserum cholesterol, lower triglyceride levels and reduce therisk of heart disease.Bios Life® C is light orange in color. It is a hygroscopic crys-talline powder that is generally soluble in water. Each serv-ing of Bios Life® C contains 3 g of fiber, 1 g of phytosterols,6 mg of policosanol, and 12.5 mg of an extract of Chrysan-themum morifolium. In addition to these active ingredients,each serving of Bios Life® C contains maltodextrin, citricacid, orange juice powder, sucralose and orange flavor.

BENEFITS AND RESEARCHIt’s estimated that Americans consume 10-12 g of total fiberper day, less than half the amount of the recommended dailyintake. Epidemiological and clinical studies have correlated

low daily fiber intake with higher incidences of hyperinsu-linemia, hypercholesterolemia, and elevated risks of cardio-vascular disease.Bios Life® C is a nutritional supplement designed to in-crease daily fiber intake. Each serving of Bios Life® C con-tains three grams of dietary fiber. When taken three times aday, this achieves nearly half of the recommended dailyvalue of fiber. Fiber supplementation has been shown to de-crease preprandial and postprandial glucose levels andlower LDL cholesterol and apolipoprotein B levels.In addition to fiber supplementation, Bios Life® C containsa patented blend of phytosterols, policosanol, Chrysanthe-mum morifolium, vitamins and minerals. This blend of in-gredients optimizes cholesterol levels through a combina-tion of four mechanisms. First, the soluble fiber matrixprevents cholesterol reabsorption in the gastrointestinaltract through bile-acid sequestration. Second, the phytoster-ols reduce dietary absorption of cholesterol. Third, poli-cosanol inhibits hepatic synthesis of cholesterol mediatedthrough HMG-CoA reductase. Fourth, Chrysanthemummorifolium provides phytonutrients that enhance conver-sion of cholesterol to 7-�-hydroxycholesterol. The fourmechanisms provide a synergistic approach to optimizingcholesterol levels. Research has shown that this productmay serve as a first line treatment option for mild hyper-cholesterolemia, as well as adjunct therapy for lipid lower-ing pharmaceutical intervention.SUGGESTED USAGEDissolve the contents of one packet or one scoop into 8 to10 fl. oz. of liquid (water or juice) and stir vigorously. Drinkimmediately. Use 15-20 minutes prior to meals up to threetimes daily.SAFETY AND WARNINGSBios Life® C is well tolerated. There may be mild gastroin-testinal discomfort, such as increased flatulence or loosestools, during the first month of initial use due to the in-creased uptake of dietary fiber. This GI disturbance usuallydisappears within the first thirty days. If the GI discomfortpersists, reduce the number of servings of Bios Life® C. Ifthe GI discomfort further persists, stop taking the productand consult your physician. Taking this product without ad-equate liquid can result in complications. If you are a dia-betic, consult a physician for proper use of this product, asthe chromium may reduce the need for medication.HOW SUPPLIEDBios Life® C is packaged in single-serving foil packets or inbulk canisters.REFERENCESSprecher, DL and Pearce GL (2002), Metabolism 51:1166-70.Verdegem, PJE; Freed, S and Joffe D (2005), American Di-abetes Assocation 65th Scientific Sessions, San Diego, CA.Duenas, V; Duenas, J; Burke, E and Verdegem, PJE (2006),7th International Conference on Arteriosclerosis, Thrombo-sis, and Vascular Biology, American Heart Association,Denver, CO.Verdegem, PJE (2007), Current Topics in NutraceuticalResearch 5: 1-6US Patent 6,933,291.* THESE STATEMENTS HAVE NOT BEEN EVALUATEDBY THE FOOD AND DRUG ADMINISTRATION. THISPRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT,CURE, OR PREVENT ANY DISEASE.

Shown in Product Identification Guide, page 329

BIOS LIFE® SLIM™ OTC[bı-os lıf slim]Advanced Fiber and Nutrient Drink

DESCRIPTIONBios Life® Slim™ is a fiber-based, vitamin-rich nutritionalsupplement. Bios Life® Slim™ contains a blend of solubleand insoluble fibers, Unicity® 7� technology, phytosterols,policosanol, an extract of Chrysanthemum morifolium, vita-mins, and minerals that when combined with a healthy dietand exercise may lower total serum cholesterol, reduce therisk of heart disease and help achieve and maintain ahealthy body weight.Bios Life® Slim™ is light orange in color. It is a hygroscopiccrystalline powder that is generally soluble in water. Eachserving of Bios Life® Slim™ contains 4 g of fiber, 1 g of phy-tosterols, 750 mg of Unicity 7�, 6 mg of policosanol and12.5 mg of an extract of Chrysanthemum morifolium. In ad-dition to these active ingredients each serving of Bios Life®Slim™ contains maltodextrin, citric acid, orange juice pow-der, sucralose and orange flavor.BENEFITS AND RESEARCHIt’s estimated that Americans consume 10-12 g of total fiberper day, less than half the amount of the recommended daily

intake. Epidemiological and clinical studies have correlatedlow daily fiber intake with higher incidences of obesity, hy-perinsulinemia, hypercholesterolemia, and elevated risks ofcardiovascular disease.Bios Life® Slim™ is a nutritional supplement designed toincrease fiber intake. Each serving of Bios Life® Slim™ con-tains four grams of fiber. When taken three times a day thisachieves half of the recommended daily value of fiber. Fibersupplementation has been shown to decrease preprandialand postprandial glucose levels; lower LDL cholesterol andapolipoprotein B levels; increase satiety and facilitateweight loss.In addition to fiber supplementation, Bios Life® Slim™ con-tains a patented blend of phytosterols, policosanol, Chry-santhemum morifolium, vitamins and minerals. Bios Life®Slim™ facilitates weight loss through five distinct mecha-nisms. First, the soluble fiber matrix promotes an increasein satiety. Second, Bios Life® Slim™ improves cholesterollevels. Reduction in LDL content removes a potent inhibitorof lipolysis. Third, Bios Life® Slim™ improves blood glucoselevels. Maintaining appropriate serum glucose levels re-duces hyperinsulinemia and promotes insulin sensitivity.Reducing insulin levels permits fatty acid oxidation to oc-cur. Fourth, Bios Life® Slim™ restores appropriate leptinsignaling. Lastly, Bios Life® Slim™, reduces triglyceridelevels allowing for leptin to cross the blood-brain barrierand effect its mechanism of action. Research has shown thatthis product may serve as a first line treatment option formild hypercholesterolemia, as well as adjunct therapy forlipid lowering pharmaceutical intervention.

SUGGESTED USAGEDissolve the contents of one packet or one scoop into 8 to10 fl. oz. of liquid (water or juice) and stir vigorously. Drinkimmediately. Use 15-20 minutes before meals up to threetimes daily.

SAFETY AND WARNINGSBios Life® Slim™ is well tolerated. There may be mild gas-trointestinal discomfort, such as increased flatulence orloose stools, during the first month of initial use due to theincreased uptake of dietary fiber. This GI disturbance usu-ally disappears within the first thirty days. If the GIdiscomfort persists, reduce the number of servings of BiosLife® Slim™. If the GI discomfort further persists, stop tak-ing the product and consult your physician. Taking thisproduct without adequate liquid can result in complications.If you are a diabetic, consult a physician for proper use ofthis product, as the chromium may reduce the need for med-ication.

HOW SUPPLIEDBios Life® Slim™ is packaged in single-serving foil packetsor in bulk canisters.

REFERENCESSprecher, DL and Pearce GL (2002), Metabolism 51:1166-70.Verdegem, PJE; Freed, S and Joffe D (2005), American Di-abetes Assocation 65th Scientific Sessions, San Diego, CA.Slavin, JL, (2005) Nutrition 21: 411-418.Delzenne NM, Cani PD, (2005) Current Opinion ClincalNutrition & Metabolic Care 8: 636-640Duenas, V; Duenas, J; Burke, E and Verdegem, PJE (2006),7th International Conference on Arteriosclerosis, Thrombo-sis, and Vascular Biology, American Heart Association,Denver, CO.Verdegem, PJE (2007), Current Topics in NutraceuticalResearch 5: 1-6US Patent 6,933,291.* THESE STATEMENTS HAVE NOT BEEN EVALUATEDBY THE FOOD AND DRUG ADMINISTRATION. THISPRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT,CURE, OR PREVENT ANY DISEASE.

BONEMATE® PLUS OTC[bon-mat plus]Advanced Bone Health Formula

DESCRIPTIONBoneMate® Plus is specially formulated to help maintainoptimal bone health.* It contains three forms of calcium andvitamin D to maximize absorption and aid in the support ofhealthy bones, teeth, nerves, heart, and muscle tissue.BoneMate® Plus is a light gray in color and is soluble inwater. Each serving of BoneMate® Plus contains the follow-ing active ingredients 600mg of calcium, 300mg of magne-sium, 30 mg of vitamin C, 2000 IU of vitamin D, 0.5mg ofboron, 5 mg of zinc, 1mg of manganese, 1mg of copper, and20mg of vitamin K. In addition, it also contains the inactiveingredients microcrystalline cellulose, croscarmellose so-dium, and magnesium stearate.

3454/UNICITY PHYSICIANS’ DESK REFERENCE®

Information will be superseded by supplements and subsequent editions

BENEFITS AND RESEARCHCalcium is the most common mineral in the body. Almost99% of the calcium in our body is found in the bones andteeth. Bone is a dynamic tissue that is constantly being re-modeled throughout our lives. A chronically low calcium in-take in growing individuals may prevent the attainment ofoptimal peak bone mass. Once peak bone mass has beenachieved, inadequate calcium intake may contribute to ac-celerated bone loss and eventually to osteoporosis.Vitamin D, a secosteroid that is produced by the body uponexposure to the sun, is required for optimal calcium absorp-tion. To ensure that calcium absorption is not limited byinadequate vitamin D levels, BoneMate® Plus contains2000 IU of vitamin D per serving. In addition to facilitatingcalcium absorption, Vitamin D has been shown to targetover 2000 different genes in the body. Vitamin D deficiencyhas been associated with increased risks for heart disease,stroke, diabetes, depression, osteoarthritis, chronic pain,and osteoporosis.USAGETake two tablets twice daily with a meal.SAFETY AND WARNINGSBoneMate® Plus is well tolerated. Some gastrointestinaldiscomfort may be experienced as with any dietary supple-ment. The Food and Nutrition Board of the Institute ofMedicine has set the tolerable upper level (UL) of intake forcalcium in adults at 2,500 milligrams (mg) of calcium/day.HOW SUPPLIEDAvailable as tablets or as a powder.REFERENCESWeaver CM, Heaney RP. Calcium. In: Shils M, Olson JA,Shike M, Ross AC, eds. Modern Nutrition in Health andDisease. 9th ed. Baltimore: Williams & Wilkins; 1999:141-155.Heaney RP. Calcium, dairy products and osteoporosis. J AmColl Nutr. 2000;19(2 Suppl):83S-99S.Food and Nutrition Board, Institute of Medicine. Calcium.Dietary Reference Intakes: Calcium, Phosphorus,Magnesium, Vitamin D, and Fluoride. Washington, D.C.:National Academy Press; 1997:71-145.Reid IR. Therapy of osteoporosis: calcium, vitamin D, andexercise. Am J Med Sci 1996;312:278-86. Food and Nutri-tion Board, Institute of Medicine. Calcium. Dietary Refer-ence Intakes: Calcium, Phosphorus, Magnesium, VitaminD, and Fluoride. Washington, D.C.: National AcademyPress; 1997:71-145.* THESE STATEMENTS HAVE NOT BEEN EVALUATEDBY THE FOOD AND DRUG ADMINISTRATION. THISPRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT,CURE, OR PREVENT ANY DISEASE.

CARDIO-BASICS™ OTCCaring for your heart*

DESCRIPTIONCardio-Basics™ is a nutritional supplement that combinesmultivitamins, minerals and antioxidants to support thecardiovascular system.Cardio-Basics™ is a light orange, water-soluble powderpressed into tablets. Each tablet of Cardio-Basics™ con-tains the following vitamins, minerals, amino acids and an-tioxidants: beta-carotene (vitamin A), thiamine (vitaminB1), riboflavin (vitamin B2), niacin (vitamin B3), calciumd-pantothenate (vitamin B5), pyridoxine hydrochloride (vi-tamin B6), folate (vitamin B9), cyanocobalamin (vitaminB12), ascorbic acid and ascorbyl palmitate (vitamin C), cho-lecalciferol (vitamin D), d-alpha-tocopherol (vitamin E), bi-otin, calcium, chromium, copper, magnesium, manganese,molybdenum, phosphorus, potassium, selenium, sodium,zinc, L-arginine, L-carnitine, L-cysteine, L-lysine, L-proline,inositol, coenzyme Q10, and maritime pine extract. In addi-tion to those active ingredients each tablet also contains mi-crocrystalline cellulose, sucrose, fatty acid esters, silicon di-oxide, magnesium stearate, and maltodextrin.BENEFITS AND RESEARCHAccording to the Center for Disease Control and Prevention,one American will die every minute as a result of heartdisease. Narrowing of the arterial walls can lead to blockedblood flow to the brain. A healthy lifestyle including beingphysically active, not smoking, and making good foodchoices can lead to a reduction of heart disease.Cardio-Basics™ provides the vitamins, minerals and anti-oxidants needed for a healthy heart. In clinical studies, par-ticipants using Cardio-Basics™ and Bio-C™ saw a signifi-cant reduction in arterial wall thickness, removal ofcalcification deposits and a reduced risk for cardiovasculardisease when compared to the placebo group. Cardio-Basics™ provides the body with the necessary vitamins andminerals needed to support a healthy vascular system.*

SUGGESTED USETake two tablets daily with food.

SAFETY AND WARNINGSCardio-Basics™ is well tolerated. Some gastrointestinaldiscomfort may be experienced as with any dietary supple-ment.

HOW SUPPLIEDAvailable in tablets

REFERENCESNiedzwiekcki, A, Rath, M. (1996) Journal of Applied Nutri-tion, 48: 67-78.Jeejeebhoy, F, Keith, M, Freeman, M, Barr, A, McCall, M,Kurian, R, Mazer, D, Errett, L, (2002), American HeartJournal 143: 1092-1100.Verdgem, PJE, Lonky, S, Curley, S. (2005) 7th Conferenceon Arteriosclerosis, Thrombosis and Vascular Biology.Lloyd-Jones D, Adams R, Carnethon M, DeSimone G, Fer-guson TB, Flegal K, Ford E, Furie K, Go A, Greenlund K,Haase N, Hailpern S, Ho M, Howard V, Kissela B, Kittner S,Lackland D, Lisabeth L, Marelli A, McDermott M, Meigs J,Mozaffarian D, Nichol G, O’Donnell C, Roger V, RosamondW, Sacco R, Sorlie P, Stafford R, Steinberger J, Hong Y;(2009) Circulation, 119: 480-486.* THESE STATEMENTS HAVE NOT BEEN EVALUATEDBY THE FOOD AND DRUG ADMINISTRATION. THISPRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT,CURE, OR PREVENT ANY DISEASE.

CARDIO-ESSENTIALS OTCCaring for your heart*

DESCRIPTIONCardio-Essentials is a nutritional supplement for the heart.Cardio-Essentials contains Coenzyme Q-10, L-carnitine,L-taurine and Hawthorn berry.Cardio-Essentials is a light tan, water-soluble powder. Eachcapsule of Cardio-Essentials contains 100 mg of CoenzymeQ-10 and 3.5 g of a blend of L-carnitine, L-taurine, andHawthorn berry. In addition to those active ingredients,each capsule also contains silicon dioxide, stearic acid andcalcium silicate.

BENEFITS AND RESEARCHOne of the leading causes of congestive heart failure (CHF),left ventricular dysfunction, affects approximately 1.5% ofthe population in the United States. CHF patients with leftventricular dysfunction have reduced levels of CoenzymeQ-10, L-carnitine and L-taurine and have an enlarged leftventricle. In a clinical study, the combination of L-carnitine,L-taurine, and Coenzyme Q10 was shown to benefit conges-tive heart failure patients by reducing left ventricular size.These ingredients are known to be important in providingadequate energy for heart muscle. Cardio-Essentials pro-vides adequate amounts of these ingredients, i.e. 100 mg ofCoQ10. Hawthorn extract is traditionally used in support-ing the heart function.

SUGGESTED USETake three capsules twice a day with food.

SAFETY AND WARNINGSCardio-Essentials is well tolerated. Some gastrointestinaldiscomfort may be experienced as with any dietary supple-ment.

HOW SUPPLIEDAvailable in capsules

REFERENCESJeejeebhoy, F et al (2002), American Heart Journal 1431092–1100.* THESE STATEMENTS HAVE NOT BEEN EVALUATEDBY THE FOOD AND DRUG ADMINISTRATION. THISPRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT,CURE, OR PREVENT ANY DISEASE.

CM PLEX™ AND CM PLEX™ CREAM OTC[CM pleks]Proprietary fatty acid blend to help alleviate symptoms

of osteoarthritis*

DESCRIPTIONCM Plex and CM Plex Cream are a softgel and topicalcream, respectively, that contain a proprietary blend of cety-lated fatty acids, soy and fish oil.CM Plex is an opaque powder that is insoluble in water. Onesoftgel capsule of CM Plex contains 350 mg of cetylated

fatty acids, 160 mg of soy oil and 25 mg of salmon oil. Inaddition to these active ingredients, each softgel capsulecontains glycerin and St. John’s Bread.CM Plex Cream is an off-white powder that is insoluble inwater. One gram of CM Plex Cream contains 7.7 mg of cety-lated fatty acids and olive oil. In addition to these activeingredients CM Plex Cream also contains glyceryl stearate,glycerin, lecithin, tocopheryl acetate, benzyl alcohol,phenoxyethanol, carbomer, PEG-100 stearate, sodium hy-droxide, methylparaben, propylparaben, butylparaben, eth-ylparaben, isobutylparaben and citrus aurantium bergamia(Bergamot) fruit oil.

BENEFITS AND RESEARCHCetyl myristoleate and related fatty acids have been provento improve joint health through their anti- inflammatory ef-fects. A clinical study indicated that subjects exhibited im-provements in knee flexion compared to placebo. A secondstudy indicated the cream is effective for improving kneerange of motion, ability to climb stairs, rise from a chair andwalk, balance, strength, and endurance.*

SUGGESTED USESoftgels: Take one to two softgels three times daily withmeals.Cream: Apply generously onto clean skin and gently mas-sage until the cream disappears. Repeat 3 to 4 times dailyas necessary. For maximum results combine both products.

SAFETY AND WARNINGSCM Plex Softgels and Cream are well tolerated. Some gas-trointestinal discomfort may be experienced with CM PlexSoftgels as with any dietary supplement.

HOW SUPPLIEDCM Plex is available in soft gels and as a topical cream.

REFERENCESHesslink, R et al (2002), Journal of Rheumatology 29, 1708–1712.Kraemer, WJ et al (2004), Journal of Rheumatology 31,767–774.* THESE STATEMENTS HAVE NOT BEEN EVALUATEDBY THE FOOD AND DRUG ADMINISTRATION. THISPRODUCT IS NOT INTENDED TO DIAGNOSE, TREATCURE, OR PREVENT ANY DISEASE.


IMMUNIZEN® OTC[ım moo nı zen]

DESCRIPTIONImmunizen® is a nutritional supplement for boosting theimmune system.Immunizen® is a modestly water soluble, white crystallinepowder. Immunizen® consists of a proprietary ingredientblend of colostrum, arabinogalactan, 1,3, 1,6 yeast beta-glucans and lactoferrin. In addition to the active ingredi-ents, each 835 mg capsule of Immunizen® contains naturalgelatin, stearic acid and silicon dioxide.

BENEFITS AND RESEARCHImmunizen® combines the positive immune modulating ef-fects of colostrum, arabinogalactans, yeast beta-glucans andlactoferrin to boost your body’s natural defenses to foreignantigens. Colostrum is composed of immunoglobulins thatbolster the body’s immune system by providing immunityagainst various pathogens.Beta-glucans are generally derived from the cell walls of theyeast species Saccharomyces cerevisiae. Beta-glucans arepotent immuno-modulating agents that prime both the in-nate and adaptive immune systems.

USAGETake six capsules with water one to two hours before a mealfor 10 days as needed.

SAFETY AND WARNINGSImmunizen® is well tolerated. Some gastrointestinal dis-comfort may be experienced as with any dietary supple-ment.

HOW SUPPLIEDAvailable in capsules.

REFERENCESLilius EM, Marnila P. (2001), Current Opinion in InfectiousDiseases 14:295-300.Hammarström L, Weiner CK. (2008), Advances in Experi-mental Medicine and Biology 606: 321-343.Chan GC, Chan WK, Sze DM. (2009), The Journal of Hem-atology and Oncology, 2: 25-

Continued on next page

PRODUCT INFORMATION UNICITY/3455

For labeling updates or more information, please visit www.PDR.net or consult mobile PDR�

Immunizen—Cont.

* THESE STATEMENTS HAVE NOT BEEN EVALUATEDBY THE FOOD AND DRUG ADMINISTRATION. THISPRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT,CURE, OR PREVENT ANY DISEASE.

OMEGALIFE-3™ OTC[omega-lıf 3]Omega-3 Fatty Acid Supplementation

DESCRIPTIONOmegaLife-3™ is a blend of omega-3 fatty acids designed tohelp maintain healthy cardiovascular and cerebral functionas well as aiding in the prevention of age-related maculardegeneration.OmegaLife-3™ is an amber-colored, semi-viscous, fat-soluble liquid. Each serving of OmegaLife-3™ contains thefollowing active ingredients 800 mg eicosapentaenoic acid(EPA), 400 mg docosahexaenoic acid (DHA), and vitamin E.In addition, it also contains the inactive ingredients gelatin,glycerin, purified water, and orange oil. OmegaLife-3™ hasbeen molecularly distilled to ensure exceptionally pure oiland includes orange oil to prevent a fishy after taste.

BENEFITS AND RESEARCHClinical research suggests that fish oil can help supportproper brain and visual function. In 2002 the FDA approvedsupplementation of DHA in infant formula. DHA is poten-tially important in fetal and infant neural development, inthat DHA and arachidonic acid have been shown to be in-corporated into brain and retinal cell membranes—particu-larly during the third trimester and early infant life.DHA is the predominant structural fatty acid in the centralnervous system and in the retina of the eyes.EPA supports the synthesis of important compounds in thebody. EPA is the precursor of thromboxane and leukotriene,compounds involved in supporting healthy circulation. Theyalso promote healthy blood vessels.*Evidence is accumulating that increasing intakes of EPAand DHA can decrease the risk of cardiovascular disease bypreventing arrhythmias, decreasing the risk of thrombosis,decreasing triglyceride levels, slowing the growth of ather-osclerotic plaque, and decreasing inflammation.*The U.S. Food and Drug Administration (FDA) has statedthat, “Supportive but not conclusive research shows thatconsumption of EPA and DHA omega-3 fatty acids may re-duce the risk of coronary heart disease.”

USAGETake two softgels per day with a meal.

SAFETY AND WARNINGSOmegaLife-3™ is well tolerated. Some gastrointestinaldiscomfort may be experienced as with any dietary sup-plement. Common side effects include a “fishy” taste uponeructation.

HOW SUPPLIEDAvailable in softgels.

REFERENCESBarter P, Ginsberg HN. Effectiveness of combined statinplus omega-3 fatty acid therapy for mixed dyslipidemia. AmJ Cardiol. 2008 Oct 15:102(8):1040-5Lee JH, Harris WS, et al. Omega-3 fatty acids for cardiopro-tection. Mayo Clin Proc. 2008 Mar;83(3):324-32.SanGiovanni JP, Chew EY, Sperduto RD, et al. The relation-ship of dietary omega-3 long-chain polyunsaturated fattyacid intake with incident age-related macular degeneration:AREDS report no. 23. Arch Ophthalmol. 2008 Sep;126(9):1274-9.SanGiovanni JP, Parra-Cabrera S, Colditz GA, Berkey CS,Dwyer JT. Meta-analysis of dietary essential fatty acids andlong-chain polyunsaturated fatty acids as they relate to vi-sual resolution acuity in healthy preterm infants. Pediatrics2000;105:1292-8.Kris-Etherton PM, Harris WS, Appel LJ. Omega-3 fatty ac-ids and cardiovascular disease: new recommendations fromthe American Heart Association. Arterioscler Thromb VascBiol. 2003;23(2):151-152.* THESE STATEMENTS HAVE NOT BEEN EVALUATEDBY THE FOOD AND DRUG ADMINISTRATION. THISPRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT,CURE, OR PREVENT ANY DISEASE.

VISUTEIN® OTC[vı s-u-ten]Clinically proven to support healthy eyes and vision.*

DESCRIPTIONVISUtein® is a nutritional supplement for maintaininghealthy eyes. VISUtein® contains lutein, anthocyanidins

from bilberry, N-acetyl cysteine, zinc, mixed carotenoids(�carotene, �carotene and zeaxanthin) and riboflavin.VISUtein® is a purple crystalline powder that is watersoluble. In addition to the active ingredients lutein, antho-cyanidins, N-acetyl cysteine, zinc, mixed carotenoids andriboflavin, each 600 mg capsule contains magnesiumstearate.BENEFITS AND RESEARCHAntioxidants from the carotenoid chemical family, such aslutein and zeaxanthin, play an important role in eye health.Low concentrations of these compounds in the retina are as-sociated with age-related macular degeneration (AMD).Supplementation with high levels of lutein can restore thelutein concentration in the retina. Further supplementationof vitamins C and E along with zinc, copper and �-carotenedelayed the onset of AMD. Low glutathione levels have beenshown to reduce protection of the eye against oxidativestress. N-acetyl cysteine has been shown to elevate gluta-thione levels in the retina. A recent clinical study withVISUtein® has shown that AMD patients experience clearimprovements in visual acuity, contrast sensitivity, and re-covery from a flash.*

USAGETake two capsules per day with a meal.

SAFETY AND WARNINGSVISUtein® is well tolerated. Some gastrointestinal discom-fort may be experienced as with any dietary supplement.

HOW SUPPLIEDAvailable in capsules.

REFERENCESNewsome, DA and Meyers, L (2004), “A RandomizedProspective Clinical Trial of Two Commercially AvailableOcular Diet Supplements”, In press.* THESE STATEMENTS HAVE NOT BEEN EVALUATEDBY THE FOOD AND DRUG ADMINISTRATION. THISPRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT,CURE, OR PREVENT ANY DISEASE.


Unimed Pharmaceuticals, Inc.A Solvay Pharmaceuticals, Inc. Company901 SAWYER ROADMARIETTA, GA 30062

www.solvaypharmaceuticals-us.com

FOR MEDICAL INFORMATION CONTACT:

GENERALLY:Medical Information Department(800) 241-1643 #8SALES AND ORDERING:

Orders may be placed by calling this toll free number:

(800) 241-1643 #1Fax # 770-578-5901Mail orders should be sent to:

Solvay PharmaceuticalsCustomer Relations Department901 Sawyer RoadMarietta, GA 30062

ANDROGEL® " �[an dro-jel](testosterone gel)

1% for topical use

� only

HIGHLIGHTS OF PRESCRIBING INFORMATION

These highlights do not include all the information needed

to use AndroGel safely and effectively. See full prescribing

information for AndroGel.

AndroGel® (testosterone gel) 1% for topical use CIII

Initial U.S. Approval: 1953

WARNING: SECONDARY EXPOSURE TO

TESTOSTERONE

See full prescribing information for complete boxed

warning

• Virilization has been reported in children who were

secondarily exposed to testosterone gel (5.2, 6.2).

• Children should avoid contact with unwashed or un-

clothed application sites in men using testosterone

gel (5.2).

• Healthcare providers should advise patients tostrictly adhere to recommended instructions for use(5.2).

- - - - - - - - - - - - -RECENT MAJOR CHANGES - - - - - - - - - - - - -• Boxed Warning 9/2009• WARNINGS AND PRECAUTIONS (5.2) 9/2009- - - - - - - - - - - - - -INDICATIONS AND USAGE- - - - - - - - - - - - - -AndroGel is an androgen indicated for replacement therapyin males for conditions associated with a deficiency or ab-sence of endogenous testosterone:• Primary Hypogonadism (Congenital or Acquired) (1.1)• Hypogonadotropic Hypogonadism (Congenital or Ac-

quired) (1.1)- - - - - - - - - -DOSAGE AND ADMINISTRATION - - - - - - - - - -

• Recommended starting dose: 5 g for adult males, appliedtopically once daily (2.1).

• Apply to clean, dry, intact skin of shoulders and upperarms and/or abdomen. Do NOT apply AndroGel to thegenitals (2.1).

• Dose adjustment for adult males: If serum testosteronelevel is below the normal range, adjust dose from 5 g to7.5 g and from 7.5 g to 10 g (2.3).

- - - - - - - - -DOSAGE FORMS AND STRENGTHS - - - - - - - - -AndroGel (testosterone gel) 1% for topical use is availableas:• 2 � 75 g pumps (each pump dispenses 60 metered 1.25 g

doses) (3)• 2.5 g packet or 5 g packet (3)- - - - - - - - - - - - - - - -CONTRAINDICATIONS - - - - - - - - - - - - - - - -• Men with carcinoma of the breast or known or suspected

prostate cancer (4, 5.1).• Pregnant or breast feeding women. Testosterone may

cause fetal harm (4)- - - - - - - - - - WARNINGS AND PRECAUTIONS - - - - - - - - - -• Patients with benign prostatic hyperplasia (BPH) treated

with androgens are at an increased risk for worsening ofsigns and symptoms of BPH (5.1).

• Secondary exposure to testosterone in children andwomen can occur with use of testosterone gel (5.2). Casesof secondary exposure resulting in virilization of childrenhave been reported (6.2).• Children and women should avoid contact with un-

washed or unclothed application site(s) in men usingtestosterone gel.

• To minimize the potential for transfer to others, pa-tients using AndroGel should apply the product as di-rected and strictly adhere to the following (5.2):• Wash hands with soap and water after application.• Cover the application site with clothing after the gel

has dried.• Wash the application site thoroughly with soap and

water prior to any situation where skin-to-skin con-tact of the application site with another person isanticipated.

• Signs of virilization in children and women and the pos-sibility of secondary exposure to testosterone gel shouldbe brought to the attention of the healthcare provider.Testosterone gel should be promptly discontinued untilthe cause of the virilization is identified (5.2).

• Due to lack of controlled evaluations in women and poten-tial virilizing effects, AndroGel is not indicated for use inwomen (5.3).

• Exogenous administration of androgens may lead to azoo-spermia (5.4).

• Edema may be a complication in patients with preexistingcardiac, renal, or hepatic disease (5.6, 6.2).

• Gynecomastia, enlargement of breast, may develop (5.7).• Sleep apnea may occur in those with risk factors (5.8).• Monitor serum testosterone, prostatic specific antigen, he-

moglobin, hematocrit, liver function test, and lipid levelsperiodically (2.3, 5.1, 5.9).

• Alcohol-based gels are flammable until dry (5.10).- - - - - - - - - - - - - - - -ADVERSE REACTIONS - - - - - - - - - - - - - - - -Most common adverse reactions (incidence � 5%) are acne,application site reaction, abnormal lab tests, and prostaticdisorders (6).Cases of testosterone secondary exposure resulting in viril-ization of children have been reported (6.2). Reported signsand symptoms have included enlargement of the penis orclitoris, premature development of pubic hair, increasederections and libido, aggressive behavior, and advancedbone age. In most cases with a reported outcome, thesesigns and symptoms were reported to have regressed withremoval of the exposure to testosterone gel (5.2, 6.2). In afew cases, however, enlarged genitalia did not fully returnto age-appropriate normal size and bone age remained mod-estly greater than chronological age.To report SUSPECTED ADVERSE REACTIONS, contact

Solvay Pharmaceuticals, Inc. at 1-800-241-1643 or FDA at

1-800-FDA-1088 or www.fda.gov/medwatch.- - - - - - - - - - - - - - - -DRUG INTERACTIONS - - - - - - - - - - - - - - - -• Androgens may decrease blood glucose, and therefore in-

sulin requirement in diabetic patients (7.1).

3456/UNICITY PHYSICIANS’ DESK REFERENCE®

Information will be superseded by supplements and subsequent editions

Documents

Bios Life Slim - Doctors Packet