Carolina Innovations Seminar February 3, 2011, 5:30-6:30pmUNC-Chapel Hill

Brooks Adams, Executive Director

Laura Faulconer, PhD, Director

Jim Roberts, Director

Accelerating Commercialization in Nanobiotechnology

1. NC COI’s

2. Nanobio opportunity

3. COIN’s role

4. Ways to participate

Topics

Nonprofits creating, organizing & building targeted biotech-related sectors central to economic development & job creation in NC

NC Centers of Innovation / NCBC

COIs

Recognize unique strengths in NC in specific sectors that can be catalyzed by focused, collaborative efforts

Assist in tech commercialization by matching industry needs & resources with focused statewide research

Virtual centers may be regionally located serving statewide network of partners & collaborators

COIs

Established by academic, industry, economic development, government consortia

Led by strong inter-university & industrial partners committed to working collaboratively

Funded COI: Medtech / Ibiliti: www.ibiliti-nc.org Drug Discovery: www.ddcoi.org Nanobiotech / COIN: www.nc-coin.org Marine Biotech

“Human health has always been determined on the nanometer scale…where the structure & properties of the machines of life work in every one of the cells in every living thing. The practical impact of nanosciences on human health will be huge.”

Dr. Richard Smalley, Nobel Laureate, 1943-2005

Nanobio opportunity

Nanobiotechnology

Application of nanotech materials, tools, & processes in the life sciences & medicine

Commercial applications: Therapeutics & diagnostics Medical technology & devices Medical research Non human health-care related

Cardiac progenitor cell cultures on PCL nanofibers., Duke University, Nicolas Christoforu & Kam Leong

Nanomedicine

COIN FOCUS

Significant federal funding

The promise & challenge

Nanotech/nanobiotech is a tool box not an industry Frequently represents platform technology Many potential high value applications Must play into value chain of pharma,

biotech, medtech Nanotech centers are forming globally

Industry clusters growing around them Only a few major centers will develop

“A Roadmap for Nanotechnology in NC’s 21st Century Economy,” March 2006

Nanobio global market

2009 nanomedicine market: N America $4.75 billion Europe $3.65 billion

Emerging nanobio companies: US 280 Ex-US 150

Hubs in Boston, San Francisco, Houston, & RTP

Significant competition from Asia/China

Sources: Business Insights (Jan 2010), Pew Charitable Trusts, COIN database

Targeted nano-enabled delivery booming

2010 market $6.8 billion 2015 market $21.1 billion

Drug delivery 97% of market today 90% by 2015

Other applications: Cosmeceuticals Nutraceuticals Ag & food

2010 2011 2012 2013 2014 2015$0

$5

$10

$15

$20

$25

Source: Lux Research

NC recognized nanotech leader

PEN 2009 survey: NC 8th in US Raleigh metro 4th in US

Small Times US University Report & Rankings 2009: Nanotech commercialization:

NCSU 3rd UNC-CH 5th

Nanotech research: NCSU 10th

NC nanobio

Gaining rapid traction NC strong in 3 key high growth nanotech

sectors: Medicine, biotech, healthcare Tools/instruments Materials

Positive political-business climate supports biotech: NC Innovation Council

Low-cost of business & high quality of life

NC nanobio ecosystem

Industry > 35 nanobio & 70 nanotech

cos > 528 bioscience cos 400 medtech cos

Academic/nonprofit 35 nano univ research centers WFIRM 2 nanotech Ph.D. programs Among 1st with nanotech A.S. 3 major nonprofit research

institutes

Medical centers 4 med schools 5 teaching hospitals Med school forming in Charlotte

Supportive infrastructure 108 medical products CRO’s 7 major research parks across

NC Active, engaged VCs & angels NC Commerce NCBC & Centers of Innovation: NC Regional Partnerships

Entrepreneur resources CED, BIG, BREC, other SBTDC Southeast TechInventures (STI) First Flight & univ-based

incubators

NC nanobio companies

DRUG DISCOVERY AND DELIVERY

Asklepios Biopharma Chapel HillBioDelivery Sciences RaleighBranthan Laboratories GreensboroCromoz Research Triangle ParkHelia MedicalRaleighLiquidia DurhamMicell Technologies RaleighNanIO BiosciencesResearch Triangle

ParkNanoCor Therapeutics Chapel HillNanoMed Corp GreensboroNanoVector RaleighPeptagen RaleighPharmAgra Laboratories BrevardQualiber Chapel HillSalzburg Therapeutics Winston SalemThermiacure Greensboro

ADVANCED MEDICAL TECHNOLOGY

Advanced Liquid Logic MorrisvilleBiomedomicsDurhamCentice MorrisvilleDental Safe GreensboroExpression Analysis DurhamFiltara CaryInanovate Research Triangle ParkLaam Science MorrisvilleNanoArt DurhamNovan Research Triangle ParkNanomics Biosciences CaryPioneer Surgical Orthobio/Greenville Optotrack CaryQuarTek International GreensboroXinRay Systems Research Triangle Park  

OTHER Blue Nano CorneliusNanoTech Labs YadkinvilleSpecialty Scientific High PointXanofi Raleigh

Liquidia Technologies

Developing highly precise particle-based vaccines & therapeutics for prevention & treatment of human disease

Combining deep understanding of particle-based drug development with breakthrough small molecule & biological therapeutics to engineer vaccines & therapies with potential to dramatically improve quality of human life

Based on PRINT® technology developed in UNC Prof Joe DeSimone’s lab

Neal Fowler, CEOFounded 2004Located in Durhamwww.liquidia.com

XinRay

Developing & manufacturing distributed x-ray sources for a broad range of applications including: Diagnostic medical, imaging, homeland security, industrial inspection

Carbon nanotube technology derives from core technologies licensed from UNC-CH & Duke

Moritz Beckmann, CEO

Founded 2007Located in RTPwww.xinraysystems.com

Qualiber

Developing NanoGTP (gemcitabine triphosphate), a novel nanoparticle-based treatment for lung, pancreatic, and other cancers Utilize enabling Lipid-Calcium-Phosphate Nanoparticle drug delivery platform developed in UNC Prof Leaf Huang’s lab

Anil Goyal, CEO

Founded in 2010Virtual Companywww.qualiberinc.com

NC univ leaders in nano-enabled drug delivery

1. University Texas2. Harvard University3. MIT4. University of Michigan5. Johns Hopkins University6. University of Illinois7. Northwestern University8. University of Washington9. Purdue University10. University of Utah11. GA Institute of Technology12. Washington University13. University of Florida14. University Pennsylvania15. Cornell University16. Univ of CA at Berkeley17. University of

Massachusetts18. Univ of CA at San

Francisco

19. University of Minnesota20. NCI21. Rice University22. Ohio State University23. Univ of CA at Los Angeles24. Univ of CA at Santa

Barbara25. University Nebraska

26. UNC27. University of Wisconsin28. Penn State University29. Massachusetts General

Hospital30. University of Kentucky31. Stanford University32. University of Maryland33. University of Southern

California34. University of Pittsburgh35. University of California at

Davis

36. Emory University37. SUNY Buffalo38. University of California at

San Diego39. Northeastern University40. Carnegie Mellon University

41. NC State University42. Vanderbilt University43. Case Western Reserve

University

44. Duke University45. Brown University46. CALTECH47. Arizona State University48. Columbia University49. Rutgers State University50. University of Delaware

Source: COIN study 2009; Based on peer-reviewed articles in Web of Science®

Thought leaders in nano drug delivery

UNC-CH Leaf Huang Joe DeSimone Rudolph Juliano Wenbin Lin Russ Mumper

Duke Ashutosh

Chilkoti Kam Leong

NCSU Nancy

Monteiro-Riviere

Roger Narayan

Source: COIN study 2009; Based on peer-reviewed articles in Web of Science®

UNC-CH nanobio IP for license Inventor

Nanoemulsion for small molecule for formulations of drugs and imaging agents (09-0011)

Russell Mumper

Hybrid Nanoparticles as Dual Therapeutic/Imaging Contrast Agents (08-0070)

Wenbin Lin

Novel nanoparticle cationic lipids that deliver & enhance therapeutic activity of siRNA, DNA, and peptides In tumor cells (08-0038, 08-0049, 08-0134)

Leaf Huang

Tag for siRNA/ Receptor Targeted Oligonucleotides (08-0016)

Rudolph Juliano

Hybrid Nanomaterials as Multimodal Imaging Contrast Agents (06-0075)

Wenbin Lin

Methods & compositions comprising cyrstalline nanoparticles of hydrophobic drugs (08-0080)

Leaf Huang

Address unmet needs of nanobio community: Business intelligence Networking & high value connections Tech scouting & industry partnering Early-stage funding Preclinical testing & regulatory guidance

COIN’s role

COIN key facts

Nonprofit 501c3 launched June 2009 $2.6 million funds committed COIN: Economic/business development catalyst

advancing nanobiotech/nanomedicine commercialization

Key asset: Knowledge & network in nanomedicine Customers: Researchers, entrepreneurs, product

developers, business managers, & investors in nanobiotech

Scope: NC & US Sustainability: Event sponsors/registrations &

member clients

COIN programs

Premier conference/networking events & workshopsBuild, connect, & inform the community… Nanobiotech Executive Roundtables Annual NC Nanotech Commercialization conference nanobio/nanomedicine content

NanoBioConnect: Knowledge-rich web portal providing open access… Trusted business intelligence Directory/compendium of resources

Innovation services:Address specific obstacles to commercialization… Grant writing Incubation partners Connections for pre-clinical testing

Desired end-game commercial outcomes

Licenses Product concepts move into clinic Product launches Funding events New co formations/growth & co expansions Job growth Wealth creation Tool & service providers achieve financial

goals

Accomplishments: Building the organization

First COI funded & launched 4 full-time hires:

Brooks Adams Strategy & program management Laura Faulconer Content Jim Roberts Connections Clare Valcore Logistics

Others professional resources: 21 university interns to date Analytics Outsource finance, marketing, & IT

BOD: 7 outside directors, cross section of nanobio ecosystem

SAB: 7 key thought leaders from academia & industry New 2400 sq ft HQ, Downtown Durham:

Dedicated collaboration meeting space Kymanox bullpen for interns & visitors

Some great partners!

March – NC Nano Commercialization (Charlotte)May – NanoBio Executive Roundtable (Triangle)August – MANCEF COMS (Greensboro)

Ways to participate: Events

Accomplishments: Events

NCNCC 2010: Nanomed track – 5 speakers/50 attendees NCNCC 2011:

Workshop, Nanobio Track, Funding Pitch Room, & Exhibit 21 speakers confirmed (more coming) 2 of 5 pitch room participants signed on

Roundtables: 3 events, 20 talks, 215 attendees from 8 states

COIN showcasing exhibit: 3 events NCNCC (Greensboro) Medtech (Triangle) NNI Summit (D.C.)

Talks by COIN staff: Brooks 8, Laura 3, Jim 1 COMS: Recruited with $53K funding commitment

secured COIN / Slide 7

When can you get involved?

NC Nanotechnology Commercialization Conference March 29-30, 2011 Charlotte, NC COIN nanomedicine workshop morning of

March 29 COIN nanobio track in afternoon March 29 Conference keynote speakers include

Travis Earles, White House Office of Science & Technology Policy

Doug Jamison, CEO, Harris & Harris

How and when can you get involved?

MANCEF COMS, based in New Mexico August 28th, 2011 500-700 people 45% international participation NCBC, RTI, NC Commerce, Joint School of

Nano Lockheed Martin (energy) Most federal granting organizations Norway 2012

Ways to participate: Media & NanoBioConnect

Raising the profile together

Raise profile of our community & our accomplishments: Routine press releases 8 to date, more in

pipeline Strong media partnerships LTW, TJS, MedCity

News, Nanomedicine Journal Routine coverage LocalTechWire, TechJournal

South, Triad Business Journal, Business NC, NanotechNow, AZO Nano, Nanowerk, NC Commerce Newsletter

Thought leadership White papers & articles for technical & scientific journals

Joint press releases with community

NanoBioConnect

Web-based portal for business intelligence & open innovation in nanomedicine Profiles of companies, university centers,

research institutes Profiles of service providers with nano expertise Interview with key thought leaders White papers and reports Candidate portal

Launched January 2011 with NC-coverage, rapidly growing to US coverage

Accomplishments: Web/social media

NanoBioConnect: Since soft launch November:

1,866 visitors , 1,047 unique visitors 8,630 page views, 4.62 pages/visit 5:24 min average 52.09% new visitors At least a hit from every continent; Most from US, Canada, India, UK Most popular: homepage, NanoBioConnect, about us, community

January full launch with press release: Profiles:

29 coos (Plus 8 in QC, 85 in preparation draft) 5 people 1 research institute 19 service providers

White papers & reports: 4 Newsletters: 1

Social media/web: 5 venues companies, LinkedIn, Twitter (300 followers!), YouTube,

Wikipedia

NanoBioConnect next goal

Develop a robust listing of preclinical testing and contract R&D resources with expertise in nano with national coverage

NC resources for pre-clinical testing

synthesis

•WFU Nanotech Center

•Nanotech Labs (Yadkinville, NC)

Characterization

•WFU Nanotech Center, JSNN, Forsyth Tech, Murdoch

In Vitro

•Murdoch, Biomedical Innovation Network, JSNN, ECU, RTI

In Vivo

•Murdoch, Biomedical Innovation Network, JSNN, UNC . RTI

Clinical Trials

•Duke, UNC, WFU , ECU med schools

•RTI, CROs

UNC Translational Oncology & Nanoparticle Drug Development Initiative Lab & GLP Bioanalytical Facility

Part of UNC Eshelman School of Pharmacy, UNC Lineberger Comprehensive Cancer Center, & Carolina Center of Cancer Nanotechnology Excellence: An analytical chemistry & pharmacology lab focusing on

pharmacologic characterization & translational development of small molecule & nanoparticle anticancer agents

Has unique methods & technologies fundamental to development of nanoparticle agents

Performs formulation, stability, efficacy, toxicity, phenotypic probe, pharmacokinetic & pharmacodynamic studies of nanoparticle agents

Bill Zamboni, DirectorFounded 2009Located in Chapel Hillhttp://www.unclineberger.org/research/cores/facility.asp?facilityID=3

Ways to participate: Grant writing services

Grants to accelerate translation

COIN offers grant-writing & other services to accelerate technology translation and development Contract grant-writing Nominal hourly rate

with significant savings over traditional agency

Partnership to submit grants Assistance identifying grant opportunities Assistance identifying collaborators Support of grants Letters of support,

commitment Southeast TechInventures partnership

Summary

COIN offers

Innovators & entrepreneurs: Resources to build relationships crucial for

technology translation & business development

Industry partners: Single point of entry to nanobiotech sectors in NC

and access to innovators & entrepreneurs

Service providers: Resources to develop nanobiotech project pipeline

Summary

Market opportunity is apparent but not without challenges

NC has the assets to continue to be a major player in nanobio

COIN can and will play on the state & national stages

COIN is coalescing the nanobio community focusing on key issues

Together we can accelerate commercialization in nanobiotechnology

The Venable Center303 S Roxboro St., Ste 30, Durham, NC 27701Office: (919) 680-2070Fax: (919) 680-2906

www.nc-coin.org

www.linkedin.com/companies/

coin-center-of-innovation-for-nanobiotechnology

@NCNanoBioTech