Upload
samantha-thompson
View
221
Download
0
Embed Size (px)
Citation preview
Carbon Chemistry and Life
• Carbon is the central element in organic chemistry, the
central chemistry of life• The properties of carbon emerge from its atomic
structure, which leads to its position in the middle of the second row of the periodic table. Carbons n=2 shell is half full, so it has four electrons and four ‘holes’ in its outer (n=2) shell. It has a strong tendecy to share, rather than donate or accept, electrons
• The most stable carbon compounds are those that make 4 strong covalent bonds. The ability to make four bonds makes carbon uniquely flexible, and organic chemistry uniquely important and rich.
QuickTime™ and aTIFF (Uncompressed) decompressorare needed to see this picture.
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
BOHR ATOM REPRESENTATION OF CARBON ATOM
ENERGY LEVEL DIAGRAM OF CARBON ATOMIC ORBITALS
http://www.edinformatics.com/math_science/c_energy.gif
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.QuickTime™ and a
TIFF (Uncompressed) decompressorare needed to see this picture.
sp hybrid orbitals
sp hybrid orbitals of two carbon atoms positioned to form a bond; a second (and even a third) bond could be formed by p orbital overlap. Sp hybridization is advantageous for a carbon atom making a triple bond (as in alkynes like acetylene, propyne, etc of the form CnH(2n-2).
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
sp2 hybridization in carbon uses two of the three 2p orbitals and the s orbital to form hybrid orbitals. The 2pz orbital is available for p bonding. This scheme is used in carbon atoms making a double bond (e.g., alkenes such as butene of the form CnH2n).
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
sp3 hybridization in carbon uses allthree 2p orbitals and the 2s orbitalto form three hybrid orbitals pointingat the vertices of a tetrahedron. This is the scheme used by tetrahedral carbon atoms that make four singlebonds (as in alkanes of the form CnH(2n+2) such as methane, ethane, butane, etc.)
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.QuickTime™ and a
TIFF (Uncompressed) decompressorare needed to see this picture.
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
Methane and ethane
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.QuickTime™ and a
TIFF (Uncompressed) decompressorare needed to see this picture.
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
Propane, butane, pentane and hexane
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
Butadiene-UNSATURATEDwith two C-C double bonds (diene).
Ethylene-UNSATURATED with C-C double bond
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
Benzene -AROMATIC- can be pictured as having three delocalized C-C bonds
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
Cyclohexane- SATURATED- a six membered ring like benzene, but not flat because all bonds are single.
In saturated compounds all carbon bonds are single because enough bond partners, usually H atoms, are available to make four bonds per carbon. Unsaturated compounds have at least one multiple bond.
SOME OTHER EXAMPLES OF CARBON CHEMISTRY IMPORTANT IN BIOLOGY:
INCLUSION OF HEROATOMS (NOT C OR H)
FUSED RING SYSTEMS.
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
Ethanol AND OTHER ALCOHOLS HAVE A SINGLE OXYGEN THAT MAKES ONE BOND WITH CARBON AND ONE WITH A HYDROGEN ATOM (A HYDROXYL OXYGEN).
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
Pyrene has four fused rings
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.Glycine
Alanine
Aspartic acid
Amino acids all have an amino (NH2) group at one end and an organic acid group (COOH) at the other. The acid is different than an alcohol (CHOH), which has only one C-O bond. The central carbon (alpha carbon) carries a variable R group. In gycine this is just H, in alanine it’s CH3 and in aspartic acid it includes a second acidic group. Twenty amino acids with different R groups are the building blocks of proteins.
H R O
C C C
H H OH
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
NUCLEOTIDES are the monomeric building blocks of nucleic acids and have many functions in energy transfer and signaling. They are complex ‘small’ ( not macro) molecules that include a base ( ring structure with heteroatoms, a ribose sugar, and phospate groups). Adenine can be sequentially phosphorylated to AMP, ADP and ATP.
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
palmitic
Oleic
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
Fatty acids and phopholipids are examples of
biomolecules that include hydrophobic alkyl regions. Note the linear alkly hydrocarbon region in palmitic acid; in contrast, a single double bond in unsaturated oleic acid has introduced a pronounced kink. Phospholipids have multiple hydrocarbon tails.
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
Carotene, an antenna pigment- eat this if you want to see well at night
Quinone, an electron ( and hydrogen) carrier
Heme with central iron
Pheophytin lacks a centralmetal, but resembles chlorophyll
Chlorophyll with central magnesium; note similarity to heme
Some important biological cofactors/prosthetic groups
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
d-glucose
l-glucose
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
sucrose
Carbohydrates tend to have approximately equal numbers of C and O and about twice as many hydrogens (differences caused by release of water when polymers are formed).