c2tn.tecnico.ulisboa.pt · C2TN / IST Annual Report 2017 Page | 1 Content FOREWORD

C2TN / IST Annual Report 2017 Page | 1

Content

FOREWORD ...................................................................................................................................................................... 3

C2TN ORGANIZATION AND COORDINATION .............................................................................................................. 5

C2TN TRACK RECORD ................................................................................................................................................... 6

THEMATIC STRANDS SCIENTIFIC REPORT 2017 ................................................................................................. 8

Radiopharmaceutical Sciences and Health Physics (RSHP) ............................................................................ 9

Earth Systems, Radioactivity and Cultural Heritage (ESRCH) ....................................................................... 13

Advanced Materials (AM) .......................................................................................................................... 17

RESEARCH GROUPS SCIENTIFIC REPORT ............................................................................................................. 20

Radiopharmaceutical Sciences Group ......................................................................................................... 21 TEAM ................................................................................................................................................................ 21 MISSION and OBJECTIVES ................................................................................................................................. 22 MAIN ACHIEVEMENTS ...................................................................................................................................... 23

Radiological Protection and Safety Group .................................................................................................. 28 TEAM ................................................................................................................................................................ 28 MISSION and OBJECTIVES ................................................................................................................................. 29 MAIN ACHIEVEMENTS ...................................................................................................................................... 30

Radiation, Elements and Isotopes Group .................................................................................................... 39 TEAM ................................................................................................................................................................ 39 MISSION and OBJECTIVES ................................................................................................................................. 40 MAIN ACHIEVEMENTS ...................................................................................................................................... 41

Nuclear Engineering and Techniques Group ................................................................................................ 47 TEAM ................................................................................................................................................................ 47 MISSION and OBJECTIVES ................................................................................................................................. 49 MAIN ACHIEVEMENTS ...................................................................................................................................... 50

f-Element Chemistry Group ........................................................................................................................ 57 TEAM ................................................................................................................................................................ 57 MISSION and OBJECTIVES ................................................................................................................................. 58 MAIN ACHIEVEMENTS ...................................................................................................................................... 59

Solid State Group ....................................................................................................................................... 66 TEAM ................................................................................................................................................................ 66 MISSION and OBJECTIVES ................................................................................................................................. 67 MAIN ACHIEVEMENTS ...................................................................................................................................... 68

SCIENTIFIC OUTPUT ................................................................................................................................................... 73

Books and chapters of international distribution ........................................................................................ 75

International Journals ................................................................................................................................. 77

Other Articles ............................................................................................................................................. 91


International Conference Proceedings ........................................................................................................ 92

Theses – concluded .................................................................................................................................... 97 PhD ................................................................................................................................................................... 97 MSc ................................................................................................................................................................... 97 Concluded Graduations .................................................................................................................................... 98

New Materials, devices, products and processes, software, computer codes and algorithms ....................... 99

Edited special issues of journals .................................................................................................................. 99

Performances and Exhibitions .................................................................................................................... 99

Research Contracts .................................................................................................................................... 101 European Research Contracts......................................................................................................................... 101 Industrial Research Contracts ......................................................................................................................... 102 FCT Projects .................................................................................................................................................... 103 Bilateral Research Projects ............................................................................................................................. 104 Research Contracts with IAEA ........................................................................................................................ 104 Other Research Projects ................................................................................................................................. 104

Invited Talks in Conferences ...................................................................................................................... 105

Contributed Talks in Conferences .............................................................................................................. 107

Seminars Given ......................................................................................................................................... 113

Seminars and Workshops at C2TN .............................................................................................................. 118

MEETINGS ................................................................................................................................................. 118

Education .................................................................................................................................................. 121 Courses given in Universities and Polytechnical Schools ................................................................................ 121 Short Courses given in International Organizations ....................................................................................... 124 Short Courses given in National Institutions .................................................................................................. 125

Scientific Committees ................................................................................................................................ 126

Coordination and/or participation in Infrastructures Networks .................................................................. 131

Participation in International platforms and networks ............................................................................... 133 European platforms ........................................................................................................................................ 133 International networks ................................................................................................................................... 134


Foreword

C2TN - Radiation for Science and Society We are very pleased to walk you through C2TN´s scientific, technical, education, training and services endeavors and achievements of 2017! C2TN, acronym for “Centro de Ciências e Tecnologias Nucleares” is an interdisciplinary Research Unit of Instituto Superior Técnico (IST), Universidade de Lisboa, established in 2013, located in Campus Tecnológico e Nuclear, the IST science and technology pole. It groups several tens of researchers (physicists, chemists, biologists, geologists, among others) recognized internationally as the Portuguese experts in matters related to Nuclear Sciences and Technologies and applications of Ionizing Radiation. This stems from the unique combination of C2TN´s knowledge, skills and competence with its experimental facilities. Indeed, C2TN has specialized scientific equipment, laboratories and infrastructures, some unique in Portugal, used as nodes in research networks: Laboratories for Synthesis & Characterization of Materials (licensed to handle radioisotopes), including at Low Temperature and High Magnetic Fields; facilities for Synthesis, Characterization & Preclinical Evaluation of Radioactive Tools for Nuclear Molecular Imaging and Therapy; Clean Rooms; Luminescence, Radiocarbon and Tritium Dating; Spectroscopy facilities - Mössbauer, X-ray fluorescence, Inductively Coupled Plasma Mass Spectrometer; alpha and gamma spectrometry laboratories; liquid scintillation counters; irradiation facilities for metrological verification of radiation detection equipment; linear electron accelerator; and access to Tandem and Van de Graaff accelerators and a Gamma Irradiation Unit, located in the Campus. During 2017, C2TN reinforced its role in the Portuguese Scientific and Technology System and in the international arena. The main axes of activities undertaken aimed at strengthening C2TN´s excellence in RD&I and to reinforce: i) Internationalization, pursuing the collaboration with reference institutions worldwide, in European platforms, international organizations and networks, nurturing new links and consolidating existing ones; ii) Engagement of young researchers, students and stakeholders in Portugal and abroad, fostering new collaborations between C2TN and RD&I and academic institutions, hospitals, municipalities, environmental, industrial, energy and services companies; iii) Outreach, dissemination and communication of Science and its activities. The motto “Radiation for Science and Society” was adopted, in order to make explicit the outstanding contributions of C2TN to several societal challenges, namely:

• Better management of cancer and neurodegenerative diseases with more effective and personalized diagnosis and treatments;

• Assessment of detrimental effects due to the exposure to ionizing radiation of patients and medical staff, aiming at the Quality and Safety of health care;


• Radiological and nuclear emergency response and preparedness; • Prevention of infectious diseases and outbreaks; • Improving the air quality and reducing the carbon footprint; • Environmental protection, management of natural resources and global changes; • Sustainable agro-industry and food safety; • Cultural Heritage leverage and safeguard; • Advanced materials for applications in physics and engineering, electronic sensors and

devices, energy conversion, cybersecurity and medical applications. 2017 was a very demanding year for C2TN with sizable uncertainties that affect the sustainability of its financial and human resources and the need to mitigate the precarious contractual link of a part of its researchers. The scientific strength of C2TN is illustrated by the number (42) of projects led by its researchers submitted in May to the national FCT Call, with additional participation in 27 projects led by other institutions. The rich variety and pluridisciplinarity of its activities were exhibited during the 1st C2TN Annual Meeting held in December of 2017 that was considered a success. The highlights of C2TN´s activities during 2017, detailed in the sequence, follow closely its structure, namely the organization in 6 interdisciplinary Groups: i) SS – Solid State: New Materials with Unconventional Electrical and Magnetic properties and characterization using Low Temperature and High Magnetic Field Techniques ii) NET – Nuclear Engineering and Techniques, Nuclear Physics, Geo-environments and Cultural Heritage using neutrons, radioactive nuclei and ion beams iii) RPS – Radiation Protection and Safety: Dosimetry, Radiobiology, Environmental Radioactivity, Radioecology, Radioactive Waste and Metrology iv) RS – Radiopharmaceutical Sciences: Nuclear Tools for Molecular Imaging and Theranostics v) REI – Environmental Processes, Archaeological Material Culture & Macromolecular Materials using Nuclear Analytical Techniques and Ionizing Radiation vi) QEf – f-Element Chemistry with the RD&I activities synergistically interwoven into 3 Thematic Strands: i) Advanced Materials ii) Radiopharmaceutical Sciences and Health Physics iii) Earth Systems, Radioactivity & Cultural Heritage. The most important asset of C2TN is its members. The Executive Commission would like to acknowledge and thank all C2TN members for their efforts, contributions and accomplishments that made possible the journey throughout 2017! C2TN Executive Commission Pedro Vaz – President Fernanda Margaça – Vice-President Dulce Belo - Vogal


C2TN Organization and Coordination

Considering the complementary know-how, common interests and facilities, the C2TN members are organized in six Research Groups: Radiopharmaceutical Sciences (RS), Radiological Protection and Safety (RPS), Radiation, Elements and Isotopes (REI), Nuclear Engineering and Techniques (NET), f-Element Chemistry (QEf) and Solid State (SS). For the period 2015-2020, the 6 groups of scientists will converge and collaborate on 3 main Thematic Strands (TS):

Scheme 1 shows the C2TN research groups and their contribution to the three Thematic Strands. Within these TS the role of the groups is well established and the overall research objectives are in line and nicely intersect with the EU Horizon 2020 initiative.

RESEARCH GROUPS

THEMATIC STRANDS

The Research Group Coordinators are: RS – António Rocha Paulo; RPS – Pedro Vaz; REI – Maria de Fátima Araújo; NET – Maria Isabel Dias; QEf –João Paulo Leal; ES – Manuel Leite de Almeida

The Thematic Strands Coordinators are: RSHP –António Rocha Paulo; ESRCH – Maria Isabel Prudêncio; AM – Manuel Leite de Almeida

Radiopharma- ceutical Sciences

and Health Physics (RSHP):

Biomedical Sciences and Medicine

Earth Systems, Radioactivity and Cultural Heritage

(ESRCH):

Environmental Sciences

Advanced Materials

(AM):

Engineering and Material Science

Radio- logical

Protection and Safety

Radiation, Elements

and Isotopes

Nuclear Engineering

and Techniques

f-Element Chemistry

Solid State

Radio- pharmaceutical Sciences

Radio- pharmaceutical

Sciences & Health Physics

Earth Systems, Radioactivity

& Cultural Heritage

Advanced Materials


C2TN Track Record

Information on the number of researchers from C2TN and peer – reviewed publications, the correspondent impact factor, PhD and MSc completed theses and values on the budget of C2TN is given for 2017 and compared with the corresponding values in previous years.

88

32

148

7 11


373

2,5

1,11


THEMATIC STRANDS SCIENTIFIC REPORT 2017


Radiopharmaceutical Sciences and Health Physics (RSHP)

Researchers of this TS used their unique know-how, expertise, competence, techniques and infrastructures to carry out cutting edge studies on Radiopharmaceutical Sciences, Radiation Protection and Dosimetry, Biological Effects of Ionizing Radiation and Metrology, aiming to contribute to the following major topics:

• Design, Synthesis and Pre-Clinical Evaluation of Radioactive Tools for Molecular Imaging and Theranostics;

• Evaluation of Biological Effects of Ionizing Radiation and Mechanisms of Action; • Medical Dosimetry and Metrology of Ionizing Radiation.

During 2017, the scientific output of the RSHP team was: 36 papers in peer-reviewed journals, 1 proceeding, 8 invited and 14 contributed lectures in conferences, 1 PhD and 5 MSc completed theses. The team´s research has been supported by European, FCT and bilateral projects. The team has participated in the organization of 5 conferences and workshops and 3 national training courses. A significant participation in the scientific and technical activities of European Union Technology Platforms and Networks, namely MELODI, EURADOS NERIS, EURAMET and COST ACTIONS CM1105, TD1004 has also taken place. During 2017 the team has also prepared and submitted several common projects under calls from EC, FCT, CERN-FCT, and Horizon 2020. From all the R&D activities performed during 2017, some relevant examples are highlighted below.


64CUCL2 AS A TOOL FOR PROSTATE CANCER THERANOSTICS Copper plays a critical role for cancer development and progression, and multiple copper isotopes are explored for cancer imaging and therapy. Studies using the simpler ionic form of a medically relevant copper radioisotope, 64Cu, have been conducted with promising results for prostate cancer theranostics. High levels of 64CuCl2 uptake were observed in prostate cancer cells, which might correlate with the different expression of native copper cellular transporters exhibited by those cell lines. The biological effects of exposure to 64Cu were also assessed using the γ-H2AX assay, evidencing higher early DNA damage in tumoral cells.


MULTIMODAL GOLD NANOPARTICLES FOR PROSTATE CANCER RADIOSENSITIZATION C2TN researchers introduced multifunctional gold nanoparticles (AuNPs) decorated with bombesin (BBN) peptide analogues to target the gastrin releasing peptide receptor, which is overexpressed in a variety of human tumors including prostate cancer. These AuNPs can be armed with imaging capabilities and show an augmented uptake in human PC3 prostate cancer cells. These favourable features pinpointed their potential relevance as multimodal radiosensitizing agents within a theranostic approach of prostate cancer. In vitro cellular studies demonstrated that the AuNPs carrying the BBN peptide possess enhanced radiosensitization properties when compared with the same nanoplatforms without the peptide. Altogether, these data corroborate the promising potential of BBN-containing AuNPs as multimodal tools for targeted cancer theranostics.


COMPUTATIONAL VOXEL PHANTOMS FOR PERSONALIZED PATIENT DOSIMETRY Computational voxel phantoms are models of the human anatomy used in the field of radiation protection, medical imaging and radiotherapy that enables evaluation of organ doses with a high degree of precision. In this field, a FORTRAN-based program was developed to semi-automatically modify the volumetric information of organs of interest in a standard voxel phantom (i.e. ICRP standard). Monte Carlo simulations were used to mimic CT scan conditions and assess organ dose in ICRP standard phantoms and in modified phantoms matched to patients’ size and overall anatomy. The modified phantoms allowed an increased accuracy in organ dose estimation, which can suffer from up to 20 % underestimation and 40 % overestimation using the standard phantoms. In summary, the voxel phantoms developed using single patient data provide more precise organ dose assessments, towards a personalized patient dosimetry.

(a) ICRP standard phantom; (b) patient CT image; (c) modified phantom according to patient lung volume. (a) (b) (c)


Earth Systems, Radioactivity and Cultural Heritage (ESRCH)

During 2017, the scientific output of the ESRCH team was: 51 papers in peer-reviewed journals, 12 book chapters, 21 proceedings, 9 invited and 33 contributed lectures in conferences, 2 PhD and 4 MSc completed theses. The team research has been supported by EC (LIFE, ERA-MIN, Interreg Sudoe and Interreg Mediterranean), FCT, IAEA, and bilateral projects. The team has participated in the organization of 10 conferences and workshops and 5 national training courses. A significant participation in the scientific and technical activities of European Union Technology Platforms and Networks, namely ALLIENCE and IGD NERIS, and in the COST ACTIONS CA16109 and ES1407 has also taken place. During 2017, the team has also prepared and submitted several common projects under calls from EC, FCT, and Horizon 2020. Two contracts were established with private companies. NORM - THE WILD VEGETATION ON THE PHOSPHOGYPSUM STOCKPILE Availability of natural radionuclides in a phosphogypsum (PG) stockpile (Barreiro) was evaluated by analysing the transfer to rooted plants and mosses growing on the PG. Mosses (Bryum sp.) content in 226Ra and 210Pb (dry weight) reached higher concentrations in biomass than in the PG. In Plantago sp., concentrations were less than one order of magnitude lower than in mosses. Only 1.6% of 226Ra in the PG matrix is bioavailable, meaning that it is bounded strongly in a crystalline matrix and just a small amount is in an ion-exchangeable form.


FOSTERING A LOW CARBON-ECONOMY IN SCHOOLS Following the EU Roadmap - by 2050, the EU should cut greenhouse gas emissions to 80% below 1990 levels. The ongoing project Interreg Sudoe ClimACT coordinated by C2TN, promotes the transition to a Low Carbon-Economy in schools. During 2017 environmental and energy performance was assessed in 39 European schools, from primary until university level. Complementary approaches such as energy efficiency, sustainable transportation, green procurement, resources conservation and behavioural change were designed to support schools managers, energy and environment players and students in the identification of smart solutions for schools for the greenhouse gas emission reduction.


RECOVERING RARE EARTH ELEMENTS FROM OLD MINE TAILINGS ENVIREE project funded by ERA-MIN program (EU, FP7) is focused on a holistic perspective (from environmental systems, LCA, leaching techniques, separation technology to remediation) to recover REE with minimal environmental impact yet in an economically sustainable process. After the identification of the tailings with favourable conditions to contain metals (Covas and Cumieira, Northern Portugal) a more detailed chemical and mineralogical characterization of these heterogeneous materials was done during 2017. Training and dissemination headed by C2TN has been a main achievement of this project through the organization of Workshops and Summer Courses on Rare Earth Elements, recovery and environmental issues.


CHALCOLITHIC AND EARLY IRON AGE JEWELLERY – 2000 YEARS OF GOLD TECHNOLOGY In the Portuguese territory, the complex typologies of gold jewellery of the Early Iron Age (c. 850-400 BC) differ significantly from the simple types of the Chalcolithic (c. 3000-2000 BC). This typological evolution was found to be related with two technological developments: the use of less expensive and more workable resources by alloying Au with Ag (up to 42%) and/or Cu (up to 6%), and the use of autogenous welding and copper-rich solder alloys that allowed the manufacture of intricate shapes by joining different components and filigree decorations.


Advanced Materials (AM)

The research activities under this thematic strand have been focused in different advanced materials, with emphasis on multifunctional and unconventional electrical and magnetic materials, with potential applications in the fields of electronic and optoelectronics, health, catalysis and energy. These activities were possible thanks to a valuable combination of a wide range of complementary techniques existing at C2TN for both preparation and characterization of materials, enabling to address current challenges in materials science research and contributing to the establishment of more detailed correlations between the structure and the physical properties. A significant part of the activities in this area has been possible by the operation and development of infrastructures and research tools, rare or even unique at national level, which have been placed open at the benefit of a large external community through an extensive network of scientific collaborations. These facilities include materials modification by ion implantation, neutrons, gama and electron irradiation, neutron tomography, several ion beam techniques for elemental composition analysis and the low temperatures and high magnetic field facilities for the study of electrical transport, magnetic properties of materials and Mössbauer spectroscopy. During 2017, the scientific output of the team involved in Advanced Materials studies was: 37 papers in peer-reviewed journals, 1 book chapter, 4 invited and 28 contributed lectures in conferences, 3 PhD, 2 MSc and 2 graduated completed theses. The team research has been supported by European (namely Marie Curie ITN) and FCT. The team has participated in the organization of 2 conferences and workshops. A significant participation in the scientific and technical activities of European Union Technology Platforms and Networks, namely COST ACTIONS CA15128 CM1105, TD1004 has also taken place. During 2017 the team has also prepared and submitted several common projects under calls from EC, FCT, CERN-FCT, and Horizon 2020. The activities had contributions from different research groups (ES, ETN, QEf, and REI) as more detailed described in their reports. The following major achievements in 2017 are highlighted.


A LAYERED EUROPIUM HYDROXIDE SYSTEM FOR PHOSPHOROUS SENSING A dual-channel sensor (LEuH-2,6-NDC) towards anions, highlighting the significant potential of LLHs as new scavenging agents for inorganic phosphate.

AD-ATOMS AND AD-MOLECULES ON GRAPHENE The configurations of freestanding Hg and HgO2 molecules with respect to the graphene surface were analysed with Density Functional Theory (DFT) probed by Perturbed Angular Correlation with 199mHg.


BILAYER POLYMORPHISM IN (CNB-EDT-TTF)4CLO4

Two polymorphs (monoclinic and triclinic), β”-(CNB-EDT-TTF)4ClO4 illustrate a new aspect of polymorphism in bilayer metal.

MAGNETISM AND STRONGLY CORRELATED ELECTRON BEHAVIOR IN INTERMETALLICS A novel ternary compound, UMo3B7, showing spin fluctuations and enlarged Sommerfeld coefficient.


RESEARCH GROUPS SCIENTIFIC REPORT


Radiopharmaceutical Sciences Group

TEAM

*50 % at the GPSR

Name Category R&D (%)

António Manuel Rocha Paulo Principal Researcher – Group Coordinator 100

João Domingos Galamba Correia Principal Researcher 100

Filipa Fernandes Mendes Auxiliary Researcher 100

Maria de Lurdes Barrela Patrício Gano Auxiliary Researcher 100

Fernanda Marujo Marques Auxiliary Researcher 100

Paula Dolores Galhofas Raposinho Auxiliary Researcher 100

Maria Cristina das Neves Oliveira Auxiliary Researcher 100

Maria Paula Cabral Campello Auxiliary Researcher 100

Célia Maria da Cruz Fernandes Auxiliary Researcher 100

Elisabete Correia Principal Professional Technician 100

Elisa Palma Post-doctoral Researcher 50

Rita Lourenço Paiva de Melo Galvão Post-doctoral Researcher 100

Francisco Silva Post-doctoral Researcher 100

Joana Guerreiro* Post-doctoral Researcher 100

Filipe Vultos PhD Student 80

Alice d’Onofrio PhD Student 100

Renan Camurça Leitão PhD Student 90

Vera Ferreira PhD Student 100

Rúben Diogo Marques da Silva MSc Student 90

Bárbara Franco Andrade Góis MSc Student 40

Sofia Batanete MSc Student 50

Mariana Andersen Morais David MSc Student 20

Elisabete Ribeiro Research Fellow 20

Ana Gonçalves Research Fellow 50

Andreia Neves Graduation Student 30

Melissa Orlanda Pereira da Costa Graduation Student 20

Salomé Alexandra Lopes Teixeira Galaio Graduation Student 20

Tânia Morais Collaborator 20


MISSION AND OBJECTIVES

The RSG develops research activities on the design and preclinical evaluation of radioprobes for Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) Imaging and Targeted Radionuclide Therapy (TRT). This research field has important translational potential in the diagnosis and/or treatment of oncological, cardiovascular or neurodegenerative diseases, and contributes for the rise of molecular and personalized medicine. The RSG gathers a multidisciplinary team of scientists with expertise in chemistry, radiochemistry and biological sciences, who run dedicated facilities for:

i) chemical synthesis (including solid phase peptide synthesis); ii) radiosynthesis; iii) biochemical, molecular biology and cellular studies; iv) animal housing and biodistribution studies.

The research group is mainly involved in the study of innovative target-specific radiopharmaceuticals, based on a plethora of imaging or therapeutic radionuclides, to image/interfere with different disease-associated molecular and biological pathways. The group is a key partner of renowned national/international institutions involved in radionuclide production, nuclear medicine and biomedical research (e.g. ICNAS (PT), Polatom (PO), CERN, Fundação Champalimaud (PT), CHUV (CH), IMM-Lisbon Medical School (PT), Ludwig Cancer Research (CH)), due to its rare combination of radiopharmaceutical chemistry expertise with preclinical evaluation skills. There is also an active collaboration with research groups engaged in the discovery and development of novel drugs, as well as technology transfer activities within research contracts with national/international biotech companies (e.g. Technophage, ProQr Therapeutics), namely in the field of antibody-based biopharmaceuticals. The RSG provides advanced training to students and young scientists on Radiopharmaceutical Sciences and Molecular Imaging. It is a partner of the Marie-Sklodowska Curie ITN “MEDICIS-produced radioisotope beams for medicine” leaded by CERN and the PhD program “ChemMedTrain” coordinated by the Universities of Coimbra and Lisboa. The RSG also receives undergraduate and graduate students for research and training activities within different graduation, master or PhD programs.


MAIN ACHIEVEMENTS

CLICKABLE RADIOCOMPLEXES FOR RADIOIMMUNOTHERAPY The major goal of this project is to design multifunctional radioimmunoconjugates for the targeting of tumor endothelial marker 1 (TEM1/endosialin), a receptor overexpressed in several human cancers with minimal expression in normal tissues. For this purpose, Tb radioisotopes produced at the MEDICIS

facility in CERN will be used. Terbium is an excellent candidate for theranostic applications possessing four clinically relevant radioisotopes (149Tb, 152Tb, 155Tb and 161Tb) for imaging and therapy. The

final conjugates will be obtained by in vivo click reactions between macrocyclic Tb radiocomplexes carrying a tetrazine moiety and antibody fragments functionalized with trans-cyclooctene (TCO), expecting to reduce the systemic radiation exposure of the patients while maximizing the therapeutic efficacy. As a first step, we succeeded on the 125I-labelling of a small panel of TEM1 targeted antibody fragments and evaluated their specific TEM1 targeting ability, which allowed us to select the best candidates for further studies with the Tb radioisotopes. INDIUM(III) COMPLEXES AS RADIOTHERANOSTIC AGENTS FOR DUAL TARGETING OF BREAST CANCER Despite the enhancement in the survival rate of breast cancer (BC) patients, there is still a need for more effective and personalized treatments to improve BC management. Radiotheranostics is particularly suitable for that purpose as the estrogen receptor (ER) status acquired by imaging can be used to targeted treatment. Thus, our approach combines into a single 111In-hybrid compound, a chelator simultaneously conjugated to an ER ligand (LXXLL peptide) and an antitumor agent (the DNA intercalating agent, acridine orange, AO) for dual targeting of BC cells aiming at the increase of therapeutic efficacy. The 111In-ER3AO is able to localize in the nucleus of BC cells and induce DNA damage in vitro. These features, along with a favourable biodistribution profile in tumor bearing mice with fast clearance from main organs and accumulation in target tissues, suggest that this hybrid radioconjugate

has potential as theranostic agent.


64CU-BASED COMPOUNDS FOR CANCER IMAGING AND THERAPY

Copper plays a critical role for cancer development and progression, and multiple copper isotopes are explored for cancer imaging and therapy. Studies using the simpler ionic form of the medically relevant copper radioisotope, 64Cu, have been conducted with promising results for prostate cancer theranostics. High levels of 64CuCl2 uptake were observed in prostate cancer cells, with a concomitant increase in DNA damage resulting from exposure to the compound (a work performed in collaboration with the RPS Group). We are currently studying whether this might correlate with the different expression of the native copper cellular transporters exhibited by those cell lines. Continuing our previous work on a family of cytotoxic bis(thiosemicarbazonato) copper(II) complexes (CuL1-CuL4), which presented significant uptake in

cancer cells, we have found that such behavior is temperature-dependent, suggesting a predominant active or facilitated uptake of the metal complexes in those cell lines.

ACRIDINE ORANGE DERIVATIVES FOR DNA-TARGETING

Applications using radioisotopes and radiopharmaceuticals are of major importance for cancer medicine and paved the way for the development of targeted radionuclide therapies and more advanced diagnostic techniques. Within targeted radionuclide therapies, Auger-emitting radiopharmaceuticals are considered best suited for the eradication of disseminated cancer metastases with minimization of deleterious effect to non-target surrounding tissues. To tackle this goal, we have been involved in the study of 125I- and 99mTc-containing acridine orange (AO) derivatives as potential Auger-emitting radiopharmaceuticals. In collaboration with the group of Carla Cruz (CICS-UBI, Covilhã), we have recently demonstrated that some of these AO derivatives are potent binders of G-quadruplex (G4) structures formed within the nuclease hypersensitive element of the KRAS promoter region. This finding might have great relevance for the design of innovative Auger-emitting radiopharmaceuticals targeted at KRAS, as KRAS is often found mutated in a variety of highly lethal cancers.


MULTIFUNCTIONAL GOLD NANOPARTICLES FOR TARGETED THERANOSTICS

The aim of this project is to develop target-specific multifunctional gold nanoparticles (AuNPs) for simultaneous delivery of radionuclides and gadolinium to cancer cells, and explore their radiosensitizing properties. In this context, we have developed AuNPs stabilized with a thiolated DOTA derivative and decorated with a bombesin (BBN) for specific targeting of the gastrin releasing peptide receptor, which is overexpressed in a variety of cancers. These AuNPs were simultaneously coordinated with Gd and 67Ga to study their multimodal imaging capabilities. The relaxivity properties measured for the Gd-containing AuNPs make them potential candidates for T1- and T2- MR imaging. Biodistribution studies in prostate cancer PC-3 xenografts, performed by gamma-counting measurements of 67Ga, showed that the multimodal AuNPs have a reasonable tumor uptake. Additionally, in vitro studies using prostate cancer cells demonstrated that these nanoparticles have radiosensitization capabilities. Altogether, these data corroborate its promising potential for targeted cancer theranostics.

DESIGN OF HER2-SPECIFIC VIRUS-LIKE PARTICLES FOR IMAGE-GUIDED DRUG DELIVERY

Modelling, docking and fitting of an HER2-specific single chain variable fragment with the transmembrane viral protein (gp41) was the key to define the best pairwise residues allowing the modeling of a fusion protein to be expressed onto the viral capsid. Considering this information, DNA recombinant technologies were used to prepare the retargeted VLP containing the fusion protein with Gp41. The tropism of the constructed HIV-based VLPs was manipulated and the particles were engineered for the specific delivery of drugs and/or radionuclides for theranostics of HER2 positive breast cancer.


RADIOMETALLATED ANTIBODY FRAGMENTS FOR CENTRAL NERVOUS SYSTEM DRUG DESIGN

Under the scope of a large cooperation research project among different groups from the Instituto de Medicina Molecular, Faculdade de Medicina, and from the Faculdade de Medicina Veterinária, Universidade de Lisboa, we have been actively involved in the design and biological evaluation of novel low molecular weight proteins, namely antibody fragments (e.g. single domain antibodies - sdAbs), for treating

central nervous system disorders (e.g. Alzheimer’s disease) that may contain specific engineered trans-blood brain barrier peptide vectors. This research work comprises an in vivo image-guided drug delivery approach, using selected sdAbs radiolabeled with the radiometals 99mTc and 67Ga, taking advantage of the expertise and facilities run by the radiopharmaceutical sciences group.

A MOLECULAR IMAGING APPROACH TO CYSTIC FIBROSIS

Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator gene (CFTR), which encodes a chloride channel present at the plasma membrane of epithelial cells. Although being one of the most intensively investigated monogenic disorders, symptomatic treatment remained the bedrock of CF patient care until the beginning of this decade. Recently, novel CF therapies based on small organic molecules that target the basic defect in CF were approved by the EMA/FDA. Despite this exciting development, from the translational medicine perspective, there remains a need to improve disease biomarkers and non-invasive therapeutic endpoints used in clinical trials. Within our goal of bringing forward new imaging biomarkers for CF management, we have explored a small-molecule based approach for the development of non-invasive probes. Currently, we are expanding these studies to other CFTR-targeting biomolecules, and in collaboration with iMed.Ulisboa, Fabs will be selected from a human library by phage display.


PRECLINICAL EVALUATION OF METALLODRUGS FOR ANTICANCER THERAPY

In collaboration with national and international research groups, we have investigated complexes with a variety of d-transition metals (Ru, V, Ag, Cu, Ga, In) as prospective metallodrugs for anticancer therapy, with a focus on the study of cell uptake and death mechanisms. Taking advantage of the unique expertise of the radiopharmaceutical sciences group, some of these studies included the evaluation of radioactive counterparts (e.g 67Ga and 111In) for a more straightforward quantification of cellular uptake and in vivo assessment of the biodistribution and stability of the compounds. Profiting from the availability of the nuclear microscopy facility at the CTN/IST, the uptake of a copper complex by PC3 cells was also

ascertained by simultaneous application of PIXE (Particle Induced X-ray Emission), RBS (Rutherford Backscattering Spectroscopy) and STIM (Scanning Transmission Ion Microscopy). These techniques, seldom used to evaluate the cellular uptake of anticancer metallodrugs, showed a preferential localization of Cu in the nuclear and perinuclear regions thus giving a clue for possible cellular targets. COMPUTER-AIDED DRUG DESIGN APPROACHES IN NEURODEGENERATIVE DISEASES Neurodegenerative disorders are characterized by a gradual loss of neurons and encompasses a broad range of clinical diseases, including progressive dementing conditions, of which the most common are Alzheimer's disease (AD) and Parkinson's disease (PD). Currently, pharmacological research has been focused on the discovery of drug candidates with neuroprotective properties, which target disease-modifying effects, contributing to the blockade of neuronal apoptosis and subsequent disease progression. Towards this goal, we have been exploring the structure-based and ligand-based computational approaches widely employed in in-silico medicinal chemistry based on protein-protein interactions. In the future, we will use these computational approaches to design other classes of drugs, including anticancer agents and potential theranostic radiopharmaceuticals, and to predict their interaction with their putative receptors.


Radiological Protection and Safety Group

TEAM


Pedro Vaz Principal Researcher - Group Coordinator 90 Isabel Paiva Auxiliary Researcher 80 Mário Capucho dos Reis Auxiliary Researcher 50 Maria José Madruga Principal Researcher 40 José Alberto Corisco Auxiliary Researcher 40 Octávia Monteiro Gil Auxiliary Researcher 90 Pedro Teles Auxiliary Researcher 67 Isabel F. Gonçalves Auxiliary Researcher 100 Jan Mihalik Researcher (Invited) 501 Maria dos Anjos Neves Collaborator: Principal Researcher (retiree) - Carlos Oliveira Collaborator: Principal Researcher (retiree) - Marta Guimarães Santos Senior Technician (with Ph.D.) 40 Yuriy Romanets Senior Technician (with Ph.D.) 40 Ana Belchior Post-doctoral Researcher 100 Salvatore di Maria Post-doctoral Researcher 100 Joana Guerreiro Post-doctoral Researcher 502 Mariana Baptista PhD student 100 Margarida Caldeira Research Fellow with PhD 30 Ana Catarina Antunes Research Fellow 100 Piménio Ferreira Research Fellow 1003 Eva Andrade Fellow (IST, services) 30 Paula Madeira Collaborator - Radiographer (CHLC) - Maria João Carapinha PhD student - Ana Cravo Sá PhD. student 100 Carina Coelho PhD student 100 Jessica Costa MSc student – thesis concluded in 2017 -

Jorge Borbinha MSc student – thesis concluded in December 2017 -

Rita Monteiro MSc student – thesis concluded in September 2017 -

Valerio Santoro MSc student (Erasmus+, U. Bologna, Italy)4 – on-going -

Filipe Pires MSc student - ongoing - Miguel Furtado MSc student – ongoing -

1 The remaining 50% at the NET Group of C2TN 2 The remaining 50% at the RS Group of C2TN 3 Until mid-2017 4 From October 2017 onwards



The main objectives of the Group activities consisted on:

• The deployment of unique scientific and technical expertise, skills and competence in radiological protection and radiation safety in Portugal.

• Keeping abreast of the state-of-art in scientific and technical topics and in international regulations and safety standards in modern radiological protection and radiation safety.

• Education and training of students and professionals in Masters and Doctoral programmes and the supervision of Ph.D. or MSc. theses´ students.

• The provision of scientific advice and support to the Portuguese competent authorities and stakeholders in the execution of policies in radiological protection and in areas involving application of ionizing radiations and radioisotopes.

• Contribute to raise the awareness of Portuguese and international stakeholders about hot topics, emerging, leading edge and multidisciplinary scientific issues associated to the biological effects arising from the medical, industrial and environmental exposures to ionizing radiation of workers, patients and members of the public.

To achieve such objectives, the GPSR was involved in fundamental and applied research activities addressing multidisciplinary, cross-cutting and leading edge topics in:

o Dosimetry and Radiobiology, o Environmental Radioactivity and Radioecology, o Radioactive Waste Management, o Metrology of ionizing radiation, o Emergency preparedness and management of radiological & nuclear accidents, o The GPSR researchers have access to laboratory infrastructures and equipment and state-of-

the-art radiobiology, radioanalytical, dosimetry and metrology techniques.

The Group´s activities:

• Were sustained by the participation in R&D projects funded by the European Union (EU) Framework Programmes and HORIZON 2020, by the Portuguese Foundation for Science and Technology, by organizations such as EURADOS (European Radiation Dosimetry Group) and EURAMET (European Association of National Metrology Institutes), in collaboration with CERN and other research centers in European countries.

• Included the participation in the EU Technological Platforms MELODI (Multidisciplinary European Low Dose Research), IGD-TP (Implementing Geological Disposal of Radioactive Waste), NERIS-TP (Preparedness for Nuclear and Radiological Emergency Response and Recovery) and Alliance (European Radioecology Alliance).

• Fostered collaborative links with Portuguese research groups, academia, hospitals and other stakeholders in Radiation Protection, in the context of scientific projects and academic, education and training activities.


MAIN ACHIEVEMENTS

DOSE OPTIMIZATION OF NUCLEAR MEDICINE PROCEDURES IN PAEDIATRIC PATIENTS: BIOKINETIC MODEL ANALYSIS AND DOSE COEFFICIENT ANALYSIS. Figure 1: Activity curve analysis in the kidneys and liver of a paediatric patient (left) injected with 99mTc-DMSA and respective biokinetic analysis (right). This study analysed the biokinetic behaviour of the radiopharmaceutical 99mTc-dimercaptosuccinic acid (DMSA), after administration in 8 infants aged 4 months to 2 years, through an imaging study in a nuclear medicine facility using a Gamma camera, and compared the obtained values with those obtained with the reference ICRP biokinetic model. The in vivo data was treated using an adapted methodology from the MIRD 16 pamphlet. The obtained results allowed for an absorbed dose estimation which is smaller than that provided by ICRP by 32.1% in the kidneys, and 18.4% in the liver.

Figure 2: Voxel phantoms BABY and CHILD were scaled to reflect the anatomical variations of patients according to age, height and weight. Dose coefficients were obtained using Monte-Carlo simulations. Dose assessment was performed using the MCNPX 2.7 code and the GsF voxel phantoms BABY and CHILD. The two phantoms were scaled according to two different methodologies - using a kidney mass function relative to age; and using body mass and height. The obtained Dose Coefficients reveal that the ‘step’ function with age as used by ICRP could be too simplistic. When using the 2nd methodology, which takes into account body weight and height, results can be fitted to a 1/m function in which m is the body mass. This function could be adapted to provide optimized values for dose in paediatric patients, especially for those aged 0-5 years old.

Scaling


DOSIMETRIC AND CANCER RISK ASSESSMENT IN CONE BEAM COMPUTERIZED TOMOGRAPHY (CBCT) Cone-Beam CT (CBCT) provides 3D images of tumor anatomy, size and location for cancer treatment by Image-Guided Radiotherapy (IGRT). Despite its benefits, imaging doses from CBCT scans are a clinical concern due to additional exposure of healthy tissues surrounding the exposed target-organs. In this study, we were able to quantify the concomitant organ doses involved in a Thorax CBCT scan for lung cancer treatment and to estimate the corresponding radiological risk of cancer incidence. For that, MCNPX simulations to model the CBCT equipment and a male voxel phantom were used to calculate the organ doses. The total CBCT imaging dose was determined, assuming that at least one CBCT scan was performed per session, for a complete course of treatment for lung cancer (24 sessions). The mean organ dose was converted to cancer risk using the BEIR VII gender, age and tissue-specific risk coefficient for lifetime attributable risk (LAR) of radiation induced cancer incidence.

Figure 1: Sagittal view of male voxel phantom in the CBCT MCNPX computational model (A). Organ doses (B) and lifetime risk (C) for Thorax CBCT during a complete course of IGRT treatment for lung cancer.


ORGAN DOSE ESTIMATES IN THORAX CT: VOXEL PHANTOM ORGAN MATCHING WITH INDIVIDUAL PATIENT ANATOMY The main objective of this investigation was to modify existing three-dimensional (3D) voxel phantom models to resemble real patients, towards the personalized patient dosimetry concept. This work focused essentially in one of the most radiosensitive organs in the thorax, the lungs. Additionally, the variations of organ doses when a standard phantom is used instead were studied. A FORTRAN-based program was developed, which is able to semi-automatically modify the volumetric information of organs of interest in a standard voxel phantom (Female ICRP Adult Reference). Monte Carlo (MC) simulations were used to mimic CT scan conditions and access organ dose in both phantoms (ICRP standard and ICRP modified). Voxel models matched to patients’ size and overall anatomy allow increased accuracy in organ dose estimation, which can suffer from up to 20% underestimation and 40% overestimation. This study demonstrates that voxel phantoms developed using single patient data provide more precise organ dose assessments.


IMAGE SEGMENTATION AND VOXELIZATION TECHNIQUES FOR DOSE ASSESSMENT IN X-RAY DIAGNOSTIC PROCEDURES Computational voxel phantoms are models of the human anatomy used in the field of radiation protection, medical imaging and radiotherapy that enables evaluation of organ doses with a high degree of precision. The gold standard of radiation dosimetry would be to obtain a computational model for each patient involved in radiation processes. Having this in mind, the aim of this work was to try to improve the implementation of a computational voxel phantom starting with a physical one for organ dose assessment and imaging studies in the X-ray diagnostic. The first step was devoted to the segmentation of CT images through thresholding methods and region growing algorithms. The second step consisted in developing a MC model for validation, dose and imaging purposes. Finally, an analysis of SNR for different calcification sizes showed the optimal energy (about 60 keV) that maximizes the image quality for 0.7 cm thick calcification detection.


MONTE CARLO DOSE DISTRIBUTION CALCULATION AT NUCLEAR LEVEL FOR AUGER-EMITTING RADIONUCLIDE ENERGIES The distribution of radiopharmaceuticals in tumor cells represents a fundamental aspect for a successful molecular targeted radiotherapy. At microscopic level only a fraction of cells in tumoral tissues incorporate the radiolabel. The most used method to perform cellular dosimetry is the MIRD one, where absorbed doses are calculated for several electron energies, nucleus diameters, and for homogeneous source distributions. However, the radionuclide distribution inside nuclei can be highly non-homogeneous. The GPSR researchers developed a study to show to what extent a non-accurate cellular dosimetry could lead to misinterpretations of surviving cell fraction vs dose relationship; the modelling of realistic radionuclide localization inside cells (for 99mTc radionuclide), including a inhomogeneous nuclear distribution, revealed that i) a strong bias in surviving cell fraction vs dose relationships (taking into account different radiobiological models) can arise; ii) alternative models might contribute to accurate prediction of the radiobiological effects inherent to specific molecular targeted radiotherapy strategies.

Left: Example of non-homogeneous source distribution inside the nucleus for a Re complex whose accumulation in the nucleus of prostate cancer (PC3) cells was visualized by fluorescence microscopy. DAPI (blue) was used to visualize the cell nucleus, while in green is shown the complex distribution. (Right) Example of a case study where the maxiumum spot intensity in a given cell inside the nucleolus. MCNP6 tally values are expressed in MeV/cm3/particle/unit.


BIOLOGICAL EFFECTS OF BETA- AND/OR AUGER-EMITTING THERAPEUTIC RADIOPHARMACEUTICALS In collaboration with the RS Group, we have been involved in the radiobiological evaluation of Auger-emitting (99mTc) or β− emitting (64Cu) radiocompounds, promising candidates for selective and targeted radiotherapy due to the very short range (micrometers to few nanometers) of the emitted β−particles and Auger electrons. Continuing our previous work on the ability of 99mTc-labelled AO-derivatives to cause DNA damage, focusing on late biological effects, an increase on the number of micronuclei (indicative of genetic lesions) induced by 99mTc-containing compounds was observed. In addition, exposure to 99mTc led to the decrease of the cellular survival fraction, indicating the occurrence of a persistent lesion, dependent on the activity of the compound. Studies using the mixed β−/Auger emitter 64Cu have also been initiated and have highlighted the ability of this radionuclide to induce both early and late DNA damage in tumoral cells.

Figure 1: Late biological effects (micronuclei yield and cellular surviving fraction) induced by 99mTc-exposure in PC3 prostate cancer cells.


A NORM CASE STUDY: THE WILD VEGETATION ON THE PHOSPHOGYPSUM STOCKPILE FROM A DISABLED PHOSPHATE FACTORY IN BARREIRO (PORTUGAL) Availability of natural radionuclides, rare earth elements (REEs) and heavy metals in a phosphogypsum (PG) stockpile remaining as the legacy of a disabled phosphate plant in the city of Barreiro, was evaluated by analyzing the transfer to rooted plants (Plantago sp.) and mosses (Bryum sp.) growing naturally on the PG stockpile. Mosses content in 226Ra and 210Pb reached concentrations several fold higher in biomass than in the PG substrate. In rooted plants, concentrations were less than one order of magnitude lower than in moss (Table), but two orders of magnitude higher than those measured in grasses from natural soils. Only 1.6% of 226Ra in the PG matrix is bioavailable, meaning that it is strongly bounded in a crystalline matrix and just a small amount is in an ion-exchangeable form. High concentrations of heavy metals (As, Cd, Zn, W) in plants and mosses are an evidence of their transport from former industrial facilities and present even more important risk to the public health and the environment than natural radionuclides and REEs from the PG stockpile.

Vegetation component Type of sample 235U 226Ra 210Pb 228Ra 40K

Plantago sp. PG Substrate 13±10 740±41 870±130 n.d. 93±43 Roots n.d. 140±10 260±41 3.6±2.0 280±37 Aerial parts n.d. 110±5 92±14 n.d. 351±33

Bryum sp. PG substrate 18±4 890±37 1000±132 8.9±1.0 38±12 Moss tissues 66±14 2900±200 4000±660 36±9 n.d.

n.d. – not detected

Table 1: Activity concentrations (Bq kg-1, dry weight) of natural radionuclides in Plantago sp., Bryum sp, and respective PG substrate. The variation intervals correspond to the expanded uncertainty of measurement (k=2) REMOBILIZATION OF 137CS FROM DEGRADATION OF PLANT BIOMASS IN SOILS This investigation was focused on the role of humic acid-like compounds during the biodegradation of plant mass contaminated with 137Cs. The experiments were set up to distinguish cases of external and internal contamination. The results showed that 137Cs was associated with humic acid-like compounds in eluates from biomass and especially with their lighter fraction. The 137Cs in detritus was markedly mobile and only minor amounts were retained in biomass. These two variants differed in the rate of 137Cs release: while in the internally contaminated biomass the rate decreased during composting, in the externally contaminated biomass the rate increased. The radionuclide was carried by humic acid-like compounds, especially by these with relatively low molecular size. The good practice would be not to leave contaminated biomass on fields if soil is to be protected. From another point of view, the activity of 137Cs in collected biomass decreases in a few months on an acceptable level if this biomass is composted under controlled conditions.

Figure 1: 137Cs release rates from externally contaminated (A) and internally contaminated (B) biomass (vertical dashed lines indicate water addition moments to reactivate biodegradation).


SCIENTIFIC METROLOGY IN SUPPORT OF RADON AND NORM ASSESSMENT Naturally occurring radionuclides are present in many natural resources such as raw materials and mineral feedstocks. Industrial activities that exploit these resources may lead to enhanced potential for exposure to Naturally Occurring Radioactive Materials (NORM) in products, by-products, residues and wastes. Over the last years, the building industry has developed new building materials that may contain significant quantities of technologically enhanced levels of natural radioactivity that should be evaluated. Building materials contribute to natural radiation exposure, either by gamma radiation from 40K, 238U and 232Th and their decay products to an external whole body dose exposure, or by radon exhalation to an internal dose exposure due to deposition of radon decay products in the human lung tissue. Reliable, traceable and consistent NORM activity measurements are necessary in order to optimize counter measures for the reduction of the exposure to the public and to NORM industry workers. This will then reduce the related follow-up costs. The lower the uncertainties of the NORM activity measurement results, the lower is the risk of possible over-responses of counter measures, with low radiological but high economic impact. The new NORM measurement methods, traceable reference materials and calibration sources developed under the EURAMET MetroNORM Joint Research Project, contribute to improve the radiological impact assessment models for the reuse of NORM residues in building materials and to establish a metrological sound basis for radiation protection in the NORM industries.

Figure: Radon tracks in a solid state nuclear track detector (left) and developed reference materials (right).


PROJECT ENVIREE - ENVIRONMENTALLY FRIENDLY AND EFFICIENT METHODS FOR EXTRACTION OF RARE EARTH ELEMENTS FROM SECONDARY SOURCES An intercomparison exercise was performed using both ICP-MS (CHALMERS) and INAA (IST-ID) for selected samples: Covas (PT), New Krankberg (SE), Ruigtepoort 1 and Ruigtepoort 2 (SA). IST-ID presented the data at the 4th ENVIREE progress meeting at AGH Krakow University and at the 5th ENVIREE progress meeting in South Africa (WP1, WP3, WP5). IST-ID continued the experiments with samples from New Krankberg and Covas using two different composition simulant solutions, to carry out a semi-quantitative analysis of the metals in the aqueous phases by ESI-MS mass spectrometer and ICP-MS. The ENVIREE Krakow Summer School on Rare Earth Elements recovery and environmental issues was carried out in 2017. Field trips took place at both progress meetings (ZGH Boleslaw Lead and Zinc Industry). Oral presentations were made by IST members during the progress meetings (INAA vs ICP-MS; Development of efficient and environment friendly separation processes for REE; Training, Education, Dissemination and Uptake in ENVIREE). Two lectures were presented by IST at the Summer Course (Secondary Sources Characterization and Sampling; and Chemical and Mineralogical Properties of REE Secondary Sources).


Radiation, Elements and Isotopes Group

TEAM

1The remaining 50% at the NET Group of C2TN. 2 from June to October.


Maria de Fátima Araújo Principal Researcher (Group Coordinator) 100

António Manuel Monge Soares Collaborator - Principal Researcher (retiree) -

António Nazareth Falcão Principal Researcher 100

Fernanda Maria Amaro Margaça Principal Researcher 100

Luís Manuel Cerqueira Alves Auxiliar Researcher 70

Luís Miguel Mota Ferreira Auxiliar Researcher 100

Paula Maria Carreira Paquete Auxiliar Researcher 100

Pedro M. F. Valério Auxiliar Researcher 90

Dina André Graduated technician 100

António Amaro Senior technician 100

Helena Marcos Senior technician 100

Manuela Correia Senior technician 100

Rute Pinheiro Senior technician 100

Catarina Galinha Post-Doctoral Researcher 501

Maria Helena Casimiro Post-Doctoral Researcher 100

Pedro Santos Post-Doctoral Researcher 100

Sandra Cabo Verde Post-Doctoral Researcher 100

Ana Monteiro Collaborator - PhD student (teacher at ESTeSL) -

Filipa Lopes PhD student 45

Filipa Pereira PhD student 50

Joana Madureira PhD student 100

Paula Alexandra Rodrigues PhD student 50

Rui Câmara Borges PhD student 40

Rute Flávia Chaves PhD student 50

Susana Sousa Gomes PhD student 100

Paulo Portela Research Fellow 100

Andreia Pereira2 MSc student 100

Andreia Severino MSc student 100

Catarina Palma MSc student 100



GREI is an interdisciplinary group with expertise on nuclear related analytical techniques and ionizing radiation dedicated to the investigation of Environmental Processes, Ancient Materials & Materials Processing. The group operates an Ionizing Radiation Facility with gamma and e-beam sources and a set of laboratory facilities and equipment to perform: elemental, isotopic and trace element determinations, radiocarbon dating; microbiological and chemical analysis of radiation effects in products; and MeV ion microbeam analytical techniques.

Concerning Environmental Processes research involves the investigation of ionizing radiation effects on the degradation of recalcitrant pollutants present in industrial wastewaters, to develop alternative strategies for remediation of their environmental impact. Also, the study of inactivation mechanisms of water and foodborne virus and bacteria suggests that ionizing irradiation is an effective tool for disinfection. Besides, studies on water resources management are being developed aiming at the evaluation of the impact of groundwater over exploitation in coastal areas in Portugal and Morocco and in the investigation of thermomineral waters circulation models in N Portugal. Finally, anthropogenic impacts and pollutant and natural sources of materials on diverse environments (aerosols, sediments, soils and plants) are being assessed based on elemental and isotopic compositions. Research on Ancient Materials are being developed aiming to assess sources, production and circulation of cultural materials (metals, glazes and glasses) from prehistoric to Early Modern Period by microanalytical (elemental and Pb isotopes) and microstructural characterization and radiocarbon dating. Besides, the seasonality of prehistoric molluscs during the Neanderthal occupation of Figueira Brava cave is being investigated by determining stable isotopes in marine shells. Research has been performed on macromolecular materials using ionizing radiation for processing or modification to obtain new properties optimized for biomedical applications (e.g., skin scaffolds) and conservation of cultural artefacts (roman mosaics).


MAIN ACHIEVEMENTS

CHALCOLITHIC AND EARLY IRON AGE JEWELLERY – 2000 YEARS OF GOLD TECHNOLOGY In the Portuguese territory, the Chalcolithic (c. 3000-2000 BC) gold jewellery mostly comprises basic shapes such as sheets, foils and wires, being quite different from the complex typologies from the Early Iron Age (c. 850-400 BC), which include the assembly of individual components and different types of adornments. The research has been identifying the technological developments that allowed this typological evolution, such as the use of less expensive and more workable raw materials by alloying the gold with silver (up to 42%) and/or copper (up to 6%). Moreover, the use of a partial melting/solid state diffusion process and/or copper-rich solder alloys allowed the manufacture of intricate shapes by joining different components and filigree decorations of Early Iron Age gold jewellery.

Copper and silver contents of Chalcolithic and Early Iron Age gold jewellery from the Portuguese territory (examples of a Bell Beaker spiral ring and an Early Iron Age pendant, both have about 2 cm width).


GOURD-SHAPED GLASS VESSELS: A PORTUGUESE LEGACY?

Late medieval gourd-shaped glass vessels are frequently found in archaeological excavations in Portugal.This type of glass shaped objects is not common in European finds, raising the possibility of a local Portuguese production. Glass material analysis using PIXE and LA-ICP-MS techniques was performed in order to identify the raw materials used and production techniques employed and to provide composition data which then allowed comparison with coeval glass objects produced in known European centres. Although the glass composition of one of these gourds is compatible with that of a Venetian glass, most of the remaining glass fragments present an high alumina content. This high content had previously been reported for other coeval Portuguese glass finds and then proposed to be the result of two yet unknown Portuguese production centres. This reinforcs the possibility of a

National production of the gourd-shaped glass vessels.

ROMAN METALLURGY IN LUSITANIA: SOURCES AND METAL FLUXES FROM REPUBLICAN PERIOD TO THE ROMAN EMPIRE.

The western end of the Roman World was occupied by the Lusitania province having important urban centres such as Conimbriga, Augusta Emerita and Mirobriga. The lead isotope and elemental characterisation of lead pipes with a Roman Empire chronology and Late Republican lead sling bullets assigned the lead sources to the Iberian Pyrite Belt (argentiferous jarosite ores) and Sierra Morena and Ossa Morena Zone (galena ores). The elemental study of anthropomorphic attachments of situlae identified a diversity of metals and alloys without standardised compositions, namely copper, leaded copper, leaded bronze, gunmetal and leaded brass. The research evidences that the Roman copper-based metallurgical production was strongly influenced by economic concerns, namely with an important use of recycling of scrap metal, a pattern that is also present in the lead technology from Roman urban centres especially during the Empire.


STRATEGIES TO MITIGATE CORK WASTEWATERS POLLUTANTS Cork wastewater is a recognized risk to the ecosystem if not properly treated before discharge. It contains phenolic acids that are recalcitrant compounds with high antioxidant activity. Their recovery could represent a potential way to valorise this wastewater. A comprehensive assessment of the toxicity and antioxidant activity of cork wastewater and the effects of gamma radiation, as an advanced oxidation treatment process, on these parameters was made aiming to access the feasibility of irradiation to reduce the environmental impact and/or increase its added value. It was observed that the radiolytic products of cork wastewater are more toxic than the parental ones and that the antioxidant potential increases. This could be relevant for a prospective application for valorisation of cork wastewater extractable phenolic compounds in other industries. Considering this, the removal of four phenolic compounds from cork wastewater was investigated using mesoporous carbons. The results suggested the use of activated carbon as an alternative technology to reduce the content of phenolic recalcitrant compounds in cork wastewaters.


ISOTOPE HYDROLOGY: MULTI-ISOTOPIC APPROACH IN COASTAL AQUIFERS AND THERMOMINERAL WATER SYSTEMS IN N PORTUGAL Discrimination between seawater intrusion (anthropic actions) and minerals dissolution (natural salinization) were the main goals of part of the investigations carried out during 2017. Studies on the impact of groundwater over exploitation in coastal areas were carried out in Algarve and at Lower Sado basin (Portugal) and in Morocco W Atlantic coast Essaouira basin. The major results obtained include: (i) evidences of mixing with ancient seawater trapped in the sediments during the Sado basin formation; (ii) evaporitic minerals dissolution at Tavira (Portugal), Essaouira (Morocco); and, active seawater mechanisms at Portimão/Faro. The study of thermomineral waters continued in the N part of Portugal, with the main objective of definition of conceptual circulation models in several aquifer systems, being the delimitation of the preferential recharge areas and evaluation of the mean residence time the main goals, to achieve a proper management and protection of this type of water resources.

Xarama river (Lower Sado Basin) - Identification of mixing processes superficial waters – groundwater systems.


ENHANCING THE SCOPE OF ICP-MS Inductively Coupled Plasma–Mass Spectrometry (ICP-MS) is a versatile technique capable of detecting and measuring concentrations of most elements of periodic table, making it suitable for a large number of analytical needs. Besides cultural heritage, which was the main focus of use of ICP-MS at C2TN, this technique has been optimised to cover more scientific areas and sample matrices. Microwave digestion was efficiently optimised for partial/total digestion of air particulate matter (APM). ICP-MS methodology was optimised for determination of major and trace elements in APM and for determination of rare earth elements in ionic liquids, soils, sediments, plants and waters from distinct environments. APM characterisation by ICP-MS allowed the application of source apportionment tools and trajectory statistical methods, which showed contribution of Sahara desert dust long range transport events to air quality in Lisbon district, and a non-crustal origin of Ni/V/Pb/Zn/Cr/Cd/Cu/As highlighting their anthropogenic sources (traffic, combustion and industrial emissions).

Crustal enrichment factors for PM2.5 sampled with a Leckel MVS6 in Teflon® filters (enrichment factors calculated using Fe as crustal reference element).


BIODEGRADABLE POLYMER MATRICES OBTAINED BY IONIZING RADIATION FOR SKIN SCAFFOLDS Progress on the optimization of biocompatible and biodegradable chitosan/polyvinyl alcohol (Chit/PVA) matrices prepared by gamma irradiation for tissue regeneration processes continued. It was found that the use of 2 freeze cycles followed by lyophilization and irradiation is more favorable to cellular growth on the matrices than the use of a freeze-dry cycle. Results also showed that the use of low molecular weight chitosan and the introduction of gelatin favor cellular growth leading to an improvement on cells’ morphology and cytoskeletal organization in comparison with previous results.

SEM images of Chitosan/PVA matrices obtained by gamma irradiation for use as skin scaffolds. HYBRID MATERIALS PREPARED BY IONIZING RADIATION FOR CONSOLIDATION AND PRESERVATION OF ROMAN MOSAICS PDMS-based ormosils with biocide activity were prepared and functionalized by gamma irradiation, aiming for application in the conservation of Roman mosaics from Conimbriga archeological site. Six different batches of PDMS-TEOS-ZrPO hybrid materials (HMs’) were prepared having attention to the variety and composition of the native materials already studied. Mosaics bioburden were also partially identified and used in the HMs’ biocide assays. Materials revealed to be compact and homogeneous with a smooth surface, transparent, monolithic and amorphous with a thermal resistance up to 350°C. All HM’s proved to be hydrophobic with the contact angle varying from 95 to 115°C. Biocide activity of HMs’ was tested with the most dangerous and resistant microorganisms found in Roman mosaics.: HMs’ with high content in ZrPO (20% wt) showed biostatic activity against Staphylococcus capitis capitis (Gram+), sporulated bacilli (Gram+) and fungi Aspergellius fumigatos (Gram+), without evidence of ionic migration (Zr) to the surrounding medium.

H1 33%PDMS/54%TEOS/7%ZrP




Nuclear Engineering and Techniques Group

TEAM


Maria Isabel Dias Principal Researcher with Habilitation – Group Coordinator 70

José Marques Coordinator Researcher with Habilitation 30

Maria Isabel Prudêncio Principal Researcher with Habilitation 80

Ulrich Wahl Principal Researcher with Habilitation 100

Nuno Barradas Principal Researcher with Habilitation (leave of absence) 10

João Guilherme Martins Correia Principal Researcher 100

José Antunes Principal Researcher 100

Fernando Carvalho Principal Researcher 30

Raquel Crespo Auxiliary Professor 80

Andreas Kling Auxiliary Researcher with Habilitation 30

Miguel A. Reis Auxiliary researcher 90

João Alves Auxiliary researcher 30

Rosa Marques Auxiliary Researcher 90

Tom Girard Auxiliary researcher 100

Marta Almeida Auxiliary Researcher 70

Ana Rita Ramos Auxiliary Researcher (leave of absence) 10

Ana Cristina Fidalgo Palma Fernandes Auxiliary researcher (contract) 100

Jan Mihalik Auxiliary researcher (contract) 501

Miguel Felizardo Auxiliary researcher (Invited) 30

Miguel Pereira Graduated technician 30

Joana Pereira Graduated technician (Grant) 30

Vincent Debut External collaborator (UNL; with PhD) 40

Vânia Martins Post-doctoral researcher 100

Joana Lage Post-doctoral researcher 100

Catarina Galinha Post-doctoral researcher 50

Nuno Canha Post-doctoral researcher 50

Tomoko Alice Morlat Post-doctoral researcher 100

P. Cristina Chaves Post-doctoral researcher 100

Margarita Evtyugina Post-doctoral researcher 30


1 The remaining 50% at the PSR Group of C2TN

Raúl De Diego Martínez Post-doctoral researcher 70

Alexandra Silva PhD Student 100

Tiago Faria PhD Student 100

Vitor Manteigas PhD Student 100

Ângelo Costa PhD Student 100

Eric Bosne PhD Student 100

Estela Vicente PhD Student 30

Miguel Carvalho PhD student (UNL) 80

Majdi Yangui PhD student (Sfax University, Tunisia) 50

Ahmad Baklouti PhD student (Sfax University, Tunisia) 50

Chaima Boussollaa PhD student (Sfax University, Tunisia) 50

Ana D’Espiney MSc Student 100

Joana Amaral MSc Student 30

Carlos Pina BSc student 100

Marta Reis MSc student 100

Marina Almeida Silva External Collaborator (with PhD) 30



The Nuclear Engineering and Techniques research group (NET) is directed towards the study and development of nuclear techniques applied in different sectors. Multidisciplinary research is paramount in all activities, playing a significant role in nuclear physics and engineering and in the use of nuclear analytical techniques (NAT) into several domains. Gamma and alpha Spectroscopy and various ion-beam based techniques (Rutherford Backscattering, Elastic Recoil Detection, Nuclear Reaction Analysis and Resonant Elastic Scattering), Particle Induced X-ray Emission (PIXE), complemented with other techniques like X-ray diffraction (XRD) are all specialized techniques available within C2TN employed by the NET group towards a deep material’s characterization. Furthermore, the group maintains an experimental infrastructure at ISOLDE-CERN using short-lived isotopes and has access to international laboratories such as GSI, GANIL, RIKEN and BNC for complementary activities. These diversified approaches enable NET to perform research on advanced materials with unique radioactive beams and nuclear techniques. Upon emission and detection of the radiation we probe their interactions with matter, providing unique information regarding the structural, electronic, magnetic and dynamical local properties. Vibratory modelling and neutron transport simulation via the Monte Carlo method is employed in various applications. The development of state-of-the-art software for X-ray analytical methods and of quantitative instrumental speciation methods, mainly for PIXE is another goal. Research on air pollution assessment and indoor air quality, developing decision support tools to the transition to a low carbon economy is also a major goal. Research is also devoted to Cultural Heritage through dynamical characterization, provenancing and absolute dating, creating a more integrated framework for the study of the immovable cultural heritage assets. Besides basic research, NET is also involved in research projects and contracts. The main areas and the most important actors in these projects are the environmental and cultural heritage, the advanced materials and the medical sectors. Moreover, education and training is a major mission of NET group, being encompassed in several PhD and MSc programs, as well as, dissemination actions bridging expertise across disciplines, promoting integration beyond the university level, and engaging academic into practical problem-solving to better reach and influence society.


MAIN ACHIEVEMENTS

SUPERHEATED LIQUID DETECTORS The superheated liquid detectors developed by our group were upgraded for the IVth phase of the SIMPLE dark matter search, and exploited towards novel applications in alpha particle detection. Developments of the SIMPLE bubble chamber aiming at a 103 sensitivity improvement comprise a new hydrophone-based acoustic instrumentation and an integrated frequency-based analysis capable of discriminating signal events from acoustic background. The alpha-droplet interaction within superheated droplet detectors (SDD) was examined via computational studies, and a geometric model developed to describe the detector response. Experiments with U and Sm-doped SDDs at 5-12oC evidenced a dependence of the event rate with the droplet sizes, in model agreement for temperatures below 8oC. Above higher temperature, the increasing bubble population yields an acoustic sensitivity loss that, once corrected by attenuation coefficient, restored the agreement with experiment. The results suggest the viability of a SDD-based alpha spectrometer using mono-sized droplets. DETAILED STUDIES OF AMPHOTERIC MG-DOPANT IN GAN Mg-doped p-type GaN is a core component of solid state white lighting or blue lasers optoelectronic devices. Despite the technological maturity of GaN, there is an inherent doping limit since above a certain concentration of substitutional Mg introduced during growth, it becomes interstitial. Using the β-emission channeling radioactive technique, we obtained direct evidence for the amphoteric nature of Mg [U.Wahl et al. PRL 118 (2017) 095501]. Recent detailed studies showed that above 400°C

interstitial 27Mg progressively converts to substitutional Ga sites in all GaN doping types with migration activation energy estimated between 1.3 and 2.1 eV. These studies performed at the CTN EC-SLI unique setup mounted at the ISOLDE beam line provide a breakthrough understanding of the Mg behaviour in GaN suggesting that ion implantation and annealing can achieve higher p-type doping levels, as required for high power electronics. Arrhenius curves plotted as a function of temperature, for interstitial 27Mg becoming substitutional at Ga sites in GaN for differently doped samples: top-left n-GaN:Si, top-right GaN (undoped), bottom-left GaN:Mg (as grown), bottom-right p-GaN:Mg.


NUCLEAR HYPERFINE INTERACTIONS ON HG HALIDES Where early experiments (Berkeley, Bonn) in the 1970s had failed, we have successfully made the first Perturbed Angular Correlations, PAC, nuclear hyperfine interactions experiments on the 5/2+ 197Hg state in free Hg-halide molecules. The use of linear molecules (HgX2, X = I, Cl, Br) allow very precise measurements of the quadrupole moments, Q, of Hg isotopes, which are currently applied in numerous material and soft matter/bio physics experiments tracking heavy metals, binding and dynamics. Such experiments also provide precise Q-values used in the refinement of nuclear fundamental theories. The data are still requiring final fitting including centrifugal stretching, vibrational excitation, quantum effects and nuclear recoil to compare with quantum chemistry calculations for Hg halides.

Plots of expected (theory) and experimental observables R(t) PAC data for the (top) free HgI2 molecules in gas phase and (bottom) with HgI2 molecules in dense Ar (1.5bar) gas.


CHARACTERISATION OF AD-ATOMS AND AD-MOLECULES ON GRAPHENE Achieving n-, p-type stable doping of graphene is being investigated for different metal dopants, particularly for Hg single atoms and the (easily made) stable linear HgO2 molecule. Several configurations of freestanding Hg and HgO2 molecules with respect to the graphene surface were analysed with Density Functional Theory (DFT). In parallel Perturbed Angular Correlation experiments were performed with 199mHg obtaining the experimental hyperfine fields characterising a specific Hg–... HgO2 ad-atom or ad-molecule configuration on the graphene layer. Among a multitude of possible configurations, the free O-Hg-O dumbbell lying in-plane with the Hg atom above the hollow site (in the centre of the C-hexagon) with oxygen bonds aligned along the C-C bonds, uniquely fit the PAC experimental results.

Simulation plot of the highly stable configuration experimentally and theoretically found for the dumbbell O-Hg-O ad-molecule “freestanding” on graphene.


X-RAY AND NEUTRON-BASED NON-INVASIVE ANALYSIS OF STONE ARTEFACTS AS A CONTRIBUTION TO UNDERSTAND MOBILITY AND INTERACTION NETWORKS IN PRE-HISTORY OF SOUTHERN IBERIAN PENINSULA Stone idols and vases from Perdigões Chalcolithic site (Portugal) were analysed. The investigation had interdisciplinary character based on physical-chemical and archaeological knowledge. These carbonate-rich archaeological artefacts are difficult to correlate with raw materials of such heterogeneous geological sources, especially when only non-invasive analysis is possible. A novel combination of X-ray and neutron-based non-invasive analysis was implemented and used for the first time to study prehistoric stone idols and vessels, comprising prompt gamma activation analysis (PGAA) and external beam particle-induced x-ray emission for chemical composition and neutron radiography to provide structure and shape diversity. Results, especially of PGAA, were capable to distinguish between marble/limestone samples originating from different known geological sources, and matching artefacts to sources. The stone artefacts show signs of both nearby and long-distance procurement, and of unknown attribution. Different raw material provenances seem to be associated with different contexts and rituals, deepening the contrasts between funerary features in Perdigões site.

Stone idols from Perdigões archaeological site, Southern Portugal (Dias, M.I., Kasztovszky, Z.S., Prudêncio, M.I., A. C. Valera, Maróti, B., Harsányi, Kovács, I., Szokefalvi-Nagy, Z. Archaeol Anthropol Sci (2017). https://doi.org/10.1007/s12520-016-0457-2).


DEVELOPMENT OF SOFTWARE FOR X-RAY ANALYTICAL METHODS AND QUANTITATIVE INSTRUMENTAL SPECIATION METHODS FOR PARTICLE INDUCED X-RAYS EMISSION (PIXE) L3 yields of Yb measured during Oxygen beam irradiations showed differences between O2+ and O3+ beam irradiations, for the same energy, after taking into account the collecting charge for each single spectrum, corrected to the ion charge. As shown below, at 3.0 MeV, the values obtained for O2+ are nearly twice the values obtained for O3+.

CHEMICAL ELEMENT ACCUMULATION IN TREE BARK GROWN IN VOLCANIC SOILS The semi-arid Cape Verde archipelago has incipient soils with high potential of imbalance of chemical elements due to diverse magmatic events. Nevertheless these volcanic soils are a valuable resource of these islands for agriculture. So the eventual impact on the health of plants and animals must be evaluated. A first assessment of elements uptake by plants grown in the island of Fogo was done using acacia bark as biomarker. High EFs found for some chemical elements in barks are certainly of geogenic origin rather than anthropogenic since industry and the use of fertilizers is scarce. Among REE, the heavy ones are significantly enriched, which agrees with their release after the primary minerals breakdown with formation of more soluble compounds than the other REE. These results show how biogeochemistry may contribute to the REE fractionation in the critical zone.


FOSTERING A LOW CARBON-ECONOMY IN SCHOOLS The EU Roadmap 2050 suggests that, by 2050, the EU should cut its greenhouse gas emissions to 80% below 1990 levels. In this framework NET is coordinating the project Interreg Sudoe ClimACT (www.climact.net) that aims to promote the transition to a Low Carbon-Economy in schools. During 2017 environmental and energy performance was assessed in 39 European schools, from primary until university level. Complementary approaches such as energy efficiency, sustainable transportation, green procurement, resources conservation and behavioural change were design to support schools

managers, energy and environment players and students in the identification of smart solutions for schools that contribute for the greenhouse gas emission reduction. The novelty of this research is the global approach considering collaboration with scientific, technology and business initiatives, the development of integrated decision support tools, the design of new business models and the development of holistic, comprehensive and technology-assisted educational platform for active learning.

DOSE ASSESSMENTS IN MEDICAL APPLICATIONS As far as mammography is concerned, one relevant work we developed characterizes the practice at 65 mammography units and the other presents dose reference levels measured with TLD and direct readings later compared with European reference documents and recommendations. Another relevant achievement in this field concerns the use of needle holders in fluoro-CT biopsies collections showing the improvements in practical radiation protection and in dose reduction.

(a) (b) (c) (d) Special glove with casings to hold extremity dosemeters; (b) dose distribution assuming the results of the 78 biopsies studied (lung, bone, etc tissue), before the use of needle holder; (c) (b) dose distribution assuming the results of the 78 biopsies studied after the use of needle holder; (d) example of a needle holder.


DEVELOPMENT OF A COMPUTATIONALLY EFFICIENT DYNAMICAL MODEL OF CONSTRAINED FLEXIBLE SYSTEMS USING A MODAL UDWADIA-KALABA FORMULATION Most structures consist on dynamical subsystems connected at constraining points. While standard modelling techniques use Lagrange multipliers or penalty methods, Udwadia & Kalaba (U-K) encapsulated the constraints into a single dynamical equation. We extended their approach to continuous flexible systems, through modal description, while addressing highly nonlinear intermittent constraints. Efficient numerical simulations performed include the (1) dynamics of a complete guitar, incorporating many modes and linear constraints; (2) flow-excited vibro-impact responses of multi-supported tubes with clearances, typical of nuclear steam generators.

Application of the modal Udwadia-Kalaba formulation to simulate the dynamical response of a guitar.

Dynamical simulation of the vibro-impact responses of a multi-supported tube of a nuclear steam generator using the modal Udwadia-Kalaba formulation.


f-Element Chemistry Group

TEAM


João Paulo Leal Auxiliary Researcher with Habilitation – Group Coordinator 90

Joaquim Marçalo Principal Researcher 90

Joaquim B. Branco Auxiliary Researcher 90

José Manuel Carretas Auxiliary Researcher 90

Leonor Maria Post-doctoral Researcher (FCT grant) 100

Bernardo Monteiro Post-doctoral Researcher (FCT project grant) 100

Ana C. Ferreira Post-doctoral Researcher (C2TN grant) 100

Adelaide Cruz Graduated Technician 100



The research activities of the QEf Group are centered in the study of the chemistry of lanthanides and actinides at fundamental and applied levels, with focus on topics of relevance in environmental, nuclear and materials sciences. The activities comprise the synthesis of new f-element compounds and materials (complexes with new coordination environments, metal-organic frameworks, ionic liquids, nanostructured intermetallic compounds and bimetallic oxides), the examination of their properties, searching for unusual or enhanced behavior, and reactivity and catalytic studies (activation of unsaturated and redox-active substrates, activation/elimination of major gaseous pollutants such as CO2, CH4 and N2O, and production of value-added compounds such as CH3OH). The investigation of the thermodynamic properties of key species in condensed and gas phases is conducted and methods for their prediction are developed. Also the recovery of Rare Earths Elements (REE), considered as critical materials by the European Commission, is carried out by QEf group. The QEf Group collaborates with other groups within C2TN: ES Group - magnetic properties of uranium complexes and layered lanthanide hydroxides; synthesis of nanostructured intermetallics, metal borides, pnictides and chalcogenides, and study of their thermoelectric properties. REI Group - use of gamma radiation for the synthesis of new polymeric materials. REI, RPS and NET Groups - within the European Project “ENVIronmentally friendly, and efficient methods for extraction of Rare Earth Elements from secondary sources” (ENVIREE). Outside the Center, the QEf Group has collaborations with: IPFN-low temperature plasmas for activation of methane and carbon dioxide; CQB-FCUL-thermochemical studies; IPMA/CERENA-IST-FCT project REEuse (Recovery versus environmental impacts of Rare Earth Elements derived from human activities,); REQUIMTE–luminescent and thermochromic ionic liquids with lanthanides; and other research groups in the framework of the Portuguese Mass Spectrometry Network. The QEf Group participates also in the FCT Doctoral Programme CATSUS-Catalysis and Sustainability and in COST ACTION ES1407 (ReCreew).


MAIN ACHIEVEMENTS

PROBING HIGH OXIDATION STATES IN THE LANTHANIDE SERIES Lanthanide (Ln) chemistry is dominated by the +3 oxidation state, although some Ln show significant +2 and +4 chemistry. Recently, the synthesis of molecular Pr(V) species, in the gas phase and/or in noble-gas matrices, was reported. We have previously demonstrated that [Ln(NO3)4]- complexes, produced by ESI-QIT-MS, yield [LnO(NO3)3]- species by collision-induced dissociation (CID) after NO2 elimination, and that their relative hydrolysis behavior is related to the stability of the Ln +4 oxidation states. For Ce, Pr and Nd, it was possible to form [LnO2(NO3)2]- ions by subsequent CID of [LnO(NO3)3]-

, and these anions revealed different reactivities with water, namely, hydrolysis for Ce, hydration for Nd and no reactivity for Pr. These differences seem to indicate that Pr is in a stable +5 oxidation state, which was confirmed by ab initio computations. Pr(V) is clearly accessible and higher oxidation state lanthanide chemistry could be richer than previously supposed.


NANOSTRUCTURED BIMETALLIC OXIDES AND INTERMETALLIC COMPOUNDS CONTAINING F-BLOCK ELEMENTS We continued our work on the preparation by electrospinning and characterization of nanoparticles and nanofibers of intermetallic compounds and bimetallic oxides containing f-block elements (lanthanides, Th and U), copper or nickel. The preparation and characterization of thermoelectric materials such as metal borides, pnictides and chalcogenides was also undertaken. Electrospinning is a reproducible and low cost route that enables the production of nanostructured materials, which expected high surface areas and tunable surface properties bring benefits to their properties. Applications of these compounds were studied: i) studies in heterogeneous phase catalysis for the production of value added products, such as methane, using primary pollutants, such as CO2 as feedstock, Figure a, and ii) for the generation and storage of energy, application as thermoelectric materials (CuxSy) and hydrogen absorbers (important for the development of fuel cells), Figure b.

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CO2 AS RAW MATERIAL FOR THE PRODUCTION OF METHANE The use of CO2 as chemical feedstock is limited to a few processes: synthesis of urea (for nitrogen fertilizers and plastics), salicylic acid (a pharmaceutical ingredient), and polycarbonates (for plastics). In this context, the hydrogenation of CO2 to methane is a major catalytic goal. The methanation of carbon dioxide has a range of applications including: i) the purification of synthesis gas for the production of ammonia, ii) the production of syngas or iii) their use to convert the Martian CO2 atmosphere into CH4 and H2O for fuel and astronaut life support systems. In this work, production of methane was achieved in a continuous atmospheric pressure flow reactor using carbon dioxide and hydrogen as reagents (250 - 500 oC, GHSV=15000 mLCO2/g.h and H2/CO2=4 mol:mol). The results confirm the potentialities of the bimetallic oxides and intermetallic compounds containing f-block elements as catalysts, especially when compared with the behavior of a commercial rhodium hydrogenation catalyst (5%Rh/Al2O3) used as reference. The Figure shows the results of methane synthesis over nanoparticles of nickel bimetallic oxides containing f block elements at 400 oC

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U…H-B AGOSTIC INTERACTIONS IN HOMOLEPTIC URANIUM(IV) BIS(MERCAPTOIMIDAZOLYL)BORATE COMPLEXES The choice of the ancillary ligand is crucial for the stabilization of metal complexes in various oxidation states and in promoting innovative reactivity. In a previous work in our lab, monoanionic hydrobis(mercaptoimidazolyl)borate ligands showed their ability to stabilize trivalent uranium complexes. Studies were pursued in order to access complexes with uranium in other oxidation states. Oxidation reactions of the trivalent uranium complex [UI(κ3-{H(Ph)B(timMe)2})2] provided access to the new homoleptic cationic uranium(IV) complexes [U(κ3-{H(Ph)B(timMe)2})3][X] (X = BPh4, I; timMe = 2-mercapto-1-methylimidazolyl). Multinuclear NMR and IR spectroscopies and X-ray diffraction analysis were consistent with a κ3-H,S,S coordination mode for the three hydrobis(mercaptoimidazolyl)borate ligands, favoring nine-coordinated U(IV) complexes in tricapped trigonal prismatic geometries. These recent results expand the field of non-aqueous uranium chemistry with soft donor ligands and demonstrate that hydrobis(mercaptoimidazolyl)borate ligands can also form robust complexes with U4+ ions. EU(III)-BASED IONIC LIQUIDS: A THERMOCHROMIC AND SELF-ORGANIZATION CASES IN A FAMILY OF HIGHLY EMISSIVE EU(III) TETRAKIS-Β-DIKETONATE IONIC LIQUIDS WITH AN ALKYLPHOSPHONIUM AS COUNTER-ION

This work identified the first example of an observable and reversible case of thermochromism of an Eu(III) room temperature ionic liquid, [P6,6,6,14][Eu(fod)4] (1). This thermochromism is characterized by the conversion from light yellow (room temperature) to a reddish hue (ca. 80 ºC) due to an unusual interaction between one fod ligand and the phosphonium counter-ion. The reversibility of this optical effect presents applicability as an alcohol sensor adressing the “Food security, (…)” societal challenge (Backcover Picture - Chem. Commun., 2017, 53, 850-853). By changing

the β-diketonate of the Eu(II) complex we extended the studies to the self-organization of the family 1, [P6,6,6,14][Eu(fod)3(dbm)] (2) and [P6,6,6,14][Eu(dbm)4] (3) highlighting the role of the cation [P6,6,6,14]+. The luminescence quantum yields determined for 1, 2, and 3 are 34%, 59%, and 64%, respectively, with the highest values being comparable with the maximum values previously reported for complexes of the same type.


LAYERED EUROPIUM HYDROXIDE SYSTEM FOR PHOSPHOROUS SENSING AND REMEDIATION Addressing the societal challenge “Climate action, environment, resource efficiency and raw materials”, we performed an experimental study of a dual-channel sensor towards anions formed by a LEuH material intercalated with 2,6-naphtalene dicarboxilate (LEuH-2,6-NDC). The sensor was tested with several biological relevant anions and the changes in NDC and europium emission intensities, upon excitation of NDC, were studied. Phosphate was found to have the highest degree of intercalation and displayed a strong increase (400%) on the fluorescence intensity of NDC. Intercalation of phosphate was further confirmed with Inductively Coupled Plasma-Atomic Emission Spectrometer (ICP-AES). Taking advantage of LEuH selectivity towards phosphate, its applicability in phosphorus remediation was studied presenting high sequestration capacity followed by controlled release of phosphate in three consecutive cycles and improved stability of the LEuH host material. These results highlight the significant potential of LLHs as new scavenging agents for inorganic phosphate.

MEMBRANES WITH A LOW LOADING OF METAL–ORGANIC FRAMEWORK-SUPPORTED IONIC LIQUIDS FOR CO2/N2 SEPARATION IN CO2 CAPTURE Answering the societal challenge “Secure, clean and efficient energy”, we studied Mixed Matrix Membranes (MMM) comprising a very low upload of IL@MOF with an improved CO2/N2 separation with applicability as CO2 adsorber for the development of fuel cells. Preparation of the MMMs starts by the immobilization of the ionic liquids (ILs), 1,1,3,3-tetramethylguanidinium azide (TMGA) and 1-ethyl 3-methylimidazolium tricyanomethane ([EMIM][C(CN)3])) into 3D metal–organic frameworks (MOFs, MOF-5 and Mg-MOF-74). The incorporation of these composites in a polyimide-based matrix (Matrimid® 5218) to yield [IL@MOF]@Matrimid®5218 proved to be an efficient strategy to improve the permeability and selectivity toward CO2/N2 mixtures, presenting also a remarkable improvement in membrane flexibility and mechanical resistance. Using MOF-5, a crystalline phase different from its original phase is obtained after the incorporation of hydrated IL without loss of adsorptive properties (Cover Picture - Energy Technol. 2017, 5, 2158-2162).


MOLECULAR ENERGETICS A great effort was done during last years to have available and reliable thermochemical data for molecules. Databases were developed, enthalpies of formation and bond dissociation enthalpies were measured, prediction properties enhanced, measuring devices built. During 2017 some achievements deserve emphasis: 1- The beginning of studies for the understanding of the influence of hydration waters in the energetics of crystalline compounds, namely alkaline, alkaline-earth and lanthanide chlorides. 2- After the first results published this year showing that a second chemical function has no effect in the energetics of a metal salt with monocations, a study with a divalent cation and trivalent cations (lanthanides) is undergoing. 3- Dissolution of metals in ionic liquids continues in order to clarify in which species the metal is in the solution. Also, the absorption of water by an ionic liquid was studied leading to the conclusion that it involves a two-step mechanism, superficial adsorption and diffusion inside the ionic liquids (a manuscript is in preparation).


RARE EARTH RECOVERY AND VALORISATION AND PROTECTION OF ENVIRONMENT The European Commission defined a list of critical materials for Europe, in terms of economic importance and supply risk. Among them are Rare Earths Elements (REE) that play an essential role in modern electronic technologies, industrial and medical products and innovative environmental technologies. The QEf group is deeply involved in defining and improving ways of recovering REE from a variety of sources: from secondary materials resulting from mining activities (European Project “ENVIronmentally friendly and efficient methods for extraction of Rare Earth Elements from secondary sources” - ENVIREE); from urban and industrial effluents (FCT Project – “Recovery versus environmental impacts of Rare Earth Elements derived from human activities” - REEuse, PTDC/QEQ-EPR/1249/2014) or from electric and electronic waste (COST action ES1407 - European network for innovative recovery strategies of rare earth and other critical metals from electric and electronic waste - ReCreew). Due to the large use of REE in industry, the discharge of these metals in the environment has increased. It is important to know their cycle in the aquatic media and this is a second area where the expertise of the QEf group can be important and is also addressed in the REEuse project.


Solid State Group

TEAM


Manuel Leite de Almeida Principal Researcher – Group Coordinator 100

António Pereira Gonçalves Coordinating Researcher 100

João Carlos Waerenborgh Principal Researcher 100

Vasco da Gama Principal Researcher 100

Laura C. J. Pereira Principal Researcher 100

Elsa Branco Lopes Auxiliary Researcher 100

Isabel Cordeiro Santos Auxiliary Researcher 100

Dulce Belo Invited Researcher (C2TN contract) 60

Sandra Rabaça Post-doctoral Researcher (FCT grant) 60

Maria Augusta Antunes Post-doctoral Researcher (FCT grant, QEf-C2TN) until March 50

Gonçalo Nuno Pinho de Oliveira Post-doctoral Researcher (C2TN grant) since March 100

Bruno Vieira Post-doctoral Researcher (C2TN grant) 100

Joana T. Coutinho PhD student (FCT grant), until June 100

Joana Catarina Capinha de Matos PhD student (FCT grant) 50

Maria Antonieta Susano Pinheiro PhD student (FCT grant) 50

Sandrina Oliveira PhD student (FCT grant) 100

Rafaela Silva PhD student (FCT grant) 100

Sangib Chowdhury PhD student 100

Ana Cristina Gonçalves PhD student (FCT grant), until September 100

Mariana Velho PhD student (FCT grant), since September 50

José Francisco Malta PhD student (FCT grant), since September 50

Frederico Malacho MSc student, until June 100

Gonçalo Domingues MSc student, until June 100

Afonso Varatojo MSc student since September 100

Tiago Alves MSc student (Erasmus+) since September 100

Gonçalo Gonçalves Brás Lopes MSc student, since February 100

Carlotta Michale MSc student (Erasmus+) until July 100



The Solid State Group is a multidisciplinary research group focused on the study of selected new materials with unconventional electrical and magnetic properties. The group combines a wide range of expertise ranging from the synthetic chemistry of either molecular materials with transition metal complexes and electro active organic molecules or intermetallic compounds, to many different specialized solid state characterization techniques. Besides molecular synthesis (organic and inorganic), high temperature synthesis and crystal growth, X-ray diffraction laboratories, the facilities developed maintained and operated by the group include the Low Temperature and High Magnetic Field Laboratory (LTHMFL) that has been developed around the only helium liquefier operational in Portugal. The LTHMFL hosts different specialized equipment for measurements at low temperatures down to 0.3 K and under high magnetic fields up to 18 T, including several magnetometers (SQUID, extraction and AC susceptibility) electronic transport and magnetotransport equipment, and Mossbauer spectrometers. The group pursued basic research activities in Molecular materials aiming at further development of multifunctional (electric and magnetic) molecular materials and the study of novel electronic states, including Neutral transition metal bisdithiolene complexes for single component molecular metals and their processing by solution techniques, Bilayer molecular conductors; based on cyano-substituted TTF donors; Single-Molecule-Magnet behaviour in mononuclear U and Ln coordination compounds. Activities in intermetallics were focused on the study of Strongly correlated electron behaviour in f-element compounds, development of materials for spallation targets and new Thermoelectric compounds with enhanced performance. The group also maintained the LTHMFL as an open facility, available to the external scientific community on a scientific collaboration basis, and participated as Director and core team members of the FCT Doctoral Programme ChemMat- Chemistry of Materials with electronic, magnetic and optical functionalities.


MAIN ACHIEVEMENTS

TWO CHAIN CONDUCTING AND MAGNETIC COMPOUNDS

Conducting perylene chains and anionic chains, that can be paramagnetic (M=Pt) or diamagnetic (M=Au). The electrical and magnetic properties of the solid solutions (Per)2[PtxAu(1−x)(mnt)2] were investigated, probing the effects of paramagnetic centers in

the diamagnetic chains, and effects of breaking the paramagnetic chains with diamagnetic centers, for low and high Pt concentrations respectively. In the low x range, there is a fast

decrease of the metal-to-insulator transition from 12.4 K in the pure Au compound to 9.7 K for x=0.1 comparable to the 8.1 K in the pure Pt compound.

In the range x=0.50−0.95, only β-phase crystals were obtained. The spin-Peierls transition of the pure Pt compound, simultaneous with metal-to-insulator (Peierls) transition, is still present for x=0.98 with transition temperature barely affected. The β-phase structure was found to contain ordered layers with segregated donors and anion stacks, alternating with disordered layers, with semiconducting properties due to disorder localization effects. NEW SINGLE COMPONENT MOLECULAR CONDUCTORS Single Component Molecular Conductors have attracted a large interest due to their potential use as the basic components in light and transparent organic electronic devices. In this context, new neutral gold and nickel bisdithiolene complexes with methyl-substituted thiophenetetrathiafulavalenedithiolate ligands -[M(α-mtdt)2]0- were prepared and characterized. Both magnetic and electric transport properties indicate that these compounds are the most recent members of a still small family of SCMC. [Au(α-mtdt)2]0 and [Ni(α-mtdt)2]0 display as polycrystalline samples properties of a metallic system with a room temperature electrical conductivity of 0.32 S/cm and ≈4 S/cm and a thermoelectric power of ≈5 µV/K and ≈32 µV/K, respectively. While [Au(α-mtdt)2] presented a Pauli like magnetic susceptibility typical of conducting systems, in [Ni(α-mtdt)2] large magnetic susceptibilities, indicative of high spin states, were observed.


CNB-EDT-TTF SALTS WITH CLO4; BILAYER POLYMORPHS AND DIFFERENT STOICHIOMETRIES The electron donor CNB-EDT-TTF was recently found to give salts with small anions, characterised by a new type of bilayer structure of the donor molecules and with unique 2D metallic properties. A study on the preparation of salts with ClO4 anions under different electrocrystallisation conditions enabled to obtain besides salts with 4:1 donor:acceptor stoichiometry and bilayer donor structure, another salt with 1:1 stoichiometry dependent on the solvent and other experimental conditions. The salts β”-(CNB-EDT-TTF)4ClO4 were obtained in two polymorphs (monoclinic and triclinic), putting into evidence a new aspect of polymorphism in these bilayer metals, associated with the orientation of donor molecules in β”- type consecutive bilayers. ER MAGNETIC AND LUMINESCENT COMPOUNDS The development of the multifunctionality approach with lanthanoid-based materials has proven to be a challenge. Lanthanides have unique properties associated parity-forbidden 4f–4f transitions and large magnetic moments of partially filled f-levels making them appealing for dual-function (optical–magnetic) materials. In this context a new Er3+ homodinuclear complex bridged by an aromatic molecule, [Er2(nd)6(μ-bpm)], (nd= 2,4-nonanedione, bpm= 2,2′-bipyrimidine) was prepared. The bridging ligand bipyrimidine allows indirect exchange between Er magnetic moments. This compound displays NIR luminescence when excited in the UV region (360-375 nm), after a ligand-to-lanthanide energy transfer and presents slow relaxation of magnetization only under a small static field. Some persistence of a relaxation by quantum tunnelling via the ground state and the first excited state could be explained by the lack of a perfect axial g-tensor, and thus by a small mixing between the ground and excited states, as elucidated by the ab-initio calculations.


IRON OXIDE NANOPARTICLES FOR HIPERTHERMIA Iron oxide nanoparticles (Fe3O4, SPIONs) are promising candidates for several biomedical applications such as magnetic hyperthermia and as contrast agents for magnetic resonance imaging (MRI). Organic incorporation in liposomes (magnetoliposomes) and inorganic encapsulation with silica are interesting possibilities. However, their colloidal stability in physiological conditions hinders their application requiring the use of biocompatible surfactant agents. Aiming at the design and development of new nanoparticles for enhanced theranostic techniques, namely for magnetic resonance imaging and for directed drug delivery, silica-based matrices were prepared and decorated with SPIONs . Good saturation of magnetization values for the specific size and morphology of the synthesized SPIONs were achieved for samples dried in vacuum at RT (∼64 emu/g), comparable with the literature results (∼60 emu/g). These results contribute to achieve a compromise between the use of oleic acid as a stabilizer of iron oxide colloids and its influence on their biomedical application. SINGLE-MOLECULE-MAGNET (SMM) BEHAVIOUR IN URANIUM COMPOUNDS Uranium complexes are unique counterparts to the lanthanides in order to understand single ion magnet behaviour and possible applications in quantum computing and spintronics. Aiming at contributing to a better description of the magnetic ground state and to separating the role of uranium and the radical ligands in the SMM behaviour of these systems, different approaches using spectroscopic (FIR and HF-EPR) and theoretical investigations have been employed. An X-ray magnetic circular dichroism (XMCD) study at ESRF beamline ID12 was performed for six uranium compounds, 3 based on hydrotris (3,5-dimethylpyrazolyl)borate (TpMe2) and other 3 based on trisamido-1,4,7-triazacyclononane [(SiMe2NPh)3-tacn]. Low temperature experiments at the M4,5-edge of uranium made possible to test and confirm the existing magnetic results and successfully deducing the spin and the orbital magnetic moment carried by the U-5f states. This separation of contribution is of paramount importance to understand the SMM behaviour of these compounds.


MÖSSBAUER SPECTROSCOPY Mössbauer spectroscopy has been extensively used as sensitive tool to determine oxidation state, coordination geometry and ordering of magnetic moments of iron in a variety of materials. In the specific case of a photoresponsive molecular polyanion prepared and characterized by Instituto de Ciencia Molecular (University of Valencia), Fe Mössbauer spectroscopy clearly showed that Fe(III) was reduced upon irradiation with UV light. The K salt of this material, in which two Fe(III) ions are simultaneously coordinated by two [A-α-PW9O34]9- polyoxometalate units and two oxalato ligands, when irradiated with UV light, exhibits a remarkable photocoloration effect due to the partial reduction of the POM units to give rise to a mixed-valence species. The process is reversible when UV light is switched off. The spectra show the material before (a) after irradiation (b), 24 h (c) and 5 days (d), after UV light switch off. MAGNETISM AND STRONGLY CORRELATED ELECTRON BEHAVIOR IN INTERMETALLICS The study of magnetism and strongly correlated electron behaviour in intermetallic systems containing f-elements has been a continuing topic of research in the Solid State group. In this context, a novel ternary compound, UMo3B7, has been synthesized and characterized. It crystallizes in the YMo3B7-type structure, which exhibits a well-developed two-dimensional boron network and is composed of boron

filled trigonal prisms as well as unfilled tetrahedra and tetragonal pyramids formed by metal atoms. Specific heat, magnetic susceptibility and electrical resistivity studies point to the inexistence of long-range magnetic order above 500 mK in UMo3B7. Rather, a spin fluctuation scenario characterizes the low temperature behavior of resistivity, magnetic susceptibility and specific heat of this compound, resulting in a moderately enlarged Sommerfeld value of γ = 28 mJ/(molK2).


SPALLATION TARGETS The ISOL method is an efficient way to produce radioisotope ion beams of good quality. In this technique, a high-energy beam (e.g., protons) hits a target to produce the radioisotopes of interest through different nuclear reactions. However, the radioisotopes must be quickly released from the target, which can be done by optimisation of the target microstructure and increasing temperature. Uranium carbide is among the best target materials due to its high temperature stability and good thermal conductivity. Aiming at increasing the release rates, nanostructured materials are being tested. In this context, YCx nanofibers were prepared by electrospinning and studied the effects of the solution characteristics and electrospinning process parameters on the as-spun materials. It was concluded that the slowly heating (1oC/ min) of fibers up to 600oC is of fundamental importance to keep the fiber morphology upon polymer decomposition. NEW THERMOELECTRIC MATERIALS The substitution of Te for Se was explored in the well-studied α-As2Te3 in order to study the changes in the electronic band structure and thermoelectric properties. The electrical resistivity and thermopower gradually increase with Se due to the progressive increase in the band gap. Se substitution further lowers the lattice contribution to thermal conductivity reaching 0.35 W m−1K−1 above 300 K in α- As2Te1.5Se1.5. Unfortunately Se substitution does not enable achieving higher thermoelectric performances in comparison to substitutions of Sn and Bi for As. Several compositions

in the Cu-As-Te glassy system were prepared by melt quenching followed by SPS. The electrical transport properties of CuxAs55-xTe45, Cu15As85-

yTey and Cu20As80-yTey compositions were probed, displaying high electrical resistivity (>10-2 Ωm) and high thermopower (>500 µVK-1), as typically observed in chalcogenide glasses. Although the thermal conductivities measured are low (<0.3 Wm-1K-1), ZT values remain below 0.1, mainly due to the too high electrical resistivity.


SCIENTIFIC OUTPUT


© March 2018

Desktop Publishing: Maria Luísa Oliveira, CTN.

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Books and chapters of international distribution

Alcácer, L., Henriques, R. T., & Almeida, M. (2017). Interacting Electrons in One Dimension; The Two Chain Perylene-Metal Dithiolate Series. In: Essays in Honour of Amílcar Sernadas, College Publications, London, pp. 303-336. Almeida. S.M., Almeida-Silva, M., Galinha, C., Ramos, C., Lage, J., Canha, N., Silva, A.V., & Dionísio, I. (2017). Performance of the Portuguese k0 Neutron Activation Analysis Laboratory during four Intercomparison Exercices. In: Proficiency Testing by Interlaboratory Comparison Performed in 2010–2015 for Neutron Activation Analysis and Other Analytical Techniques, N.P. Barradas, J. Bennett, P. Bode, J. Kučera, D. Ridikas, & A. Yunikova, IAEA-TECDOC-1831. ISBN:978-92-0-108617-4. Annex IV, pp.128-137. Barradas, N.P., Bennett, J., Bode, P., Kučera, J., Ridikas, D., & Yunikova, A. (2017). Proficiency Testing by Interlaboratory Comparison Performed in 2010–2015 for Neutron Activation Analysis and Other Analytical Techniques. International Atomic Energy Agency, Vienna. IAEA TECDOC-1831, ISBN: 978-92-0-108617-4. 84pp. https://www-pub.iaea.org/books/IAEABooks/12290/Proficiency-Testing-by-Interlaboratory-Comparison-Performed-in-2010-2015-for-Neutron-Activation-Analysis-and-Other-Analytical-Techniques. Carreira, P.M. & Marques, J.M. (2017), As águas termais das Caldas de Monção: Sua evolução hiroquímica e isotópica. In: Águas Minerais Naturais e de Nascente da Região Norte, coord. José A.S. Cortez, Mare Liberum – Editora, Cap. V, pp.195-222., ISBN:978-972-8046-28-6. Carvalho, F., Fernandes, S., Fesenko, S., Holm, E., Howard, B., Martin, P., Phaneuf, M., Porcelli, D., Pröhl, G., & Twining, J. (2017). The Environmental Behaviour of Polonium, International Atomic Energy Agency, Vienna. Technical Reports Series no. 484, 255 pp., ISBN: 78–92–0–112116–5. http://www-pub.iaea.org/books/IAEABooks/10845/The-Environmental-Behaviour-of-Polonium Kasztovszky, Z., Szilágyi, V., Biró, K.T., Zöldföldi, J., Dias, M.I., Valera, A., Abraham, E., Bessou, M., LoCelso, F., & Benfante, F. (2017). Ceramics, Marbles and Stones in the Light of Neutrons: Characterization by Various Neutron Methods. In: Neutron Methods for Archeology and Cultural Heritage, ed. Nikolay Kardjilov & Giulia Festa, Springer, Chapter 6. pp.89-140, ISBN: 978-3-319-33161-4. Marques, J.M., Carreira, P.M. & Aires-Barros, L. (2017), Avaliação dos recursos hidrominerais e geotérmicos da região de Chaves (in portugal): Uma perspectiva multidisciplinar. In: Águas Minerais Naturais e de Nascente da Região Norte, coord. José A.S. Cortez, Mare Liberum – Editora, Cap. VI, 223-264 p., ISBN:978-972-8046-28-6. Matias, H., Andrade, M.A., Costa, C., Sampaio, H.A., Simão, I., Soares, A.M.M., Soares, R.M., & Monteiro, P. (2017). O sítio de fossas da Horta do Cabral 6. Contribuição para o conhecimento da Idade do Bronze na região do Torrão (Alcácer do Sal, Portugal). In: Arqueologia em Portugal - Estado da Questão. J.M. Arnaud & A. Martins (Eds.), Associação dos Arqueólogos Portugueses, Lisboa, pp.849-864. ISBN:978-972-9451-71-3.


Verde, S.C., Nunes, I., Silva, T., Dias, M.I., Prudêncio, M.I., & Botelho, M.L (2017).Gamma radiation for microbial decontamination of cultural heritage: Case studies with parchment and ceramic tiles. In: Uses of ionizing radiation for Tangible cultural heritage conservation. IAEA, Vienna, IAEA Radiation Technology Series no. 6, chapter 19, pp.163-172. ISBN:978-92-0-103316-1. http://www-pub.iaea.org/books/IAEABooks/10937/Uses-of-Ionizing-Radiation-for-Tangible-Cultural-Heritage-Conservation. Senna-Martinez, J.C., Luís, E., Matos, R., Valério, P., Araújo, M.F., Tereso, J., & Costeira, I. (2017). O Enterramento da Idade do Bronze da Gruta das Redondas (Carvalhal de Aljubarrota). In: Arqueologia em Portugal - Estado da Questão. J.M. Arnaud & A. Martins (Eds.), Associação dos Arqueólogos Portugueses, Lisboa, pp.833-847. ISBN:978-972-9451-71-3. Soares, A.M.M., Valério, P., Araújo, M.F., & Silva, R.J.C. (2017). A metalurgia campaniforme no sul de Portugal. In: Sinos e Vasos. Junto ao Oceano e mais Longe. Aspectos da Presença Campaniforme na Península Ibérica, V.S. Gonçalves (Eds.). UNIARQ, Lisboa, pp.354-363. Valério, P., Araújo, M.F., Soares, A.M.M., Soares, R., & Baptista, L. (2017). O metal de base cobre dos objectos de uso pessoal em sepulturas da I Idade do Ferro do Monte Bolor 1-2 (Beja). In: Arqueologia em Portugal - Estado da Questão. J.M. Arnaud, & A. Martins (Eds.), Associação dos Arqueólogos Portugueses, Lisboa, pp.897-906. ISBN:978-972-9451-71-3. Valério, P., Soares, A.M.M., Araújo, M.F., & Silva, R.J.C. (2017). Tradição indígena e Orientalizante na metalurgia do bronze na bacia do Guadiana ente os séculos VIII e VI a.C. In: SIDEREUM ANA III - El Río Guadiana y Tartessos. Jiménez Avila, J. (Ed.) Merida, Consorcio de la Ciudad Monumental, Histórico-Artística y Arqueológica, pp.605-615. ISBN:978-84-697-4788-9.


International Journals

Ainsbury, E., et al.(2017). Integration of new biological and physical retrospective dosimetry methods into EU emergency response plans - joint RENEB and EURADOS inter-laboratory comparisons. International Journal of Radiation Biology, 93(1), 99-109. doi:10.1080/09553002.2016.1206233. WOS:000392891400013. Al-Rjoub, A., Costa, P., Rebouta, L., Cerqueira, M.F., Aipuim, P., Barradas, N.P., & Alves, E. (2017). Characterization of magnetron sputtered sub-stoichiometric CrAlSiNx and CrAlSiOyNx coatings. Surface & Coatings Technology, 328, 134-141. doi:10.1016/j.surfcoat.2017.08.038. WOS:000413376900015. Almeida, S.M., Wolterbeek, H., Markert, B., & Loppi, S. (2017). Biomonitoring of atmospheric pollution: possibilities and future challenges. Environmental Science and Pollution Research, 24(13), 11865-11866. doi:10.1007/s11356-016-7060-z. WOS:000400765500001. Andrade, E., Miró, C., Reis, M., Santos, M., & Madruga, M. J. (2017). Assessment of radium activity concentration and radon exhalation rates in iberian peninsula building materials. Radiation Protection Dosimetry, 177(1-2), 31-35. doi:10.1093/rpd/ncx128. WOS:000417604700008. Andrade, M.M., Silva, R.A.L., Santos, I.C., Lopes, E.B., Rabaca, S., Pereira, L.C.J., Coutinho, J.T., Telo, J.P., Rovira, C., Almeida, M., & Belo, D. (2017). Gold and nickel alkyl substituted bis-thiophenedithiolene complexes: anionic and neutral forms. Inorganic Chemistry Frontiers, 4(2), 270-280. doi:10.1039/c6qi00447d. WOS:000395802300006. Antunes, J., & Debut, V. (2017). Dynamical computation of constrained flexible systems using a modal Udwadia-Kalaba formulation: Application to musical instruments. Journal of the Acoustical Society of America, 141(2), 764-778. doi:10.1121/1.4973534. WOS:000395310100024. Augustyns, V., van Stiphout, K., Joly, V., Lima, T.A.L., Lippertz, G., Trekels, M., Menendez, E., Kremer, F., Wahl, U., Costa, A.R.G., Correia, J.G., Banerjee, D., Gunnlaugsson, H.P., von Bardeleben, J., Vickridge, I., Van Bael, M.J., Hadermann, J., Araújo, J.P., Temst, K., Vantomme, A., & Pereira, L.M.C. (2017). Evidence of tetragonal distortion as the origin of the ferromagnetic ground state in gamma-Fe nanoparticles. Physical Review B, 96(17). doi:10.1103/PhysRevB.96.174410. WOS:000414525200005. Baklouti, A., Antunes, J., Debut, V., Fakhkakh, T., & Haddar, M. (2017). A method for the identification of dynamic constraint parameters in multi-supported flexible structures. Comptes Rendus Mecanique, 345(4), 239-247. doi:10.1016/j.crme.2017.02.002. WOS:000402006700001. Balbuena, J.P., Baptista, M., Barros, S., Dambacher, M., Disch, C., Fiederle, M., Kuehn, S., & Parzefall, U. (2017). Study of gamma detection capabilities of the REWARD mobile spectroscopic system. Nuclear Instruments & Methods in Physics Research Section A-Accelerators Spectrometers Detectors and Associated Equipment, 859, 1-7. doi:10.1016/j.nima.2017.03.056. WOS:000402464700001.


Barreiros, M.A., Alves, L.C., Brites, M.J., & Corregidor, V. (2017). Depth profile by Total IBA in perovskite active layers for solar cells. Nuclear Instruments & Methods in Physics Research Section B-Beam Interactions with Materials and Atoms, 404, 211-218. doi:10.1016/j.nimb.2017.01.019. WOS:000404709900040. Bartoschewitz, R., et al., & Consortium Braunschweig Meteorite (2017). The Braunschweig meteorite - a recent L6 chondrite fall in Germany. Chemie Der Erde-Geochemistry, 77(1), 207-224. doi:10.1016/j.chemer.2016.10.004. WOS:000401042700015. Baptista, M., Di Maria, S., Vieira, S., & Vaz, P. (2017). Entrance surface dose distribution and organ dose assessment for cone-beam computed tomography using measurements and Monte Carlo simulations with voxel phantoms. Radiation Physics and Chemistry, 140, 428-434. doi:10.1016/j.radphyschem.2017.02.018. WOS:000411533500082. Batista, A.J.N., Leong, C., Santos, B., Fernandes, A., Ramos, A. R., Santos, J.P., Marques, J.G., Teixeira, I.C., Teixeira, J.P., Sousa, J., & Gonçalves, B. (2017). SEU mitigation exploratory tests in a ITER related FPGA. Fusion Engineering and Design, 118, 111-116. doi:10.1016/j.fusengdes.2017.03.106. WOS:000400226900015. Bento, J.B., Franca, R.D.G., Pinheiro, T., Alves, L.C., Pinheiro, H.M., & Lourenço, N.D. (2017). Using nuclear microscopy to characterize the interaction of textile-used silver nanoparticles with a biological wastewater treatment system. Nuclear Instruments & Methods in Physics Research Section B-Beam Interactions with Materials and Atoms, 404, 150-154. doi:10.1016/j.nimb.2017.01.016. WOS:000404709900028. Blaauw, M., Ridikas, D., Baytelesov, S., Salas, P.S.B., Chakrova, Y., Eun-Ha, C., Dahalan, R., Fortunato, A.H., Jacimovic, R., Kling, A., Muñoz, L., Mohamed, N.M.A., Párkányi, D., Singh, T., & Duong, V.D. (2017). Estimation of 99Mo production rates from natural molybdenum in research reactors. Journal of Radioanalytical and Nuclear Chemistry, 311(1), 409-418. doi:10.1007/s10967-016-5036-6. WOS:000392075200043. Borges, R., Alves, L., Silva, R.J.C., Araújo, M.P., Candeias, A., Corregidor, V., Valério, P., & Barrulas, P. (2017). Investigation of surface silver enrichment in ancient high silver alloys by PIXE, EDXRF, LA-ICP-MS and SEM-EDS. Microchemical Journal, 131, 103-111. doi:10.1016/j.microc.2016.12.002. WOS:000393009900014. Brzozowska, B., et al. (2017). RENEB accident simulation exercise. International Journal of Radiation Biology, 93(1), 75-80. doi:10.1080/09553002.2016.1206230. WOS:000392891400010. Campagnolo, D., et al. (2017). VOCs and aldehydes source identification in European office buildings - The OFFICAIR study. Building and Environment, 115, 18-24. doi:10.1016/j.buildenv.2017.01.009. WOS:000397363000002. Canha, N., Lage, J., Candeias, S., Alves, C., & Almeida, S.M. (2017). Indoor air quality during sleep under different ventilation patterns. Atmospheric Pollution Research, 8(6), 1132-1142. doi:10.1016/j.apr.2017.05.004. WOS:000417392800013. Canha, N., Lopes, I., Vicente, E. D., Vicente, A. M., Bandowe, B.A.M., Almeida, S.M., & Alves, C.A. (2017). Mutagenicity assessment of aerosols in emissions from domestic combustion processes. Environmental Science and Pollution Research, 24(13), 11867-11867. doi:10.1007/s11356-017-9035-0. WOS:000400765500002.


Cantante, C., Lourenço, S., Morais, M., Leandro, J., Gano, L., Silva, N., Leandro, P., Serrano, M., Henriques, A.O., André, A., Cunha-Santos, C., Fontes, C., Correia, J.D.G., Aires-da-Silva, F., & Gonçalves, J. (2017). Albumin-binding domain from Streptococcus zooepidemicus protein Zag as a novel strategy to improve the half-life of therapeutic proteins. Journal of Biotechnology, 253, 23-33. doi:10.1016/j.jbiotec.2017.05.017. WOS:000404314800004. Cardoso, J.M.S., Correia, I., Galvão, A.M., Marques, F., & Carvalho, M. (2017). Synthesis of Ag(I) camphor sulphonylimine complexes and assessment of their cytotoxic properties against cisplcitin-resistant A2780cisR and A2780 cell lines. Journal of Inorganic Biochemistry, 166, 55-63. doi:10.1016/j.jinorgbio.2016.11.003. WOS:000390978100007. Carvalho, F.P. (2017). Mining industry and sustainable development: time for change. Food and Energy Security, 6(2), 61-77. doi:10.1002/fes3.109. WOS:000403258500004. Carvalho, F.P. (2017). Pesticides, environment, and food safety. Food and Energy Security, 6(2), 48-60. doi:10.1002/fes3.108. WOS:000403258500003. Casimiro, M.H., Lancastre, J.J.H., Rodrigues, A.P., Gomes, S.R., Rodrigues, G., & Ferreira, L.M. (2017). Chitosan-based matrices prepared by gamma irradiation for tissue regeneration: structural properties vs. preparation method. Topics in Current Chemistry, 375(1). doi:10.1007/s41061-016-0092-5. WOS:000393673300005. Catarino, N., Barradas, N.P., Corregidor, V., Widdowson, A., Baron-Wiechec, A., Coad, J.P., Heinola, K., Rubel, M., Alves, E., & J.E.T. Contributors (2017). Assessment of erosion, deposition and fuel retention in the JET-ILW divertor from ion beam analysis data. Nuclear Materials and Energy, 12, 559-563. doi:10.1016/j.nme.2016.10.027. WOS:000417293300088. Chakraborty, S., Pallada, S., Pedersen, J. T., Jancso, A., Correia, J. G., & Hemmingsen, L. (2017). Nanosecond dynamics at protein metal sites: An application of Perturbed Angular Correlation (PAC) of -rays spectroscopy. Accounts of Chemical Research, 50(9), 2225-2232. doi:10.1021/acs.accounts.7600219. WOS:000411548800018. Chaves, P.C., & Reis, M.A. (2017). H+, O2+, O3+ and high resolution PIXE spectra of Yb2O3. Nuclear Instruments & Methods in Physics Research Section B, 410, 193-199. doi:10.1016/j.nimb.2017.08.026. WOS:000413133100028. Coentro, S., Alves, L.C., Relvas, C., Ferreira, T., Mirao, J., Molera, J., Pradell, T., Trindade, R.A.A., Silva, R.C., & Muralha, V.S.F. (2017). The glaze technology of hispano-moresque ceramic tiles: a comparison between Portuguese and Spanish collections. Archaeometry, 59(4), 667-684. doi:10.1111/arcm.12280. WOS:000405123500004. Corisco, J.A.G., Mihalík, J., Madruga, M.J., Prudêncio, M.I., Marques, R., Santos, M., & Reis, M. (2017). Natural Radionuclides, Rare Earths and Heavy Metals Transferred to the Wild Vegetation Covering a Phosphogypsum Stockpile at Barreiro, Portugal. Water, Air, & Soil Pollution, 228(7). doi:10.1007/s11270-017-3413-6. WOS:000403574400009. Correia, I., Chorna, I., Cavaco, I., Roy, S., Kuznetsov, M. L., Ribeiro, N., Justino, G., Marques, F., Santos-Silva, T., Santos, M.F.A., Santos, H.M., Capelo, J.L., Doutch, J., & Pessoa, J.C. (2017). Interaction of [VIVO(acac)2] with Human Serum Transferrin and Albumin. Chemistry-an Asian Journal, 12(16), 2062-2084. doi:10.1002/asia.201700469. WOS:000409254100012. Costa, A.R.G., Wahl, U., Correia, J.G., Bosne, E., Amorim, L.M., Augustyns, V., Silva, D.J., da Silva, M.R., Bharuth-Ram, K., & Pereira, L.M.C. (2017). Lattice location of implanted transition metals


in 3C-SiC. Journal of Physics D-Applied Physics, 50(21). doi:10.1088/1361-6463/aa6878. WOS:000400919900001. Coutinho, I., Gratuze, B., Alves, L.C., Medici, T., & Vilarigues, M. (2017). Wine Bottles From Lisbon: Archaeometric Studies Of Two Archaeological Sites Dated From The 17th To The 19th

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Silva, M.R., Coutinho, J.T., Pereira, L.C.J., Martin-Ramos, P., & Waerenborgh, J.C. (2017). Synthesis, structure and physical properties of a low dimensional compound. Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy, 172, 9-13. doi:10.1016/j.saa.2016.06.037. WOS:000389093000003. Silvestre, A.J., Rout, S., Dalui, S., Pereira, L.C.J., Viana, A.S., & Conde, O. (2017). Co and (Co,Mo) doping effects on the properties of highly reduced TiO2 anatase thin films. Current Applied Physics, 17(2), 174-180. doi:10.1016/j.cap.2016.11.015. WOS:000393245500010. Soares, A.M.M., Valério, P., Silva, R.J.C., Alves, L.C., & Araújo, M.F. (2017). The Fortios disks revisited (Una revisión de los discos de Fortios). Trabajos de Prehistoria, 74(1), 181-184. doi: 10.3989/tp.2017.12190. WOS:000407993100011. Solokha, P., Minetti, R., De Negri, S., Pereira, L.C.J., Gonçalves, A.P., & Saccone, A. (2017). The RMgSn2 series of compounds (R = Rare Earth Metal): Synthesis, crystal structure, and magnetic measurements. European Journal of Inorganic Chemistry, (24), 3040-3047. doi:10.1002/ejic.201700280. WOS:000405458700004. Susano, M.A., Martin-Ramos, P., Maria, T.M.R., Folkersma, S., Pereira, L.C.J., & Silva, M.R. (2017). Co-crystal of suberic acid and 1,2-bis(4-pyridyl)ethane: A new case of packing polymorphism. Journal of Molecular Structure, 1147, 76-83. doi:10.1016/j.molstruc.2017.06.043. WOS:000408299900011. Teles, P., Mendes, M., Zankl, M., de Sousa, V., Santos, A.I., & Vaz, P. (2017). Assessment of the Absorbed Dose in the Kidney of Nuclear Nephrology Paediatric Patients using ICRP Biokinetic Data and Monte Carlo Simulations with Mass-Scaled Paediatric Voxel Phantoms. Radiation Protection Dosimetry, 174(1), 121-135. doi:10.1093/rpd/ncw096. WOS:000400876200016. Teles, P., Nikodemova, D., Bakhanova, E., Becker, F., Knezevic, Z., Pereira, M. F., & Sarmento, S. (2017). a review of radiation protection requirements and dose estimation for staff and patients in CT fluoroscopy. Radiation Protection Dosimetry, 174(4), 518-534. doi:10.1093/rpd/ncw231. WOS:000402052400011. Trompier, F., et al. (2017). Investigation of the influence of calibration practices on cytogenetic laboratory performance for dose estimation. International Journal of Radiation Biology, 93(1), 118-126. doi:10.1080/09553002.2016.1213455. WOS:000392891400015. Trompier, F., et al. (2017). Overview of physical dosimetry methods for triage application integrated in the new European network RENEB. International Journal of Radiation Biology, 93(1), 65-74. doi:10.1080/09553002.2016.1221545. WOS:000392891400009. Tsipis, E.V., Waerenborgh, J.C., & Kharton, V.V. (2017). Grain-boundary states in solid oxide electrolyte ceramics processed using iron oxide sintering aids: a Mossbauer spectroscopy study. Journal of Solid State Electrochemistry, 21(10), 2965-2974. doi:10.1007/s10008-017-3622-3. WOS:000410749000022. Valério, P., Soares, A.M.M., Araújo, M.F., & Carvalho, A.F. (2017). Micro-EDXRF investigation of Chalcolithic gold ornaments from Portuguese Estremadura. X-Ray Spectrometry, 46(4), 252-258. doi:10.1002/xrs.2764. WOS:000403493700006. Valério, P., Vidigal, R.O., Araújo, M.F., Soares, A.M.M., Silva, R.J.C., & Mataloto, R. (2017). Manufacture of copper weapons and tools from the chalcolithic settlement of São Pedro


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Borsoi, L., Piteau, P., Delaune, X., & Antunes, J. (2017). Competition between Turbulence and Fluid-Elastic Forces in the Response of a Loosely Supported Tube under Cross-Flow. In: Proceedings of the X International Conference on Structural Dynamics, F. Vestroni, F. Romeo, & V. Gattulli (Eds.), X International Conference on Structural Dynamics, Procedia Engineering , Vol. 199, pp. 1282-1289. doi:10.1016/j.proeng.2017.09.310. WOS:000422868901072. Carreira, P.M., Carvalho, M.D., Nunes, J.C., Grassa, F., Capasso, G., & Marques, J.M. (2017). Preliminary geochemical and isotopic results in thermal and cold waters of Graciosa volcanic Island (Azores). In J. M. Marques & A. Chambel (Eds.), In: Proceedings of the 15th Water-Rock. Interaction International Symposium (WRI-15), J.M. Marques & A. Chambel (Eds.), Évora, Portugal, 16 - 21 October 2016, Procedia Earth and Planetary Science 17, pp. 630-633. doi: 10.1016/j.proeps.2016.12.169. WOS:000398020400159. Carreira, P.M., Neves, M.O., Figueiredo, P., Marques, J.M., Nunes, D., Rei, J.C.M., & Caracho, A.J.E. (2017). Geochemistry and environmental isotopes as natural tracers of groundwater flow in shallow aquifer systems within Lisbon Volcanic Complex (Portugal). In: Proceedings of the 15th

Water-Rock Interaction International Symposium (WRI-15), J.M. Marques & A. Chambel (Eds.), Évora, Portugal, 16 - 21 October 2016, Procedia Earth and Planetary Science 17, pp. 634-637. doi: 10.1016/j.proeps.2016.12.170. WOS:000398020400160. Carvalho, F.P (2017). Concentration of radionuclides in marine organisms. In: II International Conference on Radioecological Concentration Processes (50 years later), Book of proceedings. Garcia-Tenorio, R., Holm, E. & Majón, C. (eds.), Seville, Spain, November 2016: Department of Applied Physics II, University of Seville, Spain. ISBN 978-84-617-7629-0. pp.233-240. Carvalho, F.P., Oliveira, J.M. & Malta, M. (2017). Environmental behavior of radionuclides from uranium mining and milling activities. In: II International Conference on Radioecological Concentration Processes (50 years later), Book of proceedings. Garcia-Tenorio, R., Holm, E. & Majón, C. (eds.), Seville, Spain, November 2016: Department of Applied Physics II, University of Seville, Spain. ISBN 978-84-617-7629-0. pp.341-346. Carvalho, F.P., Oliveira, J.M. & Malta, M. (2017). Heavy mineral sand deposits and accumulation of radionuclides in foods. In: II International Conference on Radioecological Concentration Processes (50 years later), Book of proceedings. Garcia-Tenorio, R., Holm, E. & Majón, C. (eds.), Seville, Spain, November 2016: Department of Applied Physics II, University of Seville, Spain. ISBN 978-84-617-7629-0. pp.369-373. Chen, Y.H., et al. & n_TOF Collaboration (2017). Characterization of the n_TOF EAR-2 neutron beam. EPJ Web of Conferences, 146, 03020. doi:10.1051/epjconf/201714603020. WOS:000426429500087. Chiaveri, E., et al. & n_TOF Collaboration (2017). The n_TOF facility: Neutron beams for challenging future measurements at CERN. EPJ Web of Conferences, 146, 03001. doi:10.1051/epjconf/201714603001. WOS:000426429500069. Colonna, N., et al. & n_TOF Collaboration (2017). The Nuclear Astrophysics program at n_TOF (CERN). EPJ Web of Conferences, 165, 01014. doi:10.1051/epjconf/201716501014. WOS:000426614000014. Corisco, J.A.G. (2017). Aspects of caesium-137 transport by microalgae Chlamydomonas reinhardtii related with potassium. In: II International Conference on Radioecological


Concentration Processes (50 years later), Book of proceedings. Garcia-Tenorio, R., Holm, E. & Majón, C. (eds.), Seville, Spain, November 2016: Department of Applied Physics II, University of Seville, Spain. ISBN 978-84-617-7629-0. pp.687-692. di Maria, S.., Belchior, A., Romanets, Y., & Vaz, P. (2017). The energy deposition distribution at the micro and nano-scale for molecular targeted radiotherapy: comparison between 125I, 99MTc and 64Cu. RAD Association Journal, 2(3), 175-180. doi:10.21175/RadJ.2017.03.036. Dupont, E., et al. & n_TOF Collaboration (2017). Dissemination of data measured at the CERN n_TOF facility. EPJ Web of Conferences, 146, 07002. doi:10.1051/epjconf/201714607002. WOS:000426429500211. Fernandes, A.C., Kling, A., Vlaskin, G.N., (2017). Comparison of thick-target (alpha,n) yield calculation codes. EPJ Web of Conferences, 153, 07021. doi:10.1051/epjconf/201715307021. WOS:000426429200156. Fernandes, A.C., Morlat, T.A., Felizardo, M., Kling, A., Marques, J.G., Prudêncio, M.I., Marques, R., Carvalho, F.P., Roche, I. L., & Girard, T.A. (2017). Intrinsic noise of a superheated droplet detector for neutron background measurements in massively shielded facilities. EPJ Web of Conferences, 153, 07013. doi:10.1051/epjconf/201715307013. WOS:000426429200148. Guerrero, C., et al. & n_TOF Collaboration (2017). Time-of-flight and activation experiments on 147Pm and 171Tm for astrophysics. EPJ Web of Conferences, 146, 01007. doi:10.1051/epjconf/201714601007. WOS:000426429500007. Gunsing, F., et al. & n_TOF Collaboration (2017). The measurement programme at the neutron time-of-flight facility n_TOF at CERN. EPJ Web of Conferences, 146, 11002. doi:10.1051/epjconf/201714611002. WOS:000426429500287. Leal-Cidoncha, E., et al. & n_TOF Collaboration (2017). High accuracy 234U(n,f) cross section in the resonance energy region. EPJ Web of Conferences, 146, 04057. doi:10.1051/epjconf/201714604057. WOS:000426429500156. Lerendegui-Marco, J., et al. & n_TOF Collaboration (2017). Monte carlo simulations of the n_TOF lead spallation target with the Geant4 toolkit: A benchmark study. EPJ Web of Conferences, 146, 03030. doi:10.1051/epjconf/201714603030. WOS:000426429500097. Lerendegui-Marco, J., et al. & n_TOF Collaboration (2017). New measurement of the 242Pu(n,γ) cross section at n_TOF-EAR1 for MOX fuels: Preliminary results in the RRR. EPJ Web of Conferences, 146, 11045. doi:10.1051/epjconf/201714611045. WOS:000426429500330. Marques, J.E., Marques, J.M., Carvalho, A., Carreira, P.M., & Mansilha, C. (2017). Impact of road de-icing on the hydrogeochemistry of groundwater from a mountain area (Serra da Estrela, Central Portugal). In: Proceedings of the 15th Water-Rock Interaction International Symposium (WRI-15), J.M. Marques & A. Chambel (Eds.), Évora, Portugal, 16 - 21 October 2016, Procedia Earth and Planetary Science 17, pp. 964-967. doi: 10.1016/j.proeps.2017.01.039. WOS:000398020400243. Marques, J.M., & Carreira, P.M. (2017). Questions and answers ascribed to Chaves CO2-rich thermal waters conceptual model (N Portugal): a review. In: Proceedings of the 15th Water-Rock Interaction International Symposium (WRI-15), J.M. Marques & A. Chambel (Eds.), Évora,


Portugal, 16 - 21 October 2016, Procedia Earth and Planetary Science 17, pp. 654-657. doi: 10.1016/j.proeps.2016.12.175. WOS:000398020400165. Marques, J.M., Neves, M.O., Miller, A.Z., Rocha, C., Vance, S., Christensen, L., Etiope, G., Carreira, P.M., & Suzuki, S. (2017). Water-rock interaction ascribed to hyperalkaline mineral waters in the Cabeço de Vide serpentinized ultramafic intrusive massif (Central Portugal). In: Proceedings of the 15th Water-Rock Interaction International Symposium (WRI-15), J.M. Marques & A. Chambel (Eds.), Évora, Portugal, 16 - 21 October 2016, Procedia Earth and Planetary Science 17, pp. 646-649. doi: 10.1016/j.proeps.2016.12.173. WOS:000398020400163. Marques, R., Prudêncio, M.I., Waerenborgh, J.C., Rocha, F., da Silva, E. F., Dias, M.I., Vieira, B.J.C., Marques, J.G., & Franco, D. (2017). Volcanic conduits of the Cha das Caldeiras caldera (Fogo Island, Cape Verde) - REE and Fe crystalchemistry. In: Proceedings of the 15th Water-Rock Interaction International Symposium (WRI-15), J.M. Marques & A. Chambel (Eds.), Évora, Portugal, 16 - 21 October 2016, Procedia Earth and Planetary Science 17, pp. 928-931. doi: 10.1016/j.proeps.2017.01.023. WOS:000398020400234. Mastromarco, M., et al. & n_TOF Collaboration (2017). The 236U neutron capture cross-section measured at the n_TOF CERN facility. EPJ Web of Conferences, 146, 11054. doi:10.1051/epjconf/201714611054. WOS:000426429500339. Mendoza, E., et al. & n_TOF Collaboration (2017). Measurement of the 241Am neutron capture cross section at the n_TOF facility at CERN. EPJ Web of Conferences, 146, 11022. doi:10.1051/epjconf/201714611022. WOS:000426429500307. Mihalík, J. (2017). Behavior of 137Cs during biodegradation of contaminated biomass. In: II International Conference on Radioecological Concentration Processes (50 years later), Book of proceedings. Garcia-Tenorio, R., Holm, E. & Majón, C. (eds.), Seville, Spain, November 2016: Department of Applied Physics II, University of Seville, Spain. ISBN 978-84-617-7629-0. pp.113-114. Mingrone, F., et al. & n_TOF Collaboration (2017). High precision measurement of the radiative capture cross section of 238U at the n_TOF CERN facility. EPJ Web of Conferences, 146, 11028. doi:10.1051/epjconf/201714611028. WOS:000426429500313. Monteiro, A., Santos, M., Faria, T., Viegas, C., Cabo Verde, S. (2017). Bacteria load a surrogate to assess occupational exposure to bioaerossols? SHO 2017 - International Symposium on Occupational Safety and Hygiene, Guimarães, 10-11 April, p. 563-567. Ouhamdouch, S., Bahir, M., & Carreira, P.M. (2017). Geochemical and isotopic tools to deciphering the origin of mineralization of the coastal aquifer of Essaouira basin, Morocco. In: Proceedings of the 15th Water-Rock Interaction International Symposium (WRI-15), J.M. Marques & A. Chambel (Eds.), Évora, Portugal, 16 - 21 October 2016, Procedia Earth and Planetary Science, 17, pp. 73-76. doi:10.1016/j.proeps.2016.12.038. WOS:000398020400019. Prudêncio, M.I., Valente, T., Marques, R., Braga, M.A.S., & Pamplona, J. (2017). Rare earth elements, iron and manganese in ochre-precipitates and wetland soils of a passive treatment system for acid mine drainage, Procedia Earth and Planetary Science 17, pp. 932-935. doi: 10.1016/j.proeps.2017.01.024. WOS:000398020400235.


Sabaté-Gilarte, M., et al. & n_TOF Collaboration (2017). The 33S(n,α)30Si cross section measurement at n_TOF-EAR2 (CERN): From 0.01 eV to the resonance region. EPJ Web of Conferences, 146, 08004. doi:10.1051/epjconf/201714608004. WOS:000426429500220. Soares, A.M.M., Arruda, A.M. (2017). A cronologia de radiocarbono para a Idade do Ferro Orientalizante no território português. Uma leitura crítica dos dados arqueométricos e arqueológicos. In: Actas del Congreso de Cronometrías para la Historia de la Península Ibérica (IberCrono 2017). Barceló, J.A., Bogdanovic, I. & Morell B. (Eds.), Barcelona, 235-259. Stamatopoulos, A., et al. & n_TOF Collaboration (2017). Measurement of the 240Pu(n,f) cross-section at the CERN n_TOF facility: First results from experimental area II (EAR-2). EPJ Web of Conferences, 146, 04030. doi:10.1051/epjconf/201714604030. WOS:000426429500129. Tagliente, G., et al. & n_TOF Collaboration (2016). Recent results in nuclear astrophysics at the n_TOF facility at CERN, Proceedings of the 26th International Nuclear Physics Conference, INPC2016, 11-16 September, 2016, Adelaide, Australia. PoS -Proceedings of Science, PoS(INPC2016)161.


Theses – concluded

PhD

Coutinho, Joana Raquel Teixeira (2017). Exploring the magnetic properties of f-electron complexes with potential as single molecule magnets. Instituto Superior Técnico, Universidade de Lisboa. Supervisors: Laura Pereira Waerenborgh & Eugenio Coronado Miralles. Pereira, Filipa Isabel Peralta da Silva (2017). As primeiras etapas metalúrgicas na pré-história da estremadura portuguesa. Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa. Supervisors: Rui J.C. Silva, M.F. & A.A.M. Soares. Prado, Viviana da Silva (2017). Obtenção de complexos de GaIII e InIII com interesse em medicina nuclear a partir do desenvolvimento de ligantes multidentados. IQSC-USP, São Paulo, Brazil, within a bilateral FCT-CAPES project. Supervisors: V.M. Deflon & A. Paulo. Silva, Alexandra Maria Emídio Viana da (2017). Emissões fugitivas de partículas para a atmosfera: caracterização, impactos e mitigação, Universidade de Aveiro. Supervisors: Prof. A.I. Miranda & S.M. Almeida. Silva, Rafaela Antunes Leão da (2017). Thiophenic-TTF Derivatives and Thiophenic-Bisdithiolene Complexes for Magnetic and Conducting Materials. Instituto Superior Técnico, Universidade de Lisboa. Supervisors: M. Almeida & D. Belo. Simões, Sandrina Oliveira (2017). New Building Blocks for Molecular Conductors based on TTF Derivatives with N-Coordinating Groups. Instituto Superior Técnico, Universidade de Lisboa. Supervisors: M. Almeida & S. Rabaça. Yangui, Majdi (2017). Etude numérique et expérimentale du comportement dynamique d’une pale segmentée d’éolienne à axe horizontal. Université de Sfax, Sfax, Tunisia. Co-Supervisors: J. Antunes & V. Debut.

MSc

Amaral, Joana (2017). Estudo das condições de exposição da coleção de ourivesaria portuguesa do Museu Nacional de Arte Antiga. Faculdade de Ciências e Tecnologias, Universidade Nova de Lisboa. Supervisors: Sara Fragosos, S.M. Almeida & Luísa Penalva. Borbinha, Jorge (2017). Organ Dose Estimates in Thorax CT: Voxel Phantom Organ Matching With Individual Patient Anatomy. Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa. Supervisor: Salvatore di Maria. Borges, Inês (2017). Bioreceptividade a fungos de adesivos utilizados em conservação e restauro de documentos gráficos. Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Lisbon, Portugal. Supervisors: S. Sequeira, M.F. Macedo Dinis & M. H. Casimiro.


Costa, Jessica (2017). In vivo measurements for biokinetic and Monte Carlo simulations of absorbed dose in paediatric patients using radiopharmaceuticals. Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa. Supervisor: Pedro Teles. D’Espiney, Ana (2017). Economia de baixo carbono nas escolas: Indicadores-chave de sesempenho do projecto ClimACT. Instituto Superior Técnico, Universidade de Lisboa. Supervisors: S.M. Almeida & J. Neiva Correia. Góis, Bárbara Franco Andrade (2017). The effect of bone collagen fragments on breast and prostate cancer cells. Instituto Superior Técnico and Faculdade de Medicina, Universidade de Lisboa. Co-supervisor: J.D.G. Correia. Lopes, Gonçalo André Gonçalves Brás (2017). Síntese e Caracterização de Novos Compostos Moleculares Baseados em Doadores Tetratiafulvaleno Dissimétricos Benzociano Substituídos. Instituto Superior Técnico, Universidade de Lisboa. Supervisors: Sandra Rabaça & Dulce Elizabete Bornes Teixeira Simão. Monteiro, Rita (2017). Image segmentation and voxelization techniques for dose assessment in X-ray diagnostic procedures. Faculdade de Ciências e Tecnologia, Universidade de Coimbra. Supervisor: Salvatore di Maria. Pisolkar, M. (2017). Why CO2-rich mineral waters present peculiar signatures, when compared with other types of mineral waters? Vidago - Pedras Salgadas case study. Departamento de Engenharia Geológica e de Minas, Instituto Superior Técnico, Universidade de Lisboa. Supervisors: J. M. Marques & P.M. Carreira. Rúben Diogo Marques da Silva (2017). Estudo da Influência do pH e Temperatura na Estrutura Secundária de Agregados de Poliglutaminas. Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa. Supervisors: César Laia & J.D.G. Correia. Ruza, André Felipe de Jesus Lopes (2017). High entropy alloys for fusion applications. Instituto Superior Técnico, Universidade de Lisboa. Supervisors: M.S.R. Silva Dias & A.P. Gonçalves.

CONCLUDED GRADUATIONS

do Nascimento, Osvaldo Ariston Rodrigues (2017). Dissolução de metais em líquidos iónicos. Instituto Politécnico de Setúbal, Escola Superior de Tecnologia do Barreiro, Setúbal, Portugal. Supervisors: João Paulo Leal (C2TN) & António Pereira Gonçalves (C2TN) & Rui Antunes.

Pina, Carlos (2017). Avaliação do desempenho ambiental das escolas ClimACT localizadas em Loures e Lisboa, Escola Superior de Tecnologia da Saúde de Lisboa, Lisbon, Portugal. Supervisor: S.M. Almeida (C2TN). Seco, André Miguel Lopes (2017). Novas Perovskites baseadas em Sn(II) e Cu(II) – Propriedades térmicas e luminescentes. Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Lisbon, Portugal. Supervisors: César Laia (FCT-UNL); João Paulo Leal (C2TN).


New Materials, devices, products and processes,

software, computer codes and algorithms

A FORTRAN-based program was developed in the framework of Jorge Borbinha´s Master thesis work, which is able to semi-automatically modify the volumetric information of organs of interest in several computational voxel phantoms (i.e., ICRP Reference phantoms). An article about the capabilities and performances of this program is in progress, to be submitted to an international journal for peer reviewing.

Edited special issues of journals

Paulo, A., Correia, J. D. G. (2017). Editors of the special Issue "Metal Complexes for Imaging and Therapy", Inorganics, MDPI AG, Switzerland. Correia, J. D. G. (2017). Editor of the special Issue Frontiers in Radionuclide Imaging and Therapy” A chemical journey from naturally radioactive elements to targeted theranostic agents”, Dalton Transactions; Pub. RSC; Guest Editors: A. Casini, J. D. G. Correia and C. Orvig; Vol 42. Almeida, M. (2017). Special issue “Magnetism of Molecular Conductors”, Magnetochemistry, 3, 23.

Performances and Exhibitions

S.M. Almeida, V. Martins, T. Martins, N. Canha, J. Lage, C. Galinha, I. Dionísio (2017). Exhibition in InSS – Inovação, Sustentabilidade e Sociedade: awareness campaigns conducted within LIFE Index-Air and ClimACT projects including environment education games designed for children, Loures, Portugal. S.M. Almeida, V. Martins, T. Martins, N. Canha, J. Lage, C. Galinha, I. Dionísio (2017). Exhibition in Sustentabilis Olivais: awareness campaigns conducted within LIFE Index-Air and ClimACT projects including environment education games designed for children, Lisbon, Portugal. J. Lage, V. Martins (2017). Exhibition in Day of Green Flags 2017- Eco-Schools Awards: awareness campaigns conducted within LIFE Index-Air and ClimACT projects including environment education games designed for children, Mafra, Portugal.


M. I. Dias, M. I. Prudêncio (2017). Participation in the Exhibition InSS - Inovação, Sociedade e Sustentabilidade - Comemorações do Dia Mundial do Ambiente, Loures, Portugal. M. I. Dias, M. I. Prudêncio. Permanent Exhibition in Museu Arqueológico de Fornos de Algodres: Caracterização Química e Mineralógica de Cerâmicas: Proveniências e Tecnologias de Produção, Portugal. N. Canha (20 January 2017). Seminar on Qualidade do Ar Interior em Escolas, Seminário Nacional Eco-Escolas 2017, ABAE, Ílhavo, Portugal. S. M. Almeida (19 May 2017). LIFE Index-Air @ Conversas de Café - A agenda da Sustentabilidade. Conversas de Café – A Agenda da Sustentabilidade promoted by Junta de Freguesia dos Olivais, Lisbon, Portugal. S. M. Almeida (2017). Impacte da qualidade do ar interior na exposição diária a poluentes: o projeto LIFE Index-Air, Workshop Indoor Air Quality promoted by APAE - Portuguese Association of Environment Engineering, 26 May, Lisbon, Portugal. V. Martins (2017). Desenvolvimento de uma ferramenta integrada para reduzir a exposição a partículas em suspensão no ar. Encontro Ciência, 3-5 July, Lisbon, Portugal. J. Lage (2017). Atuar na transição para uma economia de baixo carbono – desenvolvimento de ferramentas de apoio. Encontro Ciência 2017, 3-5 July, Lisbon, Portugal. S.M. Almeida (2017). LIFE Index-Air - Development of an Integrated Exposure – Dose Management Tool for Reduction of Particulate Matter Air. Workshop “Urban Air Pollution Mitigation Tools”, 30 August, Zurich, Switzerland. S.M. Almeida (2017). LIFE Index-Air - Development of an Integrated Exposure – Dose Management Tool for Reduction of Particulate Matter Air. Intra LIFE PT 2017 promoted by Portuguese Agency of Environment (APA), 23-24 October, Alfragide, Portugal. S.M. Almeida (2017). Transição para uma Economia de Baixo Carbono em 39 escolas ClimACT do espaço Sudoe, WORKSHOP “A Eficiência Energética como Ferramenta para um Desenvolvimento Sustentável”, 13th December, Arronches, Portugal.


Research Contracts

EUROPEAN RESEARCH CONTRACTS

MEDICIS-produced radioisotope beams for medicine (MEDICIS-PROMED). ITN (H2020-MSCA-ITN-2014). Responsible: Thierry Stora – CERN; C2TN responsible: António Paulo; C2TN Research Team: António Paulo, António Gonçalves, Alice D’Onofrio, Sanjib Chowdhury. Total Funding: 2,829,269.88 €; C2TN Funding: 476,712.72 €.

LIFE Index-Air - Development of an Integrated Exposure – Dose Management Tool for Reduction of Particulate Matter in Air. LIFE15 ENV/PT/000674. www.lifeindexair.net. Project Coordinator: Marta Almeida - IST. C2TN responsible: Marta Almeida. Total budget 1369.071€; C2TN Budget: 487.159 €; EU Contribution to C2TN: 282.321€.

ClimACT - Acting for the transition to a low carbon economy in schools – development of support tools. SOE1/P3/P0429, Interreg Sudoe. www.climact.net. Project Coordinator: Marta Almeida - IST. C2TN responsible: Marta Almeida. Total budget 1.374,128 €; C2TN Budget: 255.058€; FEDER Contribution to C2TN: 191.293 €.

REMEDIO - Regenerating Mixed-Use Med Urban Communities Congested by Traffic through Innovative Low Carbon Mobility Solutions. Interreg Med project REMEDIO (Ref. 862), https://remedio.interreg-med.eu/. European Regional Development Fund (ERDF). C2TN responsible: Marta Almeida. Total budget 2.215.512,50 € €; IST Budget: 240.000,00 €.

COLOSSAL: Chemical On-Line cOmpoSition and Source Apportionment of fine aerosol. COST/CA16109 – COLOSSAL www.costcolossal.eu.

ReCreew: European network for innovative recovery strategies of rare earth and other critical metals from electric and electronic waste. COST Action ES1407 (Earth System Science and Environmental Management). C2TN Responsible: M. Isabel Dias.

IPERION CH Project H2020: BRR-527 - Personal ornaments at chalcolithic funerary contexts of SW Iberian Peninsula: The Perdigoes site. C2TN Responsible: M. Isabel Dias.

RTNORM - kQ Factors in modern external beam radiotherapy applications to update IAEA TRS–398.EMPIR/EURAMET/16RNM03. Type of funding: Joint Research Project. Leading Institution ENEA (Italy); C2TN participants: Pedro Teles (Portuguese Coordinator), Margarida Caldeira, Salvatore Di Maria, Yuriy Romanets. EU funding: 40.000 €. CONFIDENCE – Coping with uncertainties for improved modelling and decision making in nuclear emergencies. HORIZON 2020 CONCERT. Funding scheme: CONCERT. Leading institution: KIT (Germany). C2TN participants: Mário Reis (Portuguese Coordinator), Pedro Vaz, Maria José Madruga, Isabel Paiva, Octávia Monteiro Gil. EU funding (IST-ID): 69.788,00 €. CAThyMARA - Child and Adult Thyroid Monitoring After Reactor Accident, OPERRA 2nd Call, 7th FP EURATOM. Type of funding scheme: Collaborative Project (CP) & Coordination support action (CSA). Leading institution: IRSN (France); C2TN participants: Octávia Monteiro Gil (WP 2 leader), Pedro Teles, Pedro Vaz (Portuguese Coordinator). EU funding (IST-ID): 86.850,00 €.

http://www.lifeindexair.net/

http://www.climact.net/

https://remedio.interreg-med.eu/

http://www.costcolossal.eu/


EURALOC - EUropean epidemiological study on RAdiation-induced Lens Opacities among interventional Cardiologists, OPERRA 1st Call, 7th FP EURATOM. Leading institution: SCK/CEN (Belgium); C2TN participants: Pedro Teles (Portuguese Coordinator), Pedro Vaz.. EU funding (IST-ID): 37.000.00 €. ENVIREE – Environmentally friendly and efficient methods for extraction of rare earth elements from primary and secondary sources. ERA-MIN/004/2014. Funding scheme: ERAMIN. Leading institution: Chalmers University of Technology. C2TN participants: Isabel Paiva (Portuguese Coordinator), Maria Isabel Dias, Maria Isabel Prudêncio, Fátima Araújo, Leonor Maria, Rosa Marques, João Paulo Leal, João Carlos Waerenborgh, Mário Reis, Joaquim Marçalo. EU/EURAMET funding (IST-ID): 100.000 €. CHANDA – Solving CHAllenges in Nuclear Data for the Safety of European Nuclear Facilities. 7th FP EURATOM 2012. Funding scheme: CP-CSA (Combination of Collaborative projects, Coordination and Support Actions). Leading institution: CIEMAT (Spain). C2TN participants: Isabel F. Gonçalves (Portuguese Coordinator), Pedro Vaz. EU funding (IST-ID): 20.000 €. ENETRAP III - European Network for Education and Training in Radiation Protection.7th FP EURATOM. Funding scheme: Coordination and support action (CSA). Leading institution: SCK/CEN (Belgium). C2TN participants: Pedro Vaz, António Falcão. EU funding (IST-ID): 23.361,00 €. MYRTE – MYRRHA Research and Transmutation Endeavour. HORIZON 2020 EURATOM. Funding scheme: Research and Innovation Action (RIA). Leading institution: SCK/CEN (Belgium). C2TN participants: Pedro Vaz (Portuguese Coordinator), Yuriy Romanets. EU funding (IST-ID): 18,750.00 €.

INDUSTRIAL RESEARCH CONTRACTS

Synthetic Process Development and Analytical Characterization of Peptide Sequences Hovione. (Contrato IST/Hovione from 16/03/2016), 2016 – 2017. C2TN responsible : J. D. G. Correia. Luminescence tests and compositional studies for absolute dating and authenticity of terracotta and porcelains cultural heritage assets. Pprivate collectors, auctioneers. C2TN responsible: M. Isabel Dias; Ana Luísa Rodrigues. Microbiological analysis for Indoor Air Quality in the scope of the Energy Certification for Buildings, Contract IST-ATM, Responsible: S. Cabo Verde, Jan-Dec 2017, 2.300 €. Microbiological analysis for Indoor Air Quality in clean rooms, Contract IST-Tradelabor, Responsible: S. Cabo Verde, Jan – Dec 2017, 9.200 k€. Study of the resistance/degradation of API compounds to gamma radiation for validation of a sterilization process, Hovione, Responsible: S. Cabo Verde, September-November 2017, 600 €.


FCT PROJECTS

Overcoming the Brain Drug Delivery Bottleneck: Development of single domain antibodies for brain targeting and drug delivery across the Blood Brain Barrier. FCT-PTDC/BBB-BIO/0508/2014. Principal Investigator: Frederico Aires da Silva – FMV-UL. C2TN responsible: J. D. G. Correia. Total Funding: 192 320,00 €; C2TN Funding: 15 600,00 €. Peptides for blood brain barrier transmigration and drug delivery novel therapies for the central nervous system. FCT-PTDC/BBB-NAN/1578/2014. Principal Investigator: Vera Neves – IMM. C2TN responsible: J. D. G. Correia. Total Funding: 190 090 €; C2TN Funding: 12 500,00 €. Exhaust 2 Energy - Recuperação de calor dos gases de escape de automóveis com controlo térmico. PTDC/EMS-ENE/3009/2014. C2TN responsible: António Gonçalves. ISOLTOP-SUP- Novos materiais isoladores topológicos e supercondutores. PTDC/FIS-NAN/6099/2014. C2TN responsible: António Gonçalves.

f-Element Clusters in the Gas Phase – Prototypes of Catalytic Processes. PTDC/QEQ-QFI/6430/2014. C2TN participants: J. Marçalo (Coordinator); J.P. Leal, J.B. Branco, B. Monteiro. Recovery versus environmental impacts of Rare Earth Elements derived from human activities- REEuse, (PTDC/QEQEPR/1249/2014). PI: Miguel Caetano (IPMA), Team Members: J. Marçalo, J. P. Leal. RNEM - Portuguese Mass Spectrometry Network, Research Infrastructure n. 22125 (01.01.2017 – 31.12.2019). IST-Node Co-Coordinator: J. Marçalo; Team Members QEf: J.P. Leal, J.M. Carretas, L. Maria, B. Monteiro; Team Members REI: M.F. Araújo, P.M. Carreira, C. Galinha.

Low level alpha measurements using superheated droplet detectors. IF/00628/2012/CP0171/ /CT0008, Fundação para a Ciência e Tecnologia. C2TN Responsible: A.C. Fernandes. C2TN funding: 50 000 €.

Innovative measurement of alfa particle contamination in integrated circuits – a contribution to the assessment of soft error rates., PTDC/EEI-ELC/2468/2014, Fundação para a Ciência e Tecnologia. C2TN Responsible: A.C. Fernandes. C2TN funding: 171 577 €.

Material ́s Characterization with Nuclear Radioactive Techniques - synergy and complementarity applied to training and development. CERN/FIS-NUC/0004/2015. (former project: Perturbed Angular Correlations and Electron Channelling Experiments at ISOLDE-CERN). C2TN Responsible: J. Correia. C2TN budget: 190.000 €.

XPOSURE - Integrated human exposure to particles: characterization, identification of sources and health effects. IF/01078/2013, Fundação para a Ciência e Tecnologia. Project Coordinator: Marta Almeida – IST. Total budget 50.000 €; C2TN Budget: 50.000 €. SHELLS - Temperatura da água do mar superficial, afloramento costeiro, produtividade de águas costeiras e sazonalidade da colheita de moluscos pelas populações Neandertais do Centro de Portugal no Último Interglacial. PTDC/EPH-ARQ/6485/2014. Coordinator: A.M.M. Soares (C2TN). Budget: 188.000 €.


BILATERAL RESEARCH PROJECTS

Radiolabeled and Clickable Antagonists for Targeted Radionuclide. Bilateral Action Portugal/Poland. FCT/CAPES, 2017-2018. C2TN Responsible: António Paulo. Partners: Polatom, Poland. C2TN Funding: 4,000 €.

Dynamical behaviour of segmented blades for aeolic generator with horizontal axis. Bilateral scientific cooperation with the École Nationale d'Ingénieurs de Sfax (ENIS), Sfax University, Tunisia. Coordinator: M. Haddar (ENIS). C2TN responsible: J. Antunes.

Robust identification of structural constraining fixtures. Bilateral scientific cooperation with the École Nationale d'Ingénieurs de Sfax (ENIS), Sfax University, Tunisia. Coordinator: M. Haddar (ENIS). C2TN responsible: J. Antunes.

Development and analysis of optimized universal granular dampers. Bi-lateral scientific cooperation with the École Nationale d'Ingénieurs de Sfax (ENIS), Sfax University, Tunisia. Coordinator: T. Fakhfakh (ENIS). C2TN responsible: J. Antunes.

RESEARCH CONTRACTS WITH IAEA

Enhancing Nuclear Analytical Techniques to Meet the Needs of Forensic Sciences. IAEA - CRP F11021. Coordinator: Luís Alves (C2TN). Funding: 20.000 € (2017 - 5000 €). Fostering e-beam food irradiation: Modelling and Validation. IAEA – CRP D61024 Project no. 19220. Coordinator: S. Cabo Verde (C2TN). Funding: 6.000 €. IAEA Research Contract No: 18982 (2016-2018) Hybrid Materials Prepared by Ionizing Radiation for Consolidation and Preservation of Roman Mosaics. IAEA Coordinated Research Project CRP F23032 - Developing Radiation Treatment Methodologies and New Resin Formulations for Consolidation and Preservation of Archived Materials and Cultural Heritage Artefacts. Coordinator (C2TN): L.M. Ferreira. Funding: 12.000 €. IAEA Research Contract No. 18202 (2014-2019) Biodegradable polymer matrices obtained by ionizing radiation for skin scaffolds. IAEA Coordinate Research Project CRP F23030-E31007 - Instructive Surfaces and Scaffolds for Tissue Engineering Using Radiation Technology. Partners: IST; Coordinator (C2TN): L.M. Ferreira. Funding: 22.5000 €.

OTHER RESEARCH PROJECTS

Development of advanced methods in musical acoustics for tuning and restoration of historical carillons. Bi-lateral scientific cooperation with the Universidade Nova de Lisboa, Faculdade de Ciências Sociais e Humanas (UNL-FCSH). Coordinator: V. Debut (UNL). IST responsible: J. Antunes (2014-2018). PhD thesis of Miguel Carvalho to be completed in 2018.

Development and experimental validation of techniques for the modelling and identification of flow turbulence excitation of nuclear fuel bundles. Extensive research project performed under annual research contracts with the Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA, France). Coordinator: P. Piteau (CEA). C2TN responsible: J. Antunes .


IVECO-4.1 - Extension of blind identification techniques to systems with complex modes. ADIST AD-72/2016. Commissariat à l'Energie Atomique et aux Energies Alternatives, CEA/4000730471/P5B61. Budget: 14000 €.

IVECO-2017 - Identification of flow turbulence excitation from the CALVI experiments. ADIST AD-AD0072. Commissariat à l'Energie Atomique et aux Energies Alternatives, CEA/4000765990 P5B61. Budget: 9800,00 €.

Nature, Society and Monumentality: High-Resolution Archaeological Research of the Antequera Megalithic Landscape. HAR2013-45149-P, Plan Nacional I+D, Dirección General de Investigación, Ministerio de Economía y Competitividad, Secretaría General de Investigación (Spain). Coordinator: Leonardo Sanjuan, Univ. Sevilla, Spain. C2TN Responsible: M. Isabel Dias. UPCAST – Unified Platform for CBRN Attack/Accident Scenario management. Funding scheme: PT2020. Leading institution: TEKEVER. C2TN participants: Pedro Vaz (C2TN Coordinator), Octávia Monteiro Gil, Mário Reis, Catarina Antunes. C2TN Funding: approx. 140.000 €.

Invited Talks in Conferences

Gano, L., Radiopharmacy – Radiobiological concerns regarding radiopharmaceuticals applications, Conference “Proteção Radiológica na Saúde 2017”, Lisbon, September 27-29, 2017. Paulo, A., “Sondas Multimodais para Imagiologia e Teranóstica”, I Simpósio de Medicina Nuclear, ESS/P. Porto, Porto, 14th October, 2017. Correia, J.D.G., Novel radiometaled peptides translocate reversibly the blood-brain barrier, IAS Birmingham and TUM-IAS joint workshop on Inorganic Chemistry meets Medicine, TUM Institute for Advanced Study, Technical University of Munich, Garching b. München, October 25-26, 2017, Munich, Germany. Almeida, M., Rabaça, S., Oliveira, S., Gonçalves, A. C., Santos, I. C., Gama, V., Belo, D., Lopes, E. B., Canadell, E., Paixão, J.A. (24-29 September 2017). Bilayer Molecular Metals (CNB-EDT-TTF)4X; Range of Stability, Polymorphism and Superconductivity. ISCOM2017, Miyagi, Japan. J. Antunes, Overview of problems and predictive approaches in flow-induced vibrations, Keynote talk at the International Congress on Design and Modelling of Mechanical Systems, March 2017, Hammamet, Tunisia. J.G. Alves. Participação em projeto(s) financiado(s) pelo European Metrology Programme for Innovation and Research (EMPIR) Call 2017 no âmbito do programa EMPIR, Auditório LNEG, Fevereiro 2017. J.G. Alves. Interim Storage, Regulation and Practical Aspects (the case of Portugal). NEA-Nuclear Energy Agency Workshop on the Management of Non-Nuclear Radioactive Waste, Legnaro,


Padova (Itália), Maio de 2017. Technical Meeting to review the Draft Safety Guide on Preparedness and Response for an Emergency during the Transport of Radioactive Material (DS469), Viena (Áustria), Outubro de 2017. J.G. Alves. Dialogue between Coastal and Shipping States – Table Top Exercise June 2017. J.G. Alves. National Arrangements for EPR in Portugal, Transport of Radioactive Material. M.F. Pereira, J.S. Pereira, S. Rangel, A.D. Oliveira, J.V. Cardoso, L.M. Santos, J.G. Alves. Activities at the Individual Monitoring Service at IST-LPSR. 13th International Workshop on Ionizing Radiation Monitoring, Oarai (Japão), Dezembro de 2017. Cabo Verde, S. Virucidal potential of gamma radiation. International Conference on Applications of Radiation Science and Technology (ICARST-2017), 24–28 April 2017, Vienna, Austria. Cabo Verde, S. Fostering e-beam food irradiation: Modelling and Validation. IAEA 2nd Research Coordinated Meeting on New applications of Machine Generated Food Irradiation Technologies, 27-31 March 2017, Strasburg, France. Casimiro, M.H., Ferreira, L.M., Biodegradable polymer matrices obtained by ionizing radiation for skin scafflolds. 3rd IAEA Research Coordination Meeting on Instructive Surfaces and Scaffolds for Tissue Engineering Using Radiation Technology (F23030), Vienna, Austria, 2-5 May 2017. Falcão, A. N., Coeck, M., Stewart, J., Livolsi, P., Trumm, S., Actions and Achievements of the 7FP ENETRAP III Project, 13th CHERNE workshop, Covilhã, Portugal, May 2017 Ferreira, L.M., Araújo, M.F., Casimiro, M.H., Cabo Verde, S., Falcão, A.N., Alves, L.C., Rodrigues, A.P. (25-29 September 2017). Hybrid materials prepared by ionizing radiation for consolidation and preservation of Roman mosaics. 2nd IAEA Research Coordination Meeting on Developing Radiation Treatment Methodologies and New Resins Formulations for Consolidation and Preservation of Archived Materials and Cultural Heritage Artifacts (F23032), Bucharest, Romania. Ferreira, L.M., Margaça, F.M.A., Casimiro, M.H., Falcão, A.N., Miranda Salvado, I.M., Rodrigues, A.P. (2-6 October 2017). Nanostructures hybrid materials prepared by gamma irradiation: development and applications. International Atomic Energy Agency Meeting on radiation–driven processes in nanoscience/nanotechnology, Vienna, Austria. J. P. Leal , Energia das Ligações: Quem é mais Forte?, IV Encontro Internacional da Casa das Ciências - A Educação Científica e Desenvolvimento Económico, Lisboa, Portugal, July 2017. Monteiro Gil, O. (23-25 May 2017). State of emergency preparedness in Europe for thyroid monitoring. OPERRA- Open Project for European Radiation Research Area. OPERRA 3rd Periodic & Final Meeting, Budapest, Hungary. Vaz, P. (22-25 May). MPSR: A unique and innovative Master´s Degree on Radiological Protection and Safety in Portugal”. Workshop CHERNE, Covilhã, Portugal. Vaz, P. (5 July 2017). MELODI: The Strategic Research Agenda of the Multidisciplinary European Low Dose Initiative”, Presentation during the session “Proteção Radiológica na Saúde”, Encontro Ciência 2017, Lisbon, Portugal.


Paiva, I. (26-30 June 2017). Management of Radioactive Sources, Orphan Sources and Contaminated Goods, 3rd PETRUS-ANNETTE-ENEN-DECN PhD Conference 2017, IST, Campus of Alameda, Lisbon, Portugal. Reis, M. (26-30 June 2017). Radiation Protection – Radioactivity in the Environment, 3rd PETRUS-ANNETTE-ENEN-DECN PhD Conference 2017, IST, Campus of Alameda, Lisbon, Portugal. Reis, M. (15-17 May 2017). Radioactivity from Fukushima nuclear accident detected in Lisbon: concerns of and communication with the public, 17th European ALARA Network Workshop on “ALARA in emergency exposure situations”, Lisbon, Portugal.

Contributed Talks in Conferences

Paulo, A. (20-21 July 2017). Molecular and Nanosized Probes for Nuclear Medicine Imaging and Theranostics. 1º Encontro “A Química na Investigação na ULisboa”, Lisbon, Portugal. Gonçalves, A. P., Santos, I. C., Lopes, E. B., Pereira, L. C. J., Henriques, M. S., Zahurakova, N., Kontuľ, V., Reiffers, M. (26-30 March 2017). U2Sb: a novel binary uranium antimonide. 47ièmes Journées des Actinides, Karpacz, Poland. Susano, M., Gardia, A., Rybusinki, J., Martín-Ramos, P., Pereira, L. C. J., Szczytko, J., Martín-Gil, J., Ramos Silva, M. (9-12 April 2017). Synthesis, Structure, Optical and Magnetic Properties of New Multifunctional Lanthanide Complexes. Materiais 2017, Univ. Aveiro, Portugal. Susano, M., Martín-Ramos, p., Pereira, L. C. J., Lavin, V., Martin, I. R., Coya, C., Alvarez, A. L., Martín-Gil, J., Ramos Silva, M. (7-12 May 2017). Lanthanide (III) Complexes as Single-Ion Magnets and Near-Infrared Emitters. 10th European School on Molecular Nanoscience,5th Workshop on 2D Materials, El Escorial, Madrid, Spain. Matos, J. C., Pereira, L. C. J., Waerenborgh, C. J., Gonçalves, M. C. (7-12 May 2017). SPIONs: characterization for biomedical applications – preliminary results. 10th European School on Molecular Nanoscience, 5th Workshop on 2D Materials, El Escorial, Madrid, Spain. Ramos Silva, M., Susano, M., Rybusinski, J., Martín-Ramos, P., Gardias, A., Szczytko, J., Martín-Gil, J., Lahoz, F., Lavín, V., Eusébio E., Pereira, L. C. J., Inocencio, M. (3-6 July 2017). Ln(III) Complexes as Single-Ion Magnets that light can disturb. Conference on Multiscale phenomena in Molecular Matter, Kraków Poland. Matos, J. C., Pereira, L. C. J., Waerenborgh, J. C., Gonçalves, M. C. (20 November 2017). Synthesis and Characterization of Spions for Biomedical Applications. Workshop ChemMat C2TN Workshop on Advanced Materials & ChemMat Doctoral Programme, IST/CTN, Bobadela, Portugal. Pereira, L. C. J. (6 December 2017). 4f and 5f compounds with Single Molecule Magnetic Behaviour. C2TN: Radiation for Science and Society; 1st Workshop, IST/CTN, Bobadela, Lisbon. Dias, M. I., Waerenborgh, J. C., Prudêncio, M. I., Paiva, M. I., Lobarinhas, D., Carvalho, E., Marques, R., Franco, D., Cardoso, G. (16-17 November 2017). Chemistry, mineralogy and iron


speciation of mine tailings to identify potential metals secondary sources. World Congress on Geochemistry, Atlanta, Georgia, USA. Rabaça, s., Oliveira, s., Gonçalves, a. c., Lopes, G., Gama, V., Lopes, E. G., Oliveira, G., Santos, I. C., Paixão, J. A., Belo, D., Canadell, E., Almeida, M. (21 July 2017). Self-Assembled Bilayer Molecular Metals (CNB-TTF-type donors)4X: Polymorphism and Superconductivity. 1º Encontro do Colégio de Química, Lisbon University, Lisbon, Portugal. Rabaça, S., Oliveira, S., Gonçalves, C., Varatojo, A., Lopes, G., Gama, V., Lopes, E. B., Santos, I. C., Belo, D., Oliveira, G., Almeida, M. (6 December 2017). Self Assembled Bilayer Molecular Metals; A New Paradigm for Organic Conductors and Superconductors. C2TN-Radiation for Science and Society: 1st Workshop, IST/CTN, Bobadela, Portugal. Gonçalves, A. P., Lopes, E. B., Montemor, M. F., Monnier, J., Lenoir, B. (5-7 April 2017). Tetrahedrite-based Materials as a Source of Sustainable Energy. The Energy Materials Research Conference 2017, Lisbon, Portugal. Gonçalves, A. P., Lopes, E. B. (20-21 July 2017). Study of thermoelectric materials at C2TN. 1º Encontro do Colégio de Química, Lisbon University, Lisbon, Portugal. Domingos, G., Gonçalves, A. P., Lopes, E. B., Monnier, J., Lenoir, B. (7-8 September 2017). Reflections on Tetrahedrites for Thermoelectric Applications: The Preparation. First Iberian Thermoelectric Workshop 2017 (ITW2017), Lipor Company, Ermesinde, Porto, Portugal. Brisset, N., Quéméré, S., Gonçalves, A. P., Stepnik, B., Tougait, O., Pasturel, M. (5-6 October 2017). Frittage SPS de composés intermétalliques pour le nucléaire. Journées Nationales sur le Frittage par Courant Pulsé, Villetaneuse, France. Vieira, B. J. C., Waerenborgh, J. C. (27 September 2017). A espectroscopia de Mössbauer em estudos de solos vulcânicos. Workshop: Cultural Heritage & Geoprocesses, Strategic Resources and Global Change, Lisbon, Portugal. Correia, J.G. (6 February 2017). EC and TDPAC at ISOLDE: electrons & gammas, the clever messengers of tiny physics in materials. 1st International BMBF collaborator’s meeting at ISOLDE CERN, Geneva, Switzerland. U. Wahl, L M. Amorim, V. Augustyns, A. Costa, E. David Bosne, T.A.L. Lima, G. Lippertz, J.G. Correia, M.R. da Silva, M.J. Kappers, K. Temst, A. Vantomme, L.M.C. Pereira (24-28 July 2017). Lattice location of Mg in GaN of different doping types: direct evidence for amphoteric nature of Mg. 12th International Conference on Nitride Semiconductors, Symposium E: Theory, basics, Strasbourg, France. U. Wahl, A.R.G. Costa, E.D. Bosne, T.A.L. Lima, G. Lippertz, J.G.M. Correia, M.C.R. Silva, K.Temst, A. Vantomme, L.M.C. Pereira, and M. Kappers (4-6 December 2017). Influence of Fermi-level on the lattice location of 27Mg in GaN. 2017 ISOLDE Workshop and Users Meeting, CERN, Geneva, Switzerland. Prudêncio, M.I., Dias, M.I., Paiva, M.I. REE geochemistry in surficial environments and acid mine drainage. World Congress on Geochemistry and Marine Science, Atlanta, USA, Nov. 2017. Dias, M.I., Waerenborg, J.C., Prudêncio, M.I., Paiva, M.I., Lobarinhas, D., Carvalho, E., Rosa, C., Marques, R., Franco, D., Cardoso, G. Chemistry, mineralogy and iron speciation of mine tailings


to identify potential metals secondary sources. World Congress on Geochemistry and Marine Science, Atlanta, USA, Nov. 2017. Dias, M.I., Prudêncio, M.I., Azulejos de Lisboa, Portugal (XVII-XX): identificação de matérias primas e tecnologias de produção. XII Congresso Ibérico, 25-28 Outubro, Burgos, Espanha, 2017. Prudêncio, M.I., Dias, M.I., Kasztovszky, Z., Maróti, B., Harsányic, I., Kovács, I., Szőkefalvi-Nag, Z., Valera, A.C. Pre-historic funerary votive assemblages – stone vases provenancing using non-destructive neutron techniques. NINMACH 2017 – 2nd International Conference on Neutron Imaging and Neutron Methods in Archaeology and Cultural Heritage Research, 11-13 October, Budapest, Hungary, 2017. Dias, M.I., Kasztovszky, Z., Prudêncio, M.I., Harsányic, I., Kovács, I., Szőkefalvi-Nag, Z., Mihály, J. Káli, G., Valera, A.C. Investigating beads from Chalcolithic funerary cremation contexts of Perdigões, Portugal. NINMACH 2017 – 2nd International Conference on Neutron Imaging and Neutron Methods in Archaeology and Cultural Heritage Research, 11-13 October, Budapest, Hungary, 2017. Dias, M.I., Prudêncio, M.I., Paiva, M.I., Lobarinhas, D., Carvalho, E. Rosa, C. Material source analyses and geochemistry about two REE secondary deposits in northern Portugal. The 2nd Conference on European Rare Earth Resources, ERES 2017, 28-31 May, Santotini, Greece, 2017. Marques, R., Prudêncio, M.I., Rocha, F., Dias, M.I., Franco, D. Rare Earth and other Chemical Elements Accumulation in Vines of Fogo Island (Cape Verde). EGU2017, European Geosciences Union General Assembly, 23-28 April, Vienna, Austria, 2017. Rodrigues, A. L., Dias, M. I., Cardoso, G., Prudêncio, M. I., Marques, R., Franco, D. (6 December 2017). Luminescence Dating, dosimetry and compositional studies applied to cultural heritage. The international prominence of the luminescence dating laboratory of C2TN. 1st Workshop C2TN: RADIATION FOR SCIENCE AND SOCIETY, Bobadela, Portugal. Miguel A. Reis and P. Cristina Chaves (2-7 April 2017). Ta L and M shells PIXE spectra obtained at the C2TN HRHE-PIXE facility using proton and oxygen ion beams. 15th International Conference on Particle Induced X-ray Emission, PIXE 2017, Spli, Croatia. P. C. Chaves, P. Conceição, P. Madureira, M. A. Reis (2-7 April 2017). Study of geological samples from Azores ocean floor by High Resolution and High Energy PIXE. 15th International Conference on Particle Induced X-ray Emission, PIXE 2017, Spli, Croatia. N. Canha, J. Lage, J. Belo, C. Viegas, T. Faria, S. Cabo Verde, M. Meira e Cruz, C. Alves, S.M. Almeida (28 September 2017). Is the air we breathe while sleeping conditioning our sleep quality? 14th International Conference on Urban Health, Coimbra, Portugal. N. Canha, J. Lage, C. Alves, S.M. Almeida (5 July 2017). Exposure to particulate matter during sleep. 5th Iberian Meeting on Aerosol Science and Technology, Barcelona, Spain. S.M Almeida, V. Manteigas, C. Pina, N. Canha, M. Almeida-Silva, J. Lage, C. Mafra, R. Rato, M. Gomes, G. Giorgetti, K. Gonçalves, J.L. Alexandre (3-6 July 2017). Indoor air quality and energy performance in Portuguese ClimAct schools. The 5th Iberian Meeting on Aerosol Science and Technology (RICTA’17), Barcelona, Spain.


M. Almeida-Silva, P. Baptista, N. Canha, T. Faria, J. Lage, A.V. Faria, G. Duarte, C. Alves, F. Noivo, A. Gaiolas, C. Nascimento, S.M. Almeida (3-6 July2017). Source apportionment in a street canyon: first approach within REMEDIO project. The 5th Iberian Meeting on Aerosol Science and Technology (RICTA’17), Barcelona, Spain. J.S. Pereira, M.F. Pereira, S. Rangel, M. Caldeira, G. Carvalhal, L. Santos, J.V. Cardoso, J.G. Alves. Type testing of LiF:Mg,Cu,P (TLD-100H) whole body dosemeters for the assessment of Hp(10) and Hp(0.07). 27th International Conference on Nuclear Tracks and Radiation Measurements, Strasbourg, France. M. Carvalho, V. Debut, J. Antunes. A review of bell design and tuning techniques: From magic to science. International Symposium on Music Acoustics, June 2017, Montreal, Canada. V. Debut, J. Antunes. Realistic guitar modelling using a dynamical multibody approach. International Symposium on Music Acoustics, June 2017, Montreal, Canada. M. Carvalho, V. Debut, J. Antunes. Reverse engineering techniques for characterizing historical bells of the Mafra carillons, World Carillon Congress, July 2017, Barcelona, Catalonia, Spain. A. Redondo-Cubero, E. David-Bosne, U. Wahl, P. Miranda, M.R. da Silva, J.G. Correia, and K. Lorenz (2-7 July 2017). Strain detection in crystalline GaN-based heterostructures using bidimensional blocking patterns of channeled particles. 19th International Conference on Radiation Effects in Insulators (REI), Versailles, France. Daniela Pereira, M. Peres, L. C. Alves, J. G. Correia, C. Díaz-Guerra, A. G. Silva, E. Alves, and K. Lorenz (9-14 July 2017). Electrical and Structural Characterization of Molybdenum Oxide Lamellar Crystals Implanted with Oxygen. 20th International Conference on Surface Modification of Materials by Ion Beams, Lisbon, Portugal. A. Redondo-Cubero, E. David Bosne, U. Wahl, P. Miranda, M.R. da Silva, J.G. Correia, and K. Lorenz (24-28 July 2017). Strain detection in AlInN/GaN-based heterostructures using two-dimensional blocking patterns of channeled particles. 12th International Conference on Nitride Semiconductors, Symposium E: Theory, basics, Strasbourg, France. D.G. Redondo, J.G.M. Correia, L. Peralta, R. Honorio, P. Teubig, and A. Henriques (4-6 December 2017). Reinforcing the participation and contribution of the Portuguese team @ HIE-ISOLDE. 2017 ISOLDE Workshop and Users Meeting, CERN, Geneva, Switzerland. Rodrigues, A.L., Dias, M.I., Prudêncio, M.I., Marques, R., Rocha, F., Valera, A.C. (25-28 October 2017). Dinâmicas de preenchimento de uma estrutura circular no recinto de fossos dos Perdigões (Reguengos de Monsaraz, Portugal): Composição e datação por luminescência. XII Congresso Ibérico de Arqueometria, Burgos, Espanha. Rodrigues, A. L. Dias, M. I., Prudêncio, M. I., Flor, P. (6-9 September 2017). Chronological and technological issues of Della Robbia Sculptures in Portugal. European Meeting on ancient ceramics, Bordeaux, França. Rodrigues, A. L. Dias, M. I., Valera, A. C., Prudêncio, M. I. (6-9 September 2017). The contribution of ceramics to the establishment of fill dynamics in negative archaeological structures. European Meeting on ancient ceramics, Bordeaux, France.


Prudêncio, M.I., Marques, R., Waerenborgh, J.C., Vieira, B.J., Dias, M.I., Rocha, F. (23-28 April 2017). Chemistry of volcanic soils used for agriculture in Brava Island (Cape Verde). EGU 2017 General Assembly, Viena, Austria. Baptista, M. et al. (27-29 September 2017). Dosimetric link between Computed Dose Tomography Dose index (CTDI) and Cone Beam CT organ doses: case study for thorax scan protocol. Conference “Proteção Radiológica na Saúde 2017 (PRS2017)”, IST, Lisbon, Portugal. Belchior, A. et al (27-29 September 20147). Clinical issues arising from patients’ organ dose and risk assessment in interventional cardiology procedures. Conference “Proteção Radiológica na Saúde 2017 (PRS2017)”, IST, Lisbon, Portugal. Belchior, A. et al. (27-29 September 2017). Acridine-Orange derivatives as DNA-targeted radiopharmaceuticlas for Auger therapy. Conference “Proteção Radiológica na Saúde 2017 (PRS2017)”, IST, Lisbon, Portugal. Guerreiro, J. et al (27-29 September 2017). Validation and Functional Characterization of Biomarkers for Cancer Theranostics with 64CuCl2. Conference “Proteção Radiológica na Saúde 2017 (PRS2017)”, IST, Lisbon, Portugal. Di Maria, S. et al (27-29 September 2017). Deposited energies distribution comparison between 125I, 99mTc, 161Tb, 111In and 177Lu at micro and nano-scale. Conference “Proteção Radiológica na Saúde 2017 (PRS2017)”, IST, Lisbon, Portugal. Monteiro Gil, O. et al (27-29 Semptember 2017). Genetic damage induced in exfoliated buccal cells after orthopantomography. Conference Proteção Radiológica na Saúde 2017 (PRS2017)”, IST, Lisbon, Portugal. Teles, P. et al. (27-29 September 2017). Dose conversion factors for the kidney of paediatric patients from MC simulations. A new paradigma. Conference “Proteção Radiológica na Saúde 2017 (PRS2017)”, IST, Lisbon, Portugal. Di Maria, S. et al. (12-16 June 2017). Energy Deposition distribution at micro and nano-scale for molecular targeted radiotherapy: comparison between 125I, 99mTc and 64Cu. RAD2017, Fifth International Conference on Radiation applications in various fields of research, Montenegro. Teles, P. et al. (October 2017). Dose coefficients in nuclear nephrology paediatric patients and dose assessment. Age or body weight?. 2nd European Radiation Protection Week 2017 Paris, France. Monteiro Gil, O. et al. (12 January 2017). Main outcome of the CAThyMARA questionnaire. CAThyMARA Meeting, IRSN, Fontenay aux Roses, France. Monteiro Gil, O. et al. (9 February 2017). State of preparedness in Europe about monitoring of contamination/exposure to I-131. CAThyMARA Workshop “Dosimetry and health care following a nuclear accident- views from experts and civil society”, IRSN, Fontenay aux Roses, France. Moitinho de Almeida, F. et al. (18-19 May 2017). UPCAST – Unified Platform for CBRN Accident/Attack Scenario Management. 3rd NERIS Workshop. IST-CTN, Bobadela-LRS, Portugal.


Belchior, A. et al. (2017). Quantification of late biological effects induced by 99mTc-labeled Acridine Orange derivatives acting as DNA intercalators. Annual International Meeting, radiation Research Society, Cancun-Mexico. Vaz, P. et al. (20-24 August 2017). Dosimetry of digital breast tomosynthesis (DBT): where do we stand and where do we go from here?. Simposio Internacional Sobre Protección Radiológica en Medicina, Arequipa, Perú. Dias, M. I., Waerenborgh, J. C., Prudêncio, M. I., Paiva, M. I., Lobarinhas, D., Carvalho, E., Rosa, C., Marques, R., Franco, D., Cardoso, G. (16-17 November 2017). Chemistry, mineralogy and iron speciation of mine tailings to identify potential metals secondary sources. World Congress on Geochemistry and Marine Science, Atlanta, USA. Prudêncio, M. I., Dias, M. I., Paiva, M. I. (16-17 November 2017). REE geochemistry in surficial environments and acid mine drainage. World Congress on Geochemistry and Marine Science, Atlanta, USA. Soares, N., Paiva, I., Monteiro, L. M. (27-29 September 2017). Radionuclides in Waste Discharges from Health Establishments. Conference “Proteção Radiológica na Saúde 2017 (PRS2017)”, IST, Lisbon, Portugal. Cruz, A., Monteiro, B., Galinha, C., Paiva, I., Leal, J. P., Marçalo, J., Carretas J. M., Maria, L., Araújo, M. F. (20—22 September 2017). Mass Spectrometry Techniques in the Recovery of Rare Earth Elements from Mining, Industrial and Urban Wastes. 5º Encontro Nacional de Espectrometria de Massa (PTMS2017), Lisbon, Portugal. J. Cruz, V. Corregidor, M. Manso, L.C. Alves, L. Carvalho (2-6 May 2017). Combined µ-XRF and µ-PIXE/µ-EBS analysis of ancient copper coins. TECHNART 2017, Non-destructive and microanalytical techniques in art and cultural heritage, Bilbao. Inês Coutinho, Francisca Pulido Valente, Luís C. Alves, Teresa Medici. Glass bracelets in medieval Portugal: insights on production and circulation. IV Congresso Internacional Medieval Europe in Motion: A Global Context? Instituto de Estudos Medievais- NOVA FCSH, 13-15th December 2017, Fundação Calouste Gulbenkian, Lisboa Portugal. Madureira, J.. Effects of e-beam irradiation on bioactive content of cherry tomatoes (4-6 December 2017). 10º Encontro Nacional de Cromatografia (10ENC), Bragança, Portugal. Valentim, J., Risso, R., Cardoso, G., Santos, S., Casimiro, M.H., Fonseca, I, Vital, J., (8-9 June 2017). Methanolysis of soybean oil in a catalytic membrane reactor. Study of the effect of catalyst loading and polymer crosslinking of CaO/PVA composite membranes. 2nd Doctoral Congress of Engineering - Symposium on Chemical, Biological and Environmental Engineering, Porto, Portugal. Joaquim Marçalo. The f-Elements in the Gas Phase - Chemistry Challenges at the Bottom of the Periodic Table. 1st C2TN Workshop, CTN-IST, Bobadela, Poirtugal. S. Leal, J. P. Leal. Implementação de dois cursos online e-lab, IV Encontro Internacional Casa das Ciências, Lisboa, Portugal, July de 2017.


J. P. Leal, J. Marçalo, J. B. Branco, J. M. Carretas, L. Maria, B. Monteiro, A. C. Ferreira, A. Cruz, From fundamentals to applications: f-Elements – a fascinating part of the Periodic Table. 1º Encontro do Colégio de Química da Universidade de Lisboa, Lisboa, Portugal. Ana C. Ferreira. CO2 methanation over new nanostructured bimetallic oxides. C2TN Earth Systems, Radioactivity and Cultural Heritage Workshop, Bobadela, 19 September 2017. M. H. Casimiro, J. P. Leal, L. M. Ferreira. Gamma radiation induced functionalization of polymeric based materials. 2nd International Caparica Christmas Congress on Translational Chemistry, Aldeia dos Capuchos, Caparica, Portugal, Dezembro 2017. Leonor Maria. Separação de Terras Raras de resíduos de minas usando líquidos iónicos “CHON”, no âmbito do projeto ENVIREE. Workshop on Earth Systems, Radioactivity and Cultural Heritage, Centro de Ciências e Tecnologias Nucleares, Instituto Superior Técnico-Universidade de Lisboa, 27 September 2017. Bernardo Monteiro. Membranes with a low loading of MOF-Supported ILs for CO2/N2 separation in CO2 capture. Workshop on Environment and New Energy Sources, Centro de Ciências e Tecnologias Nucleares, Instituto Superior Técnico-Universidade de Lisboa, 19 September 2017. M. H. Casimiro, S. Cabo Verde, J. P. Leal, L. M. Ferreira, G. Rodrigues, D. Casal, D. Pais. Biodegradable polymer matrices obtained by ionizing radiation for skin scaffolds. 1st Workshop C2TN: Radiation for Science and Society, Bobadela, Portugal.

Seminars Given

Raposinho, P. D., Experimentação Animal, invited talk in Seminars for 4th year of Nuclear Medicine graduation, Escola Superior de Tecnologia da Saúde de Lisboa, Lisbon, Portugal, 24 November, 2017, Invited Talk. Paulo, A., Molecular and Nanosized Probes for Nuclear Medicine Imaging and Theranostics, workshop “Preclinical small animal in vivo imaging”, IMM, Lisbon, 13th October 2017 Paulo, A., DNA-targeted Metalloconjugates for Cancer Theranostics, CICS-UBI, Covilhã, 21th April 2017 Gano, L., Utilização de radionuclidos em ensaios in vitro, invited talk at Master Course on Clinical Analysis, FFUL, Lisbon, January, 2017. Correia, J.D.G, Peptides derived from Dengue virus type 2 capsid protein translocate the blood brain barrier: Radiometalation and biological evaluation, Institute of Inorganic Chemistry, University of Vienna, 21th November 2017. Melo, R., Molecular modelling in drug development and VLP design, “1st C2TN workshop Radiation for Science and Society”, December 6th, 2017.


Silva, F., Multifunctional nanoparticles for target-specific delivery of radionuclides, 1st C2TN workshop Radiation for Science and Society”, December 6th, 2017. Alice d’ Onofrio, DNA-Targeted Radioimmunotherapy with clickable 161Tb-complexes, Phd Open Days at Instituto Superior Técnico, Lisbon 5-6 April 2017. Alice d’ Onofrio, Clickable Radioimmunoconjugate – Theranostic agents for TEM1 targeting, University of Lisbon PhD Chemistry Meeting organized by Colégio de Química at Rectory of Universidade de Lisboa, Lisbon 4-5 December 2017. Belo, D. (6-19 February 2017). Os Materiais Moleculares ou a incrível história das moléculas falantes. Seminars for the Juniors in “Laboratórios Abertos 2017” from the Chemical Engineering Department from IST, IST, Lisbon, Portugal. Gonçalves, A. P. (26 January 2017). Thermoelectric Materials for Sustainable Development. Institut Català de Nanociència I Nanotecnologia, Barcelona, Spain. Almeida, M. (17 October 2017). A new paradigm of 2D Molecular Conductors by self-assembly of bilayers; the family of molecular metals (CNB-EDT-TTF)4X. RIKEN Waku Campus, Japan. Almeida, M. (18 October 2017). A new paradigm of 2D Molecular Conductors by self-assembly of bilayers; the family of molecular metals (CNB-EDT-TTF)4X. Institute of Solid State Physics, Kashinawanoha Campus University of Tokyo, Tokyo, Japan. Almeida, M. (19 October 2017). A new paradigm of 2D Molecular Conductors by self-assembly of bilayers; the family of molecular metals (CNB-EDT-TTF)4X. Tokyo Institute of Technology, Department of Materials Science and Engineering, Tokyo, Japan. Almeida, M. (23 October 2017). A new paradigm of 2D Molecular Conductors by self-assembly of bilayers; the family of molecular metals (CNB-EDT-TTF)4X. Division of Chemistry of Kyoto University, Kyoto, Japan. Almeida, M. (25 October 2017). Self-assembled bilayer molecular metals (CNB-EDT-TTF)4X; The role of C-N···H interactions in a new prototype of 2D Molecular Conductors. Department of Chemistry, Tohoku University, Sendai, Japan. Almeida, M. (26 October 2017). Conducting and Magnetic Chain Compounds; From 1D conductors to Spin-Ladders. Department of Chemistry, Tohoku University, Sendai, Japan. Pereira, L. C. J. (14 December 2017). Compostos de lantanídeos com propriedades magneto-ópticas. Course of Chemistry from the Masters in Chemistry, Chemistry and Biochemistry Department, Faculty of Sciences, University of Lisbon, Lisbon, Portugal. A.C. Fernandes, “Superheated liquid detectors: from dark matter search to environmental applications”, Seminar of the thematic strand Earth Systems, Radioactivity and Cultural Heritage, Centro de Ciências e Tecnologias Nucleares. Campus Tecnológico e Nuclear, Instituto Superior Técnico, 17-Out-2017. M. Felizardo, “Radiation detectors with superheated liquids” 1st Workshop C2TN: Radiation for Science and Society, Campus Tecnológico e Nuclear, Instituto Superior Técnico, 06-Dez-2017.


R. de Diego, R. Crespo, and A.M. Moro. Extracting three-body breakup observables from continuum-discretized coupled-channels calculations with core excitations. Phys. Rev. C 95, 044611 (2017) N. Canha (2017). Qualidade do Ar Interior em Escolas. Seminário Nacional Eco-Escolas 2017, ABAE, 20th January, Ílhavo, Portugal. S.M. Almeida (2017). LIFE Index-Air @ Conversas de Café - A agenda da Sustentabilidade. Conversas de Café – A Agenda da Sustentabilidade promoted by Junta de Freguesia dos Olivais, 19th May, Lisbon, Portugal. C. Galinha (2017). Níveis de selénio em solo agrícola e na alimentação. Seminário sobre a deficiência de selénio em Portugal, PharmaNord, 25th May, Lisboa, Portugal. S.M. Almeida (2017). Impacte da qualidade do ar interior na exposição diária a poluentes: o projeto LIFE Index-Air, Workshop Indoor Air Quality promoted by APAE - Portuguese Association of Environment Engineering, 26 May, Universidade Lusófona, Lisbon, Portugal. V. Martins (2017). Desenvolvimento de uma ferramenta integrada para reduzir a exposição a partículas em suspensão no ar, Ciência’17, 3-5 July, Lisbon, Portugal. J. Lage (2017). Atuar na transição para uma economia de baixo carbono – desenvolvimento de ferramentas de apoio. Encontro Ciência 2017, 3-5 July, Lisbon, Portugal. S.M. Almeida (2017). LIFE Index-Air - Development of an Integrated Exposure – Dose Management Tool for Reduction of Particulate Matter Air. Workshop “Urban Air Pollution Mitigation Tools”, 30 August, Zurich, Switzerland. S.M. Almeida (2017). LIFE Index-Air - Development of an Integrated Exposure – Dose Management Tool for Reduction of Particulate Matter Air. Intra LIFE PT 2017 promoted by Portuguese Agency of Environment (APA), 23-24 October, Alfragide, Portugal. J. Lage (2017). Estudo de impactes ambientais através da análise do solo. Seminar to Master students of the Master “Analysis and Control of Environmental Risks to Health” from the Escola Superior de Tecnologia da Saúde de Lisboa, Instituto Politécnico de Lisboa, 26th October, Lisbon, Portugal. C. Galinha (2017). Níveis de selénio em solo agrícola e na alimentação. Seminário sobre a deficiência de selénio em Portugal, PharmaNord, 16th November, Lisboa, Portugal. C. Galinha (2017). Níveis de selénio em solo agrícola e na alimentação. Seminário sobre a deficiência de selénio em Portugal, PharmaNord, 25th November, Porto, Portugal. S.M. Almeida, V. Martins, N. Canha, J. Lage, M. Almeida-Silva, C. Galinha, T. Faria, V. Manteigas, A. D’Espiney (2017). Integration of air pollution, climate change and health in urban systems. C2TN-Radiation for Science and Society 1st Workshop, 6th December, Lisbon, Portugal. S.M. Almeida (2017). Transição para uma Economia de Baixo Carbono em 39 escolas ClimACT do espaço Sudoe, WORKSHOP “A Eficiência Energética como Ferramenta para um Desenvolvimento Sustentável”, 13th December, Arronches, Portugal.


Reis, M. (22 November 2017). Summary of R&D activities in Environmental Radioactivity, Invited seminar at Department of Civil, Arquitectura e Georrecursos (DEC), IST, Lisbon, Portugal. Paiva, I. (22 November 2017). A Brief look into R&D activities in Radwaste and Radiological Protection, Invited seminar at Department of Civil, Arquitectura e Georrecursos (DEC), IST, Lisbon, Portugal. Paiva, I., (9 June 2017). Resíduos radioactivos, Fontes órfãs e Bens de consumo contaminados, Invited seminar on Master Course in Environmental Engineering, IPBeja, Beja, Portugal. Alves, L.C., Particle Induced X-ray emission (PIXE) in cultural heritage studies: examples of applications, The HERACLES Fall School - "Characterization Techniques in Cultural Heritage", 11-12 Oct 2017, FCT/UNL, Caparica, Portugal. Alves, L.C., Microscopy with MeV ion beams, C2TN Workshop on Advanced Materials & ChemMat Doctoral Programme, 20th November 2017, IST/CTN, Pólo de Loures, Bobadela, Portugal. Alves, L.C., MeV ion beams in CH studies, Research seminars, CORES, Ph.D. Programme in the Conservation and Restoration of Cultural Heritage, 29th Oct 2017, FCT/UNL, Caparica, Portugal. Araújo, M.F., Determination of trace elements and Pb Isotope ratios using ICP-MS – Aplications in Environmental ad Archaeometric Studies. INstruments of Change INTour (PerKin Elmer), Lisbon, 21 February. Araújo, M.F., Iron Age gold artefacts: Composition and manufacturing techniques. In: Research Seminars in Conservation Sciences, Ph.D. Programme in the Conservation and Restoration of Cultural Heritage (CORES), Departamento de Conservação e Restauro, Faculdade de Ciências e Tecnologias, Universidade Nova de Lisboa, 12 April. Cabo Verde, S., Biological effects of ionizing radiation: Radiomicrobiology, In Workshop Radiopharmaceutical Sciences and Health Physics/Diagnostic, Therapies and Public Health, Campus Tecnológico e Nuclear, Instituto Superior Técnico, Universidade de Lisboa, 26 October 2017. Cabo Verde, S., Ionizing Radiation: a tool to control environmental microbiota towards public health safety, In: 1st Workshop C2TN - Radiation for Science and Society, Campus Tecnológico e Nuclear, Instituto Superior Técnico, Universidade de Lisboa, 6 December 2017. Carreira, P.M., Datação de sistemas squíferos minerais e geotérmicos. Mestrado em Engenharia Geológica e de Minas - Disciplina Recursos Hidrominerais e Geotérmicos. IST – U. Lisboa, 21 April Carreira , P.M., Aplicações de isótopos estáveis no Ciclo da Água. Casos de estudo. Seminário da Licenciatura (3 Ano) Engenharia Geológica e de Minas. . IST – U. Lisboa, 13 December. Casimiro, M.H., Biodegradable polymer matrices obtained by ionizing radiation for skin scaffolds. In: 1st Workshop C2TN - Radiation for Science and Society, Campus Tecnológico e Nuclear, Instituto Superior Técnico, Universidade de Lisboa, 6 December 2017. Madureira, J., Development of Food Bioactives through the Valorization of Olive Oil Production Wastes, In Workshop Earth Systems, Radioactivity and Cultural Heritage ESRCH - Environment And New Energy Sources, Campus Tecnológico e Nuclear, Instituto Superior Técnico, Universidade de Lisboa, 19 September 2017.


Santos, P.M.P. (2017). Radiation for Material, Environmental and Health Sciences Research at IRIS. 1st Workshop C2TN, Bobadela, 6 December, p. 70. (comunicação em painel) Valério, P., O contributo da Quinta do Almaraz para o conhecimento da influência fenícia na metalurgia do Ocidente Peninsular. In: Passado, presente e futuro do sítio arqueológico da Quinta do Almaraz, Fórum Municipal Romeu Correia, Câmara Municipal de Almada & Centro de Arqueologia de Almada, 20 January. Valério, P., Prehistoric metallurgy in southern Portugal. In: Research Seminars in Conservation Sciences, Ph.D. Programme in the Conservation and Restoration of Cultural Heritage (CORES), Departamento de Conservação e Restauro, Faculdade de Ciências e Tecnologias, Universidade Nova de Lisboa, 12 April. Valério, P., Ancient metallurgy in the portuguese territory from the Chalcolithic to the Orientalizing period. In: 1st Workshop C2TN - Radiation for Science and Society, Campus Tecnológico e Nuclear, Instituto Superior Técnico, Universidade de Lisboa, 6 December. J. P. Leal, The elements that make the difference, ChemForum seminars, Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Fevereiro 2017. Joaquim Marçalo, A Química dos Elementos f - Desafios e Oportunidades na Parte Inferior da Tabela Periódica, Ciclo de Conferências do Núcleo de Química Aplicada da FCT-UNL, Caparica, 14 March 2017 (https://sites.fct.unl.pt/nqa/).

https://sites.fct.unl.pt/nqa/


Seminars and Workshops at C2TN

During 2017 C2TN organized and hosted several scientific meetings, as well as a regular series of seminars by internal and external researchers.

MEETINGS

17th EAN Workshop (in collaboration with NERIS)

15-16 May 2017, Bobadela, Campus Tecnológico e Nuclear of IST, Portugal. Further information here

NERIS Workshop 2017 & 8th General Assembly 17-19 May 2017, Bobadela, Campus Tecnológico e Nuclear of IST, Portugal. Further Information here

3rd PETRUS-ANNETTE-ENEN PhD and Early-Stage Researchers Conference 2017: Radioactive Waste Management and Disposal 26-30 June 2017, Lisbon, Portugal. Further Information here

Radiological Protection in Heath (PSR2017) 27-29 September 2017, Lisbon, Portugal. Further Information here

Workshop on Preclinical Small Animal in Vivo Imaging 13th October 2017, Lisbon, Portugal. Further Information here

1st C2TN Workshop 6th December2017, Bobadela, Campus Tecnológico e Nuclear of IST, Portugal. Further information here

https://www.eu-alara.net/index.php/activities/workshops/313-17th-european-alara-network-workshop-on-qalara-in-emergency-exposure-situationsq.html

https://eu-neris.net/index.php/activities/workshops/117-third-neris-workshop-17-19-may-2017-lisbon-portugal.html

http://petrus-annette-2017.strikingly.com/

http://www.ctn.tecnico.ulisboa.pt/prs2017/uk_index.html

http://c2tn.tecnico.ulisboa.pt/images/Conferences_Courses/flyerWorshop_PSAIVI_2017.pdf

http://c2tn.tecnico.ulisboa.pt/index.php/education-outreach/conferences-workshops-organized/75-workshops-conferences/1st-c2tn-workshop/372-1st-c2tn-workshop


SEMINARS

Olga Iranzo (Institut des Sciences Moléculaires de Marseille UMR CNRS 7313, Marseille, France), “Bioinspired approaches for biotechnological applications: expanding Nature's repertoire”, 18-01-2017, Bobadela (CTN Auditorium), Campus Tecnológico e Nuclear of IST, Portugal.

Sérgio Dias (Instituto de Plasmas e Fusão Nuclear IPFN/IST), “Dois Anos no Laboratório de Plasmas Hipersónicos", 23-02-2017, Bobadela (CTN Auditorium), Campus Tecnológico e Nuclear of IST, Portugal.

Johannes van Lier (Departement de Médicine Nucléaire e Radiobiologie, Faculté de Medicine et des Sciences de la Santé, Université de Sherbrooke, Quebéc, Canada), “Radioligands and Fluorescence Probes to Image Estrogen Receptors”, 27-03-2017, Bobadela (CTN Auditorium), Campus Tecnológico e Nuclear of IST, Portugal.

Isabel Almeida (Maastro Clinic, Maastricht, The Netherlands), “Imaging for Proton Therapy ”, 27-04-2017, Bobadela (CTN Auditorium) Campus Tecnológico e Nuclear of IST, Portugal.

Dominique Lorcy (Institut des Sciences Chimiques de Rennes, Université de Rennes, Rennes, France), “Effect of subtle steric differences on the conducting properties of gold bis(dithiolene) complexes”, 28-06-2017, Bobadela (CTN Auditorium), Campus Tecnológico e Nuclear of IST, Portugal.

Helena Alves (CICECO, Universidade de Aveiro, Aveiro, Portugal), “Graphene-coated textiles: a platform for wearable electronics”, 06-07-2017, Bobadela (CTN Auditorium), Campus Tecnológico e Nuclear of IST, Portugal.

Marta Ferraz Dias (DKFZ - German Cancer Research Centre, Heidelberg, Germany), “Charged particle therapy: from treatment to imaging”, 06-09-2017, Bobadela (CTN Auditorium), Campus Tecnológico e Nuclear of IST, Portugal.


Nuno Marques (Sociedade Portuguesa de Psicologia, Portugal), “Comunicação de Risco”, 12-10-2017, Bobadela (CTN Auditorium), Campus Tecnológico e Nuclear of IST, Portugal.

Vasco D. B. Bonifácio (CQFM/IN, IST-UL, Lisbon, Portugal) “Polyurea Dendrimers: Life in a box ”, 19-10-2017, Bobadela (CTN Auditorium), Campus Tecnológico e Nuclear of IST, Portugal.

Helena F. Florindo (Research Institute for Medicines, Faculty of Pharmacy, Universidade Lisboa, Lisbon, Portugal), “Multicomponent Nanoscale Systems for Immune Modulation against solid tumors”, 30-11-2017, Bobadela (CTN Auditorium), Campus Tecnológico e Nuclear of IST, Portugal.


Education

COURSES GIVEN IN UNIVERSITIES AND POLYTECHNICAL SCHOOLS

Mendes, F. - Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa:

Genetic Engineering - Integrated Masters in Biological Eng. and Biomedical Eng. ECTS 4,5 (average 3h/week – lectures and laboratory classes) Molecular Biotechnology - Masters in Biotecnology and Microbiology ECTS 4,5 (average 3h/week – lectures and laboratory classes)

Paulo, A., Invited Coordinator Professor at ESTeSL, Disciplines: Radiopharmacy I (2nd year, 2nd Semester), Radiopharmacy II (3rd year, 1st Semester) (2016/2017). Dulce Belo. Course on General Chemistry, Bachelor in Naval Engineering and Masters in Aerospace Engineering ,Instituto Superior Técnico, Universidade de Lisboa. 1st semester 2016-2017; 1st semester 2017-2018. Sandra Rabaça. Course on General Chemistry, Bachelor in Naval Engineering and Master in Electrical and Computer Engineering, Instituto Superior Técnico, Universidade de Lisboa. 1st semester 2016-2017; 1st semester 2016-2018. Laura C.J. Pereira. Course on Electrical and Magnetic Properties of Materials, Doctoral Programme in Chemistry (ChemMat),Instituto Superior Técnico, Universidade de Lisboa. 2nd semester 2016-2017. Manuel Almeida. Course on Electrical and Magnetic Properties of Materials, Doctoral Programme in Chemistry (ChemMat), Instituto Superior Técnico, Universidade de Lisboa. 2nd semester 2016-2017. J.C. Waerenborgh. Lectures on Mössbauer Spectroscopy from Radioactive wastes course, MSc in Radiation Protection and Safety, Instituto Superior Técnico, Universidade de Lisboa. 2016-2017.

Andreas Kling & Ana Fernandes, subject “Risks and Safety in the Application of Ionizing Radiations”, Master in Radiation Protection and Safety, Instituto Superior Técnico, Universidade de Lisboa. 2nd semester of 2nd year: Sep-Dec 2017.

R. de Diego - IST - practical lessons (2 hours per week) related to the subject Mecânica e Ondas (MEET).


J. Lage (2017). Professor of Higher Education at Faculty of Engineering of Universidade Lusófona de Humanidades e Tecnologias de Lisboa on the Degree in Environmental Engineering. Responsible for two curricular units of the graduation (Air Pollution and Noise Pollution) and one curricular unit of master degree (Modeling and analysis of environmental systems).

S.M. Almeida (2017). Unidade Curricular “Gestão da Qualidade do Ar”, MSc Environmental Engineering, Instituto Superior Técnico, Universidade de Lisboa.

José Marques:

regência da unidade curricular "Física de Reactores Nucleares", Mestrado em Engenharia Física Tecnológica, Instituto Superior Técnico, Universidade de Lisboa.

regência da unidade curricular "Energia Nuclear", Mestrado em Engenharia Física Tecnológica, Instituto Superior Técnico, Universidade de Lisboa.

regência da unidade curricular "Simulação por Métodos de Monte Carlo", Mestrado em Proteção e Segurança Radiológica, Instituto Superior Técnico, Universidade de Lisboa.

regência da unidade curricular "Técnicas Nucleares", Mestrado em Engenharia Física, FCUL.

M. Isabel Dias, unidade curricular, Resíduos Radioactivos, Mestrado em Proteção e Segurança Radiológica, Instituto Superior Técnico, Universidade de Lisboa. Pedro Vaz:

Responsible for the Curricular Unit “Física e Engenharia Nuclear”. Master´s degree in Radiation Protection and Safety, Instituto Superior Técnico, Universidade de Lisboa. 2nd semester 2016/2017.

Responsible for the Curricular Unit “Radiation Dosimetry and Shielding”, Master´s

degree in Radiation Protection and Safety, Instituto Superior Técnico, Universidade de Lisboa. 1st semester 2017/2018.

Octávia Monteiro Gil. Responsible for the Curricular Unit “Efeitos Biológicos das Radiações”, Master´s degree in Radiation Protection and Safety, Instituto Superior Técnico, Universidade de Lisboa. 2nd semester 2016/2017. Isabel Paiva. Responsible for the Curricular Unit “Resíduos Radioactivos”, Master´s degree in Radiation Protection and Safety, Instituto Superior Técnico, Universidade de Lisboa. 2nd semester 2016/2017. Mário Reis:

Responsible for the Curricular Unity “Radioactividade Ambiente”, Master´s degree in Radiation Protection and Safety, Instituto Superior Técnico, Universidade de Lisboa. 1st semester 2017/2018.

Responsible for the Curricular Unity “Metrologia das Radiações Ionizantes na Saúde e

na Indústria”, Master´s degree in Radiation Protection and Safety, Instituto Superior Técnico, Universidade de Lisboa. 1st semester 2017/2018.


Pedro Teles:

Collaboration as lecturer in the Curricular Unit “Radiation Dosimetry and Shielding”, Master´s degree in Radiation Protection and Safety, Instituto Superior Técnico, Universidade de Lisboa. 1st semester 2017/2018.

Mechanics and Waves (MO33645111326), Physics Department, Instituto Superior

Técnico, Universidade de Lisboa. 2nd semester 2016/2017; 1st semester 2017/2018.

Ana Belchior. Collaboration as lecturer in the Curricular Unit “Radiation Dosimetry and Shielding”, Master´s degree in Radiation Protection and Safety, Instituto Superior Técnico, Universidade de Lisboa. 1st semester 2017/2018. Maria José Madruga. Collaboration as lecturer in the Curricular Unit “Environmental Radioactivity”, Master´s degree in Radiation Protection and Safety, Instituto Superior Técnico, Universidade de Lisboa. 1st semester 2017/2018. José Corisco. Collaboration as lecturer in the Curricular Unit “Environmental Radioactivity”, Master´s degree in Radiation Protection and Safety, Instituto Superior Técnico, Universidade de Lisboa. 1st semester 2017/2018. Margarida Caldeira. Collaboration as lecturer in the Curricular Unity “Metrologia das Radiações Ionizantes na Saúde e na Indústria”, Master´s degree in Radiation Protection and Safety, Instituto Superior Técnico, Universidade de Lisboa. 1st semester 2017/2018. M. F. Araújo. Invited Lecturer, in “Energy Dispersive X-ray Fluorescence Spectrometry” in the framework of one semester course on “Examination and Analysis Methods I” for the MSc´s in “Conservation and Restoration”, Departamento de Conservação e Restauro, FCT, UNL, January – February 2017. Sandra Cabo Verde:

Sistemas de Gestão de Qualidade – HACCP: Hazard Analysis and Critical Control Point.

Faculdade de Ciências, Universidade de Lisboa, 5th April 2017. Theoretical lesson in the scope of Biotecnology discipline, MSc in Applied Microbiology.

Ionizing radiation applications. Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 8th May 2017. Theoretical lesson in the scope of the Radiation Effects discipline, Master degree in Biochemistry.

Inactivation studies of Salmonella Typhimurium in different matrices. Faculdade de Ciências, Universidade de Lisboa, 28-13 December 2017, Theoretical and laboratory classes in the scope of the discipline Microbial Biotechnology, Degree in Biology. António Falcão:

Responsible for the discipline “Fundamentals of Radiation Protection and Safety” of the Master Course on Radiation Protection and Safety, Instituto Superior Técnico, Universidade de Lisboa.

Responsible for the discipline “Biomechanics”, Degree Course on Physiotherapy, Higher School for Health Technology, Lisbon Polytechnic.


N. Pinhão & L. C. Alves. Alves, Systems and Techniques of Radiation Detection, Bologna Master Degree in Radiation Protection and Safety, Dept. de Ciências e Engenharias Nucleares, Instituto Superior Técnico, 1ºSemester 2017/2018. A.M.M. Soares, Invited Lecturer in “Isotope Analysis”, Radiocarbon Dating” and “Luminescence Dating” in the framework of one semester course on “Examination and Analysis Methods II” for the Master degrees in “Conservation and Restoration”, FCT/UNL, February 2017. P.M.P. Santos:

Fricke Dosimery. Laboratory classes in the scope of the discipline Radiation Detection Systems and Techniques of the Master Degree (MSc) in Radiation Protection and Safety; Department of Nuclear Sciences and Engineering, Instituto Superior Técnico. October 2017

Ionizing Radiation Applications and Dosimetry. Seminar and pratical class (IRIS, C2TN) of the optional MSc discipline Radiation Chemistry; Chemistry Department, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 17 May 2017.

Dosimetry in Industrial Processes. Training Course for Gamma Irradiation Facilities Operators (4th module). CTN/IST, 02 May 2017. Joaquim Marçalo, Lecturer on Actinide Chemistry in the Radioactive Waste Course of the Bologna Master Degree in Radiation Protection and Safety – IST (2nd semester 2016/2017). J. P. Leal, Invited Teacher, Department of Chemical Engineering, Instituto Superior Técnico, Universidade de Lisboa, Physical Chemistry discipline, in IST integrated Master course of Chemical Engineering (2nd semester 2016/2017). Leonor Maria, Invited Lecturer, Department of Chemical Engineering, Instituto Superior Técnico, Universidade de Lisboa, Chemistry Laboratory II discipline, in IST integrated Master courses of Chemistry Engineering and Biological Engineering (2nd semester 2016/2017).

SHORT COURSES GIVEN IN INTERNATIONAL ORGANIZATIONS

Marques F., Speaker in the MATBIO2017 Summer School, invited talk at the Scientific School on Materials for Biomedical Applications, ICMAB-CSIC, 19-22 June 2017, Barcelona, Spain. S.M. Almeida, C. Galinha (2017) Regional Training Course on Advanced Methods in Positive Matrix Factorization (PMF) and Potential Source Contribution Functions (PSCF), Instituto Superior Técnico and International Atomic Energy Agency, 13-17th November 2017, Lisboa, Portugal. J. Alves. EURADOS Training Course on Implementation of Radiation Protection 160 and lessons learned from intercomparison exercises: U.O. Fisica Sanitaria, Azienda Ospedaliero Universitaria Careggi, Florença (Itália), de 24 a 28 de Abril de 2017. Carreira, P.M., Improving Knowledge of Groundwater Resources to Contribute to their Protection, Integrated Management and Governance (ARCAL CXXXV). IAEA – Isotope Hydrology Section Expert on the introduction of isotope techniques in solving hydrological problems.


Training course organized by the IAEA and ANA (Agência Nacional de Águas –National Water Agency) Brasilia, Brazil, 6-10 March. Carreira, P.M., Regional Training Course on the Role of Isotopes in Integrated Water Resources Management, IAEA – Isotope Hydrology Section Expert on isotope hydrology. African Training course organized by the IAEA and CNESTEN Isotope Hydrology Unit, Rabat, Morocco. 20-24 November.

SHORT COURSES GIVEN IN NATIONAL INSTITUTIONS

Correia, J.D.G: Invited teacher, Lecture on “Nuclear Techniques /SPECT and PET in Drug Discovery” (7

h). Course “Analytical and Imaging Tools in Drug Discovery” from the PhD Program ChemMedTrain, Universidade de Lisboa e Universidade de Coimbra.

Invited teacher, Lecture on “Radiopharmaceutical Science and Cancer Therapy” (2 h). Course “Drug Discovery and Development in Oncology“, Mestrado em Oncobiologia da Faculdade de Medicina, Universidade de Lisboa.

Invited teacher, Lecture on “Research with Radionuclides” (2 h). Preceptorship Program in Bone metastases and bone-targeting agents” organized by Professor Luís Costa from Faculdade de Medicina da Universidade de Lisboa, IMM and Divisão de Oncologia e Radiologia do HSM.

Invited teacher, Lecture on "Nano-radioteranóstica” (2 h). Course “Bionanotecnologia” from several Master programs, da Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa. Paulo, A., Invited teacher, Lecture on “Biodistribution of Nanoparticulate Drug Delivery Systems” COURSE i3DU, PhD Program Advanced Drug Delivery, Faculdade de Farmácia da Universidade de Lisboa. Octávia Monteiro Gil:

(4 January 2017). Efeitos biológicos das radiações ionizantes. Curso para Técnicos Operadores na Indústria: Protecção e Segurança Radiológica na operação de Gamadensímetros do Grupo Teixeira Duarte, IST/CTN, Bobadela, Portugal.

(4 April 2017). Efeitos biológicos das Radiações. Curso de Formação para Operadores de Instalação de Irradiação Gama (Co-60), IST/CTN, Bobadela, Portugal.

(22-23 November 2017). Efeitos biológicos das Radiações Ionizantes. Curso de Protecção Radiológica na Operação de Gamadensímetros, IST/CTN, Bobadela, Portugal. Pedro Vaz:

(10 April 2017). Efeitos biológicos das radiações, Protecção Radiológica e Dosimetria.

Seminar at Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa.


(23 October 2017). (Ionizing) Radiation Protection in Medicine: status and prospects for future evolution, Seminar at Bioengineering Department, IST, Lisbon, Portugal. Isabel Paiva (18-22 December 2017). Management of Radioactive Wastes. Lecture at NATO Advanced Technical Course on “Improvements in radiation protection procedures: Implementation of best practices”, IST/CTN, Bobadela, Portugal. S.M. Almeida (2017) Seminar “Indoor Air Quality in Buildings’ Maintenance”, Post-Graduation in Maintenance Management, Instituto de Soldadura e Qualidade. J. Alves:

(2017) Maria Gheorge, Técnica Superior da Autoridade Nacional de Proteção Radiológica da Roménia, Formação em dosimetria individual da radiação externa, sistema da qualidade, implementação da norma ISO 17025, IAEA fellowship ROM/0/008, Setembro de 2017.

(2017) Milos Zivanovic e Sandra Ceclic, Técnicos Superiores do VINCA-Institute of Nuclear Sciences (Sérvia). Formação em Metrologia das Radiações Ionizantes em aplicações de radiodiagnóstico (mamografia), proteção radiológica e radioterapia, IAEA fellowships SRB/17007 e SRB/170033, Novembro de 2017. Falcão, A.N., Historic Overview of Radiation Protection, and Ionizing Radiation Physics, lectured in a professional refreshing course, CTN, IST, Lisbon University. Joaquim Marçalo - Member of the Scientific Committee and Lecturer on MS — Course Modern Methods of Structure Elucidation–2017, CQE-IST, Lisboa, 23-27 October 2017 (https://cqemmse.weebly.com/). Leonor Maria - member of the Organizing Committee and lecturer on NMR techniques - Course “Modern Methods of Structure Elucidation–2017”, CQE-IST/C2TN, UL, Lisboa, 23-27 October 2017 (http://cqemmse.weebly.com).

Scientific Committees

Filipa Mendes:

• Member of the organizing committee of the “1st C2TN workshop Radiation for Science and Society” December 6th, 2017.

• Member of the Life Science and Medicine Panel of Reviewers of the European Science Foundation.

https://cqemmse.weebly.com/


António Paulo and João Galamba Correia, Members of the Organizing Committee of the workshop “Preclinical small animal in vivo imaging” organized by the C2TN and IMM at IMM and sponsored by MILabs, 13th October 2017. António P. Gonçalves:

• Executive Committee of the European Thermoelectric Society. • International Advisory Board of the annual conference series “Journées des Actinides”. • International Advisory Board of the “International Conference on Solid Compounds of

Transition Elements” biannual conference series. • International Advisory Board of the “Magnetism and Low Temperatures Laboratories”,

Faculty of Mathematics and Physics, Charles University, Prague, Czech Republic. Manuel Almeida:

• Management Committee of the COST Action CA15128 – MOLECULAR SPINTRONICS (MOLSPIN).

• Director of the PhD programme “ChemMat - Materials Chemistry of Nanostructured Materials with Optic Electric and Magnetic Functionalities”, FCT (PD/0045/2013), IST, 2014-2019.

• Executive Committee for Research of 1º Colégio da Química from University of Lisbon. • Chairman of the Organizing Committee of the “UL Chemistry PhD Meeting”, 4-5

December 2017, Rectory of the University of Lisbon. • Chairman of the Organizing Committee of the "13th International Symposium on

Crystalline Organic Metals, Superconductors and Ferromagnets, ISCOM 2019" to take place September 22-27, 2019, Tomar, Portugal.

L.C.J. Pereira: Management Committee substitute member of the COST Action CA15128 – MOLECULAR SPINTRONICS (MOLSPIN). A.C. Fernandes: member of the Executive Committee of the Radiation Protection and Safety Division, American Nuclear Society (until June 2017). João Guilherme Correia:

• member of The international advisory committee of the Joint International Conference on Hyperfine Interactions and Nuclear Quadrupole Interactions, since 2007.

• member of The international advisory committee of the international conference on Application of RadiotraCers and Energetic Beams in Sciences, ARCEBS 2018.

Ulrich Wahl: member of The advisory committee on the “Use of large scale facilities for condensed matter research” of the German Federal Ministry for Education and Research, since Jan. 2013. Maria Isabel Prudêncio:

• Member of the Scientific Committee of the 2nd International Conference on Neutron Imaging and Neutron Methods in Archaeology and Cultural Heritage Research (NINMACH 2017), 11-13 October, Budapest, Hungary, 2017.

• Member of the Organizing Committee of the Word Congress on Geochemistry and Marine Science, Atlanta, USA, Nov. 2017.


M.A. Reis

• Chairman of the International Advisory Committee of the International Conference on Particle Induced X ray Emission since 2010.

• NERIS-TP (European platform on preparedness for nuclear and radiological emergency response and recovery) General Assembly. IST representative.

• Organizing Commitee: 3rd NERIS Workshop on “State of the art and Needs for further research for emergency and recovery preparedness and response”. IST-CTN, Bobadela-LRS, Portugal, 18-19 May 2017.

• Organizing Commitee: The European ALARA Network 17th Workshop – “ALARA principle in Emergency Exposure Situations”. IST-CTN, Bobadela-LRS, Portugal 15-17 May 2017.

Rosa Marques: Chair of the Workshop “Cultural Heritage & Geoprocesses, Strategic Resources and Global Change”, CTN-IST, 27 de Setembro de 2017, Bobadela, Portugal (Thematic Strand Objective Driver). S.M. Almeida and C. Galinha (2017) Scientific and organizing committee of the Regional Training Course on Advanced Methods in Positive Matrix Factorization (PMF) and Potential Source Contribution Functions (PSCF), Instituto Superior Técnico and International Atomic Energy Agency, 13-17th November 2017, Lisboa, Portugal. S.M. Almeida:

• Scientific Commitee “5th Iberian Meeting on Aerosol Science and Technology (RICTA 2017)”, Barcelona, Spain, 4 july - 6 july.

• Scientific and organizing committee of the Workshop “Urban Air Pollution Mitigation Tools”, 30 August, Zurich, Switzerland.

• Evaluation Panel FCT. Bilateral Scientific Agreements. • Evaluation Panel Academy of Finland. Panel for research proposals in the field of

Atmospheric sciences. J.G. Alves:

• Reunião anual do Technical Committee on Ionizing Radiation Technical Committee, Swiss Federal Institute of Metrology (METAS), Berna (Suiça), January de 2017.

• EURADOS Council member, summer meeting at Rudjer Boskovic Institute, Zagreb, Crotia, July 2017.

M. I. Dias: Scientific Committee of the Iberian Conference on Archaeometry, Burgos, 2017. Pedro Vaz:

• Group of Experts under Article 31 of the EURATOM Treaty – Portuguese expert (2015-2019).

• Computational Medical Physics Working Group (CMPWG) of the American Nuclear Society (ANS).

• Member of Group of Experts under Article 37 of the EURATOM Treaty – Portuguese expert.

• Member of MELODI (“Multidisciplinary European Low Dose Initiative”) Board of Directors.


• Member of MELODI E&T Working Group. • MELODI (“Multidisciplinary European Low Dose Initiative) General Assembly. IST

representative. • EURADOS (“European Radiation Dosimetry Group) General Assembly. IST

representative. • ANIMMA 2017 (“Advancements in Nuclear Instrumentation Measurement Methods and

their Applications”), Liège, Bélgica de 19-23 June 2017. • International Joint Conference RADIO 2017, Goiânia, Brasil, 24-29 September 2017. • IRPA 2018 Europe - 5th European IRPA Congress, The Hague, Netherlands, 4-8 June 2018 • RPSD-2018 (20th Annual Topical Meeting of the Radiation Protection & Shielding

Division of the American Nuclear Society, Santa Fé, New Mexico, USA, 26-31 August 2018)

• SATIF-14 (“Fourteenth Specialists´meeting on Shielding Aspects of Accelerators, Targets and Irradiation Facilities”), Bomun, Gyeongju, Coreia do Sul, 30 October to 2 November 2018.

• Scientific Committee “Proteção Radiológica na Saúde 2017 (PRS2017)”, Lisbon, Portugal, 27-29 September 2017.


• Organizing Commitee: The European ALARA Network 17th Workshop – “ALARA principle in Emergency Exposure Situations”. IST-CTN, Bobadela-LRS, Portugal 15-17 May 2017.

• Organizing Commitee “Proteção Radiológica na Saúde 2017 (PRS2017)”, Lisbon, Portugal, 27-29 September 2017.

Maria José Madruga:

• Group of Experts under Article 35 of the EURATOM Treaty – Portuguese expert. • Alliance (European Radioecology Alliance) General Assembly. IST representative.

Pedro Teles:



Isabel Paiva:

• Group of Experts under Article 37 of the EURATOM Treaty – Portuguese expert. • Member of IAEA MedNET Network on Transports of Radioactive Materials. • Member of SPAR Commission. • IGD-TP (Implementing Geological Disposal – Technology Platform). IST representative.


O. Monteiro Gil:

• EPR Biodose 2018 (“Joint International Symposyum on EPR dosimetry and dating and International Conference on Biological Dosimetry”), Munich, Germany, 11-15 June 2018.


• Conference organization: The European ALARA Network 17th Workshop – “ALARA principle in Emergency Exposure Situations”. IST-CTN, Bobadela-LRS, Portugal 15-17 May 2017.



Ana Catarina Antures:



Mariana Baptista:



Ana Belchior:



Salvatore di Maria:


• Organizing Commitee “Proteção Radiológica na Saúde 2017 (PRS2017)”, Lisbon, Portugal, 27-29 September 2017

Yuri Romanets:


• Organizing Commitee “Proteção Radiológica na Saúde 2017 (PRS2017)”, Lisbon, Portugal, 27-29 September 2017


P. M. Carreira: Organizing committee and Scientific committee of the “2nd International Multidisciplinary Conference on Mineral Waters” (MinWat2017), Vila de Luso, 26-31 March. Pedro Valério: Workshop “Cultural Heritage & Geoprocesses, Strategic Resources and Global Change”, ESRCH-C2TN Thematic Strand, CTN-IST, 27 September (organizing and scientific committee). João Paulo Leal: Member of the Local Organizing Committee of the 48èmes Journées des Actinides (JdA2018), Praia de Porto Novo, Portugal, 21-24 March 2018 (http://www.ctn.tecnico.ulisboa.pt/JDA-2018) Member of the Scientific Board of IAVE, E.P. (Educational Assessment Institute) representing the Portuguese Society of Chemistry (SPQ), (2013-2017). Elected President of the Scientific Board of IAVE, E.P. (Educational Assessment Institute) (2013-2017). Councillor of Conselho Nacional de Educação (Nacional Board of Education), (2015-2017). Management Committee Substitute Member of the COST ACTION ES1407 “European network for innovative recovery strategies of rare earth and other critical metals from electric and electronic waste (ReCreew)”. 2015 – 2018. Joaquim B. Branco: Member of the Local Organizing Committee of the 48èmes Journées des Actinides (JdA2018), Praia de Porto Novo, Portugal, 21-24 March 2018 (http://www.ctn.tecnico.ulisboa.pt/JDA-2018) Member of the Directive Board of the FCT Doctoral Programme CATSUS - Catalysis and Sustainability (PD/00248/2012; http://catsus.tecnico.ulisboa.pt). Joaquim Marçalo, Member of the International Advisory Committee of the 10th International Conference on f-Elements (ICFE-10), Lausanne (EPFL), 3-6 September 2018 (http://icfe10.epfl.ch/).

Coordination and/or participation in Infrastructures

Networks

Low Temperatures and High Magnetic Fields Laboratory. Research Team; Manuel Almeida, E.B. Lopes, L.C. Pereira, J.C. Waerenborgh ; Partners: C2TN - IST-UL, CFMC/FC/UL. ; Funding Total 879 000,00 €; C2TN -IST-UL 701 000,00 €

Portuguese Mass Spectrometry Network (RNEM) ROTEIRO/0028/2013, 2014 - 2019. Research Team: Maria Helena Florêncio (PI, FCUL), Joaquim Marçalo (C2TN -IST, Management Team member), M. Conceição Oliveira (CQE-IST, Implementation Team member); Partners/Nodes: Centro de Neurociências e Biologia Celular (CNBC/UC), Faculdade de Ciências da Universidade de Lisboa (FC/UL), Faculdade de Farmácia da Universidade de Lisboa (FF/UL), Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP), Instituto de Tecnologia Química e Biológica

http://www.ctn.tecnico.ulisboa.pt/JDA-2018

http://www.ctn.tecnico.ulisboa.pt/JDA-2018

http://icfe10.epfl.ch/


(ITQB/UNL), Instituto Nacional de Saúde Dr. Ricardo Jorge (INSARJ), Instituto Superior Técnico (IST/UTL), Universidade da Madeira (UMA), Universidade de Aveiro (UA), Universidade de Coimbra (UC); International Partners: INSTRUCT - European Research Infrastructure for Integrated Structural Biology, HUPO - Human Proteome Organization, EuPA - European Proteomics Association; Funding Total 5 820 300.00 €; IST/UL 979 000.00 €

Portuguese Platform for BioImaging (PPBI). Research Team: IST: Mario Berberan (CQFM), João Galamba Correia (C2TN); Partners: U. Porto, U. Minho, INEB, U. Coimbra, U. Aveiro, U. Beira Interior, Champalimaud Foundation, Gulbenkian Institute, U. Nova Lisboa, U. Lisboa, U. Algarve ; Funding Total: 7.5 M€; IST (CQFM+ C2TN) – 350 000,00 €


Participation in International platforms and networks

EUROPEAN PLATFORMS

MELODI. Multidisciplinary European LOw Dose Initiative is an European Platform dedicated to low dose radiation risk research. In 2010 MELODI was founded as a registered association with 15 members. The purpose of MELODI is: 1) MELODI will propose R&T priorities for Europe in its field of competence; EUROPE 2020 Strategy. 2) MELODI will seek the views of stakeholders on the priorities for research, keep them informed on progress made, and contribute to the dissemination of knowledge. 3) MELODI will interface with international partners like WHO and IAEA.

Alliance. European Radioecology Alliance is a Research Platform, in accordance with relevant European Union policies. For this purpose, it will contribute to the following: definition of priority objectives in the Research Area, identification of research programmes and resources to be implemented in order to achieve these objectives, assessment of results obtained, and promotion of communication on these issues between the various actors and parties involved.

NERIS. European Platform on Preparedness for Nuclear and Radiological Emergency Response and Recovery The mission of the NERIS Platform is to establish a forum for dialogue and methodological development between all European organisations and associations taking part in decision making of protective actions in nuclear and radiological emergencies and recovery in Europe.

EURADOS. EURopean Radiation Dosimetry Group gathers 60 institutions in European countries, Russia and USA and is a non-profit association for promoting research and development and European cooperation in the field of the dosimetry of ionizing radiation. EURADOS maintains a network which includes experts (more than 250), reference and research laboratories, and dosimetry services.

EURAMET. The European Association of National Metrology Institutes (EURAMET) is a Regional Metrology Organisation (RMO) of Europe. It coordinates the cooperation of National Metrology Institutes (NMI) of Europe in fields like research in metrology, traceability of measurements to the SI units, international recognition of national measurement standards and related Calibration and Measurement Capabilities (CMC) of its members. Through Knowledge Transfer and cooperation among its members EURAMET facilitates the development of the national metrology infrastructures. EURAMET is responsible for the elaboration and execution of the European Metrology Research Programme (EMRP) which is designed to encourage collaboration between European National Metrology Institutes (NMIs) and partners in industry or academia.


The programme funds joint research projects in specific fields of metrology with over 50 projects selected for funding so far and many more expected over the coming years.

EIMM. European Institute of Molecular Magnetism is a joint initiative stemming from the European Network of Excellence MAGMANet. The institute aims to become a centre of excellence in Europe for research and training as well as a world leading reference in the area of Molecular Magnetism.

INTERNATIONAL NETWORKS

Integrating radiation research in the European Union. FCT decided to participate in the European consortium which will submit a proposal to the HORIZON 2020 EURATOM, NFRP-7 call 2014-15. Title: Integrating radiation research in the European Union. EU provide 70% of funding total (40M euros) the FCT and equivalent research institutions cover the remaining value. They will open calls in their countries.

MEDICIS –Production of alpha –and beta emitters for medical applications (One MARIE Curie approved). New Collaboration with CERN.

n-TOF. The n-TOF collaboration is a consortium of 40 institutions in European countries, USA, Russia and Japan. It undertakes a experimental programme using the Time of Flight (TOF) spectrometer at CERN, to perform the measurement of the neutron capture and fission cross-sections in actinides, structural materials and radionuclides of relevance for nNuclear Technology and Astrophysics.

ISOLDE. ISOLDE-CERN is a facility for the production of radioactive ion beams for experiments in the fields of nuclear and atomic physics, materials science and life sciences. Since 1986 Portugal maintains an experimental infra-structure dedicated to materials science at ISOLDE, which is being developed and permanently maintained under the responsibility and coordination of C2TN.

Documents

c2tn.tecnico.ulisboa.pt · C2TN / IST Annual Report 2017 Page | 1 Content FOREWORD