Turn the Pathway Off Voltage-gated Ca 2+ channels inactivate IP
3 rapidly dephosphorylated Ca 2+ rapidly pumped out Phosphatases
are activated (CaMKII)
Slide 9
Ca 2+ as a 2 nd Messenger (contd) Ryanodine Receptors (RyR)
Important for skeletal muscle Caffeine is an example of a
reversible activator of RyRs IP3 receptors Inositol-1,4,5-P3
Paari Dominic Swaminathan et al. Circulation Research.
2012;110:1661-1677 Copyright American Heart Association, Inc. All
rights reserved.
Slide 15
The domain structure of a calmodulin-dependent protein kinase
II (CaMKII) monomer. Paari Dominic Swaminathan et al. Circulation
Research. 2012;110:1661-1677 Copyright American Heart Association,
Inc. All rights reserved.
Slide 16
Ca-Responsive Transcriptional Activation cAMP-response element
(CRE) CaM KII and Ras-ERK1/2 signaling pathways NFAT