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NONI A “BOON TO MANKIND” By Sachidananda S N B Sc (Ag), PGDMM. Director: Surabhi Organics & SSC Vanilla Vice President: APART(NGO) Mobil: 94481 57054 Phone: 08262 232454

By Sachidananda S N · On the cancer-suppressing capability of damnacanthal in colorectal tumorigenesis. Damnacanthal exhibits cell growth arrest as well as caspase activity induction

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Page 1: By Sachidananda S N · On the cancer-suppressing capability of damnacanthal in colorectal tumorigenesis. Damnacanthal exhibits cell growth arrest as well as caspase activity induction

NONI A “BOON TO MANKIND”By

Sachidananda S NB Sc (Ag), PGDMM.

Director: Surabhi Organics &

SSC Vanilla

Vice President: APART(NGO)

Mobil: 94481 57054

Phone: 08262 232454

Page 2: By Sachidananda S N · On the cancer-suppressing capability of damnacanthal in colorectal tumorigenesis. Damnacanthal exhibits cell growth arrest as well as caspase activity induction

What is Noni?

• It is Nature’s Gift to

Humanity

• A Herbal Dietary

Supplement

to keep you always Healthy,

Energetic& Strong.

Noni is a plant

Page 3: By Sachidananda S N · On the cancer-suppressing capability of damnacanthal in colorectal tumorigenesis. Damnacanthal exhibits cell growth arrest as well as caspase activity induction

Noni is a Medicinal Plant

• Morinda Citrifolia (Noni) is known in Sanskrit as Ayushka,

• Valued by traditional Ayurveda for its health benefits.

• Studied by researchers throughout the world by more than 40

universities in many countries world over.

• Used by millions of people with life changing results. Most exciting

and promising Dietary Supplement for today’s Indian Family !

• More than 16,40,000 web links are available on the Internet for

NONI.

Page 4: By Sachidananda S N · On the cancer-suppressing capability of damnacanthal in colorectal tumorigenesis. Damnacanthal exhibits cell growth arrest as well as caspase activity induction

Botany - Classification

Domain: Eukarya

Kingdom: Planteae

Phylum: Magnoliophyta

Class: Magnoliopsida (dicot)

Order: Rubiales

Family: Rubiaceae (Coffee)

Genus: Morinda

Species: Morinda citrifolia

Page 5: By Sachidananda S N · On the cancer-suppressing capability of damnacanthal in colorectal tumorigenesis. Damnacanthal exhibits cell growth arrest as well as caspase activity induction

Leaves• Juice of leaves can internally help gout,

gingivitis and sties

• Tea used to treat fever

• Chewing leaves may smooth sore throat

• Leaf extracts were used to prevent clots

• Powdered leaves administered to skin for

burns, boils and wounds

• Heated leaves used to treat joints

• Fresh crushed leaves are rubbed on chest

to relieve chest pain and cold

Parts of Noni plant used in treatment diseases

Page 6: By Sachidananda S N · On the cancer-suppressing capability of damnacanthal in colorectal tumorigenesis. Damnacanthal exhibits cell growth arrest as well as caspase activity induction

Root used to relieve pain, reduce fever and congestion internally Topically is used to treat joint swelling and gout

Fruit Fruit given internally for gingivitis, bronchitis, arthritis, rheumatism and infectionMashed unripe fruits are applied to swollen areas, deep wound, boils, broken bone and inflammed joints

Page 7: By Sachidananda S N · On the cancer-suppressing capability of damnacanthal in colorectal tumorigenesis. Damnacanthal exhibits cell growth arrest as well as caspase activity induction

• Vitamins: Rich in A, B-Complex, C, E and K2.

• Minerals: Calcium, Iron, Niacin, Folic Acid, Pantothenic Acid, Phosphorus, Magnesium, Zinc, Copper and other minerals like Chromium, Manganese, Molybdenum, Sodium, Potassium,

• Isolated Nutraceuticals: it has150+ essential Neutraceuticalsthat are needed for a healthy life.

• Amino acids: Protein assimilators

• Antioxidants

• Alkaloids

• Carbohydrates

• NONI contains Immune system boosters,

• Cancer inhibiting compounds

• NONI contains health-enhancing attributes that are Antibacterial, Anti-inflammatory, Analgesic and Anti-congestive.

Contents of Noni

Page 8: By Sachidananda S N · On the cancer-suppressing capability of damnacanthal in colorectal tumorigenesis. Damnacanthal exhibits cell growth arrest as well as caspase activity induction

(ethythomethyl) benzene,1-butanol,1-hexanol,1-methoxy-2-formyl-3-hydroxyanthraquinone,2,5-undecandien-1-

ol,2-heptanone,2-methyl-2-butenyl decanoate,2-methyl-2-butenyl hexanoate,2-methyl-3,5,5-

trihydroxyanthraquinone-6&-primeveroside,2-methyl-3,5,5-trihydroxyanthraquinones,2-methylbutanoic acid,2-

methylpropanoic acid,24-methylcycloartanol,24-methylenecholesterol,24-methylenecycloartaanyl linoleate,3-

hydroxyl-2-butanone,3-hyroxymorindone,3-hydroxymorindone-6-&-primeveroside,3-methyl-2-buten-1-ol,3-

methyl-3-buten-1-ol,3-methylthiopropanoic acid,5,6-dihydroxylucidin,5,6-dihydroxylucidin-3-&-

primeveroside,5,7-dimethylapigenin-4O-O-&-D-,D(+)=galactopyranoside,6,8-dimethoxy-3-methyl

anthraquinone-1,-O-&-rhamnosyl glucopyranoside,6-dodeceno-y-lactone,7-hydroxy-8-methoxy-2-

methylanthraquinone,8,11,14-eicosatrienoic acid,acetic acid,alizarin,alkaloids,anthragallol 1,2-dimethyl

ether,anthraquinones,anthraqallel 2,3-dimethyl ether,asperuloside,benzoic acid,benzyl alcohol,butanoic

acid,calcium,campesteryl glycoside,campesteryl linoleyl glycoside,campesteryl palmitate,campesteryl palmityl

glycoside,campestrol,carbonate,carotene,cycloartenol,cycloartenol linoleate,cycloartenol

palmitate,damnacanthal,decanoic acid,elaidic acid,ethyl decanoate,ethyl hexanoate,ethyl octanoate,ethyl

palmitate,eugenol,ferric iron,gampesteryl linoleate,glucose,glycosides,heptanoic,acid,hexadecane

,hexanamide,hexanedioic acid,hexanoic acid,hexose,hexyl hexanoate,iron,isobutyric acid,isocaproic

acid,isofucosterol,isofucosteryl linoleate,isolaveric acid,lauric acid,limonene,linoleic acid,lucidin,lucidin-3-&-

primeveroside,magnesium,methyl 3-methylthio-propanoate,methyl decanoate,methyl elaidate,methyl

hexanoate,methyl octanoate,methyl oleate,methyl palmitate,morenone-1,morenone-2,morindadiol,

morindanigrine,morindone,morindone-6-&-primeveroside,mucilaginous matter,myristic acid,n-butyric acid,n-

valeric acid,nonanoic acid,nordamnacanthal,octadecenoic acid,octanoic acid,oleic acid,palmitic

acid,parafin,pectins,pentose,phenolic body,phosphate,physcion,physcion-8-O[{L-arabinopyranosyl} (1-3){&-D-

g-D-galactopyranosyl (1-6){&-D-galactopyranoside}],potassium,protein,proxeronine,

proxeronease,resins,rhamnose,ricinoleic acid,rubiadin,rudiadin-1-methyl ether,scopoletin,sitosterol,

sitosteryl glycoside,sitosteryl linoleate,sitosteryl linoleyl glycoside,sitosteryl palmitate,sitosteryl palmityl

glycoside,sodium,sorandjidiol,& -sitoterol,stearic acid,sterols,stigmasterol,stigmasteryl glycoside,

stigmasteryl linoleate,stigmasteryl linoleyl glycoside,stigmasteryl palmitate,stigmasteryl palmityl,

glycoside,terpenoids,trioxymethylanthraquinone,undecanoic acid,ursolic acid,xeronine,

150+ essential Neutraceuticals

Page 9: By Sachidananda S N · On the cancer-suppressing capability of damnacanthal in colorectal tumorigenesis. Damnacanthal exhibits cell growth arrest as well as caspase activity induction

Amino Acids

Alanine

Histidine

Methionine

Threonine

Glycine

Arginine

Isoleucine

Phenylalanine

Tryptophan

Aspartate

Leucine

Proline

Tyrosine

Cystine

Lysine

Serine

valine

Page 10: By Sachidananda S N · On the cancer-suppressing capability of damnacanthal in colorectal tumorigenesis. Damnacanthal exhibits cell growth arrest as well as caspase activity induction

Amino Acids

Of the 20 amino acids, including the 9

essential for our health, 17 are found in

Noni juice. If an individual does not get a

complete protein balance, then production

and maintenance of muscles, connective

tissue, blood-clotting factors, blood

transport systems, visual pigments and the

protein matrix inside bones would be at

risk.

Page 11: By Sachidananda S N · On the cancer-suppressing capability of damnacanthal in colorectal tumorigenesis. Damnacanthal exhibits cell growth arrest as well as caspase activity induction

Anthraquinones :

Alizarin

Anthragallol 1, 2-dimethlyl ether

Lucidin

Nordamnacathal

5,6-dihydroxylucidin

7-hydroxy-8-methoxy-

2methylanthraquinone

3-hydroxymorindone

2-methyl-3, 5 , 6-trihydroxy-

anthraquinones

Anthragallol

Damnacanthal

Morindone

Rubiadin

Page 12: By Sachidananda S N · On the cancer-suppressing capability of damnacanthal in colorectal tumorigenesis. Damnacanthal exhibits cell growth arrest as well as caspase activity induction

Uses of Anthraquinones 1. Some of the biological activity of anthraquinones includes fighting

inflammation, bacteria, parasites and tumors. Some of these compounds are also considered analgesic (pain relievers).

2. Anthraquinones are also used to fight fungal infections in addition to improving the immunity of the body. These compounds aid in metabolism, cellular respiration and growth. Damnacanthal, one of these groups of compounds, inhibits the formation of tumors by interfering with the growth of RAS cells. It is believed that some anthraquinones cut off the blood supply to tumors, depriving them of their nutrients slowing the growth of tumors by inhibiting important enzymes needed to form them.

3. Alizarin, another anthraquinone, also slows tumor growth as well as fighting leukemia and inhibits the human immunodeficiency virus as found in (HIV).

4. Some also were found to significantly “tie-up” the mineral calcium and reduce the growth rate of urinary crystals, which benefits those afflicted with gout and kidney stones.

Page 13: By Sachidananda S N · On the cancer-suppressing capability of damnacanthal in colorectal tumorigenesis. Damnacanthal exhibits cell growth arrest as well as caspase activity induction

Damnacanthal, a noni component

On the cancer-suppressing capability of damnacanthal in colorectal tumorigenesis. Damnacanthal exhibits cell growth arrest as well as caspase activity induction in colorectal cancer cells

MW: 282.34

Formula: C16H10O5

3-Hydroxy-1-methoxyanthraquinone-2-aldehyde

Page 14: By Sachidananda S N · On the cancer-suppressing capability of damnacanthal in colorectal tumorigenesis. Damnacanthal exhibits cell growth arrest as well as caspase activity induction

Nini Suppress TumorResearch conducted by Dr. Anne Hirazumi from the University of Hawaii also indicates that Noni juice has anti-tumor effects. This time, experiments conducted on mice suffering from lung carcinoma. Anne found a possible mechanism of anti-tumor effects through the immune system. Noni fruit juice stimulated the branch in charge of the immune system destroy tumor cells.

Page 15: By Sachidananda S N · On the cancer-suppressing capability of damnacanthal in colorectal tumorigenesis. Damnacanthal exhibits cell growth arrest as well as caspase activity induction

Terpenes Sterols

Limonene

Sorandjidiol

Eugenol

beta carotene

Ursolic acid

Beta-Sitosterols

Stigmasterol

Campesterol

Page 16: By Sachidananda S N · On the cancer-suppressing capability of damnacanthal in colorectal tumorigenesis. Damnacanthal exhibits cell growth arrest as well as caspase activity induction

Role of Terpenes1. Terpenes are the major components in the oils of citrus fruits and

they include the bioflavanoids and carotenoids. These substances combat fungal and bacterial infections, and are helpful in the treatment of glaucoma, spastic symptoms of multiple sclerosis, spinal lesions and in reducing the severity and side effects of chemotherapy.

2. Eugenol, a terpene, acts as an active germicide as well as induces anesthesia of the trigeminal nerve associated with Trigeminal Neuralgia or Tic Doulureax. Eugenol relaxes smooth muscle by interfering with the muscle’s contraction, and is found in a variety of aromatherapy oils, which are used for their soothing, calming and comforting effect.

3. Beta-carotene, another terpene, is associated with a reduced rate of cancers of the cells of the lung, skin, cervix, respiratory tract and the gastrointestinal tract. This is attributed to the compound’s ability to “mop up” free radicals, thus reducing the oxidative damage.

Page 17: By Sachidananda S N · On the cancer-suppressing capability of damnacanthal in colorectal tumorigenesis. Damnacanthal exhibits cell growth arrest as well as caspase activity induction

4. The thymus gland, which helps distribute T cells that destroy invading microbes, gradually deteriorates with age and stress, mostly from oxidative damage. Supplementing the diet with beta-carotene will offer anti-oxidizing benefits to the immune system and offers protection to the large bacteria-eating immune cells called phagocytes and other immune cells.

5. It also significantly reduces cholesterol levels, and supplies about two-thirds of the vitamin A needed for our bodies. Vitamin A helps our night sight and contributes to healthy skin and mucous membranes—the body’s first defense against infection and injury. This important vitamin also cares for our gastro-intestinal tract, respiratory system and the genito-urinary tract. Daily intake of Nonijuice is a good source of this vitamin.

6. Limonene, another terpene, has been found to limit tumor formation and antimicrobial activity and is involved in Alzheimer studies.

7. Ursolic Acid, also known as urson and prunol, has medicinal value when applied topically or taken internally for relieving symptoms of inflammatory and fungal infections of the skin. Taken internally it inhibits the formation and growth of tumors of the skin and acts as an anti-inflammatory. It also has alopecia-(loss of hair) and dandruff-preventing properties.

Page 18: By Sachidananda S N · On the cancer-suppressing capability of damnacanthal in colorectal tumorigenesis. Damnacanthal exhibits cell growth arrest as well as caspase activity induction

AcidsAcetic acid

Decanoic acid

Hexanedoic

Isocaproie acid

Valeric acid

Octanoic (caprylic)

Ricinoleic acid

Unolic Acid

benzoic acid

elaidic acid

hexanoic acid

Isolavenic acid

mystiric acid

nonanoic Acid

oleic acid

slearic acid

butanoic acid

heptanoic acid

isobutyric acid

lauric acid

n-butyric acid

octaduenoic acid

plmitic acid

undecanoic acid

Sugars

Fructose

Pentose

Glucose

Hexose Rhamnose

Page 19: By Sachidananda S N · On the cancer-suppressing capability of damnacanthal in colorectal tumorigenesis. Damnacanthal exhibits cell growth arrest as well as caspase activity induction

AcidsMany important fatty acids found in Noni are important to

the overall complex metabolic processes of the body.

1. Acetic acid is the main acid that all fatty acids are made

from.

2. Caprylic acid another fatty acid, inhibits yeast and fungal

overgrowth in the body.

3. Linoleic acid which cannot be manufactured in the body,

serves these important functions:

Strengthens capillary and cell membranes and increases

skin strength Combines with cholesterol to form important

compounds Helps lower serum cholesterol levels, and aids

in the transport and metabolism of cholesterol Builds

essential compounds that regulate bodily function

Page 20: By Sachidananda S N · On the cancer-suppressing capability of damnacanthal in colorectal tumorigenesis. Damnacanthal exhibits cell growth arrest as well as caspase activity induction

Alkaloids

Scopolentin

Morindadiol

Pectin

Proxeronine

Morindine

Thanks to the outstanding scientistof the 20th century Dr. RalphHeinicke who discovered a vitalmolecule called Proxeronine in Nonifruit. According to Dr. RalphHeinicke, Proxeronine combines withan enzyme Proxeroninase in ourbody to form the above said alkaloid

Xeronine.

Page 21: By Sachidananda S N · On the cancer-suppressing capability of damnacanthal in colorectal tumorigenesis. Damnacanthal exhibits cell growth arrest as well as caspase activity induction

Pectin1. This fiber is a non-cellulose complex sugar and

performs important functions within the gastrointestinal tract. It absorbs water and slows the emptying of the stomach contents into the small intestine. It also binds bile acids and cholesterol and regulates glucose absorption through the gut wall, helping those with blood sugar conditions.

2. Pectin in the diet will increase the volume of material moving through the bowel, reducing concentration of feces and carcinogenic substances in the bowel.

Page 22: By Sachidananda S N · On the cancer-suppressing capability of damnacanthal in colorectal tumorigenesis. Damnacanthal exhibits cell growth arrest as well as caspase activity induction

Scopoletin

1. Scopoletin belongs to a group of compounds called coumarins, which cares for the liver, inhibits the growth of E.coli in the gut and is antibacterial against many other agents that cause viruses.

2. It has also shown to be five times more effective as aspirin as an anti-inflammatory effect for bronchial illnesses and asthma.

Page 23: By Sachidananda S N · On the cancer-suppressing capability of damnacanthal in colorectal tumorigenesis. Damnacanthal exhibits cell growth arrest as well as caspase activity induction

XeronineXeronine is a small alkaloid that is required in picrogram (trillionth of gram) amounts and is essential to the correct functioning of the body. Large amounts are used in times of physical or mental stress. Xeronine is produced in the body from proxeronine and the enzyme proxeronase in the small intestine. All healthy cells require xeronine to function correctly.Activates over 220 enzymes. It also helps reduce addictions, such as snuff or alcoholism.

Page 24: By Sachidananda S N · On the cancer-suppressing capability of damnacanthal in colorectal tumorigenesis. Damnacanthal exhibits cell growth arrest as well as caspase activity induction

COX enzymesCOX-1 enzyme COX-2 enzyme

Responsible for protecting Responsible for

body’s stomach lining and causing pain and

kidneys inflammation

Page 25: By Sachidananda S N · On the cancer-suppressing capability of damnacanthal in colorectal tumorigenesis. Damnacanthal exhibits cell growth arrest as well as caspase activity induction

NONI inhibit

COX-1 enzyme COX-2 enzyme

Not effected

Allow COX-1 enzyme Inhibit PG that cause

To continue functioning pain and inflammation

Anti-inflammatory and

analgesic action

Page 26: By Sachidananda S N · On the cancer-suppressing capability of damnacanthal in colorectal tumorigenesis. Damnacanthal exhibits cell growth arrest as well as caspase activity induction

In depth study of Noni Juce and its medical health benefits was conducted by

Physicion Dr Niel Soloman of John Hoplins Hospital with the help of 1227 health

professionals representing 25,314 Noni juce drinkers from over 80 countries

who received positive results

Conditions, Decreased Symptoms Total # % Helped

1. Allergy 3,198 86%

2. Arthritis 1,675 78%

3. Asthma 8,077 71%

4. Cancer 2,188 69%

5. CFIDS, Fibromyalgia 3,524 77%

6. Depression 1,512 80%

7. Diabetics, Types 1 & 2 5,575 82%

8. Digestion 3,171 90%

9. Energy, increased 16,056 90%

10. Heart Disease 2,158 76%

11. High Blood Pressure, decreased 1,869 84%

12. HIV 150 55%

13. Immune System 3,707 77%

14. Kidney Disease 3,764 67%

15. Menstruation 3,798 79%

16.Mental Acuity, increased

alertness5,543 73%

17. Multiple Sclerosis 25 52%

18. Muscle, increased body building 1,216 70%

19.Obesity, lost some excess

weight5,526 72%

20. Pain, including headaches 6,828 86%

21. Parkinson's Disease 25 52%

22. Respiratory Problems 3,857 72%

23. Skin and Hair Problems 877 78%

24. Sexual Enhancement increased 2,984 84%

25. Sleep, improved 2,025 75%

26. Smoking, stopped 876 56%

27. Stress, coped better 6,743 74%

28. Stroke 1,806 53%

29. Well-being, felt better 7,879 80%

Conditions, Decreased Symptoms Total #%

Helped

Page 27: By Sachidananda S N · On the cancer-suppressing capability of damnacanthal in colorectal tumorigenesis. Damnacanthal exhibits cell growth arrest as well as caspase activity induction

Noni is a proven ‘Adaptogen’

Noni is ‘Anti Allergic’

Noni is an ‘Anti-Oxidant’

Noni is ‘Analgesic,

and Anti Inflammatory’

Noni has a low ‘Glycemic Index’

Noni is a ‘Humectant’

Page 28: By Sachidananda S N · On the cancer-suppressing capability of damnacanthal in colorectal tumorigenesis. Damnacanthal exhibits cell growth arrest as well as caspase activity induction

Noni SupportsThe Immune SystemThe Circulatory SystemThe Digestive SystemThe Metabolic SystemThe Tissues, Cells,Skin & Hair.

Page 29: By Sachidananda S N · On the cancer-suppressing capability of damnacanthal in colorectal tumorigenesis. Damnacanthal exhibits cell growth arrest as well as caspase activity induction

DRINK NONI LIVE STRONG

LIVE LONG

Sachidananda S NB Sc (Ag), PGDMM.