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David Serantes, Roy Chantrell, Daniel Baldomir
2nd Workshop on Magnetic Nanoparticles for Hyperthermia
Challenges and opportunities
Applied Physics Department and Instituto de Investigacións Tecnolóxicas
Universidade de Santiago de Compostela, SPAIN
Computational Magnetism Group, University of York
Santiago de Compostela, July 15th 2019
Magnetic NPs - agents for nanomedicine
Santiago de Compostela, July 15th 2019
2nd Workshop on Magnetic Nanoparticles for Hyperthermia Challenges and opportunities
Magnetic NPs - agents for nanomedicine
Santiago de Compostela, July 15th 2019
2nd Workshop on Magnetic Nanoparticles for Hyperthermia Challenges and opportunities
Magnetic fluid hyperthermia
Taken from A. Andrade et al. 2011,
Coating Nanomagnetic Particles for
Biomedical Applications,
Santiago de Compostela, July 15th 2019
2nd Workshop on Magnetic Nanoparticles for Hyperthermia Challenges and opportunities
Magnetic fluid hyperthermia
Taken from A. Andrade et al. 2011,
Coating Nanomagnetic Particles for
Biomedical Applications,
Santiago de Compostela, July 15th 2019
Magnetogenetics
2nd Workshop on Magnetic Nanoparticles for Hyperthermia Challenges and opportunities
Magnetic fluid hyperthermia Magnetogenetics
2nd Workshop on Magnetic Nanoparticles for Hyperthermia Challenges and opportunities
Clinical application since 2013
glioblastoma multiforme
In-vivo magnetogenetic control of
neuronal activities in freely moving mice
Stanley et al. Nat. Med. 2014
Stanley et al. Nat. Med. 2014
Santiago de Compostela, July 15th 2019
Magnetic fluid hyperthermia Magnetogenetics
2nd Workshop on Magnetic Nanoparticles for Hyperthermia Challenges and opportunities
Clinical application since 2013
glioblastoma multiforme
In-vivo magnetogenetic control of
neuronal activities in freely moving mice
Stanley et al. Nat. Med. 2014
Stanley et al. Nat. Med. 2014
…despite the foreseen potential, no extended
routines of daily clinical practice yet
…difficulties? ways for improvement?
Still limited success
Santiago de Compostela, July 15th 2019
2nd Workshop on Magnetic Nanoparticles for Hyperthermia Challenges and opportunities
Santiago de Compostela, July 15th 2019
Multiple problems
• Biocompatibility
• Aggregation within cells
• Degradation
• Efficient delivery
• Self-heating changes
• ...
2nd Workshop on Magnetic Nanoparticles for Hyperthermia Challenges and opportunities
Santiago de Compostela, July 15th 2019
Multiple problems
• Biocompatibility
• Aggregation within cells
• Degradation
• Efficient delivery
• Self-heating changes
• ...
no accurate models able to describe the behaviour of
the MNPs in the viscous cell media, under AC fields
2 key
challenges
• Accurate description of heat dissipation
• To account for reorientation/displacement
Physics point of view:
2nd Workshop on Magnetic Nanoparticles for Hyperthermia Challenges and opportunities
Santiago de Compostela, July 15th 2019
Critical problems
1. procedural: incapability to account for ΔT≈0 heat-triggered experiments.
2nd Workshop on Magnetic Nanoparticles for Hyperthermia Challenges and opportunities
Santiago de Compostela, July 15th 2019
Critical problems
1. procedural: incapability to account for ΔT≈0 heat-triggered experiments.
2nd Workshop on Magnetic Nanoparticles for Hyperthermia Challenges and opportunities
Santiago de Compostela, July 15th 2019
Usual global (average) entire-sytem approach no longer valid
Critical problems
Need to study the heat dissipated at the individual particle level,
i.e. local heat, in addition to the global (average system) one
Need to build nm-scale time-resolved temperature profiles – requisite: accurate knowledge of the power dissipated by each particle within the system
1. procedural: incapability to account for ΔT≈0 heat-triggered experiments.
2nd Workshop on Magnetic Nanoparticles for Hyperthermia Challenges and opportunities
Santiago de Compostela, July 15th 2019
Critical problems
1. procedural: incapability to account for ΔT≈0 heat-triggered experiments.
2. interpretative: usual heating mechanisms unable to explain accurate results
2nd Workshop on Magnetic Nanoparticles for Hyperthermia Challenges and opportunities
Santiago de Compostela, July 15th 2019
Critical problems
vs.Other heating (or non-heating)
mechanisms at play??
1. procedural: incapability to account for ΔT≈0 heat-triggered experiments.
2. interpretative: usual heating mechanisms unable to explain accurate results
2nd Workshop on Magnetic Nanoparticles for Hyperthermia Challenges and opportunities
Santiago de Compostela, July 15th 2019
Critical problems
1. procedural: incapability to account for ΔT≈0 heat-triggered experiments.
2. interpretative: usual heating mechanisms unable to explain accurate results
3. descriptive: available theoretical tools unable to grasp key experimental features
K. Simeonidis et al., Sci. Rep. 6:38382 (2016)
2nd Workshop on Magnetic Nanoparticles for Hyperthermia Challenges and opportunities
Santiago de Compostela, July 15th 2019
Critical problems
1. procedural: incapability to account for ΔT≈0 heat-triggered experiments.
2. interpretative: usual heating mechanisms unable to explain accurate results
3. descriptive: available theoretical tools unable to grasp key experimental features
Experiment
K. Simeonidis et al., Sci. Rep. 6:38382 (2016)
Reorientation and SAR change
Displacement (aggregation - interactions)
2nd Workshop on Magnetic Nanoparticles for Hyperthermia Challenges and opportunities
Santiago de Compostela, July 15th 2019
2nd Workshop on Magnetic Nanoparticles for Hyperthermia Challenges and opportunities
Santiago de Compostela, July 15th 2019
Program
09:00 David Serantes (USC)Welcome/Overview of key hyperthermia (and magnetogenetics) aspects to address from a
basic-physics point of view
Theoretical challenges Chair: Pablo Taboada (USC)
09:10 Roy Chantrell (University of York) Single-particle heating
09:35 Oksana Chubykalo-Fesenko (ICMM-CSIC) Field-driven alternation between actuation domains
10:00 Òscar Iglesias (Universitat de Barcelona) Aggregates and dipolar interactions
10:25 Hamid Kachkachi (Univ. Perpignan) Beyond the non-interacting AC susceptibility approximation
10:50 Coffee break
Particle properties identification Chair: Verónica Salgueiriño (Universidade de Vigo)
11:30 Karen Livesey (University of Colorado) Better understanding relaxation times in MNPs, and ZFC/FC curves
11:55 Lucía Gutiérrez (Universidad de Zaragoza) AC susceptibility: A tool to track the transformations of MNPs
12:20 Lluís Balcells (ICMAB-CSIC) Spontaneous formation of nanoparticle chains
12:45 Sergiu Ruta (University of York) Optimisation of properties for magnetic hyperthermia beyond LRT
13:15 Lunch
Other biomedical uses Chair: Oksana Chubykalo-Fesenko (ICMM-CSIC)
14:15 José Rivas (USC) Magnetic Tissue Engineering
14:40 Beatriz Pelaz (USC) Drug release
15:05 Pablo del Pino (USC) Magnetogenetics
15:30 Ondrej Hovorka (Univ. of Southampton) Identification of nanoparticles for diseases detection
16:00 Serantes/Chantrell/Baldomir Closing of the workshop