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Blockchain-enabled solutions for clinical trials
TR IA L L . IO
© 2021 Triall (Clinblocks B.V.) | The content of these slides is privileged and confidential. Do not share or copy unless permitted.
What are clinical trials?C O N T E X T
Multi-stage research process. Typically takes 10 years or longer.
Increasingly data heavy. Result of digitalization and the adoption of mobile devices for data collection.
Complex interplay between many specialist parties.
Crucial part of the development of new medicines. Establish evidence of safety and efficacy.
Documentation and constant inspection-readinessdemanded by authorities.
What’s the problem?P R O B L E M
FragmentationData is scattered across sites and systems.1
234
Lack of oversightReported by virtually all clinical trial professionals.
Recordkeeping failureCausing significant delays, costs, and safety risks.
Data integrity issuesA growing concern according to authorities such as FDA, EMA, WHO.
Development of vaccines and drugs is destined to become unreliable and unaffordable , due to:
Verial eTMF Our MVP: Blockchain-secured verifiable proofs of clinical trial documents.
World’s first implementation of blockchain in a live and running clinical trial (July 2019).
Awarded Seal of Excellence by European Commission for underlying concept.
Commercial version being onboarded by growing number of clinical trials.
Verial eTMFBlockchain-secured document management
F I R STECOSYSTEM
APPL I CAT IONS
Triall CTMSIntegrated trial managementdashboard
Atena PRMMulti-sidedpartneringplatform
An ecosystem of industry-validated, blockchain-integrated products to streamline clinical trials
MVP HIGHLIGHTS
APIs and moreIntegrating in-house and third-party solutions
S O L U T I O N
What are the unique benefits of the Triall ecosystem?
We bring Web 3.0 to medical research,by realizing a digital ecosystem for clinical trials
System Integration & Interoperability Blockchain-agnostic, decentralized identityand access management. Secure connections and exchanges between isolated clinical trial systems and their users.
Efficiency & ComplianceIntegrated clinical trial metrics.Automation and assertion of clinical trial workflows through AI and smart contracts.
Availability & Ease of UseEcosystem utilities available from anywhere. On any device. Through a secured cloud-based environment.
S O L U T I O N
Data integrity & AuditabilityBlockchain-secured, tamper-resistant audit trails of clinical documentsand data.
Accelerated introduction of safe and affordable vaccines and drugs.
We serve a double-digit growth marketM A R K E T
$233 billion will be spend on pharmaceutical research in 2026, coming from $186B in 2019. Majority of this budget is allocated to clinical trials.
R&D BUDGET$233B
CAGR13,8%
Rapid digitalization spursdouble-digit market growth.High upside projected forthose who can underpinthis new digital playing field.Our solutions are designedto do so.
TRIALS / YEAR30K+
Over 30.000 new clinical trials are initiated each year. Roughly 70% take place in the US and Europe, where we have a strong footprint.
Our market is highly fragmented, with many small vendors of function-specific solutions. Vacuum for mid-sized players. Need for interoperability.
R&D spending on the rise. Nature Reviews Drug Discovery 13, 566 (2014).
Total global pharmaceutical R&D spending from 2012 to 2026. Statista (2019).
eClinical solutions market size, share, & trends analysis report. Grand View Research (2018).
Trends, Charts, and Maps. U.S. National Library of Medicine (retrieved April 2021, from: clinicaltrials.gov).
Sources :
Token Economics: two-token system
Access to ecosystem utilities
Direct P2P compensation
Community engagement
Ecosystem governance
Memberships & rewards
To fuel the micro-economy of the Triall ecosystem, we introduce our main network tokenTRL and its internal counterpart T-CRED.
T O K E N S A L E
Token Economics: two-token system
T-CRED gives the right to enter and use the services in the Triall ecosystemand can only be created by converting TRL (at a fixed conversion rate).
Fixed conversion rate1 T-CRED always equals $100.
Token burn policy2,5% of T-CRED burned on conversion to TRL.
Deflationary trendBurn policy stimulates a downtrend in the total TRL token supply.
Predictable & stable costsNo volatility.
T O K E N S A L E
Pre-sale & token allocationT O K E N S A L E
Private round price | hard cap$ 0,125 | $ 1.093.750,-
Retail round price | hard cap$ 0,20 | $ 875.000,-
Late bird round price | hard cap$ 0,20 | $ 1.025.000,-
Listing price$ 0,25
KEY FIGURES PRE-SALE ROUND
Private round vesting schedule3% at TGE, fully vested after 6 months
Market Cap at TGE$935.312,50 (2,1% of total supply)
8%
18%Liquidity, long-term operations & development
Pre-sale
24%Treasury
10%Triall Community Fund
12,5%Existing investors
8%Advisors
10%Founding team
9,5%Growth, acquisition & marketing
5,0% Private2,5% Retail2,9% Late Bird 4,6% Staking 3,0% Airdrop
Building out our digital ecosystem for clinical trialsF U T U R E V I S I O N & R O A D M A P
Q2 Q3 Q4 Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4
2020 2021 2022 2023
Verial eTMF
Triall CTMS
R E L E A S EAPI library
Trialwiki
Atena PRM
Ecosystem growth and support
Patient apps
Future steps
Trial l Community Fund, DAO, strategic partnering,third-party integrations, expansion into adjacent markets.
T O K E N P R E - S A L E
Meet our Management TeamT E A M & P A R T N E R S
Combined, our team has managed 100+ clinical trials across 30+ countries, and managed clinical and software companies through all stages of growth.
PRODUCT INNOVATION MANAGEMENTFINANCE & ADMINISTRATION LEGAL & COMPLIANCE
TEAMS: CLINOPSDEVELOPMENT MARKETING / BDUX / UI
Hadil Es-Sbai
Dr. Linda van de BurgwalCFO
CEO
CTO Head of Clinical Affairs Head of Product Design Head of Marketing General Counsel
Experienced CEO; Extensive experience in managing clinical trials
Academic entrepreneur; Project manager; Founder of two
successful Life Science consultancies
Experienced blockchain and SaaS developer;
Director of the Factomblockchain
Clinical researcher; Medical writer; Project
manager
Graphic designer; PhD candidate and consultant in
medical innovation management
Researcher; Consultant and copywriter focusing
on complex tech and R&D
Corporate lawyer; Extensive experience as legal counsel in healthcare and pharma
Niels Klomp Dr. Joost Flach Mark van der Waal Raymond van der Waal Rob Posthumus
Meet our Advisory BoardT E A M & P A R T N E R S
Triall brings together an international network of industry experts and thought leaders on a joint mission for smarter, safer, and more-efficient clinical trials.
Yassin MobarakDizer Capital US
Technology
Prof. Eric Claassen, PhDVU Amsterdam EU
Strategy
Prof. Niels Chavannes, MD, PhDLUMC & NeLL EU
Product Design
Prof. Sjaak Bloem, PhDNyenrode & Janssen (JnJ) EU
Product Design
Danielle BradburyGalera Therapeutics US
Quality & Compliance
Sina DjaliJanssen (JnJ) US
Product Design
Dr. Po Chi WuHKUST & UC Berkeley US
Strategy
Nick van den BulkCR2O EU
Product Design
Allan BukuyaTrialDocs AU
Product Design
Cari Jacobs-BlomCR2O EU
Quality & Compliance
Moses MaFutureLab Consulting US
Business Development
Maarten BoenderSphereon EU
Technology
Meet our Partner NetworkT E A M & P A R T N E R S
Triall unites in-depth, in-house understanding of industry needs and opportunities with the function-specific expertise of its strategic partners.
Tech Venture Capital Blockchain Innovation Agency
Deep Tech Strategy Consulting
Life Sciences Strategy ConsultingBlockchain APIs & Microservices
Enterprise Software DeveloperClinical Operations Partner
Life Sciences Recruitment & Staffing
National eHealth Institute
Industry Collaboration Platform Healthcare Research Institute Patient Recruitment & Retention
Follow the Triall project
triallcommunity @triallofficialinsights.triall.io triallofficial