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9/20/2012
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BLOOD COAGULATION AND
ANTICOAGULANT,
THROMBOLYTIC, AND
ANTIPLATELET DRUGS
Alfi Yasmina
Dea Arie Kurniawan
Antikoagulan, Antitrombotik, Trombolitik,
Hemostatik
Beberapa Istilah
• Hemostasis
• Koagulasi
• Trombosis
• Antikoagulan
• Antitrombotik
• Trombolitik
• Hemostatik
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• Indirect Trombin Inhibitor
– Heparin
– Warfarin
– Rivaroxaban
• Direct Trombin Inhibitor
– Bivalirudin, Hirudin, Lepirudin,
Argatroban
– Dabigatran, Ximelagatran
Antikoagulan
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• LMWH
– Bemiparin, dalteparin, enoxaparin,
reviparin, fondaparinux
• Monitoring pemeriksaan darah
• Indikasi: trombosis vena, emboli paru,
PJR, penyakit jantung iskemik
Antikoagulan
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Aspirin
Dipiridamol
Tiklopidin
Klopidogrel
Epoprostenol (PGI2)
Abciximab
Antitrombotik
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Fosfolipid membran
Asam arakidonat
Rangsang
Gangguan pada membran sel
Hidroperoksid
Leukotrien
Endoperoksid (PGG2/ PGH)
PGE2, PGF2, PGD2, PGI2 Tromboksan A2
Fosfolipase
SiklooksigenaseLipooksigenaseAspirin
• Indikasi: cegah trombosis pada
TIA/ stroke, infark miokard, bedah
kardiovaskuler, Raynaud’s phenomen
Antitrombotik
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• Streptokinase
• Urokinase
• Plasminogen activator
(u-PA, t-PA)
Trombolitik
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• Indikasi: infark, emboli paru, trombosis
vena/ arteri
• Mahal
Trombolitik
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• Transfusi
• Faktor VIII
• Kompleks faktor II, V, IX, X
• Fibrinogen
• Vitamin K
• Asam aminokaproat
• Asam traneksamat
• Karbazokrom
Hemostatik
Further Reading
• Katzung BG, Masters SB, Trevor AJ. Basic and
Clinical Pharmacology 11th Edition. McGraw-Hill,
2009.
• Goodman & Gilman’s Manual of Pharmacology and
Therapeutics. McGraw-Hill, 2008