Blood Vessels and Hemodynamics

Types of blood vessels

• Arteries divide– Elastic (conducting) arteries–Muscular arteries

• Arterioles branch into • Capillaries reunite to form • Venules merge into• Veins converge and convey blood

back to the heart

Arteries

• Elastic arteries or conducting arteries– Pressure reservoirs – Recoil of elastic fibers

propels the blood.

• Muscular or distributing arteries– Constrict or dilate to

adjust blood flow.

Arterioles

• Small arteries (10-300mm) that deliver blood to capillaries.

• Regulates blood flow • Regulates blood pressure

Continuous Capillaries

Fenestrated capillaries

Sinusoidal capillaries

Capillary beds: Microcirculation

•Vascular shunt

•True capillaries

Capillary exchange

• Vasomotion is slow and intermittent

Venules and veins

• Capillaries unite and form venules

• Venules converge and form veins

• Veins – No elastic layers– Large lumen– Valves

• Sinuses

Venous return

• Overcoming resistance and the force of gravity.

• Skeletal muscle pump

• Respiratory pump

• Sympathetic control

Arteries• Strong thick elastic

walls • Narrow lumens• Closer to pumping

action of heart

Veins• Thinner walls, larger

lumens• Valves • Enhanced by

skeletal activity

Arteries and Veins

• Anastomoses is the union of two or more branches of arteries.

• Varicose veins are caused by leaky venous valves that cause veins to become dilated and twisted.

Varicose Veins

Normal flow in veins. The calf muscle contacts forcing the blood past one way valves that only allow the blood to move heartward.

Refluxing (backward) flow of blood in varicose veins. The calf muscle forces blood upwards past one way valves with contraction. With relaxation the faulty valves allow the blood to fall back down the leg (reflux) with gravity.

The backward flow (reflux) in affected veins causes them to engorge and enlarge as well as to twist taking on the characteristic appearance of varicose veins. Because the blood tends to pool rather than circulate the relatively “stagnant” blood irritates nearby muscles, muscle and skin causing pain and is more likely to clot as well

Physiology of blood

• Blood flow (ml/min)

• Blood pressure (mm Hg)– force generated against arterial walls per unit

of area in mm Hg.

Terms, Definitions & Units• Systolic Pressure - peak arterial

pressure. Averages about 120 mmHg

• Diastolic Pressure - lowest arterial pressure. Averages between 70 - 80 mm Hg

• Blood Volume - quantity of blood in cardiovascular system. Varies from 4-5 L. in females to 5-6 L. in males.

• Mean arterial pressure- propels the blood to the tissues• MAP=diastolic BP+1/3(systolic BP-diastolic BP)

Blood PressureBlood pressure is

affected by several factors:– peripheral resistance– vessel elasticity– blood volume– cardiac output

Peripheral ResistanceBlood cells and plasma

encounter resistance when they contact blood vessel walls.

• If resistance , then more pressure is needed to keep blood moving. Three main sources of peripheral resistance:– blood vessel diameter– blood viscosity– total vessel length F = P/R

• Vessel Elasticity

• Blood Volume• Cardiac Output

Other Factors Affecting Blood Pressure

Velocity of blood flow

• Velocity is inversely related to the cross-sectional area.– The greater the cross

section, the slower the blood.

• Branching of blood vessels slows velocity.

• Veins coming together increases velocity

Blood flow through tissues

• Delivers O2 and nutrients and removes waste

• Gas exchange• Absorption of

nutrients from digestive tract

• Urine formation in the kidney

Monitoring Efficiency

• Pulse– Pressure points

• Blood Pressure

– Blood Pressure Animation

Blood Pressure

Monitoring blood pressure• Asculatory method uses the sphygmomanometer

– Sounds of Korotkoff

• Brachial artery is compressed and cuff pressure released – First sound is systolic blood pressure – Last sound is the diastolic blood pressure

• BP has a circadian rhythm—peaks in the morning

BP - Stimulates Cardioinhibitory center to heart rate & Vasomotor center to diameter.

Homeostatic Blood Pressure Regulation Mechanisms

• Medullary Reflex Centers:– Cardioacceleratory - increases heart rate– Cardioinhibitory - decreases heart rate– Vasomotor - changes diameter of vessels

BP - Stimulates Cardioacceleratory center to heart rate & Vasomotor center to diameter.

• Baroreceptors in aortic arch & carotid sinuses: – sensitive to changes in blood pressure.

in CO2 or in O2 stimulates Vasomotor center to diameter (vasoconstrict) of vessels to BP.

Homeostatic Blood Pressure Regulation Mechanisms

• Medullary Reflex Centers:– Cardioacceleratory - increases heart rate– Cardioinhibitory - decreases heart rate– Vasomotor - changes diameter of vessels

in CO2 stimulates Vasomotor center to diameter (vasodilate) of vessels to BP.

• Chemoreceptors in aortic bodies & carotid bodies:

– sensitive to changes in CO2 & O2 in blood.

Hypertension

• High blood pressure.• Sustained arterial blood pressure of 140/90

mm Hg or above.• Rising diastolic pressure generally indicative

of progressive hardening of arteries.• Since the heart must work harder to pump

blood against higher pressures, there is increased risk of a cardiovascular accident.

Primary hypertension• Diet—high intake of

Na+, saturated fats or deficiencies in K+, Ca2+, or Mg2+

• Obesity• Age—over 40• Diabetes mellitus• Heredity• Stress• Smoking

Hypotension

• Abnormally low blood pressure.• Sustained systolic blood pressure of

below 100 mm Hg.• Generally associated with lower risk of

cardiovascular accidents & long life providing that the tissues are adequately perfused..

Autoregulation of blood pressure

Shock and homeostasis

• Shock is the failure to deliver enough O2 to meet cellular metabolic needs.

• Four types of shock1. Hypovolemic shock—drop in fluid levels2. Cardiogenic shock—failure of heart to

pump3. Vascular shock—decrease in vascular

resistance4. Obstructive shock—blood flow through a

portion of the circulation is blocked.

Signs and symptoms of shock

• Systolic blood pressure below 90mmHg

• Weak and rapid pulse• Rapid heart rate• Cool and damp skin• Altered mental state• Reduced urine formation• Thirst• Acidosis (low blood pH)• Nausea

Circulatory Shock• Blood vessels inadequately filled to

enable normal circulation & supply of O2 & nutrients.

• May result in death of cells & damage to organs.

• Common Types:• Hypovolemic - severe blood loss• Cardiogenic - heart (pump) failure• Vascular - excessive vasodilation• Septicemic - vasodilation due to bacterial

toxins produced during an infection.

Arterial Anatomy Pay attention to position, function and structure or the following:

•Femoral artery•Superior mesenteric artery •Brachial artery•Common hepatic artery•Inferior mesenteric artery•Internal iliac artery•Aorta•Renal artery

Venous Anatomy Pay attention to position, function and structure or the following:

•Great saphenous vein•Pulmonary vein•Splenic vein. •Superior & Inferior mesenteric vein. •Hepatic portal vein. •Gastroepiploic vein. •Superior vena cava•Pulmonary trunk•External jugular vein

Resources

• Rutgers Blood Vessels