nanoimmunotech is the first European company in the Nanobiotechnology sector, dedicated to the biological and physico-chemical characterization and to the conjugation of nanoparticles and products containing them.

The company has highly qualified and internationally recognized human resources, state-of-the-art laboratory capabilities, standardized protocols and finally, the know how to perform proper supervision, advice and validation of different nanosystems, as a first step to the previous use of nanoparticles in biotechnological applications for different sectors (biomedical, pharmaceutics, cosmetics, veterinary, agro-food, enviromental, etc).

The nanoimmunotech’s business model is flexible and we have experience in participat-ing in research or on demand projects, licensing, customer-supplier relationships, etc...

CONTACT DATAPHONE (+34) 876 440 071 FAX (+34) 876 440 200

HEADQUARTERS IN ZARAGOZA HEADQUARTERS IN VIGO EDIFICIO CERO EMISIONES PLAZA DE FERNANDO CONDEAVDA. AUTONOMIA 7 MONTERO RIOS 950003 ZARAGOZA 36201, VIGO, PONTEVEDRA

COORDENATES N 41.66045º W 0.90695º COORDENATES N 42.23703º W 8.71911º

BNIT 121031

nitzipper® is a new revolutionary technology from nanoimmunotech that allows you to quickly, easily and effectively join different types of micro/nanostructures, biomolecules, dyes, linkers, drugs and many other molecules, in practically any com-bination you wish.

nitzipper® is also a multi-functionalization tool that will allow you to join more than one type of molecule or micro/nanostructure to another molecule or micro/nanostructure.

nitzipper® may be used for wide a range of applications allowing you to innova-te within various markets and industries:

Health industry: e.g. better medical imaging systems for early identification of diseases, removal of tumors by hyperthermia... Pharmaceutics: e.g. improving drug targeting and drug delivery... Cosmetics: e.g. improving the absorption and vehiculization of creams and other products... Veterinary: e.g. diagnostics for animal pathogens detection... Environment: e.g. improving biosensors sensitivity allowing a better detection of contaminants, improving the quality of water... Food and beverage: e.g. encapsulation and packaging for food substances... Agriculture, energy and clean technologies...(among many other industries)

nitzipper® works: molecules and micro/nanostructures join in a controlled and stable way, always preserving their functionality.

nitzipper® adapts itself to your necessities.

nitzipper® is an easy and quick Plug&Play solution requesting short hands on time.

nitzipper® is an inexpensive solution in comparison to other products thatalready exist on the market

nitzipper® is a revolutionary tool that allows you to do new things that you could not do before.

nitzipper® applications are only limited by your imagination

Some examples of nitzipper® linkages

nanoimmunotech is proud to offer you the nitcharacter services for the full physico-chemical characterization of your nanomaterials, accounting with a highly qualified and experienced staff and senior scientific advisors for this activity.

nitcharacter allows you to characterize your materials with leading equipment and highly specialized instrumentation.

The correct physico-chemical characterization of your nanomaterials is a crucial step to understand their real intrinsic properties and gather all the necessary information prior to their final application (e.g. in vitro or in vivo applications), besides being able to predict your product’s stability and grant a quality control over your production.

nitcharacter allows to develop a complete physico-chemical characterization of your nanomaterials on demand, taking into account the different particularities of each case. For each one of your applications, nitcharacter will give you the informa-tion you need to improve the process of synthesis and/or chemical functionalization of your nanomaterials.

nitcharacter services not only consists in executing the physico-chemical measu-res of your products, but also on the added value that nanoimmunotech offers to its customers through the interpretation of results and advices given to improve the synthesis and properties of your nanostructured materials

TEM-EDX/SEM

Analysis of elements

Nuclear magneticresonance spectroscopy (NMR)

Inductively coupled plasma (ICP)

Zeta Potential

Dynamic light scattering (DLS)

Fourier transform infrared spectrophotometry (FTIR)

X-ray photoelectron spectroscopy (XPS)

Fluorescence spectrophotometry

SQUID

UV-visible spectroscopy

Size, Shape, Monodispersity and Composition

Content analysis of C, N, H, and S

Characterization of the protective organic mo-nolayer strucutre of core-shell nanoparticles

Identification and quantification of the chemical

Measure the zeta potential charge of nanoparticles

Hydrodynamic radius and size distribution ofnanoparticles in solution

Characterization of the major functional groups present on the surface of the

Assessing the nature and chemical state of the surface atoms of the nanostructure to depth of 5 nm (4-20 atomic layers)

Analysis of fluorescent nanostructures

Magnetic properties of nanostructures

Characterization of surface plasmon of noble metal nanoparticles

nitcharacter offers you the following characterization techniques to measure the character of your nanomaterials

TECHNIQUES PHYSICO-CHEMICAL CHARACTERIZATION

nanoimmunotech offers you a complete portfolio of biological characterization services called nitbiosafe, that allows you to perform a full set of in vitro and in vivo assays to check the risks of your nanomaterials: toxicity, biocompatibility (hemo and cytocompatibility), biodistribution, immunogenicity, sterility, among other assays.

nitbiosafe services are based on standardized protocols and experimental environ-ments that ensure optimal laboratory results, implementing USA recommendations and all EU regulation regarding nanosafety.

nanoimmunotech team has been involved in the field of Nanotoxicity, being mem-bers of different workgroups and platforms, as European Platform of Nanomedicine (ETPN), having participated in several projects and networks related to nanosafety and collaborated with other partners in this field.

nanoimmunotech also accounts with an animal facility that allows the use of animal models for in vivo confirmation of nanotoxicity and immunogenicity, offering you the ultimate biological characterization assays for your products.

Aggregation analysis and colloidal stability

Oxidate Stress Study: determination of the production of reactiveoxygen species

Phagocytosis assay

Targeting

Sterility

Nonspecific adsorption of proteins

Complement activation test

Inflammation Study: production of cytokines

Cytotoxicity analysis

TDAR (T cell dependent antibody response)

Lethal Dose DL50

Biodistribution and pharmacokinetics

Hematological study

IN VITRO BIOLOGICAL CHARACTERIZATION

IN VIVO BIOLOGICAL CHARACTERIZATION