動物実験を用いた研究成果

発表論文等

（Ｈ２３年度，Ｈ２４年度，Ｈ２５年度，Ｈ２６年度，Ｈ２７年度） Matsubara T, Ikeda M, Kiso Y, Sakuma M, Yoshino K, Sakane F, Merida I, Saito N, Shirai Y , 2012, c-Abl tyrosine kinase regulates serum-induced nuclear export of diacylglycerol kinase by phosphorylation at Tyr-218., J Biol Chem 287: 5507-5517

Kajimoto, K., Shao, D., Takagi, H., Maceri, G., Zablocki, D., Mukai, H., Ono, Y., and Sadoshima, J., 2011,Hypotonic swelling-induced activation of PKN1 mediates cell survival in cardiac myocytes., Am J Physiol Heart Circ Physiol. 300 巻 H191-200. Sehrawat, S., Ernandez, T., Cullere, X., Takahashi, M., Ono, Y., Komarova, Y., and Mayadas, T.N.,2011, AKAP9 regulation of microtubule dynamics promotes Epac1-induced endothelial barrier properties.,Blood 117 巻 708 - 718.

Yasuda, H., and Mukai, H,. Electorphysiological technique for the analysis of the synaptic function of PKN1 in the hippocampus. Neuromethods（共著）,Springer, 2012 年

Yamazaki, K., Suzuki, M., Itoh, T., Yamamoto, K., Kanemitsu, M., Matsumura, C., Nakano, T., Sakaki, T., Fukami, Y., Imaishi, H., and Inui, H. (2011) Structural basis of species differences between human and experimental animal CYP1A1S in metabolism of 3,3’,4,4’,5-pentachlorobiphenyl. J. Biochem. 149(4), 487-494.

Kushima, S., Mammadova, G., Hasan, A.K.M. M., Fukami, Y., and Sato, K.-I. (2011) Characterization of Lipovitellin 2 as a Tyrosine- phosphorylated Protein in Oocytes,Eggs, and Early Embryos of Xenopus laevis. Zoological Sci. 28, 550-559.

Lisa, L. A., Elias, S. M., Rahman, M. S., Shahid, S., Iwasaki, T., Hasan, A.K.M. M., Kosuge, K., Fukami, Y., and Seraj, Z. I. (2011) Physiology and gene expression of The rice landrace Horkuch under salt stress. Func. Plant Biol. DOI:10.1071/FP10198

Mahbub Hasan AK, Fukami Y, Sato K.-I. (2011) Gamete membrane microdomains and their associated molecules in fertilization signaling. Mol Reprod Dev. Oct-Nov;78(10-11):814-30. Tokmakov AA, Iguchi S, Iwasaki T, Fukami Y. (2011) Unfertilized frog eggs die by apoptosis following meiotic exit. BMC Cell Biol. Dec 23;12(1):56.

Sakaguchi M, Oka M, Iwasaki T, Fukami Y, Nishigori C. (2012) Role and Regulation of STAT3 Phosphorylation at Ser727 in Melanocytes and Melanoma Cells. J Invest Dermatol. 2012 Mar 15. doi: 10.1038/jid.2012.45.

Persorption of IgG-Fc-coated particulates from intestinal lumen into portal blood via villous columnar epithelial cells in rat small intestine. Yuji, M., Fujimoto, M., Qi, W.-M., Takahara, E., Mantani, Y., Udayanga, K. G. S., Takeuchi, T., Warita, K., Yokoyama, T., Hoshi, N., Kitagawa, H. The Journal of Veterinary Medical Science, accepted, (2012). Immunohistochemical detection of Toll-like receptor-2, -4 and -9 in exocrine glands from exocrine glands associated with the rat alimentary tract. Mantani, Y., Yokoo, Y., Kamezaki, A., Udayanga, K. G. S., Takahara, E., Takeuchi, T., Kawano, J., Yokoyama, T., Hoshi, N., Kitagawa, H. The Journal of Veterinary Medical Science, accepted, (2012). Alteration in the apoptosis process of rat esophageal epithelium with hyperproliferation of indigenous bacteria under a physiological condition. Udayanga, K. G. S., Yamamoto, K., Miayata, H., Yokoo, Y., Mantani, Y.,

Takahara, E., Kawano, J., Yokoyama, T., Hoshi, N. and Kitagawa, H. The Journal of Veterinary Medical Science, accepted, (2012).

Site differences of the Toll-like receptor expression in the mucous epithelium of rat small intestine. Mantani, Y., Kamezaki, A., Udayanga, K. G. S., Takahara, E., Qi, W.-M., Yokoyama, T., Kawano, J., Hoshi, N., Kitagawa, H. Histology and Histopathology 26, 1295-1303, (2011). Immunohistochemical and histoplanimetrical study on the special relationship between the settlement of indigenous bacteria and the secretion of bactericidal peptides in rat alimentary tract. Yokoo, Y., Miyata, H., Udayanga, K. G. S., Qi, W.-M., Takahara, E., Mantani, Y., Yokoyama, T., Kawano, J., Hoshi, N., Kitagawa, H. Journal of Veterinary Medical Science, 73, 1043-1050, (2011). Immunohistochemical study of the apoptosis process in epidermal epithelial cells of rats under a physiological condition. Udayanga, K. G. S., Miyata, H., Yokoo, Y., Qi, W.-M., Takahara, E., Mantani, Y., Yokoyama, T., Hoshi, N., Kitagawa, H. Histology and Histopathology 26, 811-820, (2011). Immunohistohemical detection of phosphatidylserine and thrombospondin on denucleating erythroblasts in rat bone marrow. Yokoyama, T., Etoh, T., Udayanga, K. G. S., Takahara, E., Qi, W.-M., Warita, K., Matsumoto, Y., Miki, T., Takeuchi, T., Hoshi, N., Kitagawa, H. Journal of Veterinary Medical Science, 73, 949-952, (2011). Immunohistochemical study on the secretory host defense system of bactericidal peptides in rat digestive organs. Yokoo, Y., Miyata, H., Udayanga, K. G. S., Qi, W.-M., Takahara, E., Yokoyama, T., Kawano, J., Hoshi, N., Kitagawa, H. Journal of Veterinary Medical Science, 73, 217-225, (2011). 北川 浩（2011）：第 4 章 血液および骨髄，日本獣医解剖学会 編，獣医組織学 改訂第 5 版，学窓社，東京． 北川 浩（2011）：第 6 章 免疫学 1.免疫系の発生と免疫に関わる組織，見上 彪 監修，獣医免疫学，文永堂出版，東京． Hirashima Y, Moniruzzaman M, Miyano T.,2011.9,p27(Kip1) negatively regulates the activation of murine primordial oocytes., J Reprod Dev. 57(2): 217-222. Bao RM, Hayakawa K, Moniruzzaman M, Taketsuru H, Miyano T.,2011.9, FOXO3 knockdown accelerates development of bovine primordial follicles., J Reprod Dev. 57(4):475-480. Saneyasu T, Honda K, Kamisoyama H, Ikura A, Nakayama Y, Hasegawa S.,2011.5, Neuropeptide Y effect on food intake in broiler and layer chicks., Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 159 巻, 4 号, p422-p426. Toshiyuki Nakamura, Ryohei Tanaka, Hitoshi Ashida.,2011.8, Possible evidence of contamination by catechins in deconjugation enzymes from Helix pomatia and Abalone entrails, Bioscience, Biotechnology and Biochemistry, 75(8), 1506-1510 Yuki Kanamoto, Yoko Yamashita, Fumio Namba, Tadashi Yoshida, Takanori Tsuda, Itsuko Fukuda, Sachiko Nakamura-Tsuruta, and Hitoshi Ashida.,2011.7, A black soybean seed coat extract prevents obesity and glucose intolerance by up-regulating uncoupling proteins and down-regulating inflammatory cytokines in high-fat diet-fed mice., Journal of Agricultural Food Chemistry, 59(16), 8985-8993 Itsuko Fukuda, Miki Tsutsui, Tadashi Yoshida, Toshiya Toda, Takanori Tsuda, and Hitoshi Ashida.,2011.9, Acute and chronic oral toxicity studies of black soybean (Glycine max) hull extract in mice and rats, Food and Chemical Toxicology, 49(12), 3272-3278 Masaya Kawase, Tadashi Saito, Teruo Yasunaga, Tatsuya Takagi, Itsuko Fukuda, Hitoshi Ashida.,2012.2, New structure descriptor in structure-activity relationship study in the suppression of the aryl hydrocarbon receptor transformation by anthraquinones, Food Science and Technology Research, 18(2), 173-176 Shin Nishiumi, Keizo Hosokawa, Masaki Anetai, Toshiro Shibata, Rie Mukai, Ken-ichi Yoshida, Hitoshi

Ashida.,2012.4, Antagonistic effect of the Ainu-selected traditional beneficial plants on the transformation of an aryl hydrocarbon receptor, Journal of Food Science, 77(4), C420-C429 Noda T, Shidara O, Harayama H.,2012.1, Detection of the activator cAMP responsive element modulator (CREM) isoform ortholog proteins in porcine spermatids and sperm, Theriogenology 77(7):1360-1368. Yasuyuki Masuda, Toshinari Takahashi, Kazutoshi Yoshida, Yosuke Nishitani, Masashi Mizuno, and Haruhiko Mizoguchi, 2012, in press, Anti-allergic effect of lactic acid bacteria isolated from seed mash used for brewing sake is not dependent on the total IgE levels, Journal of Bioscience and Bioengineering Matsubara, M., Ikeda, M., Kiso, Y., Sakuma, M., Sakane, F., Merida, I, Saito, N. and Shirai, Y.,2012.2, c-Abl tyrosine kinase regulates serum-induced nuclear export of iacylglycerol kinase a by phosphorylation at Tyr218, J. Biol. Chem. 287 Shirai, Y., Ikeda, M., Saito, N.,2012.1, Regulation of diacylglycerol kinase by phosphorylation, Adv Biol Regul. 1 Shibata, Y., Kawada-matsuo, M., Shirai, Y., Saito, N., Li, D. and Yamashita, Y.,2011.5, Streptococcus mutans diacylglycerol kinase homologue: a potential target for anti-caries chemotherapy., J. Medical Microbiol. 60 Shirai, Y., Morioka, S., Sakuma, M., Yoshino, K., Otsuji, C., Sakai, N., Kashiwagi, K., Chida, K., Shirawaka, R., Horiuchi, H., Nishigori, C., Ueyama, T. and Saito, N.,2011.4, Direct biding of RalA to PKCh and its crucial role in morphological change during keratinocytes differentiation, Mol. Biol. Cell 22 Yamanoue, M., Ueda, S., Matsunaga, K., Onishi, K., and Sioyama, N.,2011.8, Characterization of antibodies against the connectin/titin 20-kDa fragment increased in chicken sarcoplasm during postmortem aging, Proc. 57th ICoMST, P072 上田修司・山之上 稔,2011.6, 食肉の熟成と筋漿中のコネクチン断片増加, 食肉の科学, 52(1), 120-123 山之上 稔,2011.11, 熟成中の食肉軟化と筋原線維のコネクチンの変化およびパラトロポミオシンの関与, 食肉の科学，52(2), 143-150 Udayanga, K. G. S., Miyata, H., Yokoo, Y., Qi, W.-M., Takahara, E., Mantani, Y., Yokoyama, T., Hoshi, N., Kitagawa, H. ,2011, Immunohistochemical study of the apoptosis process in epidermal epithelial cells of rats under a physiological condition., Histol Histopathol, 26: 811-820. Yokoo, Y., Miyata, H., Udayanga, K. G. S., Qi, W.-M., Takahara, E., Yokoyama, T., Kawano, J., Hoshi, N., Kitagawa, H.,2011, Immunohistochemical study on the secretory host defense system of bactericidal peptides in rat digestive organs., JVMS, 73: 217-225. Yokoyama, T., Etoh, T., Udayanga, K. G. S., Qi, W.-M., Warita, K., Matsumoto, Y., Miki, T., Takeuchi, Y., Hoshi, N., Kitagawa, H. ,2011, Immunohistochemical detection of phosphatidylserine and thrombospondin on the denucleating erythroblasts in rat bone marrow., JVMS, 73: 949-952. Mantani, Y., Kamezaki, A., Udayanga, K. G. S., Takahara, E., Qi, W.-M., Yokoyama, T., Kawano, J., Hoshi, N., Kitagawa, H. ,2011, Site differences of the Toll-like receptor expression in the mucous epithelium of rat small intestine., Histol Histopathol, 26: 1295-1303. Udayanga, K. G. S., Yamamoto, K., Miyata, H., Yokoo, Y., Mantani, Y., Takahara, E., Qi, W.-M., Kawano, J., Yokoyama, T., Hoshi, N., Kitagawa, H. ,2011, Alteration in the apoptosis process of rat esophageal epithelium with hyperproliferation of indigenous bacteria un a physiological condition., JVMS, 2011 Dec 22. Mantani, Y., Yokoo, Y., Kamezaki, A., Udayanga, K. G. S., Takahara, E., Kawano, J., Yokoyama, T., Hoshi, N., Kitagawa, H. , 2011（印刷中）, Immunohistochemical study on the secretion of soluble Toll-like receptors from exocrine glands associated with the rat alimentary tract., Histol Histopathol, Warita, K., Mitsuhashi, T., Tabuchi, Y., Ohta, K., Suzuki, S., Hoshi, N., Miki, T., Takeuchi, Y. ,2012, Microarray and gene ontology analyses reveal downregulation of DNA repair and apoptotic pathways in diethylstilbestrol- exposed testicular Leydig cells., J Toxicol Sci, 37: 287-295.

Brahmajosyula Manjula and MIYAKE Masashi,2011.11, Localization and expression of peptidylarginine deiminase 4 (PAD4) in mammalian oocytes and preimplantation embryos, Zygote, doi:10.1017/S0967199411000633, P1-11 Brahmajosyula Manjula and MIYAKE Masashi, 2012 年 in press, Role of peptidylarginine deiminase 4 (PAD4) in mammalian preimplantation embryonic development. Zygote, Zygote Takaichi, R., Odagaki, S-I., Kumanogoh, H., Nakamura, S, Morita, M., Maekawa, S.,2012 Inhibitory effect of NAP-22 on the phosphatase activity of synaptojanin-1. , J. Neuroscience Research 90, 21-27. Nakamura K, Minami K, Tamura K, Iemoto K, Miki T, Seino S. Pancreatic �-cells are generated by neogenesis from non-�-cells after birth. Biomed Res 32:167-174, 2011 Matsubara T, Mita A, Minami K, Hosooka T, Kitazawa S, Takahashi K, Tamori Y, Yokoi N, Watanabe M, Matsuo E, Nishimura O, Seino S. PGRN is a key adipokine mediating high-fat diet-induced insulin resistance and obesity through IL-6 in adipose tissue. Cell Metab 15:38-50, 2012 Yokoi, N., Hidaka, S., Tanabe, S., Ohya, M., Ishima, M., Takagi, Y., Masui, N., Seino, S. Role of major histocompatibility complex class II in the development of autoimmune type 1 diabetes and thyroiditis in rats. Genes Immun 13:139-145, 2012 南幸太郎、清野進：膵 β細胞におけるインスリン分泌制御メカニズム、最新臨床糖尿病学（上）―糖尿病学の最新動向－ 日本臨床社 p.95-98, 2012 南幸太郎：膵 β細胞の機能分化とインスリン分泌細胞の再生誘導、胆と膵 32(11):1219-1225, 2011 柴崎忠雄、清野進：スルホニル尿素薬の新たな標的分子、日本薬理学会雑誌 p.1, 2011 柴崎忠雄、清野進：インスリン分泌における cAMP センサーEpac2A の役割、内科学会雑誌 p.1418-1424, 2011 柴崎忠雄、清野進：インクレチンの分泌調節機構、日本臨床 p.803-807, 2011 柴崎忠雄、安田貴雄、清野進：インスリン開口分泌における Rim2αの役割、糖尿病学 2011 p17-25, 2011 高橋晴美、柴崎忠雄、清野進：新規標的分子 Epac：インスリン分泌における Epac2A の役割、Mebio 28:132-139, 2011 高橋晴美、柴崎忠雄、清野進：インスリン分泌における Epac2A の役割、Diabetes Journal 39:151-157, 2011 N. Hasegawa, A. Sumitomo, A. Fujita, N. Aritome, S. Mizuta, K. Matsui, R. Ishino, K. Inoue, N. Urahama, J. Nose, T. Mukohara, S. Kamoshida, R. G. Roeder, M. Ito. Mediator subunits MED1 and MED24 cooperatively contribute to pubertal mammary gland development and growth of breast carcinoma cells. Mol. Cell. Biol. 32, 1483-1495, 2012.4 宇賀昭二：生野菜と寄生虫症. 公衆衛生、76 （1）、47-49、2012.1 宇賀昭二：肝蛭症、肝吸虫症（521-525）、土壌媒介性線虫症（542-546）、感染症事典. 感染症事典編集委員会（編）、Ohmsha, 2012.1 宇賀昭二（代表編者）：アジアにおける国際保健、神戸大学国際保健教育研究センター発行、ルネック、2012.1 吉田勉（監修）、栗原伸公（編集）：公衆衛生学 -食物と栄養学基礎シリーズ-、宇賀昭二（環境衛生 19-31；感染症 121-131）､学文社、2012.1 宇賀昭二 丸山治彦（編集）：寄生虫学研究；材料と方法（ISBN978-4-88361-998-6） 三恵社、2012.6

青山倫子、宇佐美眞、上田敬博、小谷穣治,2012.2, エンドトキシン血症下の肺好中球アポトーシスへの静脈注射用免疫グロブリンの効果, 日本外科感染症学会雑誌 9 巻 1 号 63-69 頁

青山倫子、神前雅彦、井上岳人、前重伯壮、三好真琴、上田敬博、宇佐美眞、小谷穣治,2011.11, 自然免疫系の解析と病態制御 エンドトキシン血症時の性差による IL-18の役割と腸管 iNOS発現の差異, エンドトキシン・自然免疫研究 14 巻 1-5 頁

坂木宏衣、三好真琴、飯塚宣仁、宇佐美悠、青山倫子、宇佐美眞,2011.11, 経口投与によるエンドトキシン誘発肝障害の抑制, 機能性食品と薬理栄養 6 巻 6 号 337-342 頁 Koyanagi M, Asahara S, Matsuda T, Hashimoto N, Shigeyama Y, Shibutani Y, Kanno A, Fuchita M, Mikami T, Hosooka T, Inoue H, Matsumoto M, Koike M, Uchiyama Y, Noda T, Seino S, Kasuga M, Kido Y.,2011.8, Ablation of TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC1., PLoS ONE 6:e23238 木戸良明、柴崎忠雄、清野進,2011, 中外医学社, 膵 β細胞における cAMP 情報伝達系

松田友和、木戸良明,2011, 診断と治療社, 膵 β細胞における小胞体ストレスの役割 松田友和、木戸良明,2012, 中外医学社, ER stress と膵 β細胞 木戸良明,2012, 神戸大学国際保健教育研究センター, アジアにおける糖尿病 森藤武，村上慎一郎，椎名祥子，藤田直人，近藤浩代，藤野英己．自然発症２型糖尿病ラットの血糖及び骨格筋内微小血管障害に対する継続的な持久運動の予防効果．日本基礎理学療法学会誌 15(2): 22-27, 2012. 藤田直人，村上慎一郎，藤野英己．廃用性筋萎縮の予防に対する治療的電気刺激を用いた等尺性収縮の効果．日本物理療法学会会誌，in press Fujino H, Kondo H, Murakami S, Nagatomo F, Fujita N, Takeda I, Ishihara A, Roy RR.Differences in Capillary Architecture, Hemodynamics, and Angiogenic Factors in Rat Slow and Fast Plantarflexor Muscle. Muscle Nerve 45(2): 242-249, 2012. Fujita N, Murakami S, Fujino H. The combined effect of electrical stimulation and high-load isometric contraction on protein degradation pathways in muscle atrophy induced by hindlimb unloading. J Biomed Biotechnol 2011: 401493, 2011. 長井桃子，小形晶子，荒川高光，三木明徳．褥瘡様皮膚病変を誘発する動物実験モデルの開発−坐骨神経切断後のラット踵部の形態学的観察−．神戸大学大学院保健学研究科 紀要 27: 31-41, 2012. Fujiwara Y, Arakawa T, Fujita N, Fujino H, Miki A. Influence of magnetic stimulation on muscle atrophy in the rat unloading hindlimb muscles. Bulletin of Health Sciences Kobe 27: 19-26, 2012. Cancer Gene Ther. (19 (2) pp.144-52)2012 Feb E10A, an adenovirus-carrying endostatin gene, dramatically increased the tumor drug concentration of metronomic chemotherapy with low-dose cisplatin in a xenograft mouse model for head and neck squamous-cell carcinoma.Adhim Z, Lin X, Huang W, Morishita N, Nakamura T, Yasui H, Otsuki N, Shigemura K, Fujisawa M, Nibu K, Shirakawa T. Br J Cancer (105 (3) pp.393-402) 2011 Jul In vitro and in vivo inhibitory effect of three Cox-2 inhibitors and epithelial-to-mesenchymal transition in human bladder cancer cell lines. Adhim Z, Matsuoka T, Bito T, Shigemura K, Lee KM, Kawabata M, Fujisawa M, Nibu K, Shirakawa T. Kobayashi T, Ito T, Shiomi M,2011,Roles of the WHHL rabbit in translational research on hypercholesterolemia and cardiovascular diseasesJ Biomed Biotechnol,2011 巻 1 号, 406473-406473

Cao Y, Nakata M, Okamoto S, Takano E, Yada T, Minokoshi Y, Hirata Y, Nakajima K, Iskandar K, Hayashi Y, Ogawa W, Barsh GS, Hosoda H, Kangawa K, Itoh H, Noda T, Kasuga M, Nakae J,2011,PDK1-Foxo1 in agouti-related peptide neurons regulates energy homeostasis by modulating food intake and energy expenditurePLoS One,6 巻 4 号,18324-18324 Iwasaki H, Kawamoto A, Tjwa M, Horii M, Hayashi S, Oyamada A, Matsumoto T, Suehiro S, Carmeliet P, Asahara T,2011,PlGF repairs myocardial ischemia through mechanisms of angiogenesis, cardioprotection and recruitment of myo-angiogenic competent marrow progenitorsPLoS One,6 巻 9 号,24872-24872 Koyanagi M, Asahara S, Matsuda T, Hashimoto N, Shigeyama Y, Shibutani Y, Kanno A, Fuchita M, Mikami T, Hosooka T, Inoue H, Matsumoto M, Koike M, Uchiyama Y, Noda T, Seino S, Kasuga M, Kido Y,2011,Ablation of TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC1PLoS One,6 巻 8 号,23238-23238 Nagano T, Kotani Y, Kobayashi K, Hatakeyama Y, Hori S, Kasai D, Funada Y, Nishimura H, Kondoh T, Nishimura Y,2011,Long-term outcome after multidisciplinary approach for leptomeningeal carcinomatosis in a non-small cell lung cancer patient with poor performance statusIntern Med,50 巻 24 号,3019-3022 Yoshino H, Okumachi Y, Akisaki T, Yasuda H, Hara K, Yokono K, Akita H,2011,Bleeding from the small intestine and aortic regurgitation in Noonan syndromeIntern Med,50 巻 21 号,2611-2613 Bouike G, Nishitani Y, Shiomi H, Yoshida M, Azuma T, Hashimoto T, Kanazawa K, Mizuno M,2011,Oral Treatment with Extract of Agaricus blazei Murill Enhanced Th1 Response through Intestinal Epithelial Cells and Suppressed OVA-Sensitized Allergy in MiceEvid Based Complement Alternat Med,2011 巻. pii 号,532180-532180 Fujita N, Matsushita T, Ishida K, Sasaki K, Kubo S, Matsumoto T, Kurosaka M, Tabata Y, Kuroda R2011.6,An analysis of bone regeneration at a segmental bone defect by controlled release of bone morphogenetic protein 2 from a biodegradable sponge composed of gelatin and β-tricalcium phosphateJ Tissue Eng Regen Med Hayashi S, Nishiyama T, Miura Y, Fujishiro T, Kanzaki N, Hashimoto S, Matsumoto T, Kurosaka M, Kuroda R,2011.7,DcR3 induces cell proliferation through MAPK signaling in chondrocytes of osteoarthritisOsteoarthritis Cartilage,19 巻 7 号,903-910 Yamamoto K, Tanaka H, Nishitani Y, Nishiumi S, Miki I, Takenaka M, Nobutani K, Mimura T, Ben Suleiman Y, Mizuno S, Kawai M, Uchiyama I, Yoshida M, Azuma T,2011.7,Helicobacter suis KB1 derived from pig gastric lymphoid follicles induces the formation of gastric lymphoid follicles in mice through the activation of B cells and CD4 positive cellsMicrobes Infect,13 巻 7 号,697-708 Sugimoto M, Tanaka K, Matsuoka Y, Man-i M, Morita Y, Tanaka S, Fujiwara S, Azuma T,2011.7,da Vinci robotic single-incision cholecystectomy and hepatectomy using single-channel GelPort accessJ Hepatobiliary Pancreat Sci,18 巻 4 号,493-498 Komatsu S, Fukumoto T, Demizu Y, Miyawaki D, Terashima K, Niwa Y, Mima M, Fujii O, Sasaki R, Yamada I, Hori Y, Hishikawa Y, Abe M, Ku Y, Murakami M,2011.7,The effectiveness of particle radiotherapy for hepatocellular carcinoma associated with inferior vena cava tumor thrombusJ Gastroenterol,46 巻 7 号,913-920 Nakagawa T, Mure T, Yusoff S, Ono E, Kusuma Harahap IS, Morikawa S, Morioka I, Takeshima Y, Nishio H, Matsuo M,2011.7,A homozygous mutation in UGT1A1 exon 5 may be responsible for persistent hyperbilirubinemia in a Japanese girl with Gilbert's syndromeKobe J Med Sci,57 巻 1 号,26-31 Tanaka N, Kinoshita H, Nishiguchi M, Jamal M, Kumihashi M, Takahashi M, Nishio H, Ameno K,2011.7,An autopsy case of multiple psychotropic drug poisoningSoud Lek,56 巻 3 号,38-39 Hanada K, Yamanaka E, Yamamoto N, Minami H, Kawai S, Sasaki Y, Ogata H,2011.7,Effects of surgery and chronic disease states on the concentrations and phenotype distribution of α1-acid glycoprotein: studies in patients with breast cancer and patients with chronic inflammatory diseaseInt J Clin Pharmacol Ther,49 巻 7 号,415-421 Kuga A, Ohsawa Y, Okada T, Kanda F, Kanagawa M, Toda T, Sunada Y,2011.8,Endoplasmic reticulum stress response in P104L mutant caveolin-3 transgenic miceHum Mol Genet,20 巻 15 号,2975-2983

Kenzaka T, Shimoshikiryo M, Kitao A, Kario K, Hashimoto M,2011.8,Positron emission tomography scan can be a reassuring tool to treat difficult cases of infective endocarditisJ Nucl Cardiol,18 巻 4 号,741-743 Shibata S, Mu S, Kawarazaki H, Muraoka K, Ishizawa K, Yoshida S, Kawarazaki W, Takeuchi M, Ayuzawa N, Miyoshi J, Takai Y, Ishikawa A, Shimosawa T, Ando K, Nagase M, Fujita T,2011.8,Rac1 GTPase in rodent kidneys is essential for salt-sensitive hypertension via a mineralocorticoid receptor-dependent pathwayJ Clin Invest,121巻 8号,3233-3243 Akaike Y, Kurokawa K, Kajita K, Kuwano Y, Masuda K, Nishida K, Kang SW, Tanahashi T, Rokutan K,2011.8,Skipping of an alternative intron in the srsf1 3' untranslated region increases transcript stabilityJ Med Invest,58 巻 3-4 号,180-187 Iguchi T, Ozaki T, Chin T, Tsumura N, Kanemura A, Kasahara K, Kuroda R, Doita M, Nishida K,2011.8,Intimate relationship between instability and degenerative signs at L4/5 segment examined by flexion-extension radiographyEur Spine J,20 巻 8 号,1349-1354 Matsukawa T, Wang X, Liu R, Wortham NC, Onuki Y, Kubota A, Hida A, Kowa H, Fukuda Y, Ishiura H, Mitsui J, Takahashi Y, Aoki S, Takizawa S, Shimizu J, Goto J, Proud CG, Tsuji S,2011.8,Adult-onset leukoencephalopathies with vanishing white matter with novel missense mutations in EIF2B2, EIF2B3, and EIF2B5Neurogenetics,12 巻 3号,259-261 Hatakeyama M, Fukunaga A, Shimizu H, Oka M, Horikawa T, Nishigori C2011.9,Drug fever due to S-carboxymethyl-L-cystein: Demonstration of a causative agent with patch testsJ Dermatol Isogai S, Morimoto D, Arita K, Unzai S, Tenno T, Hasegawa J, Sou YS, Komatsu M, Tanaka K, Shirakawa M, Tochio H,2011.9,Crystal structure of the ubiquitin-associated (UBA) domain of p62 and its interaction with ubiquitinJ Biol Chem,286 巻 36 号,31864-31874 Akishima-Fukasawa Y, Ishikawa Y, Akasaka Y, Uzuki M, Inomata N, Yokoo T, Ishii R, Shimokawa R, Mukai K, Kiguchi H, Suzuki K, Fujiwara M, Ogata K, Niino H, Sugiura H, Ichinose A, Kuroda Y, Kuroda D, Ishii T,2011.9,Histopathological predictors of regional lymph node metastasis at the invasive front in early colorectal cancerHistopathology,59 巻 3 号,470-481 Inoue T, Shite J, Yoon J, Shinke T, Otake H, Sawada T, Kawamori H, Katoh H, Miyoshi N, Yoshino N, Kozuki A, Hariki H, Hirata K,2011.9,Optical coherence evaluation of everolimus-eluting stents 8 months after implantationHeart,97 巻 17 号,1379-1384 Furumatsu K, Nishiumi S, Kawano Y, Ooi M, Yoshie T, Shiomi Y, Kutsumi H, Ashida H, Fujii-Kuriyama Y, Azuma T, Yoshida M,2011.9,A role of the aryl hydrocarbon receptor in attenuation of colitisDig Dis Sci,56 巻 9号,2532-2544 Verjan Garcia N, Umemoto E, Saito Y, Yamasaki M, Hata E, Matozaki T, Murakami M, Jung YJ, Woo SY, Seoh JY, Jang MH, Aozasa K, Miyasaka M,2011.9,SIRPα/CD172a regulates eosinophil homeostasisJ Immunol,187 巻 5号,2268-2277 Kuramoto T, Fujii R, Nagai H, Belladonna ML, Yoshimoto T, Kohjimoto Y, Inagaki T, Hara I,2011.9,IL-23 gene therapy for mouse bladder tumour cell linesBJU Int,108 巻 6 号,914-921 Nagai H, Sakaguchi M, Ikeda T, Nishigori C,2011.9,Grayish brown macules on the axillae, lower abdomen, and groinArch Dermatol,147 巻 9 号,1097-1102 Kitajima K, Maeda T, Watanabe S, Sugimura K,2011.10,Recent issues in contrast-induced nephropathyInt J Urol,18巻 10 号,686-690 Cui CY, Kunisada M, Childress V, Michel M, Schlessinger D,2011.10,Shh is required for Tabby hair follicle developmentCell Cycle,10 巻 19 号,3379-3386

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序の解明と SSPE 治療に向けてのウイルス抑制戦略の確立 2014 年 3 月 堀田博 分担執筆 厚生労働科学研究費補助金 難治性疾患克服研究事業 プリオン病及び遅発性ウイルス感染症に関する調査 平成 25 年度総括・分担研究報告書/SSPE ウイルスの神経病原性は F、H 及び M 遺伝子の変異によって規定される 2014 年 3 月 堀田博 分担執筆 星 信彦（2013）：第 9 章 リンパ器官（担当：リンパ節），日本獣医解剖学会（編），獣医組織学 改訂第6 版，学窓社，東京 染色体と細胞核のダイナミクス 平岡泰・原口徳子 編，第７章「コヒーシンとコンデンシン」 化学同人 2013 年 11 月 李智博，平野達也 星 信彦（2013）： 農薬による野鳥への影響．野鳥，779: 8-11. 星 信彦．鳥の生殖機能に悪影響 ネオニコチノイド系農薬［共同通信（2 月 14 日，東京新聞・神戸新聞（2014 年 2 月 14 日朝刊）），（朝日・読売・毎日・日経・産経・神戸 2/17 夕刊）に掲載）］ -H26 年度 Ueyama T, Sakaguchi H, Nakamura T, Goto A, Morioka S, Shimizu A, Nakao K, Hishikawa Y, Ninoyu Y, Kassai H, Suetsugu S, Koji T, Fritzsch B, Yonemura S, Hisa Y, Matsuda M, Aiba A, Saito N Maintenance of stereocilia and apical junctional complexes by Cdc42 in cochlear hair cells 2014 年 J Cell Sci Kawara F, Inoue J, Takenaka M, Hoshi N, Masuda A, Nishiumi S, Kutsumi H, Azuma T, Ohdaira T The influences of pepsin concentrations and pH levels on the disinfective activity of ozone nanobubble water against helicobacter pylori 2014 年 Digestion 90・1 10-7 Mori M, Rikitake Y, Mandai K, Takai Y Roles of nectins and nectin-like molecules in the nervous system 2014 年 Adv Neurobiol 8 91-116 Ratnoglik SL, Jiang DP, Aoki C, Sudarmono P, Shoji I, Deng L, Hotta H Induction of Cell-Mediated Immune Responses in Mice by DNA Vaccines That Express Hepatitis C Virus NS3 Mutants Lacking Serine Protease and NTPase/RNA Helicase Activities 2014 年 6 月 PLoS One 9・6 e98877 Sakakibara S, Ishida Y, Hashikawa K, Yamaoka T, Terashi H Intima/medulla reconstruction and vascular contraction-relaxation recovery for acellular small diameter vessels prepared by hyperosmotic electrolyte solution treatment 2014 年 6 月 J Artif Organs 17・2 169-77 Tokuda E, Itoh T, Hasegawa J, Ijuin T, Takeuchi Y, Irino Y, Fukumoto M, Takenawa T Phosphatidylinositol 4-phosphate in the Golgi apparatus regulates cell-cell adhesion and invasive cell migration in human breast cancer 2014 年 6 月 Cancer Res 74・11 3054-66 Matsuzaki T, Matsushita T, Takayama K, Matsumoto T, Nishida K, Kuroda R, Kurosaka M Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice 2014 年 7 月 Ann Rheum Dis 73・7 1397-404 Takeda D, Hasegawa T, Ueha T, Imai Y, Sakakibara A, Minoda M, Kawamoto T, Minamikawa T, Shibuya Y, Akisue T, Sakai Y, Kurosaka M, Komori T Transcutaneous carbon dioxide induces mitochondrial apoptosis and suppresses metastasis of oral squamous cell

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ras がん遺伝子産物の新規立体構造情報を利用した分子標的がん治療薬の開発 2014 年 日本放射光学会誌 放射光 27・1 3-9 山下 智也, 笠原 和之, 佐々木 直人, 平田 健一 腸内細菌と心血管病 2014 年 6 月 循環器内科 75・6 号 610-617 西海 信, 寺島 禎彦, 東 健, 吉田 優 メタボロミクスによる非アルコール性脂肪性肝炎に対する治療薬の探索 2014 年 9 月 JSBMS Letters 39・Suppl. 70 戸田 達史 医学と医療の最前線 筋ジストロフィー治療の新しい展開 2014 年 11 月 日本内科学会雑誌 103・11 号 2820-2828 西田 康太郎, 高田 徹, 前野 耕一郎, 角谷 賢一朗, 由留部 崇, 黒坂 昌弘 【椎間板と痛み】 椎間板変性の疼痛発生機序について 2015 年 1 月 脊椎脊髄ジャーナル 28・1 号 25-31 Narabayashi K, Inoue T, Sakanaka T, Iguchi M, Fujiwara K, Yorifuji N, Kakimoto K, Nouda S, Okada T, Ishida K, Abe Y, Masuda D, Takeuchi T, Fukunishi S, Umegaki E, Higuchi K Oral tacrolimus for megacolon in patients with severe ulcerative colitis 2014 年 Intern Med 53・16 1755-8 Imoto A, Ooi Y, Edogawa S, Ogura T, Masuda D, Mohamed M, Takii M, Umegaki E, Kawahara R, Ukimura A, Higuchi K Liver abscess caused by CTX-M-55-type extended-spectrum β-lactamase (ESBL)-producing Salmonella enteritidis 2014 年 Intern Med 53・15 1699-703 Yu Q, Liu Z, Waqar AB, Ning B, Yang X, Shiomi M, Graham MJ, Crooke RM, Liu E, Dong S, Fan J Effects of antisense oligonucleotides against C-reactive protein on the development of atherosclerosis in WHHL rabbits 2014 年 Mediators Inflamm 2014 979132 Taketani Y, Kinugasa K, Kitajima R, Nishiumi S, Ashida, H, Nakamura H, Fujita T, Kanzaki K, Masutani H, Yodoi J Protective effects of oral administration of yeast thioredoxin against gastric mucosal injury 2014 年 Biosci Biotechnol Biochem 78 1221-1230 Li S, Liang J, Niimi M, Bilal Waqar A, Kang D, Koike T, Wang Y, Shiomi M, Fan J Probucol suppresses macrophage infiltration and MMP expression in atherosclerotic plaques of WHHL rabbits 2014 年 J Atheroscler Thromb 21・7 648-58 Murata Y, Kotani T, Ohnishi H, Matozaki T The CD47-SIRPα signalling system its physiological roles and therapeutic application 2014 年 6 月 J Biochem 155・6 335-44 Kasagi S, Zhang P, Che L, Abbatiello B, Maruyama T, Nakatsukasa H, Zanvit P, Jin W, Konkel JE, Chen W In vivo-generated antigen-specific regulatory T cells treat autoimmunity without compromising antibacterial immune response 2014 年 6 月 Sci Transl Med 6・241 241ra78 Tomotsuka N, Kaku R, Obata N, Matsuoka Y, Kanzaki H, Taniguchi A, Muto N, Omiya H, Itano Y, Sato T, Ichikawa H, Mizobuchi S, Morimatsu H Up-regulation of brain-derived neurotrophic factor in the dorsal root ganglion of the rat bone cancer pain model 2014 年 7 月 J Pain Res 7 415-23 Kawano Y, Ersoy BA, Li Y, Nishiumi S, Yoshida M, Cohen DE

Thioesterase superfamily member 2 (Them2) and phosphatidylcholine transfer protein (PC-TP) interact to promote fatty acid oxidation and control glucose utilization 2014 年 7 月 Mol Cell Biol 34・13 2396-408 Shirafuji T, Ueyama T, Yoshino K, Takahashi H, Adachi N, Ago Y, Koda K, Nashida T, Hiramatsu N, Matsuda T, Toda T, Sakai N, Saito N The role of Pak-interacting exchange factor-β phosphorylation at serines 340 and 583 by PKCγ in dopamine release 2014 年 7 月 J Neurosci 34・28 9268-80 Oshima N, Yamada Y, Nagayama S, Kawada K, Hasegawa S, Okabe H, Sakai Y, Aoi T Induction of cancer stem cell properties in colon cancer cells by defined factors 2014 年 7 月 PLoS One 9・7 e101735 Saito F, Kanagawa M, Ikeda M, Hagiwara H, Masaki T, Ohkuma H, Katanosaka Y, Shimizu T, Sonoo M, Toda T, Matsumura K Overexpression of LARGE suppresses muscle regeneration via down-regulation of insulin-like growth factor 1 and aggravates muscular dystrophy in mice 2014 年 9 月 Hum Mol Genet 23・17 4543-58 Yoshino S, Satoh T, Yamada M, Hashimoto K, Tomaru T, Katano-Toki A, Kakizaki S, Okada S, Shimizu H, Ozawa A, Tuchiya T, Ikota H, Nakazato Y, Mori M, Matozaki T, Sasaki T, Kitamura T, Mori M Protection against high-fat diet-induced obesity in Helz2-deficient male mice due to enhanced expression of hepatic leptin receptor 2014 年 9 月 Endocrinology 155・9 3459-72 Shanks NF, Cais O, Maruo T, Savas JN, Zaika EI, Azumaya CM, Yates JR 3rd, Greger I, Nakagawa T Molecular dissection of the interaction between the AMPA receptor and cornichon homolog-3 2014 年 9 月 J Neurosci 34・36 12104-20 Naito Y, Ikuta N, Nakata D, Terao K, Matsumoto K, Kajiwara N, Okano A, Yasui H, Yoshikawa Y Antidiabetic effect of the α-lipoic acid γ-cyclodextrin complex 2014 年 9 月 J Clin Biochem Nutr 55・2 97-102 Sawaengsak C, Mori Y, Yamanishi K, Srimanote P, Chaicumpa W, Mitrevej A, Sinchaipanid N Intranasal chitosan-DNA vaccines that protect across influenza virus subtypes 2014 年 10 月 Int J Pharm 473・1-2 113-25 Tanaka-Okamoto M, Itoh Y, Miyoshi J, Mizoguchi A, Mizutani K, Takai Y, Inoue M Genetic ablation of afadin causes mislocalization and deformation of Paneth cells in the mouse small intestinal epithelium 2014 年 10 月 PLoS One 9・10 e110549 Nakazawa G, Shinke T, Ijichi T, Matsumoto D, Otake H, Torii S, Hiranuma N, Ohsue T, Otsuka F, Shite J, Hirata K, Ikari Y Comparison of vascular response between durable and biodegradable polymer-based drug-eluting stents in a porcine coronary artery model 2014 年 10 月 EuroIntervention 10・6 717-23 Maegdefessel L, Spin JM, Raaz U, Eken SM, Toh R, Azuma J, Adam M, Nagakami F, Heymann HM, Chernugobova E, Jin H, Roy J, Hultgren R, Caidahl K, Schrepfer S, Hamsten A, Eriksson P, McConnell MV, Dalman RL, Tsao PS miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development 2014 年 10 月 Nat Commun 5 5214 Fang C, Ning B, Waqar AB, Niimi M, Li S, Satoh K, Shiomi M, Ye T, Dong S, Fan J Bisphenol A exposure enhances atherosclerosis in WHHL rabbits 2014 年 10 月 PLoS One 9・10 e110977

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岡田 卓也, 山口 雅人, Muradi Akhmadu, 片山 直人, 上嶋 英介, 小出 裕, 祖父江 慶太郎, 杉本 幸司 【NBCA 塞栓術の現状と病理組織学的影響】 NBCA 塞栓術の現状と病理組織学的影響 膵臓 2014 年 8 月 IVR Interventional Radiology 29・3 号 252-257 高橋 晴美, グプルジャン・ゲニ , 清野 進 糖尿病成因解明の最前線 インスリン分泌を増強するシグナルのインタープレイとその臨床的示唆 2015 年 1 月 実験医学 33・1 号 124-126 松本 知之, 新倉 隆宏, 川上 洋平, 福井 友章, 美舩 泰, 李 相亮, 川本 篤彦, 黒坂 昌弘, 浅原 孝之, 黒田 良祐 骨関節の再生医療の現状と展望 自家末梢血 CD34 陽性細胞を用いた骨・血管再生療法に関する第 I・II相臨床試験 2015 年 1 月 日本整形外科学会雑誌 89・1 号 26-32 ワクチン開発における最新動向 / 経口ワクチン 株式会社情報機構 2014 年 10 月 白川利朗 分担執筆 p187-p196 疾患モデルの作製と利用−脂質代謝異常と関連疾患 / 血管内皮リパーゼ エル・アイ・シー 2015 年 安田知行, 石田達郎 分担執筆 p450-p456 清水 まみ、安田 尚史、原 賢太、高橋 和眞、永田 正男、横野 浩一 The Dual Role of Scavenger Receptor Class A in Development of Diabetes in Autoimmune NOD Mice 2014.10 PLOS ONE 9(10) e109531 Endogenous interleukin 18 suppresses hyperglycemia and hyperinsulinemia during the acute phase of endotoxemia in mice. Yamashita H, Aoyama-Ishikawa M, Takahara M, Yamauchi C, Inoue T, Miyoshi M, Maeshige N, Usami M, Nakao A, Kotani J. Surg Infect (Larchmt). 2015 年 2 月 16(1)90-6. Miho Kanazashi, Masayuki Tanaka, Shinichiro Murakami, Hiroyo Kondo, Fumiko Nagatomo, Akihiko Ishihara, Roland R. Roy, Hidemi Fujino Amelioration of capillary regression and atrophy of the soleus muscle in hindlimb-unloaded rats by astaxanthin supplementation and intermittent loading 2014 年 8 月 Experimental Physiology Minoru Tanaka, Yusuke Hirayama, Naoto Fujita, Hidemi Fujino. Electrical stimulation using sine waveform prevents unloading-induced muscle atrophy in the deep calf muscles of rat. 2014 年 9 月 Acta Histochem. Sep;116(7)1192-8, 2014. 田中 稔，藤田 直人，藤野 英己． 「下腿深層筋の筋萎縮に対する遠心性収縮を伴う中周波電気刺激による併用効果」 2014 年 7 月 物理療法科学，vol.21，p25-31，2014． Murakami S, Ajiki T, Hori Y, Okazaki T, Fukumoto T, Ku Y. Establishment of a novel cell line from intraductal papillary neoplasm of the bile duct. 2014.9 Anticancer Res 34 2203-2210 Bartolomé A, Kimura-Koyanagi M, Asahara SI, Guillén C, Inoue H, Teruyama K, Shimizu S, Kanno A, García-Aguilar A, Koike M, Uchiyama Y, Benito M, Noda T, Kido Y. Pancreatic β cell failure mediated by mTORC1 hyperactivity and autophagic impairment. Diabetes. 2014 63 2996-3008 Kanno A, Asahara SI, Masuda K, Matsuda T, Kimura-Koyanagi M, Seino S, Ogawa W, Kido Y. Compensatory hyperinsulinemia in high-fat diet-induced obese mice is associated with enhanced insulin translateon in islets.

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Lipidomic analysis of plasma lipoprotein fractions in myocardial infarction-prone rabbits 2015 年 10 月 J Biosci Bioeng 120・4 476-82 Tanaka K, Sasayama T, Mizukawa K, Takata K, Sulaiman NS, Nishihara M, Kohta M, Sasaki R, Hirose T, Itoh T, Kohmura E Combined IDH1 mutation and MGMT methylation status on long-term survival of patients with cerebral low-grade glioma 2015 年 11 月 Clin Neurol Neurosurg 138 37-44 Hayashi S, Fujishiro T, Hashimoto S, Kanzaki N, Chinzei N, Kihara S, Takayama K, Matsumoto T, Nishida K, Kurosaka M, Kuroda R p21 deficiency is susceptible to osteoarthritis through STAT3 phosphorylation 2015 年 11 月 Arthritis Res Ther 17 314 Enatsu N, Miyake H, Chiba K, Fujisawa M Identification of Spermatogenically Active Regions in Rat Testes by Using Narrow-band Imaging System 2015 年 11 月 Urology 86・5 929-35 Murakami K, Matsuura M, Ota M, Gomi Y, Yamanishi K, Mori Y A recombinant varicella vaccine harboring a respiratory syncytial virus gene induces humoral immunity 2015 年 11 月 Vaccine 33・45 6085-92 Fujii H, Nakai K, Yonekura Y, Kono K, Goto S, Hirata M, Shinohara M, Nishi S, Fukagawa M The Vitamin D Receptor Activator Maxacalcitol Provides Cardioprotective Effects in Diabetes Mellitus 2015 年 12 月 Cardiovasc Drugs Ther 29・6 499-507 Makoto Suzuki, Shin Nishiumi, Takashi Kobayashi, Takeshi Azuma, Masaru Yoshida LC-MS/MS-based metabolome analysis detected changes in the metabolic profiles of small and large intestinal adenomatous polyps in Apc Min/+ mice 2016 年 Metabolomics Suehara T, Morishita J, Ueki M, Ueno M, Maekawa N, Mizobuchi S Effects of sevoflurane exposure during late pregnancy on brain development of offspring mice 2016 年 1 月 Paediatr Anaesth 26・1 52-9 Ikeo N, Nakamura R, Naka K, Hashimoto T, Yoshida T, Urade T, Fukushima K, Yabuuchi H, Fukumoto T, Ku Y, Mukai T Fabrication of a magnesium alloy with excellent ductility for biodegradable clips 2016 年 1 月 Acta Biomater 29 468-76 Tian H, Fukunaga A, Yodoi J, Nishigori C Aerosol Delivery Enhances Percutaneous Permeability of Epidermal Growth Factor and Thioredoxin 2016 年 1 月 J Clin Investig Dermatol 4・1 Mahmoud NF, Kawabata A, Tang H, Wakata A, Wang B, Serada S, Naka T, Mori Y Human herpesvirus 6 U11 protein is critical for virus infection 2016 年 1 月 Virology 489 151-157 Imai H, Shoji H, Ogata M, Kagawa Y, Owada Y, Miyakawa T, Sakimura K, Terashima T, Katsuyama Y Dorsal Forebrain-Specific Deficiency of Reelin-Dab1 Signal Causes Behavioral Abnormalities Related to Psychiatric Disorders 2016 年 1 月 Cereb Cortex Qi X, Okinaka Y, Nishita M, Minami Y Essential role of Wnt5a-Ror1/Ror2 signaling in metanephric mesenchyme and ureteric bud formation 2016 年 2 月 Genes Cells Iwata E, Hasegawa T, Takeda D, Ueha T, Kawamoto T, Akisue T, Sakai Y, Komori T

Transcutaneous carbon dioxide suppresses epithelial-mesenchymal transition in oral squamous cell carcinoma 2016 年 2 月 Int J Oncol Waki T, Lee SY, Niikura T, Iwakura T, Dogaki Y, Okumachi E, Oe K, Kuroda R, Kurosaka M Profiling microRNA expression during fracture healing 2016 年 2 月 BMC Musculoskelet Disord 17・1 83 Katsunuma S, Honda H, Shinoda T, Ishimoto Y, Miyata T, Kiyonari H, Abe T, Nibu K, Takai Y, Togashi H Synergistic action of nectins and cadherins generates the mosaic cellular pattern of the olfactory epithelium 2016 年 2 月 J Cell Biol 212・5 561-75 Ijuin T, Hatano N, Takenawa T Glucose-regulated protein 78 (GRP78) binds directly to PIP3 phosphatase SKIP and determines its localization 2016 年 3 月 Genes Cells Kanagawa M, Kobayashi K, Tajiri M, Manya H, Kuga A, Yamaguchi Y, Akasaka-Manya K, Furukawa J, Mizuno M, Kawakami H, Shinohara Y, Wada Y, Endo T, Toda T Identification of a Post-translational Modification with Ribitol-Phosphate and Its Defect in Muscular Dystrophy 2016 年 3 月 Cell Rep 14・9 2209-23 Eguchi N, Hishimoto A, Sora I, Mori M Slow synaptic transmission mediated by TRPV1 channels in CA3 interneurons of the hippocampus 2016 年 3 月 Neurosci Lett 616 170-6 蒲田 悦子, 河本 旭哉, 原 仁美, 大西 康央, 簑田 正也, 森下 雅之, 上羽 岳志, 黒坂 昌弘, 秋末 敏宏 骨肉腫細胞に対する Smac 模倣薬とアドリアマイシンの併用効果 2015 年 6 月 日本整形外科学会雑誌 89・6 号 S1227 金森 章泰 【NMO 最前線】 モデル動物による視神経脊髄炎の研究 2015 年 6 月 神経眼科 32・2 号 142-147 古屋敷 智之 【プロスタグランジンによる病態制御の最前線】 ストレス関連行動における COX-1-PGE2-EP1 系の役割 2015 年 6 月 細胞 47・6 号 270-273 山下 智也, 佐々木 直人, 平田 健一 慢性炎症制御による動脈硬化予防 2015 年 6 月 Bio Clinica 4・2 50-55 森下 雅之, 河本 旭哉, 蓑田 正也, 大西 康央, 原 仁美, 上羽 岳志, 蒲田 悦子, 黒坂 昌弘, 秋末 敏宏 AICAR の骨肉腫細胞に対するアポトーシス誘導効果 2015 年 6 月 日本整形外科学会雑誌 89・6 号 S1241 蓑田 正也, 河本 旭哉, 上羽 岳志, 原 仁美, 大西 康央, 森下 雅之, 蒲田 悦子, 黒坂 昌弘, 秋末 敏宏 Survivin 抑制薬"YM155"は骨肉腫細胞において腫瘍増殖を抑制する 2015 年 6 月 日本整形外科学会雑誌 89・6 号 S1238 古屋敷 智之 痛みと情動 ストレスによる情動変化と脳内の自然免疫系 2015 年 7 月 PAIN RESEARCH 30・2 号 70 蒲田 悦子, 河本 旭哉, 上羽 岳志, 原 仁美, 大西 康央, 簑田 正也, 森下 雅之, 黒坂 昌弘, 秋末 敏宏 骨肉腫細胞に対する Smac 模倣薬と抗癌剤の併用効果の検討 2015 年 9 月 日本整形外科学会雑誌 89・8 号 S1674 古屋敷 智之 【プロスタグランジンと炎症】 ストレスによる情動制御における PGE2-EP1 系の役割

2015 年 9 月 医学のあゆみ 254・12 号 1115-1120 森下 雅之, 河本 旭哉, 大西 康央, 蓑田 正也, 蒲田 悦子, 原 仁美, 上羽 岳志, 黒坂 昌弘, 秋末 敏宏 AICAR の骨肉腫細胞に対するアポトーシス誘導効果 2015 年 9 月 日本整形外科学会雑誌 89・8 号 S1802 西田 康太郎, 角谷 賢一朗, 前野 耕一郎, 高田 徹, 由留部 崇, 山本 潤哉, 平田 裕亮, 蔵川 拓外, 酒井 大輔, 持田 讓治, 舛田 浩一, 森田 有亮, 黒坂 昌弘 椎間板変性と臨床 未来への展望 椎間板変性の発生機序と臨床との関連について 2015 年 9 月 日本整形外科学会雑誌 89・9 号 579-584 北岡 志保, 古屋敷 智之 【脂質疾患学 なぜあぶらの異常が病気を引き起こすのか?その質的量的変化と肥満、がん、不妊症、免疫・皮膚・神経疾患】 (第 2 章)多彩な疾患における脂質の量的・質的変化 神経疾患 ドパミン依存的な情動行動における PGE2-EP1 経路の役割と精神疾患との関連 2015 年 9 月 実験医学 33・15 号 2468-2473 向山 順子, 下野 洋平, 船越 洋平, 河野 誠之, 山下 公大, 向原 徹, 高尾 信太郎, 南 博信, 掛地 吉弘 NK 細胞浸潤がヒト乳がん異種移植マウスの腫瘍増殖に与える影響 2015 年 10 月 癌と化学療法 42・10 号 1252-1255 江本 拓央, 山下 智也, 平田 健一 腸内細菌と循環器疾患 2015 年 10 月 臨床化学 44・4 282-289 淀井 景子, 山下 智也, 河野 浩之, 佐々木 直人, 北 智之, 笠原 和之, 佐々木 義浩, 松本 卓也, 江本 拓央, 溝口 泰司, 林 友鴻, 平田 健一 ンジオテンシン II 誘発性大動脈瘤形成に対する n-3 系多価不飽和脂肪酸 EPA と DHA の差異の検討 2015 年 10 月 薬理と治療 43・10 1409-1416 Fukuda I, Nishiumi S, Mukai R, Yoshida KI, Ashida H Catechins in tea suppress the activity of cytochrome P450 1A1 through the aryl hydrocarbon receptor activation pathway in rat livers 2015 年 Int J Food Sci Nutr Takamatsu Y, Hagino Y, Sato A, Takahashi T, Nagasawa SY, Kubo Y, Mizuguchi M, Uhl GR, Sora I, Ikeda K Improvement of learning and increase in dopamine level in the frontal cortex by methylphenidate in mice lacking dopamine transporter 2015 年 Curr Mol Med 15・3 245-52 Kasahara Y, Arime Y, Hall FS, Uhl GR, Sora I Region-specific dendritic spine loss of pyramidal neurons in dopamine transporter knockout mice 2015 年 Curr Mol Med 15・3 237-44 Uno K, Nishizawa D, Seo S, Takayama K, Matsumura S, Sakai N, Ohi K, Nabeshima T, Hashimoto R, Ozaki N, Hasegawa J, Sato N, Tanioka F, Sugimura H, Fukuda KI, Higuchi S, Ujike H, Inada T, Iwata N, Sora I, Iyo M, Kondo N, Won MJ, Naruse N, Uehara-Aoyama K, Itokawa M, Yamada M, Ikeda K, Miyamoto Y, Nitta A The Piccolo Intronic Single Nucleotide Polymorphism rs13438494 Regulates Dopamine and Serotonin Uptake and Shows Associations with Dependence-Like Behavior in Genomic Association Study 2015 年 Curr Mol Med 15・3 265-74 Ueda S, Kokaji Y, Simizu S, Honda K, Yoshino K, Kamisoyama H, Shirai Y, Yamanoue M Chicken heat shock protein HSPB1 increases and interacts with αB-crystallin in aged skeletal muscle 2015 年 Biosci Biotechnol Biochem 79・11 1867-75 Yokoi N, Beppu M, Yoshida E, Hoshikawa R, Hidaka S, Matsubara T, Shinohara M, Irino Y, Hatano N, Seino S Identification of putative biomarkers for prediabetes by metabolome analysis of rat models of type 2 diabetes 2015 年 Metabolomics 11・5 1277-1286

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2015 年 9 月 Mol Cell Neurosci 68 143-50 Yamamoto H, Mandai K, Konno D, Maruo T, Matsuzaki F, Takai Y Impairment of radial glial scaffold-dependent neuronal migration and formation of double cortex by genetic ablation of afadin 2015 年 9 月 Brain Res 1620 139-52 Zanvit P, Konkel JE, Jiao X, Kasagi S, Zhang D, Wu R, Chia C, Ajami NJ, Smith DP, Petrosino JF, Abbatiello B, Nakatsukasa H, Chen Q, Belkaid Y, Chen ZJ, Chen W Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis 2015 年 9 月 Nat Commun 6 8424 Dalli J, Kraft BD, Colas RA, Shinohara M, Fredenburgh LE, Hess DR, Chiang N, Welty-Wolf K, Choi AM, Piantadosi CA, Serhan CN The Regulation of Proresolving Lipid Mediator Profiles in Baboon Pneumonia by Inhaled Carbon Monoxide 2015 年 9 月 Am J Respir Cell Mol Biol 53・3 314-25 Kaneko C, Nitta N, Tsuchiya K, Watanabe S, Nitta-Seko A, Ohta S, Otani H, Sonoda A, Murata K, Shiomi M MRI study of atherosclerotic plaque progression using ultrasmall superparamagnetic iron oxide in Watanabe heritable hyperlipidemic rabbits 2015 年 9 月 Br J Radiol 88・1053 20150167 Naito Y, Ikuta N, Okano A, Okamoto H, Nakata D, Terao K, Matsumoto K, Kajiwara N, Yasui H, Yoshikawa Y Isomeric effects of anti-diabetic α-lipoic acid with γ-cyclodextrin 2015 年 9 月 Life Sci 136 73-8 Fujiwara M, Miyoshi M, Sakai S, Nishiokada A, Aoyama-Ishikawa M, Maeshige N, Usami Y, Hamada Y, Takahashi M, Usami M Lard-based high-fat diet increases secretory leukocyte protease inhibitor expression and attenuates the inflammatory response of acute lung injury in endotoxemic rats 2015 年 10 月 Clin Nutr 34・5 997-1009 Sakti Muliawan H, Nakayama K, Yagi K, Ikeda K, Yagita K, Hirata K, Emoto N Stable Somatic Gene Expression in Mouse Lungs Following Electroporation-mediated Tol2 Transposon Delivery 2015 年 10 月 Kobe J Med Sci 61・2 E47-53 Panza P, Sitko AA, Maischein HM, Koch I, Fl?tenmeyer M, Wright GJ, Mandai K, Mason CA, S?llner C The LRR receptor Islr2 is required for retinal axon routing at the vertebrate optic chiasm 2015 年 10 月 Neural Dev 10 23 Zhang D, Tu E, Kasagi S, Zanvit P, Chen Q, Chen W Manipulating regulatory T cells: a promising strategy to treat autoimmunity 2015 年 11 月 Immunotherapy 7・11 1201-11 Sekine H, Okazaki K, Ota N, Shima H, Katoh Y, Suzuki N, Igarashi K, Ito M, Motohashi H, Yamamoto M The Mediator Subunit MED16 Transduces NRF2-Activating Signals into Antioxidant Gene Expression 2015 年 11 月 Mol Cell Biol 36・3 407-20 Ijuin T, Hatano N, Hosooka T, Takenawa T Regulation of insulin signaling in skeletal muscle by PIP3 phosphatase, SKIP, and endoplasmic reticulum molecular chaperone glucose-regulated protein 78 2015 年 12 月 Biochim Biophys Acta 1853・12 3192-201 Andoh T, Fujimoto T, Suzuki M, Sudo T, Sakurai Y, Tanaka H, Fujita I, Fukase N, Moritake H, Sugimoto T, Sakuma T, Sasai H, Kawamoto T, Kirihata M, Fukumori Y, Akisue T, Ono K, Ichikawa H Boron neutron capture therapy (BNCT) as a new approach for clear cell sarcoma (CCS) treatment: Trial using a lung metastasis model of CCS 2015 年 12 月 Appl Radiat Isot 106 195-201

Fujimoto T, Andoh T, Sudo T, Fujita I, Fukase N, Takeuchi T, Sonobe H, Inoue M, Hirose T, Sakuma T, Moritake H, Sugimoto T, Kawamoto T, Fukumori Y, Yamamoto S, Atagi S, Sakurai Y, Kurosaka M, Ono K, Ichikawa H, Suzuki M Potential of boron neutron capture therapy (BNCT) for malignant peripheral nerve sheath tumors (MPNST) 2015 年 12 月 Appl Radiat Isot 106 220-5 Hara T, Ughi GJ, McCarthy JR, Erdem SS, Mauskapf A, Lyon SC, Fard AM, Edelman ER, Tearney GJ, Jaffer FA Intravascular fibrin molecular imaging improves the detection of unhealed stents assessed by optical coherence tomography in vivo 2015 年 12 月 Eur Heart J Imai H, Misra GP, Wu L, Janagam DR, Gardner TW, Lowe TL Subconjunctivally Implanted Hydrogels for Sustained Insulin Release to Reduce Retinal Cell Apoptosis in Diabetic Rats 2015 年 12 月 Invest Ophthalmol Vis Sci 56・13 7839-46 Chen A, Akinyemi RO, Hase Y, Firbank MJ, Foster V, Craggs L, Washida K, Okamoto Y, Thomas AJ, Polvikoski TM, Allan LM, Oakley AE, O;Brien JT, Horsburgh K, Ihara M, Kalaria RN Frontal white matter hyperintensities, clasmatodendrosis and gliovascular abnormalities in ageing and post-stroke dementia 2016 年 Brain 139・139 242-258 Fujii H, Yonekura Y, Yamashita Y, Kono K, Nakai K, Goto S, Sugano M, Goto S, Fujieda A, Ito Y, Nishi S Anti-oxidative effect of AST-120 on kidney injury after myocardial infarction 2016 年 1 月 Br J Pharmacol Sakaguchi M, Hisamori S, Oshima N, Sato F, Shimono Y, Sakai Y miR-137 Regulates the Tumorigenicity of Colon Cancer Stem Cells Through the Inhibition of DCLK1 2016 年 1 月 Mol Cancer Res 14 354-362 Hosooka T, Ogawa W A novel role for the cell cycle regulatory complex cyclin D1-CDK4 in gluconeogenesis 2016 年 1 月 J Diabetes Investig 7・1 27-8 Geng X, Mandai K, Maruo T, Wang S, Fujiwara T, Mizoguchi A, Takai Y, Mori M Regulatory role of the cell adhesion molecule nectin-1 in GABAergic inhibitory synaptic transmission in the CA3 region of mouse hippocampus 2016 年 1 月 Genes Cells 21・1 88-98 Mukai H, Muramatsu A, Mashud R, Kubouchi K, Tsujimoto S, Hongu T, Kanaho Y, Tsubaki M, Nishida S, Shioi G, Danno S, Mehruba M, Satoh R, Sugiura R PKN3 is the major regulator of angiogenesis and tumor metastasis in mice 2016 年 1 月 Sci Rep 6 18979 Cui CY, Sima J, Yin M, Michel M, Kunisada M, Schlessinger D Identification of potassium and chloride channels in eccrine sweat glands 2016 年 2 月 J Dermatol Sci 81・2 129-31 Haruta H, Hiro T, Mitsumata M, Takayama T, Sudo M, Li Y, Takahashi R, Taniguchi Y, Shiomi M, Hirayama A Stabilization of atherosclerotic plaque by pitavastatin in Watanabe heritable hyperlipidemic rabbits: A serial tissue-characterizing intravascular ultrasound study 2016 年 2 月 J Cardiol 67・2 205-11 Maruo T, Mandai K, Takai Y, Mori M Activity-dependent alteration of the morphology of a hippocampal giant synapse 2016 年 3 月 Mol Cell Neurosci 71 25-33

Kitayama M, Mizutani K, Maruoka M, Mandai K, Sakakibara S, Ueda Y, Komori T, Shimono Y, Takai Y A Novel Nectin-mediated Cell Adhesion Apparatus That Is Implicated in Prolactin Receptor Signaling for Mammary Gland Development 2016 年 3 月 J Biol Chem 291・11 5817-31 細岡 哲也, 小川 渉 インスリン作用の Key Molecules PDK1 2015 年 8 月 Diabetes Frontier 26・4 号 499-503 疾患モデルの作製と利用 脂質代謝異常と関連疾患 / 血管内皮リパーゼ エル・アイ・シー 2015 年 安田知行, 石田達郎 分担執筆 p450-p456 Neuroprotection and nueroregeneration for retinal diseases / Aquaporin in optic neuropathies Springer 2015 年 Akiyasu Kanamori 分担執筆 p161-p173 Bioactive Lipid Mediators Current Reviews and Protocols / Part III Lipid Mediators and Diseases, 22. Roles and actions of arachidonic acid-derived bioactive lipids in stress-related behaviors Springer 2016 年 3 月 Ryohei Sasaki, Hiroaki Akasaka, Yusuke Demizu, Sachiko Inubushi, Tianyuan Wang and Takumi Fukumoto 分担執筆 p324-p324 INTECH / Medical Application of Nonwoven Fabrics - Intra-abdominal Spacers for Particle Therapy INTECH 2016 年 3 月 細岡哲也, 小川渉 分担執筆 p122-p125 心血管事故を予防するための糖尿病治療戦略 / 糖尿病治療の最前線－メトホルミンの作用機序に関して教えてください－ 文光堂 2016 年 3 月 細岡哲也, 小川渉 分担執筆 p122-p125