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Centre for Centre for Centre for Centre for Health Health Health Health Engineering Engineering Engineering Engineering CNRS UMR 5146 – INSERM IFR 143 Identification of the material parameters of soft tissues in the compressed leg Laura Dubuis, Stéphane Avril, Johan Debayle, Pierre Badel

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Page 1: Centre for Centre for HealthHealthHealthEngineering

Centre for Centre for Centre for Centre for HealthHealthHealthHealth EngineeringEngineeringEngineeringEngineeringCNRS UMR 5146 – INSERM IFR 143

Identification of the material parameters of soft tissues in thecompressed leg

Laura Dubuis, Stéphane Avril, Johan Debayle, Pierre Badel

Page 2: Centre for Centre for HealthHealthHealthEngineering

LaMCoS - 2010/11/17 - Stéphane AVRIL

2

Introduction

Introduction

Context

Calf: a peripheral heart

Different types of treatments by compression

Towards patient-specific compression

FE model

Geometry and meshing

Model specifications

Constitutive equations

Identification

Identification results

Results

Results

results

Conclusion

Prospects

Acknowledgements

Page 3: Centre for Centre for HealthHealthHealthEngineering

LaMCoS - 2010/11/17 - Stéphane AVRIL

3

VeinousVeinousVeinousVeinousVeinousVeinousVeinousVeinousdiseasesdiseasesdiseasesdiseasesdiseasesdiseasesdiseasesdiseases

SportspeopleSportspeopleSportspeopleSportspeopleSportspeopleSportspeopleSportspeopleSportspeople

Context

Introduction

Context

Calf: a peripheral heart

Different types of treatments by compression

Towards patient-specific compression

FE model

Geometry and meshing

Model specifications

Constitutive equations

Identification

Identification results

Results

Results

results

Conclusion

Prospects

Acknowledgements

Page 4: Centre for Centre for HealthHealthHealthEngineering

LaMCoS - 2010/11/17 - Stéphane AVRIL

4

Calf: a peripheral heart

[P. Ducrozet. Booster study. PhD thesis, Université Jean Monnet, Saint Etienne, 2004][S. Couzan, P. Mismetti, S. Laporte, J.F. Pouget, E. Gauthier, D. Brisot, I. Quere, A. Leizorovicz. CE-Prog study. Saint-Étienne, 2009]

Introduction

Context

Calf: a peripheral heart

Different types of treatments by compression

Towards patient-specific compression

FE model

Geometry and meshing

Model specifications

Constitutive equations

Identification

Identification results

Results

Results

results

Conclusion

Prospects

Acknowledgements

Page 5: Centre for Centre for HealthHealthHealthEngineering

LaMCoS - 2010/11/17 - Stéphane AVRIL

5

Different types of treatmentsby compression

High pressure

Lowpressure

Lowpressure

High pressure

ConventionalConventionalConventionalConventional compressioncompressioncompressioncompression(compression stockings)

(1956)

Progressive compressionProgressive compressionProgressive compressionProgressive compression(BVSport patent)

(1997)

Introduction

Context

Calf: a peripheral heart

Different types of treatments by compression

Towards patient-specific compression

FE model

Geometry and meshing

Model specifications

Constitutive equations

Identification

Identification results

Results

Results

results

Conclusion

Prospects

Acknowledgements

Page 6: Centre for Centre for HealthHealthHealthEngineering

LaMCoS - 2010/11/17 - Stéphane AVRIL

6

Towards patient-specificcompression

� DeviceDeviceDeviceDevice for for for for veinousveinousveinousveinous pressure pressure pressure pressure measurementsmeasurementsmeasurementsmeasurements

� CompressionmeterCompressionmeterCompressionmeterCompressionmeter for custom compressionfor custom compressionfor custom compressionfor custom compression

���� RaisesRaisesRaisesRaises mechanicalmechanicalmechanicalmechanical issues:issues:issues:issues:� Pressure transmission from stockings to soft tissues?

� Mechanical properties of these tissues?

� Pressure field in tissues?

Introduction

Context

Calf: a peripheral heart

Different types of treatments by compression

Towards patient-specific compression

FE model

Geometry and meshing

Model specifications

Constitutive equations

Identification

Identification results

Results

Results

results

Conclusion

Prospects

Acknowledgements

Page 7: Centre for Centre for HealthHealthHealthEngineering

LaMCoS - 2010/11/17 - Stéphane AVRIL

7

FE model

Introduction

Context

Calf: a peripheral heart

Different types of treatments by compression

Towards patient-specific compression

FE model

Geometry and meshing

Model specifications

Constitutive equations

Identification

Identification results

Results

Results

results

Conclusion

Prospects

Acknowledgements

Page 8: Centre for Centre for HealthHealthHealthEngineering

LaMCoS - 2010/11/17 - Stéphane AVRIL

8

Geometry and meshing

Exteriorsurface

Musclesurface

Bonesurface

FE Mesh

FE model:FE model:FE model:FE model:

Introduction

Context

Calf: a peripheral heart

Different types of treatments by compression

Towards patient-specific compression

FE model

Geometry and meshing

Model specifications

Constitutive equations

Identification

Identification results

Results

Results

results

Conclusion

Prospects

Acknowledgements

Page 9: Centre for Centre for HealthHealthHealthEngineering

LaMCoS - 2010/11/17 - Stéphane AVRIL

9

Model specifications

� BoundaryBoundaryBoundaryBoundary conditionsconditionsconditionsconditions

� Bones clamped

� Pressure applied by the stocking

� Laplace law: P=T/Rc

FE model:FE model:FE model:FE model:

Introduction

Context

Calf: a peripheral heart

Different types of treatments by compression

Towards patient-specific compression

FE model

Geometry and meshing

Model specifications

Constitutive equations

Identification

Identification results

Results

Results

results

Conclusion

Prospects

Acknowledgements

Page 10: Centre for Centre for HealthHealthHealthEngineering

LaMCoS - 2010/11/17 - Stéphane AVRIL

10

Constitutive equations

[S. Avril, L. Bouten, L. Dubuis, S. Drapier, J-F. Pouget. Mixed Experimental and Numerical Approach for Characterizing the Biomechanical Response of the Human Leg Under Elastic Compression. J. Biomechanical Eng. 132, 2009.]

FE model:FE model:FE model:FE model:

� NeoNeoNeoNeo----HookeanHookeanHookeanHookean modelmodelmodelmodel

MRI slice

Introduction

Context

Calf: a peripheral heart

Different types of treatments by compression

Towards patient-specific compression

FE model

Geometry and meshing

Model specifications

Constitutive equations

Identification

Identification results

Results

Results

results

Conclusion

Prospects

Acknowledgements

Page 11: Centre for Centre for HealthHealthHealthEngineering

LaMCoS - 2010/11/17 - Stéphane AVRIL

11

IdentificationFE model:FE model:FE model:FE model:

Introduction

Context

Calf: a peripheral heart

Different types of treatments by compression

Towards patient-specific compression

FE model

Geometry and meshing

Model specifications

Constitutive equations

Identification

Identification results

Results

Results

results

Conclusion

Prospects

Acknowledgements

Page 12: Centre for Centre for HealthHealthHealthEngineering

LaMCoS - 2010/11/17 - Stéphane AVRIL

12

IdentificationFE model:FE model:FE model:FE model:

Inverse problem: definition of the cost functionIntroduction

Context

Calf: a peripheral heart

Different types of treatments by compression

Towards patient-specific compression

FE model

Geometry and meshing

Model specifications

Constitutive equations

Identification

Identification results

Results

Results

results

Conclusion

Prospects

Acknowledgements

Page 13: Centre for Centre for HealthHealthHealthEngineering

LaMCoS - 2010/11/17 - Stéphane AVRIL

13

� IdentifiedIdentifiedIdentifiedIdentified constitutive constitutive constitutive constitutive parametersparametersparametersparameters

11601160116011601060106010601060K (K (K (K (kPakPakPakPa))))

11.511.511.511.55555CCCC10101010 ((((kPakPakPakPa))))

MuscleMuscleMuscleMuscleFatFatFatFat

HyperelasticNeo Hookean model

FE model:FE model:FE model:FE model:Identification results

Introduction

Context

Calf: a peripheral heart

Different types of treatments by compression

Towards patient-specific compression

FE model

Geometry and meshing

Model specifications

Constitutive equations

Identification

Identification results

Results

Results

results

Conclusion

Prospects

Acknowledgements

Page 14: Centre for Centre for HealthHealthHealthEngineering

LaMCoS - 2010/11/17 - Stéphane AVRIL

14

FE model:FE model:FE model:FE model:Identification results

Introduction

Context

Calf: a peripheral heart

Different types of treatments by compression

Towards patient-specific compression

FE model

Geometry and meshing

Model specifications

Constitutive equations

Identification

Identification results

Results

Results

results

Conclusion

Prospects

Acknowledgements

Page 15: Centre for Centre for HealthHealthHealthEngineering

LaMCoS - 2010/11/17 - Stéphane AVRIL

15

Results

� HydrostaticHydrostaticHydrostaticHydrostatic pressurepressurepressurepressure

FE model:FE model:FE model:FE model:

Introduction

Context

Calf: a peripheral heart

Different types of treatments by compression

Towards patient-specific compression

FE model

Geometry and meshing

Model specifications

Constitutive equations

Identification

Identification results

Results

Results

results

Conclusion

Prospects

Acknowledgements

Page 16: Centre for Centre for HealthHealthHealthEngineering

LaMCoS - 2010/11/17 - Stéphane AVRIL

16

Results

Great saphenous

Smallsaphenous

Anteriortibial

Posteriortibial

Fibular

FE model:FE model:FE model:FE model:

Introduction

Context

Calf: a peripheral heart

Different types of treatments by compression

Towards patient-specific compression

FE model

Geometry and meshing

Model specifications

Constitutive equations

Identification

Identification results

Results

Results

results

Conclusion

Prospects

Acknowledgements

Page 17: Centre for Centre for HealthHealthHealthEngineering

LaMCoS - 2010/11/17 - Stéphane AVRIL

17

Hydrostaticpressure (kPa)

Results

� HydrostaticHydrostaticHydrostaticHydrostatic pressure pressure pressure pressure atatatat differentdifferentdifferentdifferent locationslocationslocationslocations

Appliedpressure

Fibular

Fibular

Posteriortibial

Posteriortibial

Anteriortibial

Anteriortibial

Great saphenous

Great saphenous

Small saphenous

Slmallsaphenous

1 % 3 %

6 %

3 %

0 %

FE model:FE model:FE model:FE model:

Introduction

Context

Calf: a peripheral heart

Different types of treatments by compression

Towards patient-specific compression

FE model

Geometry and meshing

Model specifications

Constitutive equations

Identification

Identification results

Results

Results

results

Conclusion

Prospects

Acknowledgements

Page 18: Centre for Centre for HealthHealthHealthEngineering

LaMCoS - 2010/11/17 - Stéphane AVRIL

18

resultsFE model:FE model:FE model:FE model:

Introduction

Context

Calf: a peripheral heart

Different types of treatments by compression

Towards patient-specific compression

FE model

Geometry and meshing

Model specifications

Constitutive equations

Identification

Identification results

Results

Results

results

Conclusion

Prospects

Acknowledgements

� HydrostaticHydrostaticHydrostaticHydrostatic pressure pressure pressure pressure atatatat differentdifferentdifferentdifferent heightsheightsheightsheights

Page 19: Centre for Centre for HealthHealthHealthEngineering

LaMCoS - 2010/11/17 - Stéphane AVRIL

19

Conclusion

Introduction

Context

Calf: a peripheral heart

Different types of treatments by compression

Towards patient-specific compression

FE model

Geometry and meshing

Model specifications

Constitutive equations

Identification

Identification results

Results

Results

results

Conclusion

Prospects

Acknowledgements

Page 20: Centre for Centre for HealthHealthHealthEngineering

LaMCoS - 2010/11/17 - Stéphane AVRIL

20

Prospects

� Compartments Compartments Compartments Compartments

and and and and aponeurosesaponeurosesaponeurosesaponeuroses

Interactions and sliding

� CouplingCouplingCouplingCoupling withwithwithwith veinousveinousveinousveinous bloodbloodbloodblood flow flow flow flow

Quantification of Quantification of Quantification of Quantification of drainingdrainingdrainingdraining effecteffecteffecteffect

Introduction

Context

Calf: a peripheral heart

Different types of treatments by compression

Towards patient-specific compression

FE model

Geometry and meshing

Model specifications

Constitutive equations

Identification

Identification results

Results

Results

results

Conclusion

Prospects

Acknowledgements

Page 21: Centre for Centre for HealthHealthHealthEngineering

LaMCoS - 2010/11/17 - Stéphane AVRIL

21

StudentsStudentsStudentsStudents: Laura Bouten & Laura Dubuis

ColleaguesColleaguesColleaguesColleagues: Pierre Badel, Johan Debayle

PhysiciansPhysiciansPhysiciansPhysicians: Serge Couzan, Jean-François Pouget

SupportSupportSupportSupport: ANR, Région Rhône-Alpes, industry

Acknowledgements

Introduction

Context

Calf: a peripheral heart

Different types of treatments by compression

Towards patient-specific compression

FE model

Geometry and meshing

Model specifications

Constitutive equations

Identification

Identification results

Results

Results

results

Conclusion

Prospects

Acknowledgements