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CD123-ECD PNB20027Antibody

Specificity: HumanCD123Clone: SSDCLY107D2Isotype: IgG1mouse

The CD123 antigen, also known as Interleukin-3 Receptor a (IL-3Ra) belongs to thecytokine receptor family. It is expressed on dendritic cells, monocytes, eosinophils andbasophils.TheCD123antigenisalsoconstitutivelyexpressedbycommittedhematopoieticstem/progenitorcells,especiallyofthemyeloidlineage(CD13+,CD14+,CD33+,CD15low),andbysomeCD19+cells,itisabsentfromCD3+cells.

uMiyajima, A., «CDw123 (interleukin 3 receptor alpha chain)Workshop Panel Report», 1997, Leucocyte Typing VI,, WhiteCellDifferentiationAntigens.Kishimoto,T., et al,Eds.,GarlandPublishing,Inc.,854-855.

uMoretti, S., Lanza, F., Dabusti, M., Tieghi, A., Campioni, D.,Dominici,M.andCastoldi,G.L.,«CD123(Interleukin3receptoralphachain)»,2001,J.Regul.Homeost.Agents,,15,98-100.

uSato, N., Caux, C., Kitamura, T., Watanabe, Y., Arai, K-I,Banchereau, J., and Miyajima, A., «Expression and factor-dependentmodulationoftheinterleukin-3receptorsubunitsonhumanhematopoieticcells»,1993,Blood,82,752-761.

uMcClanahan,T.,Dalrymple,S.,Barkett,M.,Lee,F.,“Hematopoieticgrowthfactorreceptorgenesasmarkersoflineagecommitmentduringinvitrodevelopmentofhematopoieticcells”,1993,Blood,81,2903-2915.

uKorpelainen, E.I., Gamble, J.R., Smith, W.B., Dottore, M., Vadas,M.A., Lopez, A.F., “Interferon-gamma upregulates interleukin-3(IL-3) receptor expression in human endothelial cells andsynergizes with IL-3 in stimulating major histocompatibilitycomplex class II expression and cytokine production”, 1995,Blood,86,176-182.

uvandeLaar,L.,vandenBosch.A.,vanderKooij,S.W.,Janssen,H.L.,Coffer,P.J.,vanKooten,C.,Woltman,A.M.,“Anonredundantrole for canonical NF-κB in human myeloid dendritic celldevelopmentandfunction”,2010,JImmunol;185;7252-7261.

Antigen Characteristics

References

OtherName: IL-3Ra GeneLocation: Xp22.3orYp11.3GeneName: IL3RAMolecularWeight: 70kDa

Reagent

Line: IOTestFormat: LiquidSize: 0.5mLStatus: ASR

Example of Results

DS-17378A B2012-13538

Outside the US version

ASR:AnalyteSpecificReagent.Analyticalandperformancecharacteristicsarenotestablished.

BeckmanCoulter,thestylizedlogoandIOTestaretrademarksofBeckmanCoulter,Inc.andareregisteredintheUSPTO.

Main Functions

CD123binds IL-3with lowaffinity;whenCD123associateswithCDw131 (commonβchain),itbindsIL-3withhighaffinity.CD123doesnottransduceintracellularsignalsuponbindingIL-3andrequirestheβchainforthisfunction.

Normalwholebloodsample

Formats available

Size Volume Line Status Part#PE 100tests 2mL IOTest ASR A32535ECD 50tests 0,5mL IOTest ASR B20027PC5.5 50tests 0,5mL IOTest ASR B20022

Size Volume Line Status Part#PC7 50tests 0,5mL IOTest ASR B13647APC 50tests 0,5mL IOTest ASR B06376