1

MECHLORETHAMINE

CCNS

Increased DNA repairFormation of trapping agentsDecreased accumulation(decreased transport)

Crosslinks DNA

Nitrogen mustard

MOPP

PK:

TU:

Toxicity:

CYCLOPHOSPHAMIDE

CCNS

Increased DNA repairFormation of trapping agentsIncreased inactivation

Crosslinks DNA

Nitrogen mustard

CHOPCMFFAC

PK:

TU:

Toxicity:

IFOSFAMIDE

CCNS

Increased DNA repairFormation of trapping agentsIncreased inactivation

Crosslinks DNA

Nitrogen mustard

PK:

TU:

Toxicity:

2

MESNA

PK:

TU:

Toxicity:

CARMUSTINE (BCNU)LOMUSTINE (CCNU)

CCNS

Increased DNA repairFormation of trapping agents

Crosslinks DNA

Nitrosourea

PK:

TU:

Toxicity:

CISPLATIN

CCNS

Increased DNA repair Crosslinks DNA

PVB

PK:

TU:

Toxicity:

3

CARBOPLATIN

CCNS

Increased DNA repair Crosslinks DNA

PVB

PK:

TU:

Toxicity:

BUSULFAN

CCNS

Increased DNA repairFormation of trapping agents

Crosslinks DNA

PK:

TU:

Toxicity:

DACARBAZINE

CCNS

Increased DNA repairFormation of trapping agents

Crosslinks DNA

ABVD

PK:

TU:

Toxicity:

4

MELPHALAN

CCNS

Increased DNA repairFormation of trapping agents

Crosslinks DNA

Nitrogen mustard

PK:

TU:

Toxicity:

1

DOXORUBICIN

CCNS

Changes in target proteinsIncreased inactivationDecreased accumulation

Anthracylineantibiotic

Intercalates DNA

ABVDCHOPFAC

PK:

TU:

Toxicity:Acute:

Delayed:

DAUNORUBICIN

CCNS

Changes in target proteinsIncreased inactivationDecreased accumulation

Anthracylineantibiotic

Intercalates DNA

PK:

TU:

Toxicity:Acute:

Delayed:

DACTINOMYCIN

CCNS

Increased DNA repairFormation of trapping agents

Crosslinks DNA

Antibiotic

PK:

TU:

Toxicity:Acute:

Delayed:

1

BLEOMYCIN

CCS

Increased DNA repairIncreased inactivation

Antibiotic

DNA strand breaks

ABVDPVB

PK:

TU:

Toxicity:

ETOPOSIDE

CCS

Changes in target proteinsDecreased accumulation

Plant alkaloid

DNA strand breaks

PK:

TU:

Toxicity:

IRINOTECAN

CCS

Decreased activation

Plant alkaloid

DNA strand breaks

TOPO I

PK:

TU:

Toxicity:

2

PROCARBAZINE

CCS

DNA strand breaks

MOPP

PK:

TU:

Toxicity:

1

VINBLASTINE

CCS

Changes in target proteinsDecreased accumulation

ABVDPVB

Interrupts mitosis

Plant alkaloid

PK:

TU:

Toxicity:

VINCRISTINE

CCS

Changes in target proteinsDecreased accumulation

CHOPMOPP

Interrupts mitosis

Plant alkaloid

PK:

TU:

Toxicity:

2

PACLITAXEL

CCS

Changes in target proteinsDecreased accumulation

Interrupts mitosis

Plant alkaloid

PK:

TU:

Toxicity:

IXABEPILONE

CCS

Interrupts mitosis

Antibiotic

PK:

TU:

Toxicity: