Centre for NanoHealth Swansea University Centre for NanoHealth Future Healthcare Dr Steve Conlan Director - Centre for NanoHealth

Centre for NanoHealthSwansea University www.nanohealth.swansea.ac.uk

Centre for NanoHealthFuture Healthcare

Dr Steve Conlan

Director - Centre for NanoHealthInstitute of Life Science

School of Medicine

www.nanohealth.swansea.ac.uk

Centre for NanoHealthSwansea University

Overview

• Nanotechnology

• NanoHealth

• Impact of NanoHealth

• Centre for NanoHealth

• Challenges and Opportunities

• R&D



Please turn off your Nanotechnology based devices.



The nano-scale



What is NanoHealth?



Ability to manipulate and control the properties and interaction of material where at least 1-D is nm.

• Structural• Mechanical• Electronic• Optical• Chemical• Biological• Computational• Modelling

Nanotechnology…

Multidisciplinary

…For Healthcare


The impact of NanoHealth



NanoHealth…… has the potential to impact on the prevention, early and reliable diagnosis and treatment of diseases.

European Technology Platform on NanoMedicine Vision Paper (2005)

NanoHealth embraces five main sub-disciplines

that in many ways are overlapping

• Analytical Tools

• Imaging Tools

• Materials and Devices

• Novel Therapeutics and Drug Delivery Systems: ‘Nanomedicines’

• Clinical, Regulatory and Toxicological Issues

ESF forward look on Nanomedicine (2005)



• Diagnosing and treating diseases• Enhancing early intervention• Non-hospital environments• Personalised Medicine

Impact on Healthcare



Economic Impact



Economic Impact



Global Networks/Global Investment EU, US, South America and Asia

Alliance for Nanohealth

ETP for Nanomedicine


Centre for NanoHealth



Partnership for SuccessInstitute of Life Science

£52m collaborative venture between IBM, Swansea University, WAG, opening its doors in 2007

Home in the Medical School, 25 specialist teams (27 Professors and 220 Research active staff)

Multidisciplinary Nanotechnology Centre

More than £5M funding in 2002 from HEFCW, Royal Society/ Wolfson Foundation, SRIF and Swansea University

Home in Engineering, major research centre (20 academic staff, 20 RAs and 40 PhD students)

Outstanding RAE 2008 results (THES)

MNC 5th out of 52 in UK in General Engineering, 80% of activity rated 4* and 3*

ILS 7th out of 70 in UK in Allied and Professional Health, 55% of activity 4* and 3*



Partnership for Success

• Successfully managed Objective 1 project• On time - On budget• Outputs met– sustainability/job creation/strong links with business/IP• Blue C IBM partnership• Interdisciplinary research base

• University NHS Trust• Patient base of 600,000+• Partnership with ILS and MNC • Joint MNC and ILS laboratories in Morriston Hospital• Commitment to CNH

• Successfully managed HEFCW project• Model interdisciplinary centre• Self-sustaining (£2M per year)• Strong links with business/IP• Pan-Wales focus for nanotech




• £22M EU Convergence funded project, started January 2009

• 12 new staff (8 academic, 4 project management and delivery).

• £13M investment in state of the art open access nano- and bio-facilities.

• Industry to come and work with us, access to facilities, expertise and incubation space.

Unique interdisciplinary R&D environment Based on the application of Nanotechnology Leading innovations in Healthcare.

Driving the Knowledge Economy






Project Funding

• £22 Million, 5 year Knowledge Economy project• Supported by:• WEFO [£10.5 Million]• DHSS [£1.5 Million]• Swansea University [£7.6 Million] • Industry [£2.5 Million]



CNH Targets & Deliverables

• Establishing a European R&D Centre of Excellence• Assisting 400 Enterprises (>80% Welsh SMEs)• Assisting 100 Individuals• Creating 450 Jobs• Achieving sustainability by 2014

Through Welsh, UK, Industrial and EU funding



Building opens Q3 2011Facilities available nowCNH

Bio-suite• NanoToxicology• Cell Imaging• Tissue Engineering• Molecular biology• Microbiology

Nano-suite• Class 100/1000 ‘dirty’ clean room• Bio-clean room• Nanostructure growth• SEM & AFM/SNOM• NMR & Rheology• Printing and Coating

Direct access to: Clinical Trials Unit & Patient imaging (MRI&CT)


Projects challenges & opportunities



Challenges & Opportunities

• Company recruitment

• Business development

• IP

• State Aid

• Managing stakeholder expectations

• Sustainability



Company recruitment & Business development

• Project must offer real opportunities to businesses across Wales

• Take the project to the companies

• Launch Events/BioWales/KTNs etc

• Initial assistance is only the first step in the relationship

• Ensure multiple entries for engagement

• Pool of relevant expertise is essential

• Awareness of funding opportunities is essential

• Beware of ERDF overload – internal/institutional management vital



• Access Clinical/Biomedical/Engineering teams

• Fully integrated work flow

• Access at any stage

• Translational applications

• Great opportunities in a new area of healthcare

CNH



IP / IPR

• IP policy of University has to be flexible

• Case by case consideration – one model DOES NOT fit all

• Primary consideration to companies – SHOW STOPPER

• Has to be managed differently to IP generated in house

• Early negotiation

• Companies understand and appreciate position of University

• State Aid compliance



State Aid

• Necessarily a major consideration under European law

• Documentation from WEFO offers clarity in their expectations

• Seek legal advice on wording used in business plans

• De minimus scheme easy to implement



Sustainability – R&D pipeline

• Start early

• Awareness of all opportunities

• Development pipeline



Delivery = Team work!!

• Medicine

• Engineering

• Finance

• Research and Innovation

• Procurement

• VC’s office

• ABMUHB

• External project managers / build team

• WEFO

Early/Continued/Agreed/Managed engagement



CNH operational structure


NanoHealth R&D





Ultra-sensitive biosensor for the detection of bio-markers using bio-compatible ZnO nanowires.

Diagnostics – Biosensors

ZnO nanowires (AFM)

Novel Materials

Antibody

Antigen

Nanowire

Electrode



• Surface topography.• Material properties.• Spatial resolution 5 - 20 nm.

Cellular Analysis for Clinical Diagnostics



Volume additive printing for the integration of biosensors with flexible polymer electronics, photonics and displays.

Biosensors / Biomarker Detection







Documents

Centre for NanoHealth Swansea University Centre for NanoHealth Future Healthcare Dr Steve Conlan Director - Centre for NanoHealth