Biotechnology for Human Welfare

Naiyyum ChoudhuryNaiyyum Choudhury

Professor, BRAC University &Professor, BRAC University &

Secretary, BASSecretary, BAS

BIOTECHNOLOGY-DEFINITION!

What is Biotechnology?

Biotechnology may be defined as a set of modern tools that utilize living organisms or parts of it cell or tissue or genes/DNA to make or modify or improve plants or animals or develop microorganisms for specific use and their large scale production.

Industrial use of recombinant DNA

Trangenic plant development

Cell fusion

Novel bioprocess technologies and Bioremediation

Traditional and New Biotechnology

Traditional Biotechnology

Biotechnology has been employed by humans for millenia. Examples include production of beer, cheese ans bread

New Biotechnology

Recent development in molecular biology have given biotechnology a new meaning, new horizon and new potential through use of recombinant DNA technology

Gradients 0f Biotechnology-Traditional

Microbial FermentationMicrobial Fermentation

Biological nitrogen fixationBiological nitrogen fixation

Plant Tissue CulturePlant Tissue Culture

Embryo Transfer TechnologyEmbryo Transfer Technology

Monoclonal AntibodyMonoclonal Antibody

Modern Biotechnology-cost rising!

Recombinant DNA TechnologyRecombinant DNA Technology

Genetic Engineering of MicrobesGenetic Engineering of Microbes

Genetic Engineering of PlantsGenetic Engineering of Plants

Genetic Engineering of AnimalsGenetic Engineering of Animals

Milestones in Biotechnology

1950-1960- DNA Strucure unfolded1950-1960- DNA Strucure unfolded

1960-1970- Plant Tissue Culture1960-1970- Plant Tissue Culture

Plant ProtoplastPlant Protoplast

Reverse transcriptaseReverse transcriptase

1970-1980- Restriction Enzymes1970-1980- Restriction Enzymes

Gene CloningGene Cloning

Agrobacterium in Plant Agrobacterium in Plant transformationtransformation

1980-1990- PCR Technology1980-1990- PCR Technology

GM InsulinGM Insulin

1990-2000- Dolly sheep, Animal Cloning, GM 1990-2000- Dolly sheep, Animal Cloning, GM Crops Bt CottonCrops Bt Cotton

Human Genome Project etc. etcHuman Genome Project etc. etc

Transgenic Plants

• More than 4000 plants have been More than 4000 plants have been developed with GE methods with new developed with GE methods with new characteristicscharacteristics

• Tolerant to freezeTolerant to freeze

• Modification of ripening or softeningModification of ripening or softening

• Shel life increaseShel life increase

• Modification of sweetening of fruitsModification of sweetening of fruits

Other Areas of application

• Food ingredientsFood ingredients• Starter cultureStarter culture• Peptide growth hormonePeptide growth hormone• Nutritional quality improvementNutritional quality improvement• Trasngennic animalsTrasngennic animals• Heath And diagnostic productsHeath And diagnostic products• Recombinat dairy productsRecombinat dairy products• Hazardous waste treatmentHazardous waste treatment

Food ingredients

• Amino acidsAmino acids

• VitaminsVitamins

• Sweetening agentsSweetening agents

• Organic acidsOrganic acids

• Antimicrobial agentsAntimicrobial agents

• Flavouring agent i.e. MSGFlavouring agent i.e. MSG

• Various enzymesVarious enzymes

Improvement of Nutritional quality by the Application of GE

Nutritional quality of food supply-Golden rice.

Potatoes with 30% higher solid content

Essential amino acids in cereal grain increased

Improvement of taste, texture, colour and processing charateristics

of agricultural products

Transgenic Animals

Transgenic animals for increased milk, meat and pharmaceutical products

Health and Diagnostics through GE

-Cancer imaging agents

-Recombinant dairy products

- Autoimmune therapeutics

- Diabetes therapy

- Growth/healing proteins

Genetically Engineered Pharmaceuticals

Human insulin

Human growth hormone

Alpha interferon

Hepatitis B vaccine

Interleukin

AIDS treatment

GE bacteria for agriculture

.

Modern techniques like ETT (Embryo Transfer Technology) with artificial insemination is being pursued.

Eleven types of veterinary biologics are presently being produced.

Agricultural Feedstocks &

Chemicals

Industrial inorganic chemicals

Fertilizers

Other agricultural chemicals

Medicinals & botanicals

Pharma-ceutical preparations

Diagnostic substances

Biological products

Drugs & Pharmaceuticals

Medical Devices & Equipment

Laboratory apparatus & furniture

Surgical, medical, dental, & analytical instruments & equipment

X-ray & electromedical equipment

Hospitals & Laboratories

General medical & surgical hospitals

Psychiatric hospitals

Specialty hospitals

Medical & dental laboratories

Research & Testing

Biological research

Medical research

Food & seed testing laboratories

Veterinary testing laboratories

Product-Oriented Service-Oriented

Source: Battelle Memorial Institute

Biotech Wheels

The Bioscience Subsectors• Agricultural Agricultural

Feedstock & Feedstock & ChemicalsChemicals

• Drugs & Drugs & PharmaceuticalsPharmaceuticals

• Medical Devices & Medical Devices & EquipmentEquipment

• Research & TestingResearch & Testing

13%

37%

17%

33%

13% 17%

33%37%

Agricultural Feedstock & Chemicals

Drugs & Pharmaceuticals

Medical Devices & Equipment

Research & Testing

Agri-biotechnology and Healthcare

-GM CropsGM Crops

-GM Crop based ProductsGM Crop based Products

Global GM crop scenario

• Area coverageArea coverage ~68 million hectare ~68 million hectare

• Market valueMarket value ~ US$ 5.0 billion ~ US$ 5.0 billion

• Major crops in commerceMajor crops in commerce: soybean, maize, : soybean, maize, cotton,canola, tomato, potato, ricecotton,canola, tomato, potato, rice

• Major traits of interestMajor traits of interest: insect resistance, viral : insect resistance, viral resistance, herbicide tolerance, drought/salinity resistance, herbicide tolerance, drought/salinity tolerance, nutritional quality.tolerance, nutritional quality.

• [[estimated global bio-pharma market ~US$ 15 bestimated global bio-pharma market ~US$ 15 b]]

Emerging plant-based new ventures other than GM crops• Plant based: r-therapeutics & diagnosticsPlant based: r-therapeutics & diagnostics

(human & veterinary applications)(human & veterinary applications)

• Metabolically engineered phytomedicinesMetabolically engineered phytomedicines

• Value-added herbal products (new products Value-added herbal products (new products from known herbs: target new disease/ more from known herbs: target new disease/ more knowledge rich)knowledge rich)

Important Biotech Healthcare products for molecular farming• 19861986: : Human growth hormone in tobaccoHuman growth hormone in tobacco• 19891989: : IgG in tobaccoIgG in tobacco• 19921992: : Hepatitis B surface antigen in tobaccoHepatitis B surface antigen in tobacco• 19921992: : Alpha amylase in tobaccoAlpha amylase in tobacco• 19951995: : IgA in tobaccoIgA in tobacco• 19971997: : Avidin in maizeAvidin in maize• 20012001: : Vaccine in potatoVaccine in potato• 20032003: : Functional antibody in algaeFunctional antibody in algae• 2005: Human anthrax antibodies in tobacco2005: Human anthrax antibodies in tobacco  • It is estimated that by 2010 the market for this segment will It is estimated that by 2010 the market for this segment will

touch US$ 100 billiontouch US$ 100 billion

Commercial Scope: healthcare Biotech products • R-therapeutics & diagnostics: US$ 50b (2005); R-therapeutics & diagnostics: US$ 50b (2005);

US$ 200b (2015);US$ 200b (2015);

• Phytomedicine, nutraceuticals & beauticeuticals: Phytomedicine, nutraceuticals & beauticeuticals: US$ 30b (2005); US$ 60b (2015);US$ 30b (2005); US$ 60b (2015);

• Dietetics food & enzymes: US$ 90b (2005); US$ Dietetics food & enzymes: US$ 90b (2005); US$ 250b (2015);250b (2015);

• Bioinformatics & embeded systems: US$ 02b Bioinformatics & embeded systems: US$ 02b (2005); US$ 06b (2015).(2005); US$ 06b (2015).

Mass propagation industry: Major problems • EOU vs domestic marketEOU vs domestic market

• High volume low valueHigh volume low value

• High risk on quality control & quarantine aspectHigh risk on quality control & quarantine aspect

• Highly competitiveHighly competitive

• Secured market based on IP is not possibleSecured market based on IP is not possible

• Automated production for minimizing cost of Automated production for minimizing cost of production needs production needs huge capital investmenthuge capital investment

Biotech and Electronics- A Double Helix

• The multidisplinary approach to Biotechnology has The multidisplinary approach to Biotechnology has resulted in new and unique interdisciplinary area in resulted in new and unique interdisciplinary area in which molecular biology, different branches of which molecular biology, different branches of engineering, electronics etc have played pivotal role in engineering, electronics etc have played pivotal role in making products, processes and services of the modern making products, processes and services of the modern biotechnology within reach. of common man. biotechnology within reach. of common man.

• From application point of view, like twin strands of a From application point of view, like twin strands of a double helix, biotechnology and electronics are joining double helix, biotechnology and electronics are joining forces in a technological explosion that will dwarf what forces in a technological explosion that will dwarf what will be possible by either one of them. These aspects will be possible by either one of them. These aspects will be highlighted in the paperwill be highlighted in the paper

GM Crops 2011

• This is a historical landmark in that it is the This is a historical landmark in that it is the first time for more than 160 million hectares of first time for more than 160 million hectares of biotech crops to be grown in any one year. In biotech crops to be grown in any one year. In order to appropriately account for the use of order to appropriately account for the use of two or three  "stacked traits", that confer two or three  "stacked traits", that confer multiple benefits in a single biotech variety, is multiple benefits in a single biotech variety, is 15% higher than the estimate of 160 million 15% higher than the estimate of 160 million hectares. hectares.

Biotechnology and Developing Countries

-Interseted but directly not involved in Modern -Interseted but directly not involved in Modern BiotechnologyBiotechnology

-Have National policy on Biotechnology and Have National policy on Biotechnology and research programme; little in-country modern research programme; little in-country modern

biotechnologybiotechnology

-Have national policy, research programme Have national policy, research programme and international collaborationand international collaboration

-Have national policy, modern biotech research Have national policy, modern biotech research programme; storng overseas linkage in public programme; storng overseas linkage in public

and private sectorsand private sectors

Biology is in a fundamental revolution as Biology is in a fundamental revolution as knowledge acquisition is exponentialknowledge acquisition is exponentialPost genomic pharmaceutical (targeted drugs) are Post genomic pharmaceutical (targeted drugs) are based onbased on

• Human genome at the chromosomal levelHuman genome at the chromosomal level• Advent of computer powerAdvent of computer power• RoboticsRobotics• New automated modelsNew automated models• Nano technologies Nano technologies

Key Points

Key Points

The biotechnology promiseThe biotechnology promise• Increase agricultural productivityIncrease agricultural productivity• Increase pharmaceutical specificityIncrease pharmaceutical specificity• Reduce hungerReduce hunger• Improve HealthcareImprove Healthcare

This technology will move therapeutic from This technology will move therapeutic from symptomatic treatment to disease- symptomatic treatment to disease- modifying new medicinemodifying new medicine

Key Points

Gene - environment interactionGene - environment interaction

Through knowledge of genomics Through knowledge of genomics and proteomics targeted drugs (not and proteomics targeted drugs (not based on Symptoms) can be based on Symptoms) can be createdcreated..

Key Points

The activation of research groups in the The activation of research groups in the south promoted by major research south promoted by major research institute based in developed countries by institute based in developed countries by providing stable funding for these providing stable funding for these groups. This approach could make groups. This approach could make possible the development of new possible the development of new therapeutic drugs and vaccines designed therapeutic drugs and vaccines designed specifically for LDCs relatedspecifically for LDCs related

Key Points

Technology transfer which seems to Technology transfer which seems to be a gateway to a new and promising be a gateway to a new and promising economic development in those economic development in those countries where a good level of countries where a good level of entrepreneurship is already able to entrepreneurship is already able to promote and produce innovationspromote and produce innovations

Key Points

Public awareness has to be promoted to Public awareness has to be promoted to balance fears and opportunities. Each balance fears and opportunities. Each country should be able to sort out the country should be able to sort out the benefits from the hazards of biotechnology; benefits from the hazards of biotechnology; recognizing ethical concern and helping the recognizing ethical concern and helping the public make more informed choices. This public make more informed choices. This could help foster international cooperation could help foster international cooperation in biotechnology researchin biotechnology research

• Government initiatives for Government initiatives for Biotechnology in BangladeshBiotechnology in Bangladesh

R&D Priorities for Biotechnology gineering in Bangladesh

Agriculture sector

Health sector

Industry sector

Energy sector

Environment sector

National Committee on Biotechnology Product Development

In September 1993, a National Committee on Biotechnology Product Development was formed and finally the following products were selected : Rhizobial inoculants for use as biofertilizers Yeasts as protein supplement of poultry feed Tissue culture derived post exposure anti-rabies vaccine Tissue culture based foot and mouth disease vaccine Bamboo saplings by ex-vitro and in-vitro methods Biogas technology for fuel, fertilizer and environmental Pollution controlProduction of high quality potato seeds by using tissue culture

THE NATIONAL INSTITUTE OF BIOTECHNOLOGY

Concept initiated : 1984

NCST approval : 1993

Feasibility study : 1993

PCP approval : 1995

ECNEC approval : 1999

Project work initiated : July 2000

Estimated cost : 2768.24 Lakh Taka (Revised)

Project completed in 2008

THE NATIONAL INSTITUTE OF BIOTECHNOLOGY

Located in Ganobari, Savarin the campus of Atomic Energy Research Establishment

Total Floor space of the laboratories : 2250 sq. m.

Number of Laboratory : 6

Total number of scientists to work : 100 at the moment less than 10 scientists

THE NATIONAL INSTITUTE OF BIOTECHNOLOGY

Bangladesh has adopted the National Biotechnology Policy in July 2006 to accelerate multidimensional biotechnological research for augmenting human welfare in all respects such as food security, health and a sound environment in particular. The NIB is intended for the application of biotechnology-based technologies as per guidelines of National Biotechnology Policy. The tools of biotechnology are currently being applied across the biological sciences to address problems in agricultural crop improvement, marine sciences and aquaculture, environment, pharmacy, forensics and public health.

THE NATIONAL INSTITUTE OFBIOTECHNOLOGY

National Institute of Biotechnology is situated at Ganakbari beside Shreepur Kasampur road, at a total area of 11.5 acre of land. NIB will act as a National focal point to co-ordinate biotechnological activities in the country. The institute deserves its contribution for upgrading the socioeconomic development of the country through developing of high yielding varieties of crops, generation of employment, poverty alleviation, women empowerment, human resource development and awareness creation about the importance of application of biotechnology in agriculture, environment, health and industrial sectors.Research Divisions of NIB

Research Divisions of National Institute of BiotechnologyIB

• Plant Tissue Culture• Plant GeneticTransformation• Plant Breeding• DNA fingerprinting of plants• Marker aided selection of plants• Management of crops pest and

pathogens

1. Plant Biotechnology Division

Plant tissue culture for large-scale multiplication of rare, endangered, flower and fruit plant. Development of pathogen free, insect-pest and environment stress resistant plant through tissue culture and genetic transformation. Molecular characterization of local plant species

2. Microbial biotechnology Division

•Genetic improvement of industrial microorganisms•Production of enzymes, chemicals and other biotech products of industrial importance•Development of biotech pharmaceutical products•Protein Engineering

3. Animal Biotechnology Division

•Characterization, selection, conservation and genetic improvement of animal through modern biotechnological methods

•Production of biotech-derived therapeutics / diagnostic kits, antibiotics and vaccines

•>Improvement of feed quality through biotechnological approaches

• Preservation technique of animal products.

• Gene library construction of critically endangered, endangered and vulnerable fishes of Bangladesh

• Pure Gene line (Inbreeding) preparation for carp and other fishes.

• Development of improved strains of fish through selective Breeding

• Production of Sustainable variety (out breeding) of Critically Endangered Fish

• Production of transgenic fish through gene manipulation

• Selective production of Monosex fish populations (all male or all female)

• Storage of fish sperms and embryos by freezing• Characterization of fish using molecular markers• Production of Biotech improved fish feed

4. Fisheries Biotechnology Division

Environmental Biotechnology Division

•Development of biopesticides, biofertilizer and bioremediation agents•Development of appropriate waste management programme•Evaluation of ecological impacts of transgenic organisms•Preservation, development and long term conservation of bioresources•Alternative energy from renewable bioresources•Biofertilizer for different crops•Alternative energy from renewable bioresources•bio-remediation agents•Bio-mineralization process•bio-indicators and bio-pesticides

Molecular Biology Division

•Vector preparation•Cloning•Gene expression study•DNA fingerprinting and profiling•cDNA library, genomic DNA library and gene bank construction•Sequencing of genes and DNA of interest

• NIB will play a very important role in the filed of biotechnological research for agricultural, environmental, medical, food and industrial development of the country.

• The Institute is intended for the application of biotechnology-based technologies as per guidelines of National Biotechnology Policy.

• The tools of biotechnology are currently being applied across the biological sciences to address problems in agricultural crop improvement, marine sciences and aquaculture, environment, pharmacy, forensics and public health.

NECB

• National Executive Committee on National Executive Committee on Biotechnology with Proncipal Secretary Biotechnology with Proncipal Secretary to the Prime Minister as Chairto the Prime Minister as Chair

• 12 Members including two expert 12 Members including two expert membersmembers

• Secretary, S&T is the member Secretary, Secretary, S&T is the member Secretary, NECBNECB

Ploicy Directions, Monitoring and Implementation Mechanism

• National Task Force on Biotechnology Development National Task Force on Biotechnology Development formed with Hon’ble Prime Minister as the formed with Hon’ble Prime Minister as the ChairpersonChairperson

• State Minister for Science and Technology- Vice State Minister for Science and Technology- Vice ChairmanChairman

• 25 Members including Secretaries of relevant 25 Members including Secretaries of relevant mninistries, Chairman, BCSIR,BAEC and BARC mninistries, Chairman, BCSIR,BAEC and BARC and one expert member on Biotechnology by nameand one expert member on Biotechnology by name

• Secretary, S&T is member Secretary of the NTBBSecretary, S&T is member Secretary of the NTBB

National Technical Committee NBT Policy 2006

• NTC for BiodiversityNTC for Biodiversity

• NTC for BiosafetyNTC for Biosafety

• NTC for Crop BiotechnologyNTC for Crop Biotechnology

• NTC for Livestock and FisheriesNTC for Livestock and Fisheries

• NTC for Medical BiotechnologyNTC for Medical Biotechnology

NTC as per National Biotechnology Policy 2012

• 1. NTC Agricultural Biotechnology1. NTC Agricultural Biotechnology• 2. NTC Animal Biotechnology2. NTC Animal Biotechnology• 3. NTC on Fisheries Biotechnoology3. NTC on Fisheries Biotechnoology• 4. NTC on Env. Biotechnology4. NTC on Env. Biotechnology• 5. NTC on Medical Biotechnology5. NTC on Medical Biotechnology• 6. NTC on Industrial Biotechnology6. NTC on Industrial Biotechnology• 7. NTC on Human Resource Development7. NTC on Human Resource Development

• 8. NTC on Biosafety 8. NTC on Biosafety

Coordination and Management Committee as per NBT Policy 2012

• 18 Member Coordination and 18 Member Coordination and Management Committee with Secretary, Management Committee with Secretary, S&T as Chair andS&T as Chair and

• DG NIB as member SecretaryDG NIB as member Secretary

• Experts from relevant disciplines and Experts from relevant disciplines and representatives from relevant ministriesrepresentatives from relevant ministries

Ministry of Science and Information & Communication

Technology

• Focal Ministry for coordinating activities of all Focal Ministry for coordinating activities of all the National Technical Committeesthe National Technical Committees

• Secretary, MOSICT is the Member Secretary Secretary, MOSICT is the Member Secretary of the National Task Force and also the of the National Task Force and also the National Executive CommitteeNational Executive Committee

Conclusion

• It is encouraging to note that Biotechnology has It is encouraging to note that Biotechnology has been take as a thrust area like ICT by the present been take as a thrust area like ICT by the present government.government.

• The initiatives at the highest level of the Policy The initiatives at the highest level of the Policy makers may result in some fruitful biotechnology makers may result in some fruitful biotechnology work at all levelswork at all levels

• Promotion of appropriate Biotechnology will play Promotion of appropriate Biotechnology will play a significant role in Poverty alleviation, Food a significant role in Poverty alleviation, Food security, improved health and environment and security, improved health and environment and overall socioeconomic development of the countryoverall socioeconomic development of the country

Draft National Biotechnology 2012

• National Biotechnology Policy updated National Biotechnology Policy updated and a draft National Biotechnology and a draft National Biotechnology Policy 2012 is in the process of approval Policy 2012 is in the process of approval by the government.by the government.

Strategic Roadmap

• Strategic Roadmap to implement Strategic Roadmap to implement National Biotechnology Policy has been National Biotechnology Policy has been drafted containing strategic goals, policy drafted containing strategic goals, policy support, human development and support, human development and research and innovations in some research and innovations in some selected areas of biotechnology with selected areas of biotechnology with short, medium and long term activities short, medium and long term activities by the relevant agenciesby the relevant agencies

Research and Innovation• Plant biotechnologyPlant biotechnology

• Animal biotechnologyAnimal biotechnology

• Fisheres biotechnologyFisheres biotechnology

• Medical biotechnologyMedical biotechnology

• Industrial biotechnologyIndustrial biotechnology

• Environmental biotechnologyEnvironmental biotechnology

• Nano biotechnologyNano biotechnology

• Bioinformatics and IT enabled Bioinformatics and IT enabled biotechnologybiotechnology

Strategic RoadmapIn each of these areas action plans for short, In each of these areas action plans for short, medium and long term implementation have medium and long term implementation have been developed with strategy actions like been developed with strategy actions like

•regulatory measuresregulatory measures

• institutional capacity building and institutional capacity building and strengthening andstrengthening and

•Priority research programmes for the Priority research programmes for the implementing agenciesimplementing agencies

Strategic Roadmap

• Also includes biotech entrepreneurship Also includes biotech entrepreneurship development, awareness creation development, awareness creation programmeprogramme

Recent initiatives by the NIBEstablishment of Gene Bank at the NIB Establishment of Gene Bank at the NIB CampusCampus•To conserve existing plants, animals, fish and To conserve existing plants, animals, fish and microbial genetic resourcesmicrobial genetic resources•To make available gentic resources and relevant To make available gentic resources and relevant information to different organizations for research information to different organizations for research and development purposesand development purposes•Human resource development awarenesws Human resource development awarenesws creation and formulate necessary guidelines for creation and formulate necessary guidelines for conservation of genetic resourcesconservation of genetic resources

Biotechnology Incubator

• Objective;Objective;

• Establishment of internationally Establishment of internationally acceptable GMO testing and certifying acceptable GMO testing and certifying centrecentre

• Establishment of an analytical facilities Establishment of an analytical facilities and providing necessary assistance for and providing necessary assistance for commercialization of biotechnology commercialization of biotechnology resarchresarch

National National BiotechnologyBiotechnology

Policy 2006 and Draft National Biotech Policy

2012

.

Time frame set for the draft

• National Biotechnology Policy Formulation Committee formed onNational Biotechnology Policy Formulation Committee formed on• May 17, 2004May 17, 2004• First Meeting of the Committee held on First Meeting of the Committee held on May 22, 2004May 22, 2004• Decisions: A Working Group formed to prepare a draft of the NBPDecisions: A Working Group formed to prepare a draft of the NBP• National Technical Committees will send respective Committee’s input to National Technical Committees will send respective Committee’s input to

the Working Group by the Working Group by June 05, 2004June 05, 2004• Working Group will submit the first draft by Working Group will submit the first draft by June 12, 2004June 12, 2004• Next Meeting of the Committee will be held on Next Meeting of the Committee will be held on June 19, 2004(today)June 19, 2004(today)• Second draft will be submitted by the Working Group on Second draft will be submitted by the Working Group on May 26, 2004May 26, 2004• 33rdrd Meeting of the Committee to consider the 2 Meeting of the Committee to consider the 2ndnd draft will be held on draft will be held on• July 01, 2004 July 01, 2004 • Final draft will be submitted by the Working Group based on comments Final draft will be submitted by the Working Group based on comments

received on received on July10, 2004July10, 2004

Working Committee for preparation of the Draft National

Biotechnology Policy

• Dr. Naiyyum Choudhury, BASDr. Naiyyum Choudhury, BAS

• Dr. Md Abdur Razzaque, BARCDr. Md Abdur Razzaque, BARC

• Dr. M.S. Islam, NIBDr. M.S. Islam, NIB

• Dr. Kh. Md. Nasiruddin, BAUDr. Kh. Md. Nasiruddin, BAU

• Dr. Mustafizur Rahman, D.U.Dr. Mustafizur Rahman, D.U.

• Dr. Haseena Khan, D.U.Dr. Haseena Khan, D.U.

• Dr. Md. Mokbul Hosain, BAEC.Dr. Md. Mokbul Hosain, BAEC.

Preamble• Biotechnology includes Any Biotechnology includes Any

technological application that uses technological application that uses biological system, living organisms biological system, living organisms or derivatives thereof to make or or derivatives thereof to make or modify products or processes for modify products or processes for specific usespecific use

• Has helped increase productivity Has helped increase productivity in crops, livestock, fisheries and in crops, livestock, fisheries and forestryforestry

• Spectacular development has taken Spectacular development has taken place in medical biotechnology, place in medical biotechnology, environmental biotechnology and environmental biotechnology and fermentation technologyfermentation technology

World Scenario

• Last 20-25 years have been the golden age of Last 20-25 years have been the golden age of BiotechnologyBiotechnology

• DNA technology has strongly captured the DNA technology has strongly captured the market in pharmaceutical field with hitherto market in pharmaceutical field with hitherto unknown genetically engineered drugs,unknown genetically engineered drugs,

• In agriculture, animal health, fermentation In agriculture, animal health, fermentation and environment protection significant and environment protection significant achievement has taken place globallyachievement has taken place globally

Status of Biotechnology in Bangladesh

• Bangladesh has made some Bangladesh has made some strides in traditional strides in traditional Biotechnology like tissue Biotechnology like tissue culture ,traditional culture ,traditional fermentationfermentation

• Yet to start in real earnestness Yet to start in real earnestness new Biotechnology for new Biotechnology for improvement of plants, animals improvement of plants, animals industrial microorganisms etc.industrial microorganisms etc.

..

Vision

• Sustained food ,health and livelihood and health Sustained food ,health and livelihood and health security through environment friendly security through environment friendly biotechnology research and development biotechnology research and development

• Establishing research-extension-end user Establishing research-extension-end user linkage and public-private-partnershiplinkage and public-private-partnership

• Meet millennium Development Goals through Meet millennium Development Goals through promotion of conventional and modern promotion of conventional and modern Biotechnologies for socio-economic development Biotechnologies for socio-economic development

Goal The main goal of the NAIONAL The main goal of the NAIONAL

BIOTECHNOLOGY POLICY would be to BIOTECHNOLOGY POLICY would be to ensure sustainable development of ensure sustainable development of agriculture-food, nutrition, health, agriculture-food, nutrition, health, environment and livelihood of people environment and livelihood of people through strengthening national capacity in through strengthening national capacity in conventional as well as modern conventional as well as modern biotechnology, biosafety, bioethics, IPR and biotechnology, biosafety, bioethics, IPR and biosurveillancebiosurveillance

Objectives

• Bio-resources InventoryBio-resources Inventory• Infrastructure developmentInfrastructure development• Human resource development Human resource development • BioinformaticsBioinformatics• Bio-safety, Bioethics,Bio-safety, Bioethics,• IPRIPR• Entrepreurship developmentEntrepreurship development• Public –Private -PartnershipPublic –Private -Partnership

Opportunity Areas of Biotechnology

• Agriculture-FoodAgriculture-Food• Animal and FishAnimal and Fish• Medical/ Human and Medical/ Human and

Animal Health careAnimal Health care• EnvironmentEnvironment• Biotech Products and Biotech Products and

ProcessesProcesses• Biodiversity Biodiversity

ConservationConservation

Policy Statements

• Infrastructure Development Infrastructure Development

• Human Resource Development Human Resource Development

• Identification of priority areas Identification of priority areas of Biotechnology Research and of Biotechnology Research and Development Development

• Funding Mechanisms for Funding Mechanisms for Biotechnology ResearchBiotechnology Research

Policy Statement(contd) Infrastructure Development

• Optimum utilization of existing facilitiesOptimum utilization of existing facilities

• Strengthening of existing biotechnology Strengthening of existing biotechnology laboratories in R&D organizations and laboratories in R&D organizations and academic institutionsacademic institutions

• Creation of Centre(s) of ExcellenceCreation of Centre(s) of Excellence

Policy Statement-contd.Human Resource Development• Academic ProgrammeAcademic Programme• Short Term Training for biotech Short Term Training for biotech

ResearchersResearchers• Training of Policy MakersTraining of Policy Makers• Training on IPRTraining on IPR• Training on Risk Analysis and Risk Training on Risk Analysis and Risk

Management in biotech Research and Management in biotech Research and ApplicationsApplications

Policy Statement-Identification of Priority Areas

• Plant BiotechnologyPlant Biotechnology• Animal BiotechnologyAnimal Biotechnology• AquacultureAquaculture• Medical BiotechnologyMedical Biotechnology• Industrial BiotechnologyIndustrial Biotechnology• Environmental BiotechnologyEnvironmental Biotechnology• Biodiversity Conservation Biodiversity Conservation • Human Genetics and GenomicsHuman Genetics and Genomics• BioinformaticsBioinformatics• Biosafety and BioethicsBiosafety and Bioethics• IPR related IssuesIPR related Issues

Policy Statement-Funding Mechanisms for

Biotechnology• Government FundingGovernment Funding

• Self Reliance and SustainabilitySelf Reliance and Sustainability

• Contract ResearchContract Research

• Innovation incentives for ResearchersInnovation incentives for Researchers

• Public-Private Sector PartnershipPublic-Private Sector Partnership

• International FundingInternational Funding

Policy Statements (Cont.)

• Creation of Enabling Environment for Creation of Enabling Environment for Biotechnology EnterpriseBiotechnology Enterprise

• CommercializationCommercialization• Management of Intellectual PropertyManagement of Intellectual Property• Indigenous Community Knowledge and IPRIndigenous Community Knowledge and IPR• Bio-safety, Bio-surveillance and Bio-ethics Bio-safety, Bio-surveillance and Bio-ethics • Regional and International CollaborationRegional and International Collaboration• Public Awareness measures For Transparency in Public Awareness measures For Transparency in

Biotechnology Work Biotechnology Work

Creation of Enabling Environment for Biotechnology Enterprise

• Establishment of Biotechnology Establishment of Biotechnology Enterprise (Bio-Valley)Enterprise (Bio-Valley)

• Biotech IncubatorsBiotech Incubators

Policy Statements(contd.)

• CommercializationCommercialization• Management of Intellectual PropertyManagement of Intellectual Property• Indigenous Community Knowledge and IPRIndigenous Community Knowledge and IPR• Bio-safety, Bio-surveillance and Bio-ethics Bio-safety, Bio-surveillance and Bio-ethics • Regional and International CollaborationRegional and International Collaboration• Public Awareness measures For Transparency Public Awareness measures For Transparency

in Biotechnology Work in Biotechnology Work

Implementation and Monitoring

• Immediate Action ProgrammeImmediate Action Programme• Formation of National Task ForceFormation of National Task Force• National Executive Committee on National Executive Committee on

Biotechnology NationalBiotechnology National Authority on Authority on Biotechnology)Biotechnology)

• Priority Plan for different Areas of Priority Plan for different Areas of Biotechnology (Biotechnology (Twenty Year Perspective Plan for Priority Twenty Year Perspective Plan for Priority

Programme)Programme), Funding for Human Resource , Funding for Human Resource Development, Institutional development, Development, Institutional development, Centre(s) of ExcellenceCentre(s) of Excellence

Organizational Arrangement for the Policy Document

Ministry Of Science and Information & Ministry Of Science and Information & Communication Technology being the Communication Technology being the focal Ministry for promoting focal Ministry for promoting Biotechnology will review the National Biotechnology will review the National Policy from time to time for updating, Policy from time to time for updating, harmonizing and standardizing the harmonizing and standardizing the Policy document in the light of global Policy document in the light of global development in this field keeping in view development in this field keeping in view our national needs and interest.our national needs and interest.

National Taskforce Meeting, July 19, 2006

The TF Meeting chaired by Ho’ble The TF Meeting chaired by Ho’ble Prime Minister approved the Prime Minister approved the

National Biotechnology Policy for National Biotechnology Policy for BangladeshBangladesh

National Biosafety GuidelinesNational Biosafety Guidelines

Guidelines for programmes on Guidelines for programmes on Crop Biotechnology; Medical Crop Biotechnology; Medical

Biotechnology and Livestock and Biotechnology and Livestock and Fisheries BiotechnologyFisheries Biotechnology

Biosafety Aspects

• Ministry of Environment and Forest is the Ministry of Environment and Forest is the Focal Ministry for dealing with all aspects Focal Ministry for dealing with all aspects related to biosafetyrelated to biosafety

• The Biosafety Guidelines has been re-examined The Biosafety Guidelines has been re-examined and updatedand updated

• Work in progress on Biosafety FrameworkWork in progress on Biosafety Framework• Biosafety Act formulation may take some timeBiosafety Act formulation may take some time