Breast Cancer Metastasis and 20 Years of Computational ......Breast Cancer Metastasis and Drug Resistance Progress and Prospects This volume comprehensively covers recent prog-ress

News 10/2012 Biomedicine

11

A. Ahmad, Wayne State University, Detroit, MI, USA (Ed)

Breast Cancer Metastasis and Drug ResistanceProgress and Prospects

This volume comprehensively covers recent prog-ress in breast cancer research.

Features 7 Explores breast cancer, the factors that make it lethal and current research progress, includ-ing stem cells, microRNAs, epigenetics, genomics and some novel signaling pathways 7 Excellent source for of reference for researchers 7 Features up-to-date research

Contents Preface.- Demystifying breast cancer – its various subtypes.- Understanding Triple negative breast cancers – what makes them so lethal.- Racial disparity in breast cancer research.- Available models for breast cancer research.- Breast cancer metastasis – what makes breast cancer cells to migrate and where do they go.- Bone metasta-sis of breast cancer.- Brain metastasis of breast cancer.- Novel signaling pathways implicated in metastasis of breast cancers.- Tamoxifen resistant breast cancer.- Doxorubicin resistant breast cancer.- Herceptin resistant breast cancer.-Natural agents as sensitizing agents that enhance the ef-ficacy of therapeutic drugs.- microRNAs in breast cancer research.- Role of epithelial-mesenchymal transition in aggressiveness of breast cancers.- Cancer stem cells and breast cancer.- Chemistry of novel chemical compounds for the development of targeted therapeutic drugs to counter breast cancer.- Novel agents for chemoprevention of breast cancer.- Epigenetic factors in breast cancer progression.- Novel biomarkers for breast cancer.- Index.

Fields of interestCancer Research; Drug Resistance

Target groupsResearch

Discount groupProfessional Non-Medical

Due November 2012

2013. V, 485 p. 58 illus., 45 in color. Hardcover7 $209.00ISBN 978-1-4614-5646-9

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J. M. Bower, University of Texas, San Antonio, TX, USA (Ed)

20 Years of Computational NeuroscienceContents 1. “Computational Neuroscience: What have we learned in 20 years and what do we still need to know?” --*James M. Bower (University of Texas Health Science Center, San Antonio).- 2. “Analysis of invertebrate nervous systems as models for understanding complex function” --*Dr. John Miller (Montana State University).- 3. “The more we look, the more biological variation we see: How has and should this influence modeling of small networks?” --*Dr. Ron Calabrese (Emory University).- 4. “The Nervous System, still noisy after all these years?” --Dr. Alain Destexhe (CNRS - France).- 5. “Still looking for the memories: molecules and synaptic plasticity.” --Dr. Upinder Bhalla (NCBS- Bangalore India).- 6. “Modeling neuronal dynamics - our trajectory?” --Dr. John Rinzel (NYU).- 7. “Learning about vision: ques-tions we’ve answered, questions we haven’t an-swered, and questions we haven’t yet asked.” --Dr. Bruno Olshausen (University of California Berke-ley).- 8. “Learning from the past: Approaches for Reproducibility in Computational Neuroscience” --*Dr. Sharon Crook (Arizona State University).- 9. “Calcium: the Answer to Life, the Universe, and Everything” --*Dr. Avrama Blackwell (George Mason University).- 10. “The olfactory system, still computing, but how?” --*Dr. Christiane Linster (Cornell University).- 11. “20 years of oscillations and memory: The long and winding road linking cellular mechanisms to behavior” --*Dr. Michael Hasselmo (Boston University).- 12. “Reinforce-ment learning models then and now: from single cells to modern neuroimaging” --Dr. Reed Mon-tague (Baylor College of Medicine)

Fields of interestNeurosciences; Neurobiology; Computation by Abstract Devices

Target groupsGraduate


Due December 2012

2013. 300 p. (Springer Series in Computational Neuroscience, Volume 9) Hardcover7 $189.00ISBN 978-1-4614-1423-0

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R. Chen, Toronto Western Research Institute, Toronto, ON, Canada; J. C. Rothwell, University College London, UK (Eds)

Cortical ConnectivityBrain Stimulation for Assessing and Modulating Cortical Connectivity and Function

The study and modulation of cortical connections is a rapidly growing area in neuroscience.

Features 7 A unique book on cortical connections and their modulation by leaders in the field 7 Covers topics from non-human primates work, studies in human subjects to neurological and psychiatric diseases with up to date information 7 A useful text for both students and established researchers in neuroscience

Contents Modulation of motor cortical connections through timed stimulation: animal studies.- Connec-tion between premotor and motor cortices in primates.- Excitability of intracortical circuits in the primary motor cortex.- Effects of cortical stimulation on cortical functional connectivity: Imaging studies.- Accessing cortical connectivity using TMS.- Connections between cortical areas during grasping and modulation by brain stimula-tion.- Modulation of functional connectivity with transcranial direct current stimulation.- Cortical connections to motor cortex and their modula-tion in behavioural tasks (e.g. posterior parietal cortex, premotor cortex).- The functional role of interhemispheric interactions in human motor control.- Functional modulation of primary motor cortex during action selection.- Enhancement of normal cortical functions through brain stimula-tion.- Movement disorders.- Stroke.- Multiple sclerosis.- Spinal cord injury.- Psychiatric diseases.

Fields of interestNeurosciences; Human Physiology; Neurology



Due October 2012

2013 2012. VII, 450 p. 63 illus., 37 in color. Hardcover7 $209.00ISBN 978-3-642-32766-7

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www.springer.com/978-1-4614-5646-9



Biomedicine springer.com/NEWSonline

12

Current Topics in Microbiology and ImmunologyR. W. Compans, M. D. Cooper, H. Koprowski, F. Melchers, Series editors: M. B. Oldstone, P. K. Vogt, T. Honjo, Y. Gleba, B. Malissen, Y. Kawaoka, K. Aktories, R. Rappuoli, J. E. Galan

Volume 364

A. Rummel, T. Binz, Medizinische Hochschule Hannover, Germany (Eds)

Botulinum NeurotoxinsThe extremely potent substance botulinum neurotoxin (BoNT) has attracted much interest in diverse fields. Originally identified as cause for the rare but deadly disease botulism, military and terrorist intended to misuse this sophisticated molecule as biological weapon. This caused its classification as select agent category A by the Centers for Diseases Control and Prevention and the listing in the Biological and Toxin Weapons Convention. Later, the civilian use of BoNT as long acting peripheral muscle relaxant has turned this molecule into an indispensable pharmaceuti-cal world wide with annual revenues >$1.5 billion. Also basic scientists value the botulinum neurotoxin as molecular tool for dissecting mechanisms of exocytosis. This book will cover the most recent molecular details of botulinum neurotoxin, its mechanism of action as well as its detection and application.

Features 7 Written by leading experts in the field botuli-num neurotoxins 7 Provides the current status of basic botulinum neurotoxin research 7 Pro-vides in depth articles on neurotoxins for further medical applications by means of recombinant technologies

Fields of interestPharmacology/Toxicology; Neurosciences



Due November 2012

2013. VII, 389 p. 46 illus., 36 in color. Hardcover7 $189.00ISBN 978-3-642-33569-3

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R. Dermietzel, Ruhr University Bochum, Germany (Ed)

The CytoskeletonImaging, Isolation, and Interaction

Features 7 Collects expert contributions involving an overview of the cytoskeleton followed by its spe-cific relation to the brain and peripheral nervous system 7 Includes detailed protocols, ready for the laboratory 7 Features a mild focus on proteomic techniques

Contents Fluorescence Proteins and Time-Lapse Imag-ing of the Cytoskeleton.- Visualizing In Vitro Trafficking.- Interaction of the Glycocalyx with the Actin Cytoskeleton.- Cytoskeleton Dynam-ics and Binding Factors.- Principles of Proteomic Approaches to the Cytoskeleton.- Analyzing the Cytoskeletal Transcriptome: Sex Differences in Rat Hypothalamus.- Proteomic Approaches for the Study of Electrical Synapses and Associated Protein-Interaction Complexes.- The Cytoskeleton as a Pharmacological Target in Neurodegenerative Diseases.- Neurofilaments: Properties, Functions, and Regulation.- From an Axon into a Growth Cone after Axotomy: A Model for Cytoskeletal Dynamics.- Isolation of the Postsynaptic Density: A Specialization of the Subsynaptic Cytoskeleton.- Cell-to-Cell Communication in Astroglia and the Cytoskeletal Impact.- Reactive Astrocytes, Astro-cyte Intermediate Filament Proteins, and Their Role in the Disease Pathogenesis.- Microtubules and Associated Proteins in Oligodendrocytes, the Myelin Forming Cells of the Central Nervous System.- Myelin Proteome Analysis: Methods and Implications for the Myelin Cytoskeleton.

Fields of interestNeurosciences; Neurobiology

Target groupsProfessional/practitioner


Due December 2012

2013. XII, 226 p. 52 illus., 31 in color. (Neuromethods, Volume 79) Hardcover7 $139.00ISBN 978-1-62703-265-0

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M. Hayat, Kean University, NJ, USA (Ed)

Stem Cells and Cancer Stem Cells, Volume 9Therapeutic Applications in Disease and Injury

Contents Prelims. I. Umbilical cord blood stem cells.-1 Cryopreservation of hematopoietic stem cells from umbilical cord blood for transplantation.-2 Expan-sion of mesenchymal stem cells derived from umbilical cord in media containing human serum (method).-3 Transformation of human umbilical cord blood cells to support neuro-regeneration in the diseased brain.-5 Clinical application of umbilical cord blood-derived stem cells for tissue regeneration.II. Induced pluripotent stem cells.-6 Differentiation of induced pluripotent stem cells into oligodenndrocytes: increased efficiency of se-lecting oligodendrocyte precursor cells using a2b5 monoclonal antibody.-7 Epigenetic reprogram-ming without genetic modification: use of sendai virus vectors for generating safe induced pluripo-tent stem cells.-8 Differentiation and use of cardio-myocytes derived from human pluripotent stem cells.-9 Metabolism in cancer cells and pluripotent stem cells.-10 Treatment of patients with long- qt syndrome: differentiation of patient-derived induced pluripotent stem cells into functional cardiac myocytes.III. Embryonic stem cells.-11. Protein kinase c signaling in embryonic stem cell self renewal and cardiac differentiation.-12 Main-tenance of pluripotency in mouse embryonic stem cells with micrornas.-13 Uni-directional neuronal differentiation of embryonic stem cells by the neural stem sphere method.-14 Embryonic stem cell-derived motoneurons develop aberrant axonal sprouting. IV Hematopoietic stem cells. [...]

Fields of interestCancer Research; Biomedicine general; Medicine/Public Health, general

Target groupsGraduate


Due December 2012

2013. XIV, 379 p. 54 illus., 38 in color. (Stem Cells and Cancer Stem Cells, Volume 9) Hardcover7 $239.00ISBN 978-94-007-5644-1

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13

R. Küppers, University of Duisburg-Essen, Germany (Ed)

LymphomaMethods and Protocols

Contents Origin and Pathogenesis of B Cell Lymphomas.- Flow Cytometry for Non-Hodgkin and Classical Hodgkin Lymphoma.- Laser-Based Microdis-section of Single Cells from Tissue Sections and PCR Analysis of Rearranged Immunoglobulin Genes from Isolated Normal and Malignant Hu-man B Cells.- PCR-Based Analysis of Rearranged Immunoglobulin or T-Cell Receptor Genes by GeneScan Analysis or Heteroduplex Analysis for Clonality Assessment in Lymphoma Diagnostics.- Expression Cloning of Human B Cell Immuno-globulins.- Studying the Replication History of Human B Lymphocytes by Real-Time Quantita-tive (RQ)-PCR.- The Detection of Chromosomal Translocations Involving the Immunoglobulin Loci in B-Cell Malignancies.- Stereotyped B Cell Receptors in B Cell Leukemias and Lymphomas.- Flow Cytometric MRD Detection in Selected Mature B-Cell Malignancies.- MRD Detection in B-Cell Non-Hodgkin Lymphomas Using Ig Gene Rearrangements and Chromosomal Transloca-tions as Targets for Real-Time Quantitative PCR.- Enrichment of Methylated DNA by Methyl-CpG Immunoprecipitation.- Gene Expression Profile Analysis of Lymphomas.- FISH and FICTION to Detect Chromosomal Aberrations in Lympho-mas.- Identification of Pathogenetically Relevant Genes in Lymphomagenesis by shRNA Library Screens.- Studying MicroRNAs in Lymphoma.- Molecular Methods of Virus Detection in Lym-phoma.- High Throughput RNA Sequencing in B-Cell Lymphomas.Expression Cloning of Human B Cell Immunoglobulins.- Studying the Replication History of Human B Lymphocytes by Real-Time Quantitative (RQ)-PCR. [...]

Fields of interestCancer Research; Gene Expression



Due December 2012

2013. XII, 340 p. 45 illus., 26 in color. (Methods in Molecular Biology, Volume 971) Hardcover7 $139.00ISBN 978-1-62703-268-1

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G. Laviola, S. Macrì, Istituto Superiore di Sanità, Rome, Italy (Eds)

Adaptive and Maladaptive Aspects of Developmental StressSince the very early stages of life, we all experience some form of stress.

Features 7 Written by experts in the field 7 Contains up-to-date information 7 Features full-color images

Contents Making Sense of Stress: An Evolutionary-Devel-opmental Framework.- Prenatal and maternal psy-chosocial stress in primates: adaptive plasticity or vulnerability to pathology?.- The Everyday Stress Resilience Hypothesis: Unfolding resilience from a perspective of everyday stress and coping.- On-togeny of stress reactivity in the human child: Phe-notypic flexibility, trade-offs, and pathology.- Con-sequences of Developmental Stress in Humans: Prenatal Stress.- Consequences of Developmental Stress in Humans: Adversity experienced during Childhood and Adolescence.- Behavioural and neuroendocrine consequences of prenatal stress in rat.- Developmental consequences of prenatal ad-ministration of glucocorticoids in rodents and pri-mates.- Early developmental trajectories of brain development: New directions in the search for early determinants of health and longevity.- Adap-tive regulations in developing rodents following neonatal challenges.- Adaptive and maladaptive regulations in response to environmental stress in adolescent rodents.- Oxidative stress and hormetic responses in the early life of birds.

Fields of interestNeurosciences; Psychiatry; Biomedicine general



Due December 2012

2013. 300 p. 52 illus., 30 in color. (Current Topics in Neurotoxicity, Volume 3) Hardcover7 $209.00ISBN 978-1-4614-5604-9

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H. Mehlhorn, Heinrich Heine University, Düsseldorf, Germany; K. S. Tan, National University of Singapore, Singapore; H. Yoshikawa, Nara Women’s University, Kitauoya-Nishimachi, Japan (Eds)

Blastocystis: Pathogen or Passenger?An Evaluation of 101 Years of Research

The stages of Blastocystis have been known for 101 years. However, many facts are still disputed, e.g. even the question whether it is a true pathogen or a commensal present in sometimes life-threaten-ing diarrheas.

Features 7 Gives an update of the most recent knowledge on the potential pathogenicity of this enigmatic organism that endangers worldwide hundreds of millions of humans and animals 7 Written by experts 7 With numerous illustrations

Contents Landmarks in the discovery of Blastocystis stages.- Morphology of human and animal Blastocystis isolates with special references to reproductive modes.- Epidemiology, transmission and zoo-notic potential of Blastocystis stages in humans and animals.- Blastocystis – Host interactions: insights from in-vitro model systems.- Clinical aspects of Blastocystis infections: advancements admidst controversies.- Molecular approaches on systematic position, genetic polymorphism and classification of Blastocystis isolates from humans and animals.- What do we know about Blasto-cystis analyzing research studies with statistical methods.- Behavioral decision analysis: how do we decide what makes us sick?.- Diarrheas in humans due to agents of diseases.- What are zoonotic diseases?.- Conclusions.

Fields of interestParasitology; Medical Microbiology; Health Pro-motion and Disease Prevention



Due November 2012

2012. X, 210 p. 91 illus., 44 in color. (Parasitology Research Monographs, Volume 4) Hardcover7 $189.00ISBN 978-3-642-32737-7

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14

R. I. Morimoto, University of Illinois, Chicago, USA; Y. Christen, Fondation Ipsen pour la Recherche Therapeutique, Boulogne Billancourt, France (Eds)

Protein Quality Control in Neurodegenerative DiseasesThe health of the proteome depends upon protein quality control to regulate the proper synthesis, folding, translocation, and clearance of proteins.

Features 7 Written by leading experts in the fields Neuro-science and Endocrinology 7 Provides topical research results 7 Another excellent group of authors and their chapters collected by Fondation Ipsen

Contents The Regulation and Function of the Heat Shock Response by Eric Guisbert and Richard I. Morimoto.- The Endoplasmic Reticulum Unfolded Protein Response and Neurodegenera-tion by David Ron.- Proteostasis and the aging pathways by Ian Nicastro and Andrew Dillin.- The Membrane Sources of Macroautophagy by Daniel J. Klionsky, Melinda A. Lynch-Day, Jiefei Geng, and Wei-Lien Yen.- Selective Autophagy in Cellular Quality Control by Susmita Kaushik and Ana Maria Cuervo.- Quality Control of Proteins and Organelles by Autophagy by Noboru Mizushima.- The Role of the Co-Chaperone BAG3 in Selective Macroautophagy: Implications for Aging and Disease by Christian Behl.- Predicting Fates in Models of Neurodegenerative Disease: Longitudinal Measures of Protein Homeostasis in Live Neurons by Steven Finkbeiner.- Therapeutic Potential of Longevity Modulators as Neuropro-tective Targets in Neurodegenerative Disease by Rafael Vazquez-Manrique, Cendrine Tourette and Christian Neri.- Subject code

Fields of interestNeurosciences; Neurochemistry; Molecular Medicine



Due December 2012

2013. X, 150 p. (Research and Perspectives in Alzheimer’s Disease) Hardcover7 $189.00ISBN 978-3-642-27927-0

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M.‑O. Parat, University of Queensland School of Pharmacy,Woolloongabba, QLD, Australia (Ed)

Morphine and MetastasisThis book would combine chapters written by the most qualified authors around the world whose research encompasses the effect of morphine or other opioids on tumor growth and metastasis. This includes clinicians involved in trials deter-mining which type of post surgical pain man-agement can minimize the risk of recurrence or metastasis, researchers working on animal models and studying the effect of morphine on tumors, and most importantly the mechanism for this ef-fect, and lastly cell biologists.

Features 7 No similar book published on this top-ic 7 The breadth of fields of research from the authors reflects the variety of academics, clinicians or scientist that will be interested in owning this book 7 Written by the most qualified researchers in the filed

Contents 1 Morphine and metastasis: from bench to bedside.- 2 Interaction of Naloxone and Estrogen Receptor in Breast Cancer.- 3 Morphine and im-munosuppression in the context of tumor growth and metastasis.- 4 Opioid Regulation of Vascular Integrity.- 5 Iatrogenic Angiogenesis.- 6 Could opioids affect cancer recurrence or metastases? Current experimental and Translational Evi-dence.- 7 Genetic polymorphisms in the µ-opioid receptor gene and breast cancer survival.- 8 Anaesthetic and pain management technique in long term cancer outcome - benefits of regional anaesthesia and analgesia in the context of cancer surgery.- 9 Perioperative morphine and cancer recurrence.

Fields of interestCancer Research; Pharmacy; Pharmacology/Toxi-cology



Due October 2012

2013. III, 151 p. 16 illus., 13 in color. Hardcover7 $139.00ISBN 978-94-007-5677-9

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D. W. Pfaff, Y. Christen (Eds)

Multiple Origins of Sex Differences in BrainNeuroendocrine Functions and their Pathologies

Contents Donald PFAFF (The Rockefeller University, New York, USA) Hormone-dependent chromatin modifications regulating sexually differentiated animal behaviour.- Eric B. KEVERNE (Univer-sity of Cambridge, Cambridge, UK) Importance of genomic imprinting in the evolution and development of the maternal brain.- Catherine DULAC (Harvard University & Howard Hughes Medical Institute, Cambridge, USA) Sex battles in the brain: genomic imprinting in the developing and adult CNS.- Javier DE FELIPE (Universidad Politécnica de Madrid, Madrid, Spain) Gender differences in human cortical synaptic den-sity.- Melissa HINES (University of Cambridge, Cambridge, UK) Androgenic influences on human neurobehavioral development: outcomes and mechanisms.- Simon BARON-COHEN (Cambridge University, Cambridge, UK) The foetal androgen theory of autism.- Francesca DUCCI (King’s College, London, UK) Genetic variation within serotonin genes, hormones, and aggression.- Jay GIEDD (National Institute of Mental Health, Bethesda, USA) Does size mat-ter? Sex differences in the developing brain.- Jill GOLDSTEIN (Brigham and Women’s Hospital and Harvard Medical School, Boston, USA) Fetal hormonal programming of the brain: Implications for understanding sex differences in depression and risk for cardiovascular disease. [...]

Fields of interestNeurosciences; Endocrinology; Human Genetics



Due December 2012

2013. VII, 200 p. 37 illus., 17 in color. (Research and Perspectives in Endocrine Interactions) Hardcover7 $189.00ISBN 978-3-642-33720-8

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15

P. J. Quesenberry, Rhode Island Hospital, Providence, RI, USA; J. J. Castillo, The Warren Alpert Medical School of Brown University, Providence, RI, USA (Eds)

Non-Hodgkin LymphomaPrognostic Factors and Targets

This book will be the first that focuses on solely on model organisms for lymphoma. It’s editors are internationally recognized in the field.

Features 7 This book will be the first that focuses on solely on model organisms for lymphoma 7 The editor Peter J. Quesenberry is internationally recognized in the field 7 In-depth discussion of lymphoma models and their prognostic factors

Contents Cancer Stem Cells: A Matter of Perspective.- B and T-cell development.- HIV lymphomagen-esis.- Epstein-Barr Virus Lymphomagenesis and Therapeutic Targets.- Antigen driven lymphoma-genesis.- Pre-clinical lymphoma models.- Prog-nostic factors in B-cell lymphoma.- Prognostic factors in T-cell lymphoma.- Prognostic factors in HIV-associated lymphoma.- Future directions on the treatment of aggressive non-Hodgkin lym-phoma.- New monoclonal antibodies for indolent non-Hodgkin lymphomas.- Current therapies for T-cell lymphoma.- Stem Cell Transplantation for lymphoma.- Autologous stem cell transplanta-tion in non-Hodgkin lymphoma.- The role of Stem Cell Transplantation for HIV-associated lymphoma.- Stem Cell Transplantation for T-cell lymphoma.- Index.

Fields of interestCancer Research; Pharmacology/Toxicology



Due January 2013

2013. X, 310 p. 15 illus., 11 in color. (Cancer Drug Discovery and Development) Hardcover7 $189.00ISBN 978-1-4614-5850-0

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P. M. Rabinovich, The Anlyan Center, Yale School of Medicine, New Haven, CT, USA (Ed)

Synthetic Messenger RNA and Cell Metabolism ModulationMethods and Protocols

Contents Cell Engineering with Synthetic Messenger RNA.- In vitro Transcription of Long RNA Containing Modified Nucleosides.- HPLC Purification of in vitro Transcribed Long RNA.- Synthetic mRNAs with Superior Translation and Stability Proper-ties.- Non-Viral, Cationic Lipid-Mediated Delivery of mRNA.- Light-Induced mRNA Transfection.- Engineering B Cells with mRNA.- Programming Human Dendritic Cells with mRNA.- Large Volume Flow Electroporation of mRNA: Clinical Scale Process.- Retrovirus-Based mRNA Transfer for Transient Cell Manipulation.- mRNA Delivery to Human Dendritic Cells by Recombinant.- Non-Viral RNA Transfection to Transiently Modify T Cells with Chimeric Antigen Receptors for Adop-tive Therapy.- Natural Killer Cell Reprogramming with Chimeric Immune Receptors.- Reprogram-ming to Pluripotency and Differentiation of Cells with Synthetic mRNA.- Anti-Tumor Vaccination with Synthetic mRNA: Strategies for in vitro and in vivo Preclinical Studies.- Mannosylated and Histidylated LPR Technology for Vaccination with Tumor Antigen mRNA.- Analysis of Surviving-Specific T Cells in Breast Cancer Patients Using Human DCs Engineered with Survivin mRNA.- mRNA electroporation as a Tool for Immuno-monitoring.- mRNA PCR-Based Epitope Chase Method.

Field of interestHuman Genetics



Due December 2012

2013. XV, 370 p. 50 illus., 23 in color. (Methods in Molecular Biology, Volume 969) Hardcover7 $139.00ISBN 978-1-62703-259-9

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Reviews of Physiology, Biochemistry and PharmacologySeries editors: S. G. Amara, R. Jahn, R. Lill, B. Nilius, O. H. Petersen, T. Gudermann, S. Offermanns

Volume 163Reviews of Physiology, Biochemistry and Pharmacology, Vol. 163Induced pluripotent stem cells in cardiovascular research.- TRPs in the brain.- Chemosensory re-ceptors and channels in the respiratory tract: role in toxic lung injury and potential as “sweet spots” for targeted therapies. - The channel physiology of the skin.

Features 7 Written by leading experts in the fields 7 Pro-vides current and comprehensive view 7 This volume offers high-quality, in-depth reviews in the fields cardiovacular system, respiratory tract, channel physiology and TRPs

Contents Induced pluripotent stem cells in cardiovascular research.- TRPs in the brain.- Chemosensory re-ceptors and channels in the respiratory tract: role in toxic lung injury and potential as “sweet spots” for targeted therapies. - The channel physiology of the skin.

Fields of interestHuman Genetics; Cardiology; Pneumology/Respi-ratory System



Due November 2012

2012. X, 110 p. 20 illus., 10 in color. Hardcover7 approx. $139.00ISBN 978-3-642-33520-4

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16

U. Schmitz, O. Wolkenhauer, J. Vera, University of Rostock (Eds)

MicroRNA Cancer RegulationAdvanced Concepts, Bioinformatics and Systems Biology Tools

Contents Preface.- 1 MicroRNAs in human cancer.- 2 Bio-informatics, non-coding RNAs and its possible ap-plication in personalized medicine .- 3 MicroRNA target prediction and validation.- 4 MicroRNA-regulated networks: the perfect storm for classical molecular biology, the ideal scenario for systems biology.- 5 The p53/microRNA network in cancer: experimental and bioinformatics approaches.-6 MicroRNAs in melanoma biology.- 7 MicroRNA in the lung.- 8 The E2F1-miRNA cancer progres-sion network.- 9 Modeling of microRNA-tran-scription factor networks in cancer.- 10 Coordi-nated networks of microRNAs and transcription factors with evolutionary perspectives.- 11 Mathematical modeling of microRNA-mediated mechanisms of translation repression.- 12 Web resources for microRNA research.- 13 Discovery of microRNA regulatory networks by integrat-ing multidimensional high-throughput data.- 14 Discovering the functional microRNA-mRNA regulatory modules in heterogeneous data.- 15 Elucidating the role of microRNAs in cancer through data mining techniques.- 16 Working to-gether: Combinatorial regulation by microRNAs.

Fields of interestCancer Research; Bioinformatics; Computational Biology/Bioinformatics



Due December 2012

2013. VI, 444 p. 92 illus., 69 in color. (Advances in Experimental Medicine and Biology, Volume 774) Hardcover7 $209.00ISBN 978-94-007-5589-5

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E. Skouras, Universität zu Köln, Germany; S. Pavlov, Medical University Varna, Bulgaria; H. Bendella, D. N. Angelov, Universität zu Köln, Germany

Stimulation of Trigeminal Afferents Improves Motor Recovery After Facial Nerve InjuryFunctional, Electrophysiological and Morphological Proofs

Contents First major set: mild indirect stimulation of the trigeminal afferents after combined surgery on the infraorbital and facial nerves by removal (clipping) of the contralateral vibrissal hairs.- Second major set: intensive indirect stimulation of the trigeminal afferents after facial nerve surgery by extcision of the contralateral infraorbital nerve.- Third major set: direct stimulation of the trigeminal and facial nerves after facial nerve surgery by massage of the vibrissal muscles .- Fourth major set: direct stimulation of the trigeminal and facial nerves after facial nerve surgery by application of electric current to the vibrissal muscles.- RESULTS.- Mild indirect stimulation of the trigeminal afferents after combined surgery on the infraorbital and facial nerves by removal of the contralateralvibris-sal hairs improves vibrissal function.- Intensive indirect stimulation of the trigeminal afferents by excision of the contralateral ION attenuates the degree of collateral axonal branching and im-proves the accuracy of muscle reinnervation.- Di-rect stimulation of the trigeminal and facial nerves by massage of the vibrissal muscles improves the quality of target reinnervation and promotes full recovery of whisking function. [...]

Fields of interestNeurosciences; Neurosurgery



Due December 2012

2013. X, 110 p. 15 illus., 12 in color. (Advances in Anatomy, Embryology and Cell Biology, Volume 213) Softcover7 $139.00ISBN 978-3-642-33310-1

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Documents

Breast Cancer Metastasis and 20 Years of Computational ......Breast Cancer Metastasis and Drug Resistance Progress and Prospects This volume comprehensively covers recent prog-ress