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Blood Physiology
Demuel Dee L. Berto
• Describe the components of blood and their origins, and the role of hemoglobin in transporting oxygen in red blood cells.
• Understand the molecular basis of blood groups and the reasons for transfusion reactions.
• Delineate the process of hemostasis that restricts blood loss when vessels are damaged, and the adverse consequences of intravascular thrombosis.
• Understand the significance of immunity, particularly with respect to defending the body against microbial invaders.
• Identify the functions of hematopoietic growth factors, cytokines, and chemokines.
• Delineate the roles and mechanisms of innate, acquired, humoral, and cellular immunity.
References
• Medical Physiology by Guyton 12th Edition
• Review of Medical Physiology by Ganong 23rd Edition
• Basic Pathology by Kumar 8th Edition
• Clinical Physiology by Ashis Banerjee , 2005
General Functions
• Delivery of substances needed for cellular metabolism in the tissues
• Defense against invading microorganisms and injury
• Acid-base balance
http://www.icr.org/article/4823/
Erythrocytes
Transport Hemoglobin
Transport CO2
Acid Base Buffer
Functions
Shape and Size of Red Blood Cells
Concentration of Red Blood Cells in the Blood
Quantity of Hemoglobin in the Cells
Maxwell et al: Renal erythropoietin-producing cells
Clinical Correlate
MATURATION OF RED BLOOD CELLS
Vitamin B12
Folic acid
Receptor for AGEs
THE RH GROUP
HEMOSTASIS
Immunity
Immuno-competence
Inflammation
Acquired Immunity
Innate Immunity
INNATE IMMUNITY
Nucleated Cells
Gregersen and Behrens Nature Reviews Genetics 7, 917–928 (December 2006) | doi:10.1038/nrg1944