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BIVALIFE BIVALIFE

Management of infectious diseases in Management of infectious diseases in oysters and mussels in Europeoysters and mussels in Europe

Kick off meetingKick off meeting

Issy les Moulineaux - 7 & 8 April 2011Issy les Moulineaux - 7 & 8 April 2011

FP7-KBBE-2010-4FP7-KBBE-2010-4KBBE.2010.1.2-08: Improving European KBBE.2010.1.2-08: Improving European

mollusc aquaculture: disease detection and mollusc aquaculture: disease detection and managementmanagement

Expected impact:Expected impact:

The European added value lies in the project´s contribution The European added value lies in the project´s contribution to improving competitiveness and sustainability of the to improving competitiveness and sustainability of the mollusc industry. mollusc industry.

It will help It will help managing the diseasemanaging the disease in the in the different culture different culture situations throughout Europesituations throughout Europe. .

It will also contribute to It will also contribute to a more efficient control of mortality a more efficient control of mortality levels and health status of cultured molluscslevels and health status of cultured molluscs, taking into , taking into consideration the specificities and culture methods of each consideration the specificities and culture methods of each species concerned. species concerned.

Last but not least, it will provide solution for Last but not least, it will provide solution for improved improved biosecurity of mollusc hatcheries.biosecurity of mollusc hatcheries.

Participants : 12Participants : 12

- - Ifremer, France (coordinator)Ifremer, France (coordinator)- Cefas, Weymouth, UK (S. Feist and M. Longshaw)- Cefas, Weymouth, UK (S. Feist and M. Longshaw)- CSIC, Vigo, Spain- CSIC, Vigo, Spain- Central Veterinary Institute of Wageningen, The Central Veterinary Institute of Wageningen, The NetherlandsNetherlands- Marine Institute, Galway, Ireland- Marine Institute, Galway, Ireland- University Cork, Ireland- University Cork, Ireland- Department of Biology, University of Genoa, Italy- Department of Biology, University of Genoa, Italy- IRTA, Spain- IRTA, Spain- University of Padova, Italy- University of Padova, Italy- CNRS, Brest and Montpellier, France- CNRS, Brest and Montpellier, France-Atlantium, IsraëlAtlantium, Israël- EMPA (European Mollusc Producers Association), EMPA (European Mollusc Producers Association), Paris, FranceParis, France

Présence relativement homogène des pathogènes identifiés

BIVALIFE – General objectivesBIVALIFE – General objectivesThe two core objectives of BIVALIFE The two core objectives of BIVALIFE areare: :

(i)(i) to provide to provide innovative knowledgeinnovative knowledge related torelated to pathogens infecting pathogens infecting oysters and musselsoysters and mussels;;

(ii)(ii)to develop to develop practical approachespractical approaches for for thethe control of infectious diseasescontrol of infectious diseases and and resultingresulting mortality outbreaksmortality outbreaks these these pathogens induce. pathogens induce.

Présence relativement homogène des pathogènes identifiés

BIVALIFE - Specific objectivesBIVALIFE - Specific objectives(i)(i) Improve, Improve, validate and transfer existing validate and transfer existing methods for detection and identification of methods for detection and identification of Pacific cupped oyster and mussel Pacific cupped oyster and mussel pathogens;pathogens;

(ii)(ii)Search and characterise Pacific cupped Search and characterise Pacific cupped oyster and mussel pathogens in relation oyster and mussel pathogens in relation to the presence or absence of mortality;to the presence or absence of mortality;

(iii)(iii) Assess the relationship between the Assess the relationship between the presence of Pacific cupped oyster and presence of Pacific cupped oyster and mussel pathogens and environmental risk mussel pathogens and environmental risk factors in the development of mortality or factors in the development of mortality or disease;disease;

Présence relativement homogène des pathogènes identifiés

BIVALIFE – Specific objectivesBIVALIFE – Specific objectives(iv) Investigate mechanisms allowing Pacific (iv) Investigate mechanisms allowing Pacific

cupped oyster and mussel pathogens to cupped oyster and mussel pathogens to survive outside the hostsurvive outside the host

(v) Identify pathogen intrinsic virulence (v) Identify pathogen intrinsic virulence factors and effects on host defence factors and effects on host defence mechanisms;mechanisms;

(vi) Develop methods and recommendations (vi) Develop methods and recommendations for pathogen control and eradication in for pathogen control and eradication in Europe.Europe.

Présence relativement homogène des pathogènes identifiés

ObjectivesObjectives

Présence relativement homogène des pathogènes identifiés

Expected achievements Expected achievements - Harmonisation of diagnostic techniques Harmonisation of diagnostic techniques (histology, bacteriology and molecular (histology, bacteriology and molecular techniques) for Pacific cupped oyster and mussel techniques) for Pacific cupped oyster and mussel pathogens through method transfer and large pathogens through method transfer and large scale validation (inter-laboratory assays);scale validation (inter-laboratory assays);

- Detection of relevant pathogens in European sites - Detection of relevant pathogens in European sites based on the based on the use of validated common use of validated common techniques; techniques;

- Development of tools to measure pathogen Development of tools to measure pathogen survival in various environments;survival in various environments;

- Detection of viable/infective relevant pathogens in - Detection of viable/infective relevant pathogens in different compartments (animals, water, different compartments (animals, water, sediment);sediment);

Présence relativement homogène des pathogènes identifiés

Expected achievments Expected achievments - IIdentification of relevant host defense dentification of relevant host defense

mechanisms in contrasted biological material mechanisms in contrasted biological material (infected versus non-infected individuals, resistant versus (infected versus non-infected individuals, resistant versus susceptible individuals, susceptible versus non-susceptible susceptible individuals, susceptible versus non-susceptible species);species);

- Identification of virulence factors in relevant Identification of virulence factors in relevant pathogens;pathogens;

- Identification of relevant potential determinants Identification of relevant potential determinants related to disease manifestation;related to disease manifestation;

- Development of practical methods and general Development of practical methods and general recommendations for infectious disease control recommendations for infectious disease control drawn from knowledge acquired during the drawn from knowledge acquired during the project.project.

Work packages: 6Work packages: 6

WP1 – WP1 – Project managementProject management

WP2 – WP2 – Detection and identification of relevant Detection and identification of relevant pathogens and associated risk factorspathogens and associated risk factors

WP3 - WP3 - Mechanisms allowing concerned pathogens to Mechanisms allowing concerned pathogens to survive outside the hostsurvive outside the host

WP4 – WP4 – Pathogens of interest: identification of Pathogens of interest: identification of intrinsic virulence factors and effects on host intrinsic virulence factors and effects on host defence mechanismsdefence mechanisms

WP5 – WP5 – Pathogen control and eradication: Pathogen control and eradication: development of methods, field tests and development of methods, field tests and recommendationsrecommendations

WP6 - WP6 - Exploitation and disseminationExploitation and dissemination

Merci de votre Merci de votre attentionattention