radiation research

/./. broerse, g.w. barends&n

h.b. kal, a.j. van der kogel(editors)radiobiological institute tno

rijswijk, the netherlands

proceedingsof the

seventh

international

congress of

radiation

research

amsterdam

July 3-8,1983

biologysessions

B

martinus nijhoff publishers

CONTENTS V

CONTENTS

RADIATION BIOCHEMISTRY: MECHANISMS OF DAMAGE

B1-01 SIZE DISPERSITY OF MAMMALIAN DNA OBTAINED DUKING ALKALINE ELUTION.

Ankeren S.C. van,Wheeler K.T.

B1-02 SYNTHESIS AND PHOSPHORYLATION OF HISTONE H1 IN THE REGENERATING RAT LIVER

AFTER X-IRRADIATION

Asami K., Fujlwara A., Yasumasu I.

B1-03 MODIFIED COPOLYMERS WITH RADIOPROTECTIVE ACTION.Bruma M., Dumitresou Gh., Dumltreseu E.

B1-04 THE CORRELATIONS BETWEEN CELL SURVIVAL, MUTATION FREQDENCY, CHROMOSOMALABERRATIONS AND DNA STRAND BREAKAGE.

Chadwiok K.H., Leenhouts H.P.

B1-05 THE EFFECTS OF SELECTED CHEMICAL AGENTS WITH DIFFERENT BOND DISSOCIATION

ENERGIES (D(H-X)) ON SPECIES INDUCED IN IRRADIATED DRIED SPORES.

Collett J.H., Tallentire A.

B1-06 STUDIES OF THE UNWINDING AND RENATURATION OF THE DNA-MOLECULE.

Edvardsson K.A.

B1-07 EFFECT OF WHOLE BODY-GAMMA (60-Co) IRRADIATION (I.R.) IN DNA/RNA/PROTEINFUNCTION IN DEVELOPING CNS.

Egana E., Llona I., Ramirez M.T.

B1-08 THE EFFECT OF ORGANIC SOLVENTS ON THE RADIATION SENSITIVITY OF E. COLIK12

AB1157Gillies N.E., Ratnajothi N.H.

B1-09 VERATRIDINE-STIMULATED SODIUM UPTAKE IN RAT BRAIN SYNAPTOSOMES IS REDUCED

BY LOW DOSES OF IONIZING RADIATION.

Hunt W.A., Wixon H.N., Mullin M.J.

B1-10 CORRELATION BETWEEN CHEMICAL CHANGE OF THYMINE DERIVATIVES AND BIOLOGICAL

INACTIVATION BY IONIZING RADIATION IN AQUEOUS SOLUTION.

Kagiya V.T., Nishimoto S., Ide H., Wada T.

B1-11 AN APPROACH TO THE STUDY OF RADIATION-ACTIVATION OF GERMINATION IN

BACTERIAL SPORES.

Lefebvre G.M.

VI CONTENTS

B1-12 THE DOPAMINE IN HYPERTROPHY HEARTS AFTER IRRADIATION OF X-RAYS.

Maruahin J., Blaszezyk M.

B1-13 THE ROLE OF WATER RADICALS BY GAMMA-RAYS ON VIRAL ACTIVITIES AND THEIRGLYCOPROTEINS OF SENDAI VIRUS.

Megumi T., Ito T.

B1-14 THYMINE DIMER INDUCTION IN E. COLI DNA BY CERENKOV EMISSION ASSOCIATED

WITH HIGH ENERGY X-IRRADIATION.

Morgan T.L., Redpath J.L., Ward J.F.

B1-15 ALTERED PROTEIN PRODUCTION IN ATAXIA-TELEANGIECTASIA FIBROBLASTS

Murnane J.P., Painter R.B.

B1-16 EFFECT OF SAPONIN ON THE PHOTOREACTIVATION OF UV DAMAGE IN ESCHERICHIA

COLI,Park H.-S., Ann I.-S.

B1-17 ULTRAVIOLET RADIATION-INDUCED CHANGES IN THE TRANSCRIPTIONAL ATTRIBUTESOF CHROMATIN ISOLATED FROM YOSHIDA ASCITES TUMOR CELLS.Ramakrishnan N., Pradhan D.S.

B1-18 EFFICIENCIES OF DNA INACTIVATION BY TRITIATED WATER IN BACTERIAL SYSTEMS.

Sadaie Y., Inoue T., Kada T.

B1-19 THE RESPONSE OF UV-IRRADIATED ESCHERICHIA COLI CELLS TO INFECTION WITHTHE LAMBDA PHAGE.

Salaj-Smio E., Trgovoevio Z., Petranovio D., Petranovio M., Serman D.

B1-20 INHIBITORY EFFECT OF IRRADIATION PRODUCTS OF CYCLIC ADENOSINE

MONOPHOSPHATE (oAMP) ON THE RELAXING ABILITY OF SMOOTH MUSCLEPREPARATIONS.

Sohaohinger L., Srivastava A., Kloter H., Sohippel CH., Hagen U.

B1-21 THE EFFECT OF TEMPERATURE ON THE FAST REPAIR OF OXYGEN DEPENDENT DAMAGEIN IRRADIATED BACTERIA.

Weiss H., Santomasso A.

B1-22 WAVELENGTH DEPENDENCE OF INACTIVATION AND MUTAGENESIS IN CHINESE HAMSTERCELLS.

Zolzer F., Kiefer J.

DNA DAMAGE AND REPAIR IN CELLS

B2-01 MULTIPHASE DNA REPAIR KINETICS IN MAMMALIAN CELLS IRRADIATED WITH

IONIZING RADIATION.

Ahnstrom G., Bryant P.E.

CONTENTS VII

B2-02 MOLECULAR REPAIR CHANGES OF DNA FROM WHEAT SEEDLINGS AFTER IRRADIATION.Bekhoev I.D., Boudnitskaya E.V.

B2-03 CHANGE OF KINETICS OF DNA SINGLE-STRAND BREAKS REJOINING IN STIMULATED TO

THE PROLIFERATION HEPATOCYTES OF RATS.

Bezdrobnaya L.K.

B2-04 A COMPARISON OF ALKALI UNWINDING AND ALKALI FILTER ELUTION: ESTIMATES OF

SLOW DNA STRAND BREAK REPAIR KINETICS,

Blakely W.F., Erixon K., Ward J.F.

B2-05 HYPERTHERMIA INHIBITS THE REPAIR OF X-RAY INDUCED DNA DOUBLE-STRANDBREAKS.

Bowden G.T., Cater K., Kasunio M.

B2-06 PROPERTIES OF A HUMAN LYMPHOBLAST AP ENDONUCLEASE ACTIVITY ASSOCIATED

WITH AN ACTIVITY THAT SPECIFICALLY INCISES UV- OR X-IRRADIATED DNA.

Brent T.P.

B2-07 STUDIES ON ULTRAVIOLET LIGHT INDUCTION AND EXCISION REPAIR OF PYRIMIDINEDIMERS IN HUMAN SKIN FIBROBLASTS.

Carrier W.L., Lee W.H., Regan J.D.

B2-08 THE EFFECT OF HYDROXYUREA (HU) ON EXCISION REPAIR OF ULTRAVIOLET LIGHTINDUCED PYRIMIDINE DIMERS IN PROLIFERATING AND QUIESCENT HUMANFIBROBLASTS.

Castellani A., Carrier W.L., Regan J.D.

B2-09 REPAIR OF ALTERATIONS IN GAMMA-IRRADIATED TRANSFORMING BACILLUS SUBTILIS

DNA BY EXTRACT FROM THE BLUE-GREEN ALGAE,

Dmitriev A., Shevohenko T., Gusoha N., Grodzinsky D.

B2-10 KINETICS OF THE INDUCTION OF THE reoA GENE PRODUCT BY ULTRAVIOLET LIGHTAND X-RAYS.

Fluke D.J., Kazanis D., Bronner E.C., Pollard E.C.

B2-11 EVIDENCE FOR RECOMBINATIONAL INTERMEDIATES IN THE REPAIR OF DNA DOUBLE

STRAND BREAKS IN X-IRRADIATED MAMMALIAN CELLS.Fonok K., Barthel R., Bryant P.E.

B2-12 REPAIR OF DNA DOUBLE-STRAND BREAKS AS A DETERMINANT OF RBE OF ALPHA

PARTICLES.

Frankenberg-Sohwager M., Frankenberg D., Harbioh E.

B2-13 MEA-EFFECT ON DNA DEGRADATION AND REPAIR IN GAMMA-IRRADIATED THERMOPHILICBACTERIA.

Gaziev A.I., Kuznetaova E.A., Phomenko L.A.

B2-14 REPAIR OF PHOTOACTIVATED 8-METHOXYPSORALEN DAMAGE IN HUMAN CELLS.

Gruenert D.C., Cleaver J-E.

B2-15 ULTRAVIOLET LIGHT SENSITIVITY AND UNSCHEDULED DNA SYNTHESIS IN VARIOUS

CELL STRAINS DERIVED FROM C57BL MOUSE.Ikebuohi M., Shima A., Aoyama T.

VIII CONTENTS

B2-16 DNA REPAIR ENZYME ACTIVITIES IN DIFFERENTIATED AND UNDIFFERENTIATEDCULTURED HUMAN NEUROBLASTOMA CELLS.Jensen L., Linn S.

B2-17 INFLUENCE OF MACROMOLECULAR DNA OF EXOGENOUS ORIGIN ON UNSCHEDULED DNASYNTHESIS IN LS/B1 CELLS.

Karpfel Z., Benes L.t Slotova J.

B2-18 THE PYRIMIDINE DIMER EXCISION REPAIR PATHWAY IN PERMEABLE OR LYSED HUMANFIBROBLASTS.

Kaufmann W.K., Bodell W.J.

B2-19 EFFECTS OF MISONIDAZOLE ON DNA DAMAGE AND REPAIR IN HYPOXIC CELLS.

Keng P.C., Thomas R., Sutherland R.M.

B2-20 REPAIR OF DNA CROSS-LINKS IN DEINOCOCCUS RADIODURANS

Kitayama S.

B2-21 A VIRAL PROBE APPROACH TO INTRACELLULAR REPAIR OF DOUBLE- ANDSINGLE-STRAND DNA BREAKS IN HIGHER CELLS.Krisoh R.E., Tan P.M.

B2-22 DNA REPAIR: GENETIC DISSECTION AND CHROMOSOMAL LOCATION OF THE GENESREQUIRED FOR ULTRAVIOLET RADIATION INDUCED DNA DAMAGE IN MAN USING HUMANX MOUSE SOMATIC CELL HYBRIDS.

Lalley P.A.,Diaz J.A.,Franois A.A.,Dunn W.C.,Carrier W.L.,Regan J.D.

B2-23 SINGLE- AND DOUBLE-STRAND BREAK-INDUCED DNA CONFORMATION CHANGES ANDTHEIR REPAIR AS DETERMINED BY VISCOELASTOMETRY.Lange C.S.

B2-24 POST-IRRADIATION TREATMENT OF CHO CELLS WITH DIAMIDE INHIBITS DNA STRANDBREAK REJOINING.

Meyn R.E., Jenkins W.T., Jenkins S.F.

B2-25 ROLE OF CHLOROPLAST IN THE REPAIR OF NUCLEAR DNA DAMAGE INDUCED BYGAMMA-RADIATION IN EUGLENA GRACILIS CELLS,

Netrawali M.S., Nair K.A.S.

B2-26 MECHANISM OF DIMER-ASSOCXATED STRAND BREAKAGE OF DNA IN UV-IRRADIATEDDICTYOSTELIUM DISCOIDEUM.

Ohnishi T., Deerlng R.

B2-27 OBSERVATION OF DNA STRAND BREAKAGE IN AN UV-IRRADIATED NUCLEI ANDMITOCHONDRIA FRACTION PREPARED FROM-DICTYOSTELIUM DISCOIDEUM NC-1| AND THEDNA SYNTHESIS AFTER UV IRRADIATION TO THE FRACTION.Okaiohi K., Nozu K.

B2-28 CHROMATIN STRUCTURE AS A FACTOR IN THE FORMATION AND REJOINING OFRADIATION-INDUCED DNA SINGLE-STRAND BREAKS IN MAMMALIAN CELLS.

Oleiniok N.L., Chiu S.-M., Friedman L.R.

B2-29 DNA DAMAGES STUDIED BY MICROELECTROPHORESIS OF DNA.Ostling 0., Johanson K,J.

CONTENTS IX

B2-30 ERROR-FREE uvr+-DEPENDENT INDUCIBLE REPAIR IN ESCHERICHIA COLI B/r Hcr+CELLS.

Pirsel M., Hasek F., Sedliakova M.

B2-31 CAN DNA DOUBLE STRAND BREAKS IN MAMMALIAN CELLS BE REPAIRED WITHOUT HELPFROM A HOMOLOGOUS DNA MOLECULE?

Rydberg B.

B2-32 DNA DOUBLE STRAND BREAKS IN MAMMALIAN CELLS: PRODUCTION AND REPAIR INX-IRRADIATED HUMAN AND CHINESE HAMSTER CELLS.

Sapora 0,, Padovani L., Quintiliani M.

B2-33 MUTAGEN SENSITIVITY AND DNA REPAIR IN RADIATION-SENSITIVE MUTANTS OFMOUSE CELLS.

Sato K., Hana-Inaba H., Shiomi T., Takahashl E., Nakazawa T.

B2-31 THE INDUCTION AND REPAIR OF UV-TYPE DAMAGE IN DNA IN MAMMALIAN CELLSEXPOSED TO 60-Co GAMMA-RAYS.

Schans G.P. van der , Centen H.B., Lohman P.H.M.

B2-35 OER OF STRAND BREAKS AFTER 6-3H-IUDR INCORPORATION IN DNA OF T1-CELLS.Sohneeweiss F.H.A., Tisljar-Lentulis G., Wermelskirchen D.,Feinendegen L.E.

B2-36 DOSE-DEPENDENT REPAIR KINETICS OF DNA STRAND BREAKS INDUCED BY GAMMA RAYSAND FAST NEUTRONS.

Sohroy C.B., Ngo F.Q.H., Koumoundourous I.P., Glassner B.J.

B2-37 MINIMAL MEDIUM RECOVERY IS DUE TO INDUCIBLE POSTREPLICATION REPAIR IN

UV-IRRADIATED ESCHERICHIA COLI K-12 uvrASharma R.C., Smith K.C.

B2-38 ACCUMULATION OF DNA STRAND BREAKS IN MAMMALIAN CELLS AFTER INCUBATIONWITH 125I-TRIIOD0THYR0NINE AT 37 DEGREES C.

Sundell-Bergnan S., Johanson K.J.

B2-39 INCREASES IN DOUBLE STRAND BREAK YIELD RESULTING FROM EXPOSURE OFINTRACELLULARLY IRRADIATED DNA TO ELEVATED PH, ETHANOL OR REPAIRPROCESSES

Tllby M.J., Loverook P.S.

B2-40 MECHANISMS FOR THE recF-DEPENDENT AND reoB-DEPENDENT PATHWAYS OF

POSTREPLICATION REPAIR IN UV-IRRADIATED ESCHERICHIA COLI uvrB.

Wang T.-C.V., Snith K.C.

B2-41 EFFECTS OF HYPOTONIC SALT TREATMENT ON DNA DAMAGE PRODUCTION AND ITS

REPAIR IN HELA CELLS.Ward J.F., Jonsr E.I., Blakely W.F.

B2-»2 THE ACCESSIBILITY OF MAMKALIAN CHROMATIN TO EXOGENOUS NUCLEASES AND ITSIMPLICATIONS FOR DNA REPAIR.

Viarowaki J.V.

B2-43 MUTATION INDUCTION IM DBINOCOCCUS RADIODUBANS.

Yatagai F., Kltayaan S.

X CONTENTS

EFFECTS ON DNA AND MEMBRANES

B3-01 CELL BIOLOGICAL STUDY ON CELLS OBTAINED FROM PATIENTS WITH ADENOMATOSIS

COLI. AN AUTOSOMAL DOMINANT HEREDITARY DISEASE.

Ban S., Iida S., Hamilton H.B., Fujikura T., Tamura T.

B3-02 ADRIAMYCIN-RESISTANT MAMMALIAN CELLS AND RADIATION RESPONSE: ROLE OF THE

CELL MEMBRANE.

Belli J.A., Zhang Y.

B3-03 INTERACTION OF BACTERIAL CHROMOSOME WITH MEMBRANE IN DNA REPAIR

SYNTHESIS.

Bezlepkin V.G., Malinovsky Y.Y., Gaziev A.I.

B3-01 CHARACTERISATION OF DNA PHOTOPRODUCTS BY RADIOIMMUNOASSAY AND HIGH

PERFORMANCE LIQUID CHROMATOGRAPHY

Clarkson J.M., Mitchell D.L.

B3-05 THE TRANSFER OF PLASMID ENCODED GENES INTO CULTURES OF NORMAL AND

ATAXIATELANGIECTASIA HUMAN CELLS.

Cox R., Debenham P.G., Masson W.K., Webb M.B.T.

B3-06 INTERCELLULAR CO-OPERATION IN REPAIRING DNA STRAND BREAKS. STUDIES WITH

GLUTATHIONE DEFICIENT AND PROFICIENT HUMAN FIBROBLASTS.

Edgren M.

B3-07 THE ACUTE EFFECTS OF VERY LOW-LEVEL DOSES OF IONIZING RADIATION AND

COOPERATIVE CELLULAR PROCESSES

Evseev V.S.

B3-08 EARLY EFFECTS OF IRRADIATION ON GAMMA-AMINOBUTYRIC ACID RECEPTOR BINDING

IN MOUSE CEREBELLUM. PROTECTIVE ACTION OF CYSTEAMINE.

Fatone M., Roman V.

B3-09 LOSS OF HALF-EXCISION OF MITOMYCIN C CROSSLINKS IN CYCLING FANCONI ANEMIA

CELLS AND IN NON-CYCLING NORMAL AND XERODERMA CELLS.

Fujiwara Y., Kano Y.

B3-10 RADIATION EFFECT ON MEMBRANE AND ITS RELATION ON CELL SURVIVAL AND DNA OF

E.COLI.

Gholipour-Khalili K.

B3-11 RECOVERY OF DNA SYNTHETIC RATES FOLLOWING EXPOSURE OF NORMAL AND EXCISION

REPAIR DEFICIENT MAMMALIAN CELLS TO ULTRAVIOLET LIGHT.

Griffiths T.D.

B3-12 STRUCTURAL MODIFICATIONS OF PHOSPHATIDYLCHOLINE MULTILAYERS INDUCED BY

Co-60 GAMMA RAYS.

Guidoni L., lanzini F., Indovina P.L., Viti V., Erriu G., Ladu M.,Randaoolo P.

B3-13 BIOCHEMICAL EVIDENCE OF CHANGES IN THE SALT TRANSPORT SYSTEM OF THEEUROPEAN EEL AFTER IONIZING IRRADIATION.

Hansen H.J.M,

CONTENTS XI

B3-1H EFFECTS OF IRRADIATION AND INHIBITION OF POLY (ADP-RIBOSE) POLYMERASE ON

L5178Y-R AND L5178Y-S CELLS.Johanson K.J., Sundell-Bergman S., Wlodek D., Szumiel I.

B3-15 EFFECTS OF COBALT-60 IRRADIATION ON ERYTHROCYTE GHOSTS USING THE

FLUORESCENT PROPERTIES OF 1,6-DIPHENYL-1,3,5-HEXATRIENE (DPH).Joshi N., Swenberg C.E., MoCreery M.J.

B3-16 LEAKAGE OF INTRACELLULAR MATERIAL AFTER TREATMENT OF ESCHERICHIA COLI

WITH UV RADIATION OR MILD-HEAT: EVIDENCE FOR MEMBRANE DAMAGE.

Kelland L.R., Moss S.H., Davles D.J.G.

B3-17 ENHANCEMENT BY AMPHOTERICIN B OF X-RAY LETHAL DAMAGE IN MAMMALIAN CELLS

IN CULTURE.

Khokhar M.T., Gillies N.E.

B3-18 PRIMARY EFFECT OF RADIATION ON BIOLOGICAL SYSTEMS AND OBJECTS.

Kudryaahov Y.

B3-19 MONOCLONAL ANTIBODY TO DNA CONTAINING THYMINE GLYCOL

Leadon S.A., Hanawalt P.C.

B3-20 ALTERATIONS OF 4-MALEIMIDO-SPIN LABELED MOIETIES IN RAT SYNAPTOSOMAL

PLASMA MEMBRANE BY LOW DOSE 6OC0 IRRADIATION.

Lunsford A.E., MoCreery M.J., Swenberg C.E,

B3-21 THE REACTION OF BIOLOGICAL MEMBRANES ON THE ACTION OF RADIATION.

Mirakhmedov A., Muradillaev A., Djuraeva M.M., Khamidov D.KH.

B3-22 EFFECT OF COBALT-60 GAMMA RAYS, MPG AND WR-2721 ON ACID AND ALKALINE

PHOSPHATASE IN TISSUE HOMOGENATES.

Mishra V.S., Srivastava P.N.

B3-23 INTERRELATIONSHIP BETWEEN MEMBRANE LIPID PEROXIDATION, LYSOSOMAL ENZYME

RELEASE AND DOSE-RATE. A HYPOTHESIS FOR CHEMICAL RADIOPROTECTION BY

SULPHYDRYL DRUGS.

Mishra V.S., Srivastava P.N.

B3-24 RADIOSENSITIVITY OF LIPIDS IN MODEL SYSTEMS.

Mooibroek J., Konings A.W.T.

B3-25 PROCESSES OF LIPID PEROXIDATION IN MEMBRANES IRRADIATED WITH VARIOUS

DOSES.

Nakazawa T., Terayama K.t Okuaki H.

B3-26 POLY(ADP-RIBOSE) SYNTHETASE INHIBITOR, 3-AMINOBENZAMIDE, INHIBITS

EXCISION REPAIR IN D. DISCOIDEUM AND ENHANCES

GAMMA-GLUTAMYLTRANSPEPTIDASE POSITIVE FOCI IN RAT LIVER.

Ohnishi T., Takahashi S., Okaiohi K., Denda A., Konishi Y.

B3-27 EFFECT OF GAMMA-RADIATION ON AMINO ACIDS TRANSPORT IN YEAST.

Prasad H., Trivedi A., Khare S., Kesavan P.C.

B3-28 THE USE OF DNA-MEDIATED GENE TRANSFER TECHNIQUES TO STUDY THE HUMAN DNA

REPAIR SYSTEM,Rubin J.S., Joyner A.L., Bernstein A., Whitnore G.F.

XII CONTENTS

B3-29 THE INFLUENCE OF MEMBRANE-ACTIVE DRUGS ON THE RADIOSENSITIVITY OF EHRLICH

ASCITES TUMOR CELLS.

Sohorn H., Bertsche U., Nusse M.

B3-30 RADIATION-INDUCED STRUCTURAL CHANGES IN MEMBRANE PROTEINS OF HUMAN

ERYTHROCYTES AND GHOSTS AND THE RELATION TO CELLULAR MORPHOLOGY.

Schuurhuls G.J., Homines J., Vos J., Molenaar I., Konings A.W.T.

B3-31 RADIATION CHEMICAL AND BIOLOGICAL OBSERVATIONS ON THE ROLE OF GLUTATHIONEIN AFFECTING RADIOSENSITIVITY AND OXYGEN ENHANCEMENT RATIO.

Simone G., Tamba M., Capuano V., Quintiliani M.

B3-32 THE OXYGEN EFFECT OF TRANSCRIPTION INHIBITION IN YEAST CELLS.

Weber K.J., Kiefer J.

B3-33 MEMBRANE INVOLVEMENT IN CELLULAR RADIOSENSITIVITY

Wolters H., Konings A.W.T.

B3-34 THE INFLUENCE OF MEMBRANE-BINDING DRUGS AND MEMBRANE LIPID COMPOSITION ON

EXCISION REPAIR OF DNA IN UV-IRRADIATED ESCHERICHIA COLI.

Yonei S., Todo T., Tachibana A., Kato M.

B3-35 MECHANISM OF RADIATION DAMAGE IN LIVER MICROSOMAL MEMBRANES - LIPID

PEROXIDATION AND ENZYME INACTIVATION -

Yukawa 0., Nagatsuka S., Nakazawa T.

B3-36 DNA-TURNOVER AND ITS IMPORTANCE IN RADIATION BIOLOGY.

Zipfel P., Kasohe V.

B3-37 TEMPORAL VARIATIONS OF THE TRANSMEMBRANE RESTING POTENTIAL OF HUMAN CELLSAFTER HIGH- AND LOW LET-IRRADIATION.

Stelnhausler F., Reubel B., Huber M.

MUTAGENESIS AND CHROMOSOME CHANGES

B4-01 MEASUREMENT OF CHROMOSOME DAMAGE BY FLOWMICROFLUOROMETRY IN RELATION TO

OTHER RADIATION RESPONSES OF MAMMALIAN CELLS.

Aten J.A., Kooi M.W., Kipp J.B.A., Barendsen G.W.

B4-02 DNA SEQUENCE ANALYSIS OF REVERTANTS FROM UV-IRRADIATED SV40 TS MUTANTBC245 PROPAGATED IN MONKEY CELLS.

Braggaar H., Cornells J.J., Eb A.J. van der

B4-03 MICRONUCLEUS FORMATION AS A MEASURE OF SURVIVING FRACTION IN IRRADIATED

CELL POPULATIONS.Brook W.A., Williams M., Meistrlch M.L., Grdina D.J.

CONTENTS XIII

B»M)4 THE RETENTION, DISTRIBUTION, DOSE AND CYTOGENETIC EFFECTS OF INHALED239Pu02 OR 239Pu(N03)l| IN NONHUMAN PRIMATES.Brooks A.L., Rednan H.C., Hahn F.F., Mevhinney J.A., Smith J.M.,MoClellan R.O.

B4-05 INCREASED FREQUENCY OF X-RAY INDUCED CHROMOSOME ABNORMALITIES IN

STATIONARY CELLS TREATED WITH 9-BETA-D-ARABINOFURANOSYLADENINE: A

POSSIBLE CONSEQUENCE OF INHIBITED DNA DOUBLE STRAND BREAK REPAIR.Bryant P.E.

B4-06 INCREASE IN MOUSE BONE MARROW CELL SISTER CHROMATID EXCHANGE (SCEs)FOLLOWING CHRONIC TRITIATED WATER INGESTION OR DOSE EQUIVALENT EXTERNALGAHHA RAY EXPOSURES.

Carsten A.L., Benz R.D., Ikushima T.

B4-07 MUTAGENICITY AND DNA REPAIR IN ALPHA PARTICLE IRRADIATED HUMANFIBROBLASTS.Chen D.J., Raju M.R., Tokita N.T.

B4-08 RADIATION DAMAGE AND REPAIR IN MAMMALIAN CHROMOSOMES AND CHROMATIN

Cole A., Cooper W.G.

B4-09 X-RAY INDUCED BREAKS IN HUMAN INTERPHASE CHROMOSOMES BY LOW DOSES:DOSE-RESPONSE AND REJOINING CHARACTERISTICS.Cornforth M.N., Bedford J.S.

B4-10 MUTATIONS IN CONTINUOUS CULTURES OF CHINESE HAMSTER CELLS INDUCED BY LOW

DOSE HATE GAMMA IRRADIATION.

Crompton N.E.A., Kiefer J., Schneider E., Zolzer F.

B4-11 THE CLONING OF AN E. COLI GENE ASSOCIATED WITH A SPECIFIC SENSITIVITY TO

IONISING RADIATION.

Debenham P., Law J., Webb M.B.T.

B4-12 ON THE ROLE OF DNA LESIONS IN PRODUCTION OF CHROMOSOME ABERRATIONS.

Ganassl E.E., Zaichklna S.I., Aptikaeva G.F.

B4-13 CHROMOSOMAL ABERRATION INDUCTION BY CHARGED PARTICLES OVER A RANGE OF

L.E.T.'s: CELL CYCLE VARIATIONS.

Geard C,R.

B4-14 CHROMOSOMAL SHATTERING INDUCTION BY BLACK LIGHT IRRADIATION DURING LATE

G2/PR0PHASE IN CELLS WITH UNIFILARLY BROMOSUBSTITUTED GENOME.

Gonzalez-Fernandez A., Aller P., Palencia F., Torre C. de la

B4-15 MUTAGENESIS AND LETHALITY FOLLOWING S-PHASE IRRADIATION OF XERODERMA

PIGMENTOSUM AND NORMAL HUMAN FIBROBLASTS WITH ULTRAVIOLET LIGHT.

Grosovsky A.J., Little J.B.

B4-16 DOSE EFFECT RELATIONSHIPS FOR CHROMOSOME ABERRATIONS IN LYMPHOCYTES OF

CHINESE HAMSTERS AFTER LONG TERM EXPOSURE TO INCORPORATED ALPHA EMITTERS.

Heinze B., Grillmaier R., Muth H.

B4-17 ALPHA IRRADIATION INDUCES MAMMALIAN GERES.

Hieber L,, Malliok U., Luoke-Huhle C, Herrlich P.

XIV CONTENTS

B4-18 RADIATION-INDUCED MUTAGENICITY AND LETHALITY IN SALMONELLA TYPHIMURIUM

Isildar H., Bakale G.

B4-19 COMPARATIVE STUDIES BY ALKALINE/NEUTRAL ELUTION TECHNIQUE AND ELECTRONMICROSCOPY OF THE PRIMARY LESIONS IN THE IRRADIATED CHROMATIN NETWORK.Kananisbi N., Kinjo Y., Watanabe M., Tanaka N.

B4-20 KINETICS OF UV-INDUCED SV40-PRODUCTION FROM TRANSFORMED MAMMALIAN CELLS.Lubbe J. van der , Eb A. van der , Decaesteoker M., Cornells J.,Dinsart C, Rommelaere J.

B4-21 QUANTIFICATION OF THE FREQUENCY OF OCCURRENCE OF DICENTRIC CHROMOSOMES BYSLIT-SCAN FLOW CYTOMETRY.

Luoas J.N., Gray J.W.

B4-22 GENOME AMPLIFICATION IN CHINESE HAMSTER V79 CELLS AFTER EXPOSURE TO 3.4MeV ALPHA PARTICLES

Luoke-Huhle C.

B4-23 INDUCTION OF CELL KILLING, MICRONUCLEI AND MUTATION TO 6-THIOGUANINERESISTANCE AFTER EXPOSURE TO LOW DOSE-RATE GAMMA-RAYS AND TRITIATED

WATER, AND THEIR POTENTIATION BY DEUTERIUM OXir>E IN CULTURED MAMMALIANCELLS L5178Y.Matsudalra H., Ueno A.M., Furuno-Fukushi I.

B4-24 CHROMATIN REPAIR AND CHROMOSOMAL ABERRATION AND SISTER CHROMATID EXCHANGEFORMATION: INTERACTION OF RADIATION AND CHEMICAL DAMAGE IN HUMANLYMPHOCYTES.

Morimoto K., Miura K., Koizumi A.

B4-25 THE DNA REPAIR GENES, polA AND reoB, TO PROTECT ESCHERICHIA COLI AGAINSTOXYGEN TOXICITY.

Morimyo M.

B4-26 CHROMOSOME ABERRATIONS IN CHINESE HAMSTER CELL CULTURES INDUCED BY HEAVYION IRRADIATION.

Muller W., Mlltenburger H.G., Kraft G.

B4-27 INDUCTION OF INTRACHROMOSOMAL RECOMBINATION BY RADIATIONS IN THE YEASTSACCHAROMYCES CEREVISIAE.Nakai S., Maohida I.

B4-28 MUTATIONS INDUCED BY LOW DOSES OF GAMMA-RAYS WITH DIFFERENT DOSE-RATES INCULTURED MOUSE LYMPHOMA CELLS.

Nakamura N., Okada S.

B4-29 TRANSFECTION OF HUMAN GENOMIC WILD-TYPE DNA INTO XERODERMA PIGMENTOSUMGROUP A.

Poting A,, Luoke-Huhle C., Peon M., Herrlioh P., Rahmsdorf H.J.

B4-30 ABNORMAL ENHANCED REACTIVATION AND MUTAGENESIS OF UV-IRRADIATEDADENOVIRUS IN ATAXIA TELANGIECTASIA FIBROBLASTS.Rainbow A.J., Jeeves W.P., Bennett C.B., Howes M.

CONTENTS XV

B4-31 EFFECTS OF UV-IRRADIATION ON MUTAGENESIS AND GENETIC RECOMBINATION INMAMMALIAN CELLS USING SIMIAN VIRUS 40 AS A MOLECULAR PROBE.

Saraain A., Gentil A., Bourre F., Mezzina M., Armier J.

B4-32 3-AMINOBENZAMIDE IS A COMUTAGEN IN MAMMALIAN CELLS.Schwartz J.L., Morgan W.F,, Weiohselbaum R.R., Wolff S.

B4-33 X-RAY INDUCED CHROMOSOMAL ABERRATIONS IN SOMATIC CELLS OF THE EXCISIONREPAIR DEFICIENT MUTANT mei-9 OF DROSOPHILA.

Sohweizer P.

B4-34 CELL KILLING, CHROMOSOME DAMAGE AND CELL CYCLE PROGRESSION IN NORMAL ANDATAXIA-TELANGIECTASIA CELLS TREATED WITH X-RAYS OR BLEOMYCIN.Scott D., Zampetti-Bosseler F.

B4-35 TO WHAT EXTENT DO DIFFERENTIAL GROWTH RATES OF X-RAY INDUCED MUTANTS

INTERFERE WITH THE ESTIMATION OF MUTANT FREQUENCIES IN CULTURED MAMMALIANCELLS?

Simons J.W., Knaap A.G.A.C.

B4-36 METABOLIC RADIATION BIOLOGY: A PROBABLE MECHANISM FOR SPONTANEOUSMUTAGENESIS AND CARCINOGENESIS.

Smith K.C, Sargentini N.J.

B4-37 ENHANCED REACTIVATION AND MUTAGENESIS OF HERPES VIRUS IN 5-AZACYT-TREATEDCV-1 MONKEY CELLS.

Takimoto K.

B4-38 A MICRONUCLEUS TECHNIQUE FOR DETECTING SPECIES DIFFERENCES IN CHROMOSOMAL

RADIOSENSITIVITY OF PRESPERMATID STAGES OF MAMMALS.

Tates A.D., Bos A., Neuteboom I., Vogel N. de

B4-39 USE OF A CLONED GENE TO STUDY MUTATION IN MAMMALIAN CELLS.

Thaoker J., Debenham P., Stretch A., Webb M./

B4-40 THE SPECTRUM OF CHANGES IN DNA BASE SEQUENCE INDUCED BY GAMMA RAY

MUTAGENESIS OF LAMBDA PHAGE.Tindall K.R., Hutchinson F.

B4-41 UV-INDUCED WIDE-RANGE MUTATIONS IN A CYANOBACTERIUM.

Vaishampayan A.

B4-42 COMPARISON OF OBSERVED PINK MUTATIONS IN TRADESCANTIA DUE TO CALIFORNIUM

NEUTRONS WITH CALCULATED VALUES USING HIT-SIZE WEIGHTING THEORY.

Varma M.N., Bond V.P., Marshall I.R., Robinaon C.V., Sohairer L.A.

B4-43 MUTAGEN-INDUCED CHROMOSOMAL ABERRATIONS AND SISTER-CHROMATID EXCHANGE IN

FRIEDREICH'S ATAXIA LYMPHOCYTES.

Vijayalaxmi , Evans H.J.

B4-44 FLOW CYTOMETRIC DETERMINATION OF RADIATION INDUCED CHROMOSOME DAMAGE AND

ITS CORRELATION WITH CELL SURVIVAL.

Welleweerd J., Wilder M.E., Carpenter S.G., Raju M.R.

B4-45 CLONING OF DNA REPAIR GENES OF THE YEAST SACCHAROMYCES CEREVISIAE

Yasui A., Fukui A., Chevallier M.R.

XVI CONTENTS

LETHAL, SUBLETHAL AND POTENTIALLY LETHAL DAMAGE IN CELLS

B5-01 EFFECTS OF MULTIFRACTIONATED X-RAY DOSES ON HUMAN CANCER NODULES IN LONG

TERM ORGAN CULTURE.

Baroche C, Beaupain R.

B5-02 CHANGES IN RADIOSENSITIVITY AND MUTATION FREQUENCY DURING PROTRACTED

LOW-DOSE-RATE (0.003-0.03 GY/HR) X IRRADIATION OF L5178Y-R AND L5178Y-SCELLS.

Beer J.Z., Mencl J., Horng M.F., Gregg E.C, Evans H.H.

B5-03 MAMMALIAN CELL STUDIES USING COMBINED RADIATIONS OF DIFFERENT QUALITY.

Bird R.P., Zaider M., Ro3si H.H., Hall E.J., Marino S.A., Rohrig N.

B5-04 PITFALLS IN THYROID CELL SURVIVAL ASSAY IN VIVO: REPRODUCTIVE DEATH,METABOLIC SURVIVAL AND DATA INTERPRETATION.

Clifton K.H., Could M.N., Muloahy R.T.

B5-05 THE RADIOSENSITIVITY OF CYTOCHALASIN-INDUCED MULTINUCLEATE.

Court J.B., Peplinska A., Moore J.L.

B5-06 VARIATION WITH RADIATION QUALITY OF THE PROBABILITY OF LETHAL AND

POTENTIALLY LETHAL LESION PRODUCTION IN THE LPL MODEL.

Curtis S.B.

B5-07 RECOVERY FROM RADIATION DAMAGE OF CULTURED CELLS AFTER IRRADIATION OF

PHOTON, PROTON AND NITROGEN-ION.

Eguchi K., Inada T., Ohno T., Satoh S., Kaneko I.

B5-08 LOW DOSE RATE IRRADIATION: ITS EFFECTS ON THE SURVIVAL AND MUTATION OF

RADIATION SENSITIVE AND RESISTANT MOUSE LYMPHOMA CELLS.

Evans H.H., Horng M.F., Menol J., Gregg E.C, Evans T., Beer J.Z.

B5-09 SCALING OF HUMAN CELL LINE RADIOSENSITIVITY BY THE MEAN INACTIVATION

DOSE.

Fertll B., Malaise E.P.

B5-10 RELEVANCE OF DSB REPAIR FOR SPLIT DOSE RECOVERY IN EUKARYOTIC CELLS.

Frankenberg D., Frankenberg-Sohwager M., Harbich R.

B5-11 REPAIR OF SUBLETHAL RADIATION DAMAGE: A COMPARISON BETWEEN DIPLOID HUMANFIBROBLASTS AND RODENT CELL LINES.Freeman M.L., Sierra E., Hall E.J.

B5-12 EFFECT OF IN VIVO IRRADIATION UPON COLONY SIZE DISTRIBUTION OF RAT

FIBROBLASTS IN PRIMARY CULTURE: A DOSE-EFFECT RELATIONSHIP.

Fritseh P., Beauvallet M., Lombard N., Masse R.

B5-13 ANALYSIS OF THE DECREASED RADIOSENSITIVITY OF A STATIONARY PHASE CELLPOPULATION AFTER PROTRACTED IRRADIATION.

Gilet R., Santier S.

CONTENTS XVII

B5-14 4-NITROQUINOLINE OXIDE-INDUCED CELL KILLING AND MUTAGENESIS INSYNCHRONOUS CHINESE HAMSTER OVARY CELLS.

Goth-Goldstein R.

B5-15 RECOVERY FROM POTENTIALLY LETHAL ULTRAVIOLET DAMAGE IN NORMAL AND

XERODERMA PIGMENTOSUM CELLS: EFFECT OF CAFFEINE ON THE RECOVERY.

Ikenaga M., Nagata H., Ohtani H.

B5-16 REPAIR AND FIXATION OF POTENTIALLY LETHAL DAMAGE AS FACTORS RESPONSIBLEFOR THE VARIATIONS IN THE SURVIVAL OF CELLS IRRADIATED IN VARIOUS PHASESOF THE CELL CYCLE.

Iliakis G., Nusse M.

B5-17 SURVIVAL OF TUMOUR CELLS IN MIXED BEAM IRRADIATION; PION BEAMS.

Juling L.

B5-18 INHIBITION BY NOVOBIOCIN OF REPAIR OF POTENTIALLY LETHAL DAMAGE OFGAMMA-IRRADIATED MAMMALIAN FIBROBLASTS.

Kaneko I., Ohno T., Okada G., Ichikawa Y.

B5-19 REPAIR OF SUBLETHAL AND POTENTIALLY LETHAL RADIATION DAMAGE IN A HIGHLY

RADIORESISTANT CELL LINE.

Koval T.M.

B5-20 DOSE RATE EFFECT DUE TO SUBLETHAL DAMAGE REPAIR AT DOSE RATES OF 1.0 TO

10.0 GY/MIN.

Ling C.C., Spiro I.J., Stickler R.

B5-21 THE STUDY OF RADIOSENSITIVITY OF MOUSE L7712 LEUKEMIC CELLS BY DIFFUSION

CHAMBER.

Luo Z., Lin W., Ma C.

B5-22 HUMAN THYROID CELL RESPONSE TO SINGLE AND FRACTIONATED DOSES OF X-RAYS.

Miller R.C., Hiraoka T., Gould M.N., Clifton K.H.

B5-23 RESISTANCE OF FISH CELLS TO IONIZING RADIATION IN VITRO.

Mitani H., Egami N.

B5-24 CONTINUOUS LOW DOSE RATE IRRADIATION OF B14 CELLS, A MODEL FOR

INTERSTITIAL THERAPY.Muller R.G.

B5-25 THE EFFECTS OF 3'-DE0XYGUAN0SINE ON RECOVERY FROM X-RAY INDUCED

POTENTIALLY LETHAL DAMAGE (PLD), HEAT-INDUCED CELL KILLING, AND THE

ACTIVITIES OF DNA POLYMERASE ALPHA AND BETA IN PLATEAU PHASE CULTURES OF

CHO CELLS IN VITRO.

Nakatsugawa S., Hivechl N.F., Dewey W.C.

B5-26 CORRELATION BETWEEN CELL SURVIVAL, SUBLETHAL DAMAGE REPAIR, AND AGE

DISTRIBUTIONS IN PLATEAU-PHASE MAMMALIAN CELLS.

Nelson J.H., Braby L.A., Roesch W.C, Betting N.F.

B5-27 PIEVENTIOti OT IKCTPH13I DEATH IM DAT THYMOCYTES BY CA-DEFLETION FROM

POST-IRRADIATION IMCDBATIOB MEDIUM.Ohyaaa H,, Hori I., Yaaada T.

XVIII CONTENTS

B5-28 REPAIR OF SUBLETHAL AND POTENTIALLY LETHAL DAMAGE IN MAMMALIAN CELLS

IRRADIATED WITH FAST NEUTRONS OR GAMMA RAYS.

Osmak M., Petrovio D., Ferle-Vidovic A., Kadija K., Rendic D.

B5-29 REPRODUCTION OF THE SHOULDER IN SPLIT DOSE EXPERIMENTS BY REPAIR OF

POTENTIALLY LETHAL LESIONS.

Pohllt W.

B5-30 GROWTH DELAY OF MICRASTERIAS DENTICULATA CAUSED BY GAMMA-, PROTON- AND

NEUTRON-IRRADIATION,

Reubel B.( Steinhausler F., Pohl E.

B5-31 R.B.E. OF PROTRACTED NEUTRON IRRADIATION ON THE BEGINNING OF SURVIVAL

CURVES (LOW DOSES) FOR AUTOTROPHIC EUCARYOTIC CELLS.

Roux J.-C.

B5-32 RADIATION-INDUCED REMAINING DNA DAMAGES AND SLD RECOVERY IN CULTURED

MAMMALIAN CELLS.Sakai K., Okada S.

B5-33 LETHAL, MUTAGENIC AND DNA RADIATION DAMAGE IN CULTURED MAMMALIAN CELLS;INFLUENCE OF OXYGEN AND DMSO.

Sapora 0., Belli M,, Tabooohini A., Quintillani M.

B5-34 TIME-LAPSE PHOTOGRAPHIC STUDIES ON PROLIFERATION KINETICS OF HELA CELLS

IRRADIATED WITH ALPHA-PARTICLES AS COMPARED TO X-RAYS.

Sasaki H.

B5-35 INVOLVEMENT OF CHROMATIN STRUCTURE IN DOSE-RATE EFFECT ON CELL KILLING INCULTURED MAMMALIAN CELLS L5178Y.

Ueno A.M., Watanabe I., Matsudaira H.

B5-36 POTENTIALLY LETHAL DAMAGE AND ITS REPAIR IN EXPONENTIALLY GROWING NORMALAND ATAXIA TELANGIECTASIA HUMAN FIBROBLASTS.

Utsumi H., Sasaki S.

B5-37 THE EFFECT OF IRRADIATION ON CULTURED ENDOTHELIAL-CELL MONOLAYERS.

Vegt G.B., Di Bon-de Ruijter M., Boon A.

B5-38 INVESTIGATION OF IRRADIATION INDUCED INTERPHASE DEATH USING PERCOLL

FRACTIONATED THYMOCYTES.

Viokers E,J,, Sturrook M.G., Chapman I.V.

B5-39 EFFECT OF RAPID CHILLING ON THE RADIOSENSITIVITY OF ESCHERICHIA COLI B/r.

Watanabe H., Takehisa M.

B5-40 RADIOSENSITIVITY, REPAIR OF POTENTIALLY LETHAL DAMAGE, AND CELL KINETICSOF TISSUE CULTURED HUMAN MELANOMA (HMV-1) CELLS IN CONFLUENT STATE.

Watanabe I., Nojiri I.

B5-41 A POST IRRADIATION REPAIR PROCESS MAY EXPLAIN THE DIFFERENTIAL RESPONSEOF HUMAN TUMORS TO FRACTIONATED RADIATION.

Weichselbaum R.R., Little J.B.

B5-42 DOSE FRACTIONATION EFFECTS U) NON-CYCLING C3H10T1/2 CELLS.Zeman E.H,, Bedford J.S.

CONTENTS XIX

SENSITISATION AND PROTECTION

B6-01 A MECHANISM FOR OXYGEN ENHANCEMENT OF GAMMA RADIATION INDUCED LETHALITY

IN A REPAIR DEFICIENT STRAIN OF ESCHERICHIA COLI.

Ahmed A.H., Moss S.H., Davies D.J.G.

B6-02 THE POSSIBLE RADIOPROTECTIVE ROLE OF CAROTENOIDS IN SARCINA FLAVA.

Al-Wandawi H.K., Al-Shaikly K.A., Abdul-Rahman M.H.

B6-03 THE EFFECT OF UNCOUPLERS OF OXIDATIVE PHOSPHORYLATION ON THE

RADIOSENSITIZATION OF HYPOXIC AND AEROBIC E. COLI CELLS.

Anderson R.F., Patel K.B.

B6-04 MODIFICATION OF RADIOSENSITIVITY AND CHEMOSENSITIVITY OF CHO CELLS BYDIBUTYRYL CYCLIC AMP.

Aoyama T., Yamada T., Shinohara S., Otsu Y.

B6-05 IN VITRO STUDIES WITH TWO HUMAN CELL LINES DEFICIENT IN GLUTATHIONE.

Astor M.B., Hall E.J., Biaglow J.E., Hartog B. .

B6-06 RESPONSE OF MICROCOCCUS RADIODURANS RII5 TO COMBINATION OF GAMMA

RADIATION AND CHEMICAL SENSITIZERS.

Auda H., Saed F.A,

B6-07 INHIBITION OF X-RAY INDUCED POTENTIALLY LETHAL DAMAGE (PLD) REPAIR INAEROBIC PLATEAU-PHASE CHINESE HAMSTER (HA-1) CELLS BY MISONIDAZOLE

Brown D.M., Dionet C, Brown J.M.

B6-08 SPIN-LABELED PLATINUM COMPLEXES AS RADIOSENSITIZERS.

Clayoamp H.G., Mathew A., Morgan R., Shaw E.I., Zimbrlck J.D.

B6-09 TESTING OF NEWLY SYNTHETIZED CHEMICAL RADIOPROTECTORS IN CULTURED CELLS

AFTER LOW- AND HIGH-LET IRRADIATIONS.

Ferle-Vidovio A., Petrovic D., Osmak M., Iskric S., Kveder S.,Trescec A,, Dentes J., Skare D.

B6-10 THE ROLE OF INTRACELLULAR SULPHYDRYLS IN THE DEPENDENCE OF OER ON LET;A

STUDY WITH GLUTATHIONE-DEFICIENT BACTERIAL MUTANTS, COMPARINGGAMMA-RAY AND NEUTRON IRRADIATION.

Harrop H.A., Davies S., Maughan R.L., Roper M.J., Michael B.D.

B6-11 INTERACTIONS OF OXYGEN AND. SULFHYDRYL-CONTAINING RADIOPROTECTORS IN

DETERMINING RADIATION-INDUCED HAMMALIAN CELL KILLING AND DNA DAMAGE.

Held K.

B6-12 INTERACTION OF RAZOXANE (ICRF 187) AND RADIATION ON THE SURVIVAL OF

CULTURED 9L RAT BRAIN TUMOR CELLS.

Henderson S.D., Kimler B.F.

B6-13 EFFECTS OF 2-DEOXY-D-GLUCOSE ON THE X-RAY INDUCED MICRONUCLEI FORMATION

IN NORMAL AND MALIGNANT HUMAN CELLS.

Kalia V.K., Jain V.K.

XX CONTENTS

B6-14 ANOMALOUS RADIOSENSITIZATION BY NSC 38087, A 5-SUBSTITUTED

4-NITROIMIDAZOLE - A RAPID-MIX STUDY.

Kandaiya S., Adams G.E.

B6-15 PHYSICOCHEMICAL VIS-A-VIS BIOCHEMICAL INTERPRETATIONS OF OXIC PROTECTION

AND ANOXIC SENSITIZATION BY CHEMICALS.

Kesavan P.C

B6-16 OXYGEN DEPENDENCE OF MUTANT INDUCTION AND LOSS OF COLONY FORMING ABILITY

AFTER X-RAY EXPOSURE IN RADIATION SENSITIVE STRAINS OF HAPLOID YEAST.

Kiefer J., Sellmer M.

B6-17 MECHANISMS OF THE INTERACTION BETWEEN AMINO-SUBSTITUTED ANTHRAQUINONES

AND IONIZING RADIATION FOR THE INDUCTION OF MAMMALIAN CELL LETHALITY.

Kimler B.F.

B6-18 NICOTINAMIDE PROTECTS HUMAN LYMPHOCYTES FROM RADIATION INHIBITION OF

MITOGENIC STIMULATION.

Koi R., Ben-Hur E.

B6-19 CELLULAR GLUTATHIONE AND OXYGEN EFFECT.

Konstantinova M., Minin A.A., Dontzova G.V.

B6-20 A COMPARATIVE STUDY OF THE CYTOTOXIC AND RADIOSENSITIZING EFFECT OF

PHENOTHIAZINES TOWARDS AERATED AND HYPOXIC MAMMALIAN CELLS.

Lehnert S.

B6-21 EFFECTS OF NITROAROMATIC RADIOSENSITIZERS ON RADIOLYTIC OXYGEN DEPLETION

IN MAMMALIAN CELLS AND IN AQUEOUS SOLUTION.

Michaels H.B.

B6-22 DEXAMETHASONE INHIBITS SHOULDER MODIFICATION BY UNCHARGED NITROXYL

BIRADICALS IN MAMMALIAN CELLS IN VITRO.

Millar B.C., Jenkins T.C, Fielden E.M., Jinks S.

B6-23 THE EFFECT OF MISONIDAZOLE AS A HYPOXIC RADIOSENSITIZER AT LOW DOSES.

Palcio B., Faddegon B., Skarsgard L.D.

B6-24 THE RADIOCHEMICAL AND ELECTROCHEMICAL REDUCTION OF NITROIMIDAZOLES;

CORRELATIONS WITH BIOLOGICAL EFFECTS.

Rauth A.M., Battlstella R., McClelland R.A.

B6-25 CELL SURVIVAL AND DNA REPAIR CAPACITY AFFECTED BY THE RADIOPROTECTIVE

COMPOUND WR-2721.Riklis E., Green M., Prager A.

B6-26 CHEMOSENSITIZATION IN VITRO.

Roizin-Towle L., Hall E.J., Meltzer H.L., Hartog B.

B6-27 NATURAL OXIDE-REDUCTION COMPOUNDS AS RADIOPHOTECTANTS IN RABBIT

ERYTHROCYTES.

Rojo M.I., Fernandez M., Tomicic I., Toha J.

B6-28 THE EFFECT OF BUTHIONINE SULFOXIMINE ON RADIOSENSITIVITY OF EHRLICH

ASCITES TUMOR CELLS AND HELA CELLS IN VITRO.

Schorn H., Bertsche U., Vos 0.

CONTENTS XXI

B6-29 PLATINUM COMPLEXES OF HITROIMIDAZOLES AS RADIOSENSITIZERS.Skov K.A.,Parrel! N.P.,Gomes da Caneiro T.,Jones T..Einstein F.W.B.

B6-30 RAPID-MIX AND STEADY-STATE STUDIES ON THE SENSITIZATION OF V79 CELLS BY

NITROIMIDAZOLES: EFFECTS OF LIPOPHILICITY AND ENVIRONMENT ON

INTRACELLULAR CONCENTRATIONS, PROTEIN BINDING AND SULPHYDRYL LEVELS.Watts M.E., Dennis M.F., Hodgkiss R.J., Jones N.R., Woodcock H.

B6-31 GLYOXAL AS A MISONIDAZOLE-MIMMETIC AGENT.Whitaore G.F., Varghese A.J., Gulyas S.

REPAIR IN CELLS, CELL CONTACT

B7-01 MULTICELL SPHEROIDS: ENVIRONMENTAL MODULATIONS OF TUMOR CELL

PROLIFERATION AND RADIATION SENSITIVITY.

Bauer K.D., Keng P.C, Luk C.K., Sutherland R.M.

B7-02 ENHANCED X-RAY KILLING OF CHINESE HAMSTER CELLS BY INHIBITORS OF POLY

(ADP-RIBOSE) SYNTHESIS.Ben-Hur E., Utsuni H,, Elkind M.M.

B7-03 THIOL DEPLETION AND RADIATION RESPONSE OF A549 LUNG CELLS: ON THE LACK OFAN EFFECT OF GLUTATHIONE REMOVAL ON THE OXYGEN ENHANCEMENT RATIO.

Biaglow J.E., Clark E., Epp E., Varnes M.E., Mitchell J.

B7-04 AGE RESPONSE AND CELL PROGRESSION OF HUMAN CELLS IN CULTURE EXPOSED TO

HEAVY ION BEAMS.

Blakely E.A., Ngo F.Q.H., Tobias C.A.

B7-05 CELL RADIOSENSITIZATION INDUCED BY THE THIOL DEPLETING AGENT, BUTHIONINESULFOXIMINE.Clark E.P., Epp E.R., Biaglow J.E.

B7-06 RADIO-INDUCED LENGTHENING OF THE MITOTIC DURATION, DIFFERENTIAL EFFECT ONTHE PHASES OF THE MITOSIS.

Collyn-d'Hooghe M., Malaise E.P.

B7-07 RAPID AGE RESPONSE TO RADIATION BY FLOW SORTING WITHOUT CELLSYNCHRONIZATION.

Freyer J.P., Wilder M.E., Raju M.R.

B7-08 RADIATION DAMAGE TO HUMAN THYROID CELLS AND FOLLICLES.Hiraoka T., Miller R.C., Clifton K.H., Itoh T., Omotehara T., Ezaki H.

B7-09 REPRODUCTIVE CELL KILLING AND MITOTIC DELAY IN G1, S AND G2-M STAGES OFTHE CYCLE OF CHO-FIBROBLASTS.

Hoppe J., Hagemann G.K.

XXII CONTENTS

B7-10 INHIBITION OF REPAIR OF PREMDTATIONAL DAMAGE IN PLATEAU PHASE CHINESE

HAMSTER CELLS EXPOSED TO GAMMA RADIATION.

Hopwood L.E., Rao B.S.

B7-11 EFFECTS OF POST TREATMENT WITH 3'-DEOXYURIDINE ON THE SENSITIVITY TO

ULTRAVIOLET LIGHT IRRADIATION ON CHINESE HAMSTER HA-1 CELLS IN VITRO.

Kumar A., Nakatsugawa S., Sugahara T.

B7-12 FIBROBLAST OUTGROWTH FROM RAT CUTANEOUS EXPLANTS. EFFECT OF IN VIVO

IRRADIATION.

Lombard N., Beauvallet M,, Fritsch P., Masse R.

B7-13 CLONAL GROWTH OF PIG FIBROBLAST IN PRIMARY CULTURE. EFFECT OF IN VITRO

IRRADIATION.

Martin M., Remy J., Fritsch P.

B7-14 EFFECT OF MEDIUM PH ON THE RESPONSE OF KBE CELLS IN MULTICELLULAR

SPHEROIDS TO X-IRRADIATION.

Meltz M.L., Ng C, Pomeroy T.C.

B7-15 EXTRACELLULAR PH AND THE CELL CYCLE; POSSIBLE LINKS TO HADIORESISTANCE.Mendonca M., Alpen E.L.

B7-16 COMPARATIVE RADIATION SENSITIVITY OF THYROID EPITHELIAL CELLS IRRADIATED

IN VIVO, OR IN VITRO AS MONOLAYERS OR AS THREE DIMENSIONAL FOLLICLES.Mulcahy R.T.

B7-17 MODIFICATION OF GROWTH RATE AND RADIATION RESPONSE OF CULTURED HUMAN

GLIOMA CELLS BY TREATMENT WITH GLUCOCORTICOSTEROIDS OR INTERFERON.

Nederman T., Carlsson J., Kuoppa K., Benediktsson G.

B7-18 CELL CYCLE DELAY IN UV-IRRADIATED ATAXIA TELANGIECTASIA FIBROBLASTS.Oleinick N.L., Evans H.H., Friedman L.R., Sokany N.M.

B7-19 MITOTIC DELAY AND REPAIR IN HUMAN LYMPHOCYTES.Olivieri G.

B7-20 2-DE0XY-D-GLUC0SE (2-DG) AS A POSSIBLE ADJUVANT TO RADIOTHERAPY OFTUMOURS: I. POST-IRRADIATION GROWTH INHIBITION OF EHRLICH ASCITES TUMOUR

CELLS (EATC) IN VITRO AND IN VIVO BY 2-DG AND ITS MODE OF ACTION.

Purohlt S.C, Pohlit W.

B7-21 2-DE0XY-D-GLUC0SE (2-DG) AS A POSSIBLE ADJUVANT TO RADIOTHERAPY OF

TUMOURS: II. THE COMBINED EFFECTS OF X-RAYS AND 2-DG ON THE PROLIFERATION

KINETICS, CELL CYCLE KINETICS AND DIVISION DELAY OF CULTURED EHRLICHASCITES TUMOUR CELLS.

Purohlt S.C, Nusse M., Pohlit W., Jain V.K.

B7-22 REPAIR AND FIXATION OF RADIATION DAMAGE IN V79 CELLS, INFLUENCES OF DMSOBrdUrd AND ANISOTONIC NaCl SOLUTIONS.

Raaphorst G.P., Azzam E.I.

B7-23 RADIOSENSITIZATION BY CONTROL OF THE INHERENT RADIOPROTECTION OF CELLS.

Revesz L., Edgren M., Midander J.

CONTENTS XXIII

B7-24 EFFECT OF POLY(ADENOSINE-RIBOSE) SYNTHETASE INHIBITORS AND CAFFEINE ONRADIATION-INDUCED G2-ARREST.

Rowley R.

B7-25 THE OXYGEN EFFECT IN YEAST CELLS EXPOSED TO HIGH LET PARTICLE RADIATION.Schneider E., Schopfer F., Kiefer J.

B7-26 EFFECTS OF PROLONGED HYPOXIA AND RE-AERATION ON THE GROWTH AND RADIATIONSENSITIVITY OF MAMMALIAN CELLS IN CULTURE.

Shrieve D.C, Harris J.W.

B7-27 SENSITIVITY OF LUNG CELLS TO ALPHA PARTICLE IRRADIATION.

Simmons J.A., Conn P., Min T.

B7-28 THE DEPENDENCE OF DOSE RATE ON OXYGEN RADIOSENSITIZATION.

Splro I.J., Ling CC, Stickler R.

B7-29 METABOLIC AND INTERCELLULAR CONTACT MEDIATED REGULATION OF CELLULAR AND

MICHOENVIRONMENTAL HETEROGENEITY IN MULTICELL TUMOR SPHEROIDS.

Sutherland R.M., Bauer K.D., Freyer J.P., Keng P.C.,Mueller-Klieser V., Wigle J.C.

B7-30 G-2-PHASE ARREST AND DNA CONTENT IN GENERATION 1 OF GAMMA-IRRADIATEDCULTURED HUMAN CELLS.

Wood J.C.S, Todd P.

B7-31 ANTIMUTAGENIC EFFECT OF INTERFERON IN HUMAN CELLS - ONE OF PLEIOTROPIC

PROPERTIES OF INTERFERON.

Zasukhlna G.D., Makedonov G.P., Shvetsova T.P., Sinelshohikova T.A.