BIOTECH ANTI HAIR LOSS

REV. 1

2-7

-20

21

MARKET POSITIONING

Anti hair loss complexReduction of hair fibrosis

Prevention of hair follicle miniaturizationStimulation of bulb germ cells, restoring the physiological condition for growth

Hair follicle regenerationHair anti-ageing, volumizing and softening (ideal also for beard and eye-lashes care) Ideal for hydro-alcoholic, glycolic lotions + masks, leave on and rinse-off treatments

STIMUCAP: TECHNOLOGY

STIMUCAP: TECHNOLOGY

Stimucap impacts the hair care treatments with a uniquedualistic approach

▪ «Follicle care» through a specific activity in keeping the homeostasis of the hair follicle, by preventing inflammationsand free radical related damages

▪ «Regeneration of hair stem cells» as complementarymechanism for treatments where regrowth stimulation isnecessary

STIMUCAP works with specific ubiquitous mechanismsIts beneficial activities are indistinctly attributable to HAIR, BEARD and EYE-LASHES

TEST VS BENCHMARK

COSMETICS IN VIVO TEST

Once/day for 3 months (controls @ 1,2 and 3 months)

30 volunteers (age between 29 and 55 years) affected by ALOPECIA & TELOGEN EFFLUVIUM15 volunteers treated with Stimucap, 15 with Minoxidil

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IN VIVO TEST

0

0,5

1

1,5

2

2,5

T0 T 1 month T 2 months T 3 months

Hair resistance scoreStimucap lotion Benchmark lotionPULL TEST

The hair traction resistance was determined by a traction force applied to hair locks at 3 different scalp site: the resistance was scored by a semi-quantitative scale expressing the number of removed hair in the 3 areas:

0 = > 6 1 = 6 ÷ 42 = 3 ÷ 1

3 = 0.

Stimucap lotion showed performances superior to the benchmark lotion, with a statistically significative overall hair resistance to traction of +40% (T3 – T0)

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IN VIVO TEST

0

0,2

0,4

0,6

0,8

1

1,2

1,4

1,6

1,8

2

T 1 month T 2 months T 3 months

Perceived efficacyStimucap lotion Benchmark lotion

PERCEIVED EFFICACY TEST

Stimucap lotion showed performances superior to the benchmark lotion in terms of efficacy perceived after the application

The effects are evident at the second and third month of the treatment

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IN VIVO TESTTEST OVERVIEW

• During the treatment, both the lotions reduced significantly itching and burning

• No seborrhea or dandruff changes were observed in any of the treatments

• Stimucap does not contain drugs but performs in comparable way to the benchmark, showing in some specific tests even better results

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STIMUCAP IN VIVO TESTSAFETY PROFILE

Stimucap is made of safe ingredients not implied in mechanisms of vasodilatation and cardiovascular alterations, as it happens with other benchmarks

Its tolerability makes it ideal for men and women with no specific restrictions

MARKETING CLAIMS

• Anti hair loss• Reduction of hair follicle miniaturization• Hair reinforcement• Fibrosis and inflammation reduction• Prevents premature «telogen phase» onset• Stimulation of bulb germ cells• Creation of the physiological condition for the

hair follicle to stimulate hair growth• Hair anti-ageing• Hair softness increase• Effective also on hairs and eye-lashes

Claims

ALTERNATIVE APPLICATIONSEYE LASHES CARE

Stimucap is able to:

• increase eye lashes softness• provide stimulation for their growth • moist the eyelash shaft with filming

features given by DNA polymeric structure• reduce inflammation and stress related to

the use of the eyelash crease

Ideal for mascara, eyelashes primers and serums

BEARD CARE

Stimucap is able to promote the beard softness, moist the hairs through the DNA

filming features and CLA (essential fatty acid) emolliency and anti-inflammatory

features

Ideal for beard density increase, volumizing and softening treatments

ALTERNATIVE APPLICATIONS