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7/29/2019 Biotecnology Journal
1/17
Updated: June 2013
Biotechnology Journal
Instructions to Authors
Manuscript submission:
http://mc.manuscriptcentral.com/btj
Contact the Editorial Office at:[email protected]
Authors are requested to follow these Instructions carefully. Manuscripts not prepared accordingly
will be returned to authors and this will inevitably lead to a delay in the editorial processing of the
manuscript. Please refer to our Appendix B for Authors to comply with all requirements.
1. Terms of publication ........................................................................................................................ 2
2. Manuscript preparation .................................................................................................................. 5
3. Online submission of manuscripts ................................................................................................ 13
4. Manuscript publication ................................................................................................................. 14
Appendix A: BTJ Keywords .................................................................................................................... 16
Appendix B: Checklist for Authors ......................................................................................................... 17
http://mc.manuscriptcentral.com/btjmailto:[email protected]:[email protected]:[email protected]:[email protected]://mc.manuscriptcentral.com/btj7/29/2019 Biotecnology Journal
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www.biotechnology-journal.com
Manuscript submission: http://mc.manuscriptcentral.com/btj
Contact the Editorial Office at: [email protected]
Page 2 of17
1. Terms of publicationAll scientific contributions will be peer-reviewed on the criteria of originality and quality. Authors
may suggest up to five potential referees, including their e-mail addresses, as well as individuals
whom they wish to be excluded from the review process. The reason for excluding certain refereesshould be stated. Upon acceptance, papers may be subjected to editorial changes. A revised paper
will retain its original date of receipt only if it is resubmitted to the Editors within three months after
revision was requested. Responsibility for the factual accuracy of a paper rests entirely with the
author.
Upon acceptance of the manuscript the corresponding author is required to fill in the Copyright
Transfer Agreement, sign it and submit it to the Editorial Office.
1.1. Aims and scopeBiotechnology Journal (BTJ) is an international resource for both biotechnology researchers and
professionals in related disciplines. Fully comprehensive in its scope, the Journal publishes strictly
peer-reviewed papers covering novel aspects and methods in all areas of biotechnology. Special
attention is also paid to the public, legal, ethical and cultural aspects of biotechnological research in
the Forum section. Some issues are devoted to a special topic, providing the latest comprehensive
information on the most crucial areas of research and technological advances. In addition to special
issues, the journal welcomes unsolicited submissions both for primary research articles and for
review articles (see 4) for additional review article).
The Journal contains original papers in the form of Research Articles, Rapid Communications and
Technical Reports, illustrating the latest research results. BTJ welcomes submission of papers in areasincluding DNA/protein engineering, all -omics fields (genomics, proteomics, metabolomics, systems
biology etc.), bioinformatics (algorithms and modeling), imaging, analytical biotech
(sensors/detectors for analytes/macromolecules), plant/agricultural, food or environmental
biotechnology, health and therapeutical biotechnology (including antisense/siRNAs, enzymes,
peptide, etc.), regenerative medicine (stem cells, tissue engineering and biomaterials), translational
immunology (antibody engineering, xenotransplantation, T-cell therapies), and biosafety or
biosecurity.
BTJ promotes a special emphasis on:
Systems Biotechnology
High-Throughput and Microarray Technologies Synthetic Biology and Metabolic Engineering
Nanobiotechnology
Medical Biotechnology
Translational Biotechnology and Applied Microbiology
Methods and Advances
Biosafety, Biotech Ethics, Science Communication
http://media.wiley.com/assets/1540/92/ctalsweinheimglobal.pdfhttp://media.wiley.com/assets/1540/92/ctalsweinheimglobal.pdfhttp://media.wiley.com/assets/1540/92/ctalsweinheimglobal.pdfhttp://media.wiley.com/assets/1540/92/ctalsweinheimglobal.pdf7/29/2019 Biotecnology Journal
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In particular, BTJ welcomes submissions on
Systems Biology/Bioinformatics: Overview and interplay between biological system components and
their functional implications (e.g. enzymes and metabolites in a metabolic pathway). Computational
analysis of all topics mentioned below (modeling, algorithms, data deconvolution).
Synthetic Biology: The design and construction of new biological parts, devices and systems; re-
design of natural biological systems for useful purposes.
Nanobiotech/ Biomaterials: Nanomaterials for industrial (white) biotech, drug delivery therapeutics,
biochips, micro- and nanofluidics, nanosensors, and nanosystems for imaging; engineering materials
for biological application, molecular imprinting, and biomimetics.
Medicine/ Red Biotech/ Stem cells: Therapeutic cloning (somatic cell nuclear transfer), tissue
engineering, xenotransplantation; DNA or RNA therapeutics (gene therapy, targeting,
immunogenicity); vaccines and applied immunology (Ab engineering, T-cell therapies, therapies
exploiting innate immunity, antigen delivery vectors and approaches; viral or non-viral strategies for
drug delivery.
Mammalian Biotech/Genetics: Manipulating gene structure and control of gene expression;
transgenic animals, knockouts, reproductive cloning, biopharmaceutical and enzyme production,
transgene targeting and expression strategies.
Metabolic Engineering: Genetic manipulation of species of interest to modify or allow the
production of a commercially or therapeutically relevant compound.
Biocatalysis: Evolution and protein design (antibodies, enzymes, drugs, etc.)
White/Industrial Biotechnology: Chemical synthesis by bacteria, yeast or other organisms, use of
enzymes as industrial catalysts, biopharmaceutics, biofuels.
Omics, Analytical Biotech, Biosensors: (Meta)genomics, structural genomics, gene function analysis
(e.g. arrays, SAGE), pharmacogenomics (SNPs), gene structure analysis, chemogenomics, proteomics
(e.g. mass spectrometry, yeast two hybrid, arrays and chips, NMR, SPR), metabolomics
(chromatography, mass spectrometry). Analytical methods and systems for monitoring research,
development and production of biotechnological products.
Methods: Technical aspects and practical protocols for all biotech applications; expression systems in
mammalian, insect, bacterial, fungal or plant cells; screening methods; novel
organism/cell/molecular imaging techniques; high-throughput imaging tools for drug screening,
fluorescence microscopy, electron microscopy/tomography, confocal imaging, etc.
Biochemical Engineering/ Downstream Processing: Chemical engineering aspects of biological
processes from primary material to product recovery; separation, purification, and packaging after
fermentation or bioconversion.
Plant Biotechnology: Crop improvement (resistance to stress, disease, pests), nutraceuticals, forest
biotech, plant vaccines or bioreactors, biosecurity and gene-containment strategies, bioenergy,
microbial biodegradation, food biotech, environmental biotech: bioremediation, biomining,
phytoremediation, monitoring.
Food Biotechnology: Application of microbiology and metabolic aspects to food and beverage
systems; food safety and pathogens, food fermentation, food bioactive compounds.
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Manuscript submission: http://mc.manuscriptcentral.com/btj
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Page 4 of17
Biosafety, Biotech Ethics, Science Communication
Out of scope
Biotechnology Journal will NOT consider submissions consisting of marginal advancements, for
example cloning without functional relevance, characterizations without functional data orapplications, fermentation optimizations without technical novelty, adsorption and chromatography
studies without a deeper insight into the process, or separation studies without a modeling support.
In silico predictions with no supporting experimental data or implications for further studies will also
not be considered.
Readership
Including, but not limited to: biotechnologists, microbiologists, bioengineers, medical and
pharmaceutical scientists, food and nutrition scientists, agriculturists, environmental scientists,
patent lawyers, and public authorities.
1.2. Publication Ethics1.2.1. Ethical misconductThis Journal endorses the COPE (Committee on Publication Ethics) guidelines and will pursue cases of
suspected research and publication misconduct. In such cases, the Journal will follow the processes
set out by COPE. For more information about COPE please visit the COPE website at
http://www.publicationethics.org.uk. All instances of publishing misconduct, including, but not
limited to, plagiarism, data fabrication, image/data manipulation to falsify/ enhance results, etc. will
result in rejection/retraction of the manuscript.
It is the authors responsibility to obtain permissions for reproduction of figures, tables, or text from
published works. In many cases, the publisher of a journal or book is the copyright owner from whom
the written permission must be obtained. Permission from authors is also encouraged as a
professional courtesy.
1.2.2. Sharing of materialAll materials and reagents that are not commercially available (antibodies, cell lines, constructs, etc.)
and associated protocols detailed in manuscripts published in Biotechnology Journalare to be freelyavailable to academic researchers in a timely manner upon request. The authors agree to this
condition by submitting a manuscript to Biotechnology journal.
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Page 5 of17
2. Manuscript preparation2.1. Language assistanceBiotechnology Journalpublishes articles in English. American spelling is preferred. Manuscripts mustbe grammatically and linguistically correct, and authors less familiar with English usage are advised to
seek the help of English-speaking colleagues. These authors may also choose to have their
manuscript professionally edited prior to submission. Help and suggestions for language services can
be found at http://authorservices.wiley.com/bauthor/english_language.asp.
2.2. Types of contributions2.2.1. Scientific contributionsFour categories ofscientific contributions are published in Biotechnology Journal:
1) Research Articles
2) Rapid Communications
3) Technical Reports
4) Review Articles
Research Articles describe complete investigations. Original research articles should not exceed 6500
words; this limit includes references, figure legends and tables. Longer manuscripts will be
considered but only if the increased length is a reflection of the amount of data presented and not a
result of inclusion of unnecessary information. Manuscripts may not have been published previously,
except in the form of a preliminary communication such as meeting abstracts. Research Articles
should be divided into the following sections: Introduction, Materials and methods, Results,
Discussion,Acknowledgementand References. We recommend a maximum of five display elements
(figures/tables).
Rapid Communications describe the latest biotechnological discovery in a brief and succinct form.
These manuscripts should bear the words Rapid Communication immediately above the title on
the first page. Rapid communications should not exceed 2500 words (including references as well as
figure and table legends) and contain no more than three display elements (figures and tables). Rapid
Communications should be divided into the following sections: Introduction, Materials and methods,
Results, Discussion,Acknowledgementand References.
Technical Reports describe the development of a novel method or an improvement or noteworthymodification of an already existing technique or platform used in biotechnology. These manuscripts
should bear the words Technical Report immediately above the title on the first page. Technical
Reports should not exceed 4000 words (including references as well as figure and table legends) and
contain no more than three display elements (figures and tables). Technical Reports should be
divided into the following sections: Introduction, Materials and methods, Results, Discussion,
Acknowledgementand References.
Reviews Articles are to be invited by the Editor. Authors planning to submit unsolicited reviews
should send a brief outline of its contents to the Editorial Office([email protected])prior to writing the
full article. The articles should be divided into sections that are appropriate to the topic. Authors
should also submit a short biography of the corresponding and optionally, one additional author (up
http://authorservices.wiley.com/bauthor/english_language.aspmailto:[email protected]:[email protected]:[email protected]:[email protected]://authorservices.wiley.com/bauthor/english_language.asp7/29/2019 Biotecnology Journal
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Page 6 of17
to 100 words each) accompanied by a portrait image (TIFF or JPEG file). There are two types of
reviews:
Reviews (full-length) should be reserved for subject areas that have not been previously
reviewed in detail. Full-length reviews should not exceed 8000 words (including references
and figure/table legends).
Mini-Reviews provide an update of the latest research. Authors should refer to previous
reviews for detailed background of the subject area. Mini-reviews should not exceed 4000
words (including references and figure/table legends).
For both review types, the article should provide novel insights and synthesis of available literature
within the topic of the review; reviews SHOULD NOT be a mere listing of available information;
reviews should provide a balanced view of the field by citing and discussing relevant data. Authors
are also encouraged to raise controversial opinions - these however, must be supported by relevant
literature and NOT the author's unpublished data. Authors are encouraged to avoid excessive
reference to their own unpublished data. As the peer-review process of Reviews do not allow for
detailed scrutiny of research data, Review articles must not contain previously unpublished data.
IMPORTANT: due to rising printing costs, BTJ must levy page charges on lengthy manuscripts
manuscripts that exceed the above limitations by more than 25% will be requested to cover the costs
of the extra pages. We appreciate the authors understanding in the matter.
2.2.2. Other contributionsBiotechnology journalalso accepts Other contributions of the following types:
Commentaries describe the latest research results published in the same issue of
Biotechnology Journal. These articles are invited by the Editors. Commentaries discuss the
studies in light of current knowledge. Recommended word limit is 2000 words (including
references and figure/table legends); authors are also encouraged to submit summary
figures that support the thesis of the Commentary.
Forum Articles describe the latest news and events in biotechnology, and also relevant
ethical and socioeconomic issues. Examples include:
- Important publications and awards
-Institute or company highlights
- New trends or policies
- Meetings reports
- Industry highlights
- Ethical issues surrounding biotechnology
- Biotech around the world
Please contact the Editorial Office ([email protected])before writing or submitting a contribution to
the BTJ Forum.
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2.3. Cover letterThe manuscript should be accompanied by a letter of transmittal that includes the following
statements:
1) Why the paper is suitable for publication in Biotechnology Journal?
2) All authors concur with the submission and have seen a draft copy of the manuscript and
agree with its publication.
3) The work has not been published elsewhere, either completely, in part, or in another form.
4) The manuscript has not been submitted to another journal and will not be published
elsewhere within one year after its publication in this journal. Publication in any reasonably
retrievable source constitutes prior publication. Meeting abstracts or preprints do not
constitute prior publication.
5) Conflict of Interest statement: authors are responsible for disclosing all financial and
personal relationships between themselves and others that might bias their work. To prevent
ambiguity, authors must state explicitly whether potential conflicts do or do not exist. Thisstatement will not influence the decision. Intentional omission of any potential conflict of
interest may however, negatively impact the decision to publish the manuscript.
6) The manuscript does/does not contain experiments using animals. The permission of the
national or local authorities (giving the permission or the accreditation no. of the laboratory
and of the investigator) should be stated if animal experiments are included. If no such rules
or permissions have been implicated in the particular country, this must be stated.
7) The manuscript does/does not contain human studies. If such studies are included, it should
be stated that local Ethical Committee approval was received for the studies and that the
informed consent of all participating subjects was obtained. Permission statements relating
to points 4 and 5 should also be included in the text of the manuscript.
Permission statements relating to points 6) and 7) should also be included in the text of the
manuscript.
2.4. Format and style of manuscripts2.4.1. Title pageThe first page of all manuscripts should contain only the following:
i. Title of the paper - containing only the most important keywords pertaining to the subject
matter.ii. Full names (including full first name, middle initial/s, and full family name) of the authors and
the name of their institute(s). If the publication originates from several institutes the
affiliations of all authors should be clearly stated by using superscript numbers after the
name and before the institute.
iii. Name, title and full postal address of the author to whom all correspondence (including
galley proofs) is to be sent. This should also include the e-mail address.
iv. Keywords: provide a list of 3-5 keywords
v. A list of abbreviations used in the paper. Keeping in mind that abbreviations may be a
hindrance to those not familiar with the field of study. Therefore, abbreviations should be
restricted to a minimum. Abbreviations should be introduced only when repeatedly used.
Abbreviations used only in a table or a figure may be defined in the legend.
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2.4.2. AbstractAn Abstract of the manuscript should be included. This should provide a brief background to the
study rationale; present the hypothesis; highlight significant findings/results; and emphasize the
take-home message of the study. This must be self-explanatory and intelligible without reference tothe main text. It should not exceed 200 words. The abstract should not contain any references.
2.4.3. Practical applicationsWhen submitting your manuscript the submission system will ask you to provide the Practical
Applications of your work. The limit is 150 words. This text should highlight the uses either actual
or potential of the research you are presenting. Providing this information will ensure the content
is widely accessible by both academic and corporate audiences. This text should also be included on
the second page of the manuscript. This does not apply to Reviews and Other contributions.
2.4.4.
Guidelines to manuscript sections
Introduction
The Introduction section should contain a description of the problem under investigation and a brief
survey of the existing literature on the subject. The study rationale/hypothesis should also be clearly
described.
Materials and methods
The Materials and Methods section should describe all materials and methods used in the study in
sufficient detail so that an independent, trained reader may repeat the studies. Any materials and
experiments that are used only in the Supporting Information, do not need to be described in the
main text and instead should be included in the Supporting Information. Authors are encouraged to
refer to previously published descriptions of methods and provide only a brief summary of the
method. Any modifications to published methods should be described in detail. Sources (name and
location) of reagents and equipment should be provided.
Results
The Results section describes the main experimental finding of the study. Sub-sections should be
provided to reflect the key messages of the study. Full statistical analysis should be performed. The
name of each test used and its outcome should be detailed, as should the number of samples,
replicates and data presentation (SD vs SEM).
Discussion
The Discussion section describes the findings in light of current knowledge. It should enrich, but not
repeat, the Introduction and the Results sections.
Concluding remarks
The Concluding Remarks section is only applicable to Rapid Communications and Technical Reports,
in which the Results and Discussion sections are combined. Concluding Remarks should provide the
take-home message in a short and succinct manner.
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Acknowledgements
Acknowledgements should be provided on a separate page at the end of the text (before the
References). ALL funding sources for the study and each authors contribution to the article should be
stipulated.
Conflict-of-interest statement
Authors are responsible for disclosing all financial and personal relationships between themselves
and others that might bias their work (e.g. an author writing on advances in basic research on
antibiotics might be a paid consultant, or external contractor, to a biotech or pharmaceutical
company). To prevent ambiguity, authors must state explicitly whether potential conflicts do or do
not exist. At the time of first submission a statement about any conflict of interest MUST be included
in the cover letter and in the manuscript after theAcknowledgements section.
Either: The authors declare no commercial or financial conflict of interest
Or: Conflict of interest: Nature of the conflict of interest, e.g. "Author X is a paid consultant forcompany Y."
This statement will not influence the peer review and the decision on the manuscript. Intentional
omission of any potential conflict of interest however, may negatively impact the decision to publish
the manuscript.
References
References, including those in tables and figure legends, should be numbered sequentially in the
order in which they appear in the text. The numbers should be set in square brackets in the text i.e.
[2, 18]. References are to be collected in numerical order at the end of the manuscript under the
heading References, they should also be typed with double spacing throughout. Titles of journals
should be abbreviated according to the practice ofPubMed. The abbreviated journal title and the
volume number should be in italics.
If necessary, cite unpublished or personal workin the text but do not include it in the reference list.
Articles that have been submitted but not yet accepted should NOT be included in the reference list.
The DOI for the reference should be included at the end of the reference, if no print reference is
available. Abstracts and posters in meeting books must not be cited unless they are generally
accessible. Please note that website addresses must not be included as a reference but should be
inserted in the text directly after the data to which they refer.
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Please note the following examples:
Journals:
[1] Liebeton, K., Eck, J., Identification and
Expression in E. coliof novel nitrile hydratasesfrom the metagenome. Eng. Life Sci. 2004, 4,
557562.
[2] Schmoekel, F. E.,Weber, J. C., Schense, J. C.,
Gratz, K.W. et al., Bone repair with a form of
BMP-2 engineered for incorporation into fibrin
cell ingrowth matrices. Biotechnol. Bioeng. 2005,
DOI: 10.1002/bit.20168.
Books:
[3] Geis, A., Perspectives of genetic engineering
of bacteria used in food fermentations, in:Heller,K. J. (Ed.), Genetically Engineered Food
Methods and Detection, Wiley-VCH Verlag,
Weinheim 2003, pp. 100118.
[4] Chrisou, P., Klee, H. (Ed.), Handbook of Plant
Biotechnology, John Wiley & Sons, 2004
Patents:
[5] Pandey, R., Ratnani, K., Ahmed, S.,Williams, J.,
Direct conversion of methane to hythane.
US Patent 5516967, 1996.
[6] Nadeau, E., Fairbrother J., Use of live bacteriafor growth promotion in animals. US Patent
Application 2007/0218035 A1.
Note that
Papers with multiple authors should be limited to listing the first four authors,
followed by et al.
Papers published online in advance of print should be cited with their DOI.
Other serial publications should be cited in the same manner as journals.
Responsibility for the accuracy of bibliographic references rests entirely with the author.
Tables
Tables with suitable captions at the top and numbered with Arabic numerals should be collected at
the end of the text on separate pages for different tables. Column headings should be kept as brief as
possible and indicate units. Footnotes to tables should be indicated with a), b), c), etc. and typed at
the bottom of the Table.
Figures and legends
Figures should be numbered in the order of their appearance in the text with Arabic numerals. Each
Figure must have a separate legend, which should be self-explanatory and allow readers tounderstand the data presented without reference to the main text. The legends should not appear
under the figures, but be gathered in a separate section (Figure legends) after the references and
tables. The figures should be submitted separately and not included into the main document. The
responsibility for obtaining permissions to reprint Figures and Tables and any associated costs rests
entirely with the author.
Color figures can only be printed if the author is prepared to pay for the extra cost incurred. At the
time of submission the author is asked to state whether he/she is willing to cover these expenses.
The prices (incl. VAT) are EUR 595 for one Figure, 990 for two, 1485 for three and 1980 for four. Click
hereto download the color figure order form.
http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1860-7314/homepage/2446_color_fig.pdfhttp://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1860-7314/homepage/2446_color_fig.pdfhttp://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1860-7314/homepage/2446_color_fig.pdfhttp://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1860-7314/homepage/2446_color_fig.pdfhttp://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1860-7314/homepage/2446_color_fig.pdfhttp://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1860-7314/homepage/2446_color_fig.pdf7/29/2019 Biotecnology Journal
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2.4.5. Guidelines for figure preparationFor initial submission, it is not necessary to submit graphics with high resolution; however, if your
manuscript is accepted, high resolution graphics will be required as detailed in this section. Each
figure should be given in a separate file. Please prepare your figures according to the following
guidelines: Crop, or scale, art to the size intended for publication; no enlargement or reduction should
be necessary. If this is not possible. Figures should be submitted in a format which can be
reduced to publication size i.e. a width of 5585mm or 120175mm.
Figure panels should be indicated by capital letters (A, B, C, etc.) on the top left hand corner
As far as possible, all comparable labels should have the same size lettering, and the font size
should be consistent throughout the Figures. Use standard fonts such as Times, Times New
Roman, Arial and Helvetica. Symbols and labels should be aheight of 1.52.0 mm at their
final published size.
Make sure that any labeling is legible against the background, and that lines are of a suitable
thickness. The recommended minimum line weight is 0.3 pt for black lines on a light
background, and 0.4 pt for white lines on a black background; do not define lines as hairlinewidth.
Gridlines are not allowed except for log plots.
Remove excess space and elements from around the image.
Type, lines or other elements not intended for publication should be removed before
submission.
Make the image orientation the same as that intended for publication.
Flatten images prior to submission, i.e. they should not contain layers and/or transparent
objects.
Figures should have the following resolution at their final published size:
Graphs 800-1200 DPIPhotos 400-800 DPI
Color (RGB) 300-400 DPI
Do not use higher resolutions than those given in the Table above as these will not improve
the quality of your image but will produce very large files.
An easy way to check the quality (resolution) of Figures files is to use the zoom function: if an
image viewed at 400% on screen is blurry (pixellated), then the image will not reproduce well
in print. An image viewed at 100% on screen may look fine but will not necessarily reproduce
well as the screen resolution is much lower (only 72-96 dpi) than that of a printing press.
Changing the size of a digital image changes the resolution; however, as the area is increased
the overall dpi actually remains the same; as an example, a photographic image that is threeinches (76.2 mm) across at final size should be saved as TIFF with a width of 900 pixels (final
size: 3 in; resolution: 300 dpi). If the size is increased to six inches, a width of 1800 pixels
would be required to obtain a resolution of 300 dpi.
Images (photos) with lettering should be saved at a higher resolution (minimum 600 dpi)
than a photographic image alone (minimum 400 dpi) to avoid the text and line art appearing
jagged.
Photographic images often produce very large files; however, most software has an option to
compress the file using LZW compression and this will produce smaller files, especially when
the image contains large areas of single color or repeating textures and patterns.
Keeping an image simple is the best way to produce good output. Try to avoid adding more
to your graph or illustration than is necessary. Avoid 3D charts, excessive shading, stipples,
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lines and symbols (if there are several symbols, try and add them to the legend rather than a
key).When using shades of grey or other tints, be wary of using shades too close together
an ideal separation is 20%.
Remember that supplying high-quality electronic artwork can reduce delays in production
time as it minimizes the need for artwork to be resupplied.
Image manipulation
Manipulation of images is unacceptable. All figures must accurately reflect the original data.
Information should not be enhanced, eliminated, added, obscured or moved. In cases where
manipulation is unavoidable, this should be clearly detailed in the Figure legend. All instruments,
software and processes used to obtain the images must be fully detailed in the manuscript either in
the Figure legends or in the Materials and methods section. Acceptable image manipulation includes
uniformly adjusting the contrast of an entire image and any control images, ensuring that all original
data, including the background, remains visible and that no new features are introduced. Cropping of
gels, or re-positioning of lanes/fields, is permitted providing that all alterations are clearly indicatedby the use of dividing lines in the image itself, vital data are not removed, an explanation of the
alterations is included in the Figure legend and images of full blots or gels that the figures are derived
from are supplied in the supporting information. Unacceptable manipulation includes, but is not
limited to, the enhancement of one feature/ band over others, removal of background noise/bands,
etc. Authors must be able to produce all data in their raw format upon editorial request.
2.4.6. Other guidelinesStatistical analysis standard requirements
Full statistical analysis of your data should be detailed in the manuscript, preferably in the Figurelegends to allow each Figure to be easily understood without reference to the main text of the
article. The name of each statistical test used and the results obtained (including a description of the
comparisons made to obtain the p values, if not clearly indicated in the Figures themselves) should
be stated. The number of samples, experiments, replicates etc. should be detailed; data presentation
(mean +/ SD or SEM etc.) should be noted. Authors are encouraged to analyze data across multiple
experiments, if at all possible, and should note that analyzing replicates within a single experiment
does not provide information regarding experimental reproducibility.
Structural formulae
Structural formulae should be drawn in the manuscript in the position where they belong. They mustbe numbered in consecutive order with the other figures.
Equations
Mathematical and chemical equations are to be written in the manuscript at the place in which they
belong and should be marked by Arabic numerals in parentheses in the right margin in the order of
their appearance.
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www.biotechnology-journal.com
Manuscript submission: http://mc.manuscriptcentral.com/btj
Contact the Editorial Office at: [email protected]
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2.4.7. Supporting InformationSupporting Information can be a useful way for an author to include important but ancillary
information with the online version of an article. Examples of Supporting Information include
additional tables, data sets, figures, movie files, audio clips, 3D structures, and other related
nonessential multimedia files. Supporting Information should be cited within the article text, and adescriptive legend should be included. It is published as supplied by the author, and a proof is not
made available prior to publication; for these reasons, authors should provide any Supporting
Information in the desired final format. Where possible, authors are encouraged to submit
Supporting Information as a single PDF file.
For further information on recommended file types and requirements for submission, please visit:
http://authorservices.wiley.com/bauthor/suppinfo.asp
It is at the Editor-in-Chiefs discretion to decide which part of the manuscript will be published as
Supporting Information.
3. Online submission of manuscripts3.1. Original manuscriptsBiotechnology journaloffers a web-based manuscript submission and peer review system accessible
at: http://mc.manuscriptcentral.com/btj
To submit your manuscript online, please proceed along the following steps:
Prepare your manuscript and illustrations in the appropriate format, according to the
instructions given (see Section Format and style of manuscripts) and ensure that data are
given in the correct order and style for the journal.
Main text (including front material) as well as figure legends and tables (in this order) should
be given in one file, preferably saved in .doc or .rtf format. Figures should be submitted
separately (not included in the main document) in TIFF, EPS, PPT or the original format.
If you have not already done so, create an account for yourself in the system by clicking on
the Create an Account button.
The system will guide you through the submission process. Online help is available to you at
all times during the process. You are also able to exit/re-enter at any stage before finallysubmitting your work. All submissions are kept strictly confidential. To monitor the
progress of your manuscript throughout the review process, just login periodically and check
your Author Center.
All submissions will be converted to PDF format during the upload process. The system
automatically generates one PDF file which contains all parts of the manuscript.
Check the final PDF! The information you see will be the same as that seen by the editors
and reviewers, it is therefore critical that you ensure all information is provided in this file
prior to clicking the submit button.
If you have any questions concerning the online submission program, do not hesitate to contact the
Editorial Office [email protected].
http://authorservices.wiley.com/bauthor/suppinfo.aspmailto:[email protected]:[email protected]:[email protected]:[email protected]://authorservices.wiley.com/bauthor/suppinfo.asp7/29/2019 Biotecnology Journal
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www.biotechnology-journal.com
Manuscript submission: http://mc.manuscriptcentral.com/btj
Contact the Editorial Office at: [email protected]
Page 14 of17
3.2. Revised manuscriptsThe revised manuscript, as a file, on which all alterations are clearly marked and visible, should be
submitted via the submission site. The revised manuscript must be accompanied by a point-by-pointletter summarizing the changes that have been made in response to the referees comments. This
letter must be uploaded with the manuscript files as Supporting information for the Editor and Peer
review, which should appear as the first file in the final PDF, which is sent to the reviewers. Please
note that when revised manuscripts are submitted online, only the changed files need to be
replaced.
4. Manuscript publication4.1. Author ServicesOnce an article is accepted, Wileys Author Services provides the functionality for authors to track
the production progress of their articles. Authors will also receive free access to the final published
version of their articles.
When an article is accepted, the corresponding author receives an e-mail with a unique code and
link. Logging in to Author Services with the same e-mail address where the alert is received
automatically connects the author to the article. Alternatively, authors may register with any e-mail
address: use the "add article" feature and enter the unique code contained in the initial e-mail to
connect to the article. There may be a short delay from when the article is accepted by the journal
and when it has been received at Wiley-Blackwell.
Go tohttp://authorservices.wiley.com/bauthor/ for further information.
4.2. Proofs and reprintsGalley proofs will be sent as low-resolution PDF-file by e-mail together with a reprint order form. The
proofs should be carefully corrected following the instructions provided with the galley proofs. The
proofs together with the reprint order form should be completed and returned by e-mail to the
Editorial Office ([email protected]) within 48 h. Reprints ordered later in the production process are
more expensive. Authors may be charged for extensive alterations of their article that are a result ofwrong files supplied by the authors. Reprints and/or high resolution PDF can be ordered at prices
shown on the reprint order form. Note that authors will be provided a low resolution final PDF via
Wileys Author Services. Reprints always have the BTJ cover page of the issue in which the article is
printed.
http://authorservices.wiley.com/bauthor/http://authorservices.wiley.com/bauthor/mailto:[email protected]:[email protected]://authorservices.wiley.com/bauthor/http://authorservices.wiley.com/bauthor/http://authorservices.wiley.com/bauthor/mailto:[email protected]://authorservices.wiley.com/bauthor/7/29/2019 Biotecnology Journal
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www.biotechnology-journal.com
Manuscript submission: http://mc.manuscriptcentral.com/btj
Contact the Editorial Office at: [email protected]
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4.3. Copyright transfer agreement / OnlineOpenThe need to sign the copyright transfer agreement depends on whether you would like to publish
your article Open Access:
4.3.1. Open Access: for authors choosing OnlineOpenIf the Open Access / OnlineOpen option is selected the corresponding author will sign the Open
Access Agreement (www.wiley.com/go/ctalsweinheimglobaloaa) which offers a choice of the:
Creative Commons Attribution License;
Creative Commons Attribution Non-Commercial License; or,
Creative Commons Attribution Non-Commercial -NoDerivs License
To preview the terms and conditions of these open access agreements please visit the Copyright
FAQs hosted on Wiley Author Services
http://authorservices.wiley.com/bauthor/faqs_copyright.aspand visit
http://www.wileyopenaccess.com/details/content/12f25db4c87/Copyright--License.html
If you select the OnlineOpen option and your research is funded by The Wellcome Trust or members
of the Research Councils UK (RCUK) you will be given the opportunity to publish your article under a
CC-BY license supporting you in complying with Wellcome Trust and Research Councils UK
requirements. For more information on this policy and the Journals compliant self-archiving policy
please visit:http://www.wiley.com/go/funderstatement.
4.3.2. No Open Access: authors sign the copyright transfer agreementIf the OnlineOpen option is not selected, the corresponding author will sign the copyright transfer
agreement (www.wiley.com/go/ctalsweinheimglobal). The terms and conditions of the copyright
transfer agreement can be previewed in the samples associated with the Copyright FAQs:
http://authorservices.wiley.com/bauthor/faqs_copyright.asp
4.4. Funder arrangementsCertain funders, including the NIH, Howard Hughes Medical Institute, members of the Research
Councils UK (RCUK) and Wellcome Trust require deposit of the Accepted Version in a repository after
an embargo period. Details of funding arrangements are set out at the following website:
http://www.wiley.com/go/funderstatement
4.4.1. InstitutionsWiley has arrangements with certain academic institutions to permit the deposit of the Accepted
Version in the institutional repository after an embargo period. Details of such arrangements are set
out at the following website:http://www.wiley.com/go/funderstatement
http://www.wiley.com/go/ctalsweinheimglobaloaahttp://www.wiley.com/go/ctalsweinheimglobaloaahttp://www.wiley.com/go/ctalsweinheimglobaloaahttp://authorservices.wiley.com/bauthor/faqs_copyright.asphttp://authorservices.wiley.com/bauthor/faqs_copyright.asphttp://www.wileyopenaccess.com/details/content/12f25db4c87/Copyright--License.htmlhttp://www.wiley.com/go/funderstatementhttp://www.wiley.com/go/funderstatementhttp://www.wiley.com/go/ctalsweinheimglobalhttp://www.wiley.com/go/ctalsweinheimglobalhttp://www.wiley.com/go/ctalsweinheimglobalhttp://authorservices.wiley.com/bauthor/faqs_copyright.asphttp://www.wiley.com/go/funderstatementhttp://www.wiley.com/go/funderstatementhttp://www.wiley.com/go/funderstatementhttp://www.wiley.com/go/funderstatementhttp://www.wiley.com/go/funderstatementhttp://www.wiley.com/go/funderstatementhttp://www.wiley.com/go/funderstatementhttp://authorservices.wiley.com/bauthor/faqs_copyright.asphttp://www.wiley.com/go/ctalsweinheimglobalhttp://www.wiley.com/go/funderstatementhttp://www.wileyopenaccess.com/details/content/12f25db4c87/Copyright--License.htmlhttp://authorservices.wiley.com/bauthor/faqs_copyright.asphttp://www.wiley.com/go/ctalsweinheimglobaloaa7/29/2019 Biotecnology Journal
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www.biotechnology-journal.com
Manuscript submission: http://mc.manuscriptcentral.com/btj
Contact the Editorial Office at: [email protected]
Page 16 of17
Appendix A: BTJ Keywords
BTJ primary keywords/areas of expertise: select at least 1
Analytical biotechnology Biocatalysis
Biochemical engineering Biomaterials
Bioprocess engineering Downstream processing
Food biotechnology Computational biology
Green/plant biotechnology Metabolic engineering
Nanobiotechnology Omics
Red/medical biotechnology Science communication
Systems biology Synthetic biology
White/industrial biotechnology Other
BTJ secondary keywords/areas of expertise: select 3-4
Algae Antibodies Bacteria Biochemistry
Bioelectronics Bioenergy Bioengineering Bioethics
Biofuels Bioinformatics Biomaterials Biomedical engineering
Biophysics Biopolymers Bioreactor Biorefinery
Bioremediation Biosafety Biosensors Bioseparation
Biosynthesis Biotransformation Blue/marine
biotechnology
Cancer
Cell biology Cell culture Cellular engineering Cellular therapy
Chromatography Crystallization Diagnostics Diseases
Drug delivery Environmental
biotechnology
Enzymes Expression systems
Fermentation Food Fungi Gene expression
Gene regulatory network Gene therapy Genetic engineering Genetics
Genomics Glycobiotechnology High-throughput Imaging
Insect cells Mammalian cells Mass spectrometry Materials
Medical applications Metabolic flux analysis Metabolic network Metabolomics
Micro/nanofluidics Microarrays Microbiology Microreactors
Modeling Molecular biology Molecular engineering Plants
Polymers Process development Process monitoring Protein engineering
Protein expression Protein folding Protein purification Protein stability
Proteomics Recombinant proteins Regenerative medicine RNA interference
Scale-up/down Screening Signaling network Stem cellsTextile biotechnology Tissue engineering Transcriptomics Transgenic organisms
Translational medicine Vaccines Viruses Yeast
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www.biotechnology-journal.com
Manuscript submission: http://mc.manuscriptcentral.com/btj
Contact the Editorial Office at: [email protected]
Appendix B: Checklist for Authors
CHECKLISTWhich manuscript type?
1. Research Article: Describing complete
investigations. Maximum of 6500 words,including references, figure legends and tables.
Not more than 5 figures.
2. Review:Only invited by the Editors.
- Full-length Review: 8000 words maximum
- Mini-Review: 4000 words maximum
3. Technical Report:Short description ofthe
developmentof a novel method or an
improvement or noteworthy modification of an
already existing technique or platform used in
biotechnology. Maximum 4000 words, 3 display
elements (Figures and/or Tables)
4. Rapid Communication: Brief, timely and/or of
such importance that rapid publication is
warranted. Maximum 2500 words, 3 displayelements (Figures and/or Tables)
5. Other contribution:Forum column (500 to 2000
words), letter, meeting report, book review
Manuscript style and format OK?
Manuscripts should be submitted in English (American
spelling).
The first page of the manuscript should contain:
1. Title (concise, only standard abbreviations).2. Full author names (including first name) and the
name of their institute(s), using superscript
numbers after name to indicate multiple
affiliations.
3. Keywords (3 to 5).4. Correspondence: name, title, full postal address
and e-mail address of the author to whom all
correspondence (including galley proofs) is to be
sent.
5. Abbreviations: alphabetical order.The second page: abstract (maximum 200 words, only
standard abbreviations allowed)
Number the sections:
1 Introduction
2 Materials and methods
3 Results (or Results and discussion)
4 Discussion (or Concluding remarks)
5 References
Reference format OK?
References, including those in tables and figure
legends, should be numbered sequentially in square
brackets [2, 18] in the order in which they appear in
the text.
Reference list (collected at the end of the manuscript)
as in the following examples:
Journals:
[1] Liebeton, K., Eck, J., Identification and Expression in
E. coli of novel nitrile hydratases from the
metagenome. Eng. Life Sci. 2004, 4, 557562.
[2] Hugo, G., Schmoekel, F. E., Weber, J. C., Jason C., et
al., Bone repair with a form of BMP-2 engineered for
incorporation into fibrin cell ingrowth matrices.
Biotechnol. Bioeng. 2005, in press.
DOI:10.1002/bit.20168.
Books:
[3] Geis, A., Perspectives of genetic engineering of
bacteria used in food fermentations, in: Heller, K.J.
(Ed.), Genetically Engineered FoodMethods and
Detection, Wiley-VCH Verlag, Weinheim 2003, pp.
100118.
[4] Chrisou, P., Klee, H. (Ed.), Handbook of Plant
Biotechnology, John Wiley & Sons, 2004.
Note that
When more than 5 authors: list 4, et al. Papers in press: cite DOI.
Other serial publications: cite in the same style asjournals
Website addresses not as references but insertedin the text directly after the data to which they
refer
Abstracts and posters in meeting books must notbe cited unless they are generally accessible
Personal communication or unpublished datashould be cited in the text.
Figures and tables OK?
Tables with title and footnotes included at theend of the text
Figure legends at the end of the text Figures should be submitted in original format
(preferably TIFF, EPS or PPT) at high resolution
(300 dpi)
Please note that a fee has to be charged forcolor figure printing
Supporting information online
Extensive tables Text exceeding the maximum word count Other files like animations and video sequencesFigures and tables have to be accompanied by
appropriate legends. Has to be submitted along with
the manuscript body and in final form, preferably as
PDF. (no typesetting or galley proofs beforepublication)Cover letter complete?
Please state:
1. Why is the paper suitable for publication in BTJ?2. Do all the authors concur with the submission?3. Can you confirm that the work has not been
submitted to another journal and will not be
published elsewhere within one year after its
publication in this journal?
4. Does the manuscript contain experiments usinganimals?
5. Does the manuscript contain human studies?