Endocrine Toxicology

on plasma LH levels and histological changes following castration of mature male pigs. As cited in: Toxicological evaluation of certain veterinary drugs in food. 34th Meeting of Joint FAO/WHO Expert Committee (1990), WHO Food Additives Series 25, Geneva, pp 101-109

Van den Dungen HM, Jager LP, Lucas Luykx NBL et al. (1991) Adrenal toxicity of carbadox and furazolidone in vitro. Acta Vet Scand Suppl 87:338-340

Van der Molen EJ, Nabuurs MJA, Jager LP (1985) Pathological and

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clinical changes related to toxicity of carbadox in weaned pigs. Zentralbl Veterinarmed [A] 32:540-550

Van der Molen EJ, De Graaf GJ, Spierenburg TJ et al. (1986) Hypoaldesteronism in piglets induced by carbadox. Experientia 42:1247-1249

Van Leeuwen FXR, Franken MAM, Loeber GJ (1987) The endocrine system as the target in experimental toxicology. In: Rico AG (ed) Advances in veterinary science and comparative medicine, Aca- demic Press, London, pp 121-147

Book Review

Cytokines in Haemopoiesis, Oncology, and AIDS II. Edited by M. Freund, H. Link, R. E. Schmidt and K. Welte. Spr inge r -Ver l ag , N e w Y o r k . 1992. Pages: 800, I l lus t ra t ions : 208. I S B N 3-540-55242-1.

The publication of new data on the results of research into cytokines as they relate to a number of major issues as a follow up to the First international Symposium held in Hannover 1989, seems timely in the light of rapid progress. This second 'Symposium Proceedings' has been prepared with consider- able thoroughness. A total of 433 contributors (inclusive of 24 researchers from 12 industrial groups from seven countries) from 17 nations have contributed 101 papers.

After a short group of introduction papers, 38 papers are grouped around subjects of preclinical nature whereas 49 papers deal with clinical trials results and other forms of clinically oriented research. There is a strong domination of German input with 36 of 54 preclinical papers (with two papers each from France, Italy, Russia, Poland, USA and the UK, and one paper each from Australia, Austria, Switzerland

and Hungary) and 28 out of 49 clinical papers (France 6, Spain 3, 2 each from Italy, Poland, USA and UK, 1 each from Portugal, Japan and Rumania).

Many of the authors, however, are experts in their field and have taken great care to produce concise, well illustrated presentations, which include literature lists of varying lengths, and degrees of up to datedness. Although published in the second half of 1992, using a systematic sample of 20 papers, with just over 17 references per paper, 69% of these are more recent than 5 years, 37% dating from 1990-92, the volume offers an excellent introduction to many specialised fields of research. Many authors have taken care to provide detailed descriptions of methods and study design making this a valuable reference volume as well as introductory reader.

At the price requested, a reasonable investment, although much of the most recent research will no doubt already be in a phase of re-investigation in the many laboratories and research groups who have contributed to this comprehensive overview.

LYNNE BALL