Glycotope Biotechnology’s expertise reaches from ELI-

SAs to FACSs to cell-based bioassays, from antibodies

to hormones to blood factors. Whether you start from

scratch or already have a partially developed method –

we design, and develop your assay for release testing.

Pre-developed Bioactivity Assays

Bioactivity of final products is one of the key features

in the specification of biopharmaceutical drug sub-

stances and clinical samples.

Based on our kits for cell assays which we market

since more than 10 years

With our broad experience in GCLP assay develop-

ment, we at Glycotope Biotechnology has a proven

track-record when it comes to establishing qualified

and validated methods for product quality control.

For decades, we have successfully used our capability,

proficiency and expertise in immunology and routine

assays.

We focus on Customized Functional Cell Assays for analy-

sis of migration capabilities, burst-activity, induction

of degranulation, proliferation, invasion and apoptosis.

We specialize in: Specific binding assays FcγRIIIa binding assays Antibody-dependent cell-mediated cytotoxicity

(ADCC) Cell proliferation assays, cell based potency assays for

rhGH, G-CSF and GM-CSF Custom-made NK cell cytotoxicity assays Custom-made lymphocyte proliferation assays Evaluation of customer-provided samples

Cell-Based Assays for

Drug Substance Release Testing

Cell-based assays are powerful in-vitro test systems -

they are very versatile and measure almost any induced

physiological product response in a living system and

consequently provide vital information on the product.

Cell-based assays are mandatory when drug candidates

are finally released for human use in clinical trials.

Immunomodulator Testing

Benefit from our expertise in testing the effects of dif-

ferent test substances on the phagocytic or oxidative

burst activity of neutrophilic granulocytes and mono-

Cellular Bioactivity Assays

Analytical ServicesProtein Analytics

Cellular Bioactivity Assays

Host Cell Contaminants

Immunomonitoring

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Analytical Services

Dr. Sünje Fischer

Manager Sales & Marketing

Phone: +49 30 9489 2600

Email: bioassay@glycotope-bt.com

Contact us to learn more about our services!

Glycotope Biotechnology GmbH

Czernyring 22

D-69115 Heidelberg | Germany

www.glycotope.com

Antibody Dependent Cellular Cytotoxicity (ADCC)

cytes. Our PHAGOTEST™ and PHAGOBURST™ reagent

kits engage flow-cytometric measurement.

Our NKTEST™ is the reagent kit of choice to investigate

the effects of test compounds on the activity of natural

killer cells. The kit also uses flow-cytometric measure-

ment.

Choosing the right partner for bioactivity and cell-

based assays is decisive for your project. Successful de-

velopment of such assays requires profound expertise -

and that only comes with experience. Cell based assays

are among the most challenging to perform. Consistent

assay performance requires a controlled setting, highly

skilled analysts with in-depth understanding of cell

physiology and a well-developed and characterized

method.

Glycotope Biotechnology is your dedicated expert part-

ner for all aspects of bioassay development, validation,

method transfer and long-term assay maintenance.

With our broad experience, we stand for quality com-

pletion of your testing program.

NK cell

NK cell

NK cellmAb

Tumor cell Tumor cell

Effector T cell

Effector T cell

Regulatory T cell

Regulatory T cell