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RNpedia.com“Nursing Notes and Community”
Drug Name Dosages Therapeutic Actions
Indications Adverse effects Contraindications
Nursing considerations
bumetanide (byoo met' a nide) Bumex, Burinex (CAN)
Pregnancy Category C
Drug class Loop (high-
ceiling) diuretic
Oral edemao Adult: 1 mg
once daily. Give 2nd dose 6-8 hr later if necessary.
o Elderly: 0.5 mg daily.
Refractory edema
o Adult: Initially, 5 mg daily increased by 5 mg every 12-24 hr as required. High doses may be divided in 2-3 doses. Max: 10 mg/day.
hypertension
o Adult: 0.5-1 mg daily. Max: 5 mg/day.
Intravenous pulmonary
edema Adult: 1-2 mg IV
repeated 20 min later if necessary, or 2-5 mg in 500 ml of a suitable infusion fluid
Bumetanide induces diuresis by inhibiting reabsorption of water and electrolytes (sodium and chloride) in the ascending loop of Henle and proximal renal tubule.
Absorption: Almost completely and rapidly absorbed from the GIT.Distribution: 95% bound to plasma proteins.Excretion: Elimination half-life: about 1-2 hr. About 80% excreted in the urine; 50% as unchanged drug.
Edema associated with CHF, cirrhosis, renal disease
IV: Acute pulmonary edema
Unlabeled use: Treatment of adult nocturia (not effective in men with BPH)
Muscle cramps, dizziness, hypotension, headache, nausea, impaired hearing, pruritus, ECG changes, musculoskeletal pain, rash, chest discomfort, renal failure, premature ejaculation, thrombocytopenia, hypokalaemia, hypomagnesaemia, hyponatraemia, hyperuricaemia, hyperglycaemia, hypocalcaemia.
Potentially Fatal: Encephalopathy (in patients with preexisting liver disease).
Hypersensitivity, progressive renal failure and anuria, hepatic coma, severe electrolyte depletion.
Assessment History: Allergy to bumetanide,
electrolyte depletion, anuria, severe renal failure, hepatic coma, SLE, gout, diabetes mellitus, lactation
Physical: Skin color, lesions; edema; orientation, reflexes, hearing; pulses, baseline ECG, BP, orthostatic BP, perfusion; R, pattern, adventitious sounds; liver evaluation, bowel sounds; urinary output patterns; CBC, serum electrolytes (including calcium), blood glucose, LFTs, renal function tests, uric acid, urinalysis
Interventions Give with food or milk to
prevent GI upset. Mark calendars or use
reminders if intermittent therapy is best for treating edema.
Give single dose early in day so increased urination will not disturb sleep.
Avoid IV use if oral use is possible.
BLACK BOX WARNING: Arrange to monitor serum electrolytes, hydration, liver function during long-term therapy, water and electrolyte depletion can occur.
RNpedia.com“Nursing Notes and Community”
given over 30-60 min.
Parenteral Emergency cases
of edema Adult: 0.5-1 mg
via slow IV/IM inj, subsequently adjust dose according to response.
Provide diet rich in potassium or supplemental potassium.
Teaching points Record alternate day or
intermittent therapy on a calendar or dated envelopes.
Take the drug early in day so increased urination will not disturb sleep; take with food or meals to prevent GI upset.
Weigh yourself on a regular basis, at the same time and in the same clothing; record the weight on your calendar.
You may experience these side effects: Increased volume and frequency of urination; dizziness, feeling faint on arising, drowsiness (avoid rapid position changes; hazardous activities, such as driving; and alcohol consumption); sensitivity to sunlight (use sunglasses, sunscreen, wear protective clothing); increased thirst (suck sugarless lozenges; use frequent mouth care); loss of body potassium (a potassium-rich diet, or supplement will be needed).
Report weight change of more than 3 pounds in 1 day; swelling in ankles or fingers; unusual bleeding or bruising; nausea, dizziness, trembling, numbness, fatigue; muscle weakness or cramps.
RNpedia.com“Nursing Notes and Community”
http://RNpedia.com- “Nursing Notes and Community”