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Bononi DMPharmacotherapyOlderAdultFinal...2/24/20 2 Establish Goals of Therapy Case • 74 year old male, T2D x 20 years • A1c had been 7.2%, recently 9.0% • Glyburide, metformin

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Page 1: Bononi DMPharmacotherapyOlderAdultFinal...2/24/20 2 Establish Goals of Therapy Case • 74 year old male, T2D x 20 years • A1c had been 7.2%, recently 9.0% • Glyburide, metformin

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Page 2: Bononi DMPharmacotherapyOlderAdultFinal...2/24/20 2 Establish Goals of Therapy Case • 74 year old male, T2D x 20 years • A1c had been 7.2%, recently 9.0% • Glyburide, metformin

2/24/20

2

Establish Goals of Therapy

Case• 74 year old male, T2D x 20 years• A1c had been 7.2%, recently 9.0%• Glyburide, metformin- doses recently increased to 20 mg glyburide

and 1000 mg bid• More forgetful and disoriented recently• Blurry vision, nocturia• PMH HTN, HLD• No SMBG• PE remarkable for older than stated age, oriented to person and

place only, BMI 27.4, BP 165/95, absent pedal pulses and monofilament sensation

• eGFR 36 ml/min/1.73m2, urine alb/Cr 279 mg/g

What would be your target HbA1c for this patient ?

• A. Less than 9% and ≥8.5%• B. Less than 8.5%• C. Less than 8.0% and ≥7.5%• D. Less than 7.5%

Page 8

Which Target??

Page 3: Bononi DMPharmacotherapyOlderAdultFinal...2/24/20 2 Establish Goals of Therapy Case • 74 year old male, T2D x 20 years • A1c had been 7.2%, recently 9.0% • Glyburide, metformin

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Algorithm for Individualizing Glycemic Targets

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! Few long term studies in older adults demonstrating benefits of intensive glycemic, BP, and lipid control.

! Poor diabetes control is associated with decline in cognitive function.

! Cognitive impairment makes it challenging to help patients reach individualized glycemic, BP, and lipid targets.

! Polypharmacy/pill burden/complexity of regimen! COST!!!

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Page 4: Bononi DMPharmacotherapyOlderAdultFinal...2/24/20 2 Establish Goals of Therapy Case • 74 year old male, T2D x 20 years • A1c had been 7.2%, recently 9.0% • Glyburide, metformin

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Page 5: Bononi DMPharmacotherapyOlderAdultFinal...2/24/20 2 Establish Goals of Therapy Case • 74 year old male, T2D x 20 years • A1c had been 7.2%, recently 9.0% • Glyburide, metformin

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Page 6: Bononi DMPharmacotherapyOlderAdultFinal...2/24/20 2 Establish Goals of Therapy Case • 74 year old male, T2D x 20 years • A1c had been 7.2%, recently 9.0% • Glyburide, metformin

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Page 7: Bononi DMPharmacotherapyOlderAdultFinal...2/24/20 2 Establish Goals of Therapy Case • 74 year old male, T2D x 20 years • A1c had been 7.2%, recently 9.0% • Glyburide, metformin

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Page 8: Bononi DMPharmacotherapyOlderAdultFinal...2/24/20 2 Establish Goals of Therapy Case • 74 year old male, T2D x 20 years • A1c had been 7.2%, recently 9.0% • Glyburide, metformin

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Page 41

Older Adult with Diabetes

Medical Complications

Cognitive Function

Geriatric Syndromes

PhysicalFunction

Pharmacologic Considerations

Individualize Targets and Strategies

Standard InterventionsHypoglycemia Prevention Telemedicine

MonitorSupport Educate

Functional Medicine

Engage Family & Social Resources