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Issue 6 | Volume 4 | 2013
Championing innovations, leading change
S e p t e m b e r 1 5 , 2 0 1 5
Third Quarter
Table of Contents
2 | Table of Contents Esco News
03 Letter from the CEO
News06 Another NSF Certifier added to Esco Roster 06 NUS conducted biosafety training using Esco BSCs07 A new home for Esco South Africa07 Visit new Esco China website08 The World's first Chemical Evaluation App, now on iOS 08 Spotted on TV08 Ted 2, featuring IVF Workstation
Laboratory09 Science updates : Turning back cancer into healthy tissue10 Premium hospital in the US chose to use Esco BSCs11 University of Maryland relies on Labculture® Reliant11 All about standards : Biological Safety Cabinets
Medical
09 A new level of quality control in IVF
Technology and Innovation
14 A note from Prof. Hakan of Anatolia IVF and Women?s Health Center
Training and Seminars17 Esco South Africa, pushing forward18 Esco China Annual Distributors' Engineers Training18 Medical Team held its annual training in Singapore19 Biosafety seminars in Bangladesh, held in series20 Biological safety seminars held in China
Events21 ACHEMA21 ESHRE22 LabWorld22 R3 Nordic Symposium23 IVF Experts23 Lab Africa
Products24 Esco Product Guide
Global Network25 World Class. Worldwide.
Esco products boosting cancer research in Czech Academy of Sciences
10
14
17
04 Singapore at 50
Success stories with the Esco Miri
Esco meets Distributors during ACHEMA 2015
Letter from the CEO | 3Esco News
Letter from the CEO
Dear Colleagues and Partners,
Growth in the global life sciences market is expected in all market segments through 2020. Strong competition is anticipated but we are confident to continue achieving steady growth in the coming years. We are developing new technologies and moving towards automation for improved laboratory efficiency, standardization, quality control, and documentation.
In our Lab Equipment business, we are expanding our product portfolio and deepening our offering in existing categories. We have invested in our sales and service infrastructure to provide our customers with better support wherever they may be in the world. These strategies are expected to create greater returns and contribute to the positive growth of the business in the coming years.
IVF is a rapidly growing field globally with demographic tailwinds. We are Lin Xiang Qian, CEO
Regards,
XQ LinGroup President and CEOEsco Group of Companies
working to automate and standardize the IVF lab, first with the recent roll out of our time lapse technology, a new modality for non-invasive embryo assessment. Development of controlled environment systems for IVF/ICSI and new technologies for future IVF lab automation are underway. We will also strengthen our patient outreach efforts to make them aware of the impact these new technologies can have on success rates and outcomes.
Our Pharma division has launched new strategic partnerships that will further expand the product line up and deliver more complete solutions. Key project wins have been secured in the US this year and we are also investing in and expanding our European footprint in this business.
The Group is establishing new companies and investing in new technologies which address unmet needs via Esco Ventures, the corporate venture arm. These activities will strengthen the Group?s business long term and support our vision: to provide enabling technologies for scientific discovery, clinical practice and pharmaceutical manufacturing to make human lives healthier and safer.
As always, I would like to acknowledge the efforts of the entire Esco family and thank our partners for their continued support.
4 | News Esco News
Singapore at 50
Singapore, a longtime British colony, became part of Malaysia in 1963, declared independence on Aug 9, 1965. The founding father, Lee Kuan Yew, led the country since independence and is known to have contributed immensely in turning Singapore into one of the world's richest countries.
Since last year, as part of their preparation for their 50th year of Independence, Singapore started to reflect on their journey and took pride in how far they have become as a country. In the beginning of 2015, Singapore started celebrating on different parts of the country. On April, the Youth celebrated by showcasing their talents, June was the SEA Games, and recently, last August 9, the National Day Parade.
The overall theme for SG50 is for all Singaporeans to celebrate as one people. The SG50 logo celebrates the Singaporean spirit ? signifying that their dreams are not limited by the physical size of the island nation. Singapore is celebrating their shared values, affirming their aspirations and committing to a brighter future.
On the eve of the National Day Parade, Prime Minister Lee Hsien Loong, Lee Kuan Yew's son, said: "At 50 years, as we stand at a high base camp, we look back and marvel how far we have come. We are grateful to those who made it happen. From this base camp, we can also look forward to new peaks ahead. The journey ahead is uncharted. But we must press on, because we aspire to do better for ourselves and our children."
The values and discipline made Singapore one of the most developed economies in the world, and is expected to continue its success for another 50 years.
The Founding Father
Driven, persistent, with a solid dedication and passion, a man of foresight with a fighting spirit, the one who believes in every person?s capability to contribute to the growth of the society.
For three decades, during his governance, goods jobs were created, education system was intensified, and infrastructures were heightened; a vibrant economy emerged. He led Singapore from 1965 until his death on March 2015. Through his efforts and great leadership, Lee Kuan Yew has transformed Singapore from a Third World to a First World Country.
His death was mourned not only by Singaporeans, but by people who believes in his principles and teachings, from different nations. Along with grief, his passing inspired many to hope, dream and to have a good heart for others.
Lee Kuan Yew is a gift not only to Singapore but to all nations around the world.
Esco is a microcosm of Singapore. Our story is affirmed each day by many individuals born of cultural and ethnic diversity. Despite our differences, our values make us one, working together for one goal, being the Tiger in our industry. Like Singapore, many did not believe at the beginning, but with our good leaders and their teachings, Esco is now one of the leading laboratory equipment manufacturers in the world and is continuously blossoming throughout the years. Esco will forever be humble and a proud Singaporean company that will be here to celebrate the Centennial of Singapore.
News | 5Esco News
The Merlion
The Merlion is the national personification of Singapore.
Its name combines "mer" meaning the sea and "lion". Its head represents Singapore?s original name, Singapura, or ?lion city? in Malay. The body symbolizes Singapore's humble beginnings as a fishing village when it was called Temasek, meaning 'sea town' in Old Javanese.
Some Destinations
Gardens by the Bay
Part of the government?s plan to create a city in a garden, two glass conservatories host plants from around the world, replicating conditions as diverse as tropical highlands and 2,000-metre high peaks.
Sentosa
An Island Playground Field with resorts, theme park, beaches and parks.
Singapore Art Museum
The Singapore Art Museum focuses on international contemporary art practices, specializing in Singapore and Southeast Asia.
Only in Singapore
It is good to know some of the customs that you can experience only in Singapore.
Singlish ? Singaporean English, very short and direct to the point
It helps to speak a little bit of Singlish when you come to Singapore. This way you can assimilate yourself with the people and be one with Singaporeans, at least during your stay there.
Lah ? such as okay-lah, can-lah, whatever-lah.
Makan ? eat; usually used when inviting colleagues to eat. Example: Let?s go Makan, or just Makan.
Shiok ? to some it means extreme pleasure; example: this movie is so shiok.
CBD- Central Business District
MBS- Marina Bay Sands
SBS- Singapore Bus Service
MRT ? Mass Rapid Transit
PIE ? Pan Island Expressway
ECP ? East Coast Parkway
TPE ? Tampines Expressway
AYE ? Ayer Rajah Expressway
MCE ? Marina Coastal Expressway
Acronyms ? Singaporeans use many acronyms, why? Because they are too busy to speak full sentences. They use it to
save time.
A Glimpse of Singapore
A country with very few resources, and a vastly different ethnic groups, many thought that it is impossible for this Island to succeed, but succeeded it had, on an unimaginable scale. Singapore today is one of the four Asian Economic Tigers. Yet, despite being one of great global cities in the world, Singapore still embraces its Asian Culture and Traditions.
Singapore Art Museum Inside the Gardens by the Bay
6 | News Esco News
Another NSF Certifier added to Esco RosterWe are proud to announce that another Esco Service Engineer has passed the NSF Class II Biosafety Cabinet Field Certification process last 5th of August 2015.
Wellington Ma. V. Ferino is the Field Service Engineer of Esco Singapore. Working for more than 10 years in the field of automation, semi-conductor and medical technology industries and a year in Esco, he gained extensive knowledge in the laboratory and medical equipment. Ferino is experienced in servicing, calibrating, installation and commissioning of Esco biological safety cabinets, laminar flow cabinets, and fume hoods.
With this recent achievement, Esco again demonstrates its being an Excellent Service Company.
Congratulations to Wellington Ferino! The Esco family is proud of you.
The NSF accreditation program evaluates the proficiency of individuals who perform routine field certification of biological safety cabinets. The program includes written exam which covers areas such as testing, biosafety, decontamination and cabinet design, and practical exam to evaluate an applicant?s ability to perform all of the tests identified in the NSF/ANSI Standard 49 Biosafety Cabinetry: Design, Construction, Performance, and Field Certification.
When people see the NSF Mark, they know the individual has met the initial and continued stringent accreditation requirements of NSF, the premier, independent, not-for-profit organization for public health, safety and environmental quality standards and certification.
Wellington at work
Wellington Ferino, NSF Certifier
NUS conducted biosafety training using Esco BSCs
National University of Singapore (NUS) is one of the loyal users of Esco products. Recently, NUS trained more than 50 new operators of biological safety cabinet(s) (BSC) using Esco BSCs. They use these units in clinical, life sciences, research, industrial, laboratory and pharmaceutical applications. NUS has more than 100 BSC units now, used by different departments. NUS preferred Esco products because they are
National University of Singapore
Training participants
Labculture® BSC in one of the
laboratories in NUS
user-friendly, which makes it perfect for students? use and for those who are new to using biological safety cabinets.
News | 7Esco News
A new home for Esco South AfricaEsco South Africa, recently relocated to Landsmark Business Park, located off Samrand offramp in Centurion. The new facility has a training room equipped for in-house seminars as well as a showroom for practical training on Esco equipment. On display in our showroom, Frontier® Acela? Fume Hood, Airstream® S-Series Biological Safety Cabinet, HP Series Refrigerator, Lexicon® II ULT freezer with Aalto Platinum Controller, Esco Protect Software, Provocell Microplate Shaker, and 170L CelCulture® CO2 Incubator.
This transfer has been necessary for Esco to cater to the growing demands of our products in South Africa. Furthermore, this will strengthen the knowledge of our staff, partners and customers as training and seminars would be easier and more practical due to the presence of Esco equipment in the facility.
You can contact us at:
Esco Technologies Pty LtdUnit 2 Landsmark Park, 17 Landsmark Avenue, Kosmosdal Extension 11, Centurion, South Africa 1057Email: [email protected]: +27 (0) 79 4909 529
Website: http://za.escoglobal.com
Esco South Africa Office
Visit new Esco China websiteEsco is continuously looking for solutions and developing our systems and means to easily reach to our customers around the world, anytime, anywhere.
With that in mind, we have improved Esco China website and is now ready to cater our Chinese clients. The goal is to provide our visitors with an easier way to learn about our products and services. The new website is faster and is easier to navigate. The design allows the users to view news, videos, customer references at one glance. This site will allow Esco to communicate better and in turn provide services faster.
We hope that this will yet be another tool to reinforce our business with our Chinese partners and clients.
Visit us at http://escolifesciences.cnChina website home page
Showroom Training Room
8 | News Esco News
The World's first Chemical Evaluation App, now on iOSEsco is proud to be the first in the world to develop and launch an App that is able to evaluate the right ductless fume hood and filter for your laboratory. The FiltraCheck? App is part of our continuous pursuit to offer the best support to our customers.
Before, it requires filling out and submitting a FiltraCheck? Assessment form through our website which takes more than 24 hours. Now through the FiltraCheck? App, current and potential ductless fume hood users get real-time advice on the right ductless fume hood model and its estimated filter life.
Esco FiltraCheck? is supported by our dedicated in-house test laboratory, trained experts on carbon adsorption technology, external consultants from independent organizations, and world's leading carbon suppliers. Our in-house computer simulations can be used to estimate carbon adsorption capacity, efficiency and simulate competitive adsorption scenarios where multiple types of chemicals may be used.
Current works are also being done to make this app available for Android users.
Dr. Einesco's recommendationsFiltraCheck home page
Spotted on TV!Esco?s Biosafety Cabinets and CO2 incubators appeared in News Network on CCTV News Channel, the national news platform in China.
These products are used in the laboratories of Mr. Duanqin Pei, the Dean of Guangzhou Institute of Biomedicine and Health Chinese Academy of Sciences.
This is another confirmation that Esco?s products are truly world class, worldwide.
Ted 2, featuring IVF WorkstationEsco IVF products do not only aid in fulfilling the dreams of human couples - having babies - come true, but to a human-teddy bear couple as well.
Yes, a human-teddy bear couple, Ted and his wife, decided to have a baby via IVF in the movie Ted 2. The scene is inside Boston Fertility Clinic where Fertilisafe? IVF workstation is seen on the background, twice. See for yourself, at 26:10 and 27:15 minutes.
Esco products are becoming Hollywood Extras, with the recent appearance of Labculture® Biological Safety Cabinet
Esco products on CCTV News ChannelClick the image to watch the news
in Spider Man 2 and now, this in Ted 2. It is our pride and joy to see Esco products in the big screen.
Esco News
Science Updates
Putting on the brakes
It brings together two strands of science - cell adhesion and microRNA (miRNA) biology - that, until now, had not been linked.
Scientists had thought adhesion molecules were simply the glue that holds cells together. But then others found they might
Healthy cells
Turning cancer back into healthy tissueBBC News, Aug 25, 2015
Scientists believe they may have found a way to turn cancerous cells back into healthy tissue.
Their lab-based work suggests there is a biological step that can restore normality and stop cells replicating out of control.
When the US researchers added molecules called microRNAs, it put the brakes on cancer, Nature Cell Biology reports.
Although the early tests in a dish look promising, it is unclear whether it will help treat people with cancer.
The Mayo Clinic researchers are hopeful that the new mechanism they have found could apply to all types of cancer. Cancer cells
have signalling roles.
The Mayo Clinic work shows adhesion molecules connect cells and signal via miRNAs to control cell growth.
If this becomes deregulated it can drive cancer.
But replenishing cells with miRNAs can remedy this.
Lead researcher Dr Panos Anastasiadis said: "By administering the affected miRNAs in cancer cells to restore their normal levels, we should be able to re-establish the brakes and restore normal cell function.
"Initial experiments in some aggressive types of cancer are indeed very promising."
Henry Scowcroft, Cancer Research UK's senior science information manager, said: "This important study solves a long-standing biological mystery, but we mustn't get ahead of ourselves.
"There's a long way to go before we know whether these findings, in cells grown in a laboratory, will help treat people with
Esco supports worldwide cancer research efforts. Our role in this battle is to provide laboratory equipment that deliver accurate results, aiding our hero researchers as they find cure against this disease. Accuracy, reliability and efficiency, are the keys for a successful research - the same elements that Esco products bring. Let us support cancer research for a better and healthier world.
Laboratory | 9
cancer. But it's a significant step forward in understanding how certain cells in our body know when to grow, and when to stop. Understanding these key concepts is crucial to help continue the encouraging progress against cancer we've seen in recent years."
Source URL: http://www.bbc.com/news/health-34041374?error_code=4201&error_message=User+canceled+the+Dialog+flow#_=_
10 | Laboratory Esco News
Esco products boosting cancer research in Czech Academy of Sciences
The Institute of Microbiology of the Academy of Sciences is one of the biggest research center in the Czech Republic covering the areas of biochemistry, genetics and physiology of microorganisms, molecular biology and molecular microbiology, microbial products and their formation, biodegradation activities of microorganisms and symbiotic relations in biological models, and new biotechnological processes. It includes also laboratories dedicated to investigate the various aspects of immunology (from its evolution to the functions of its various components) in relation to infection, inflammation, autoimmunity and cancer.
The Laboratory of Immunotherapy is in the main research premises in Prague where we concentrate a lot of our efforts within the academic market sector. Thus we are in repeated contact with the head of the laboratory Dr. Luca Vannucci, M.D., PhD. and we are thankful for his friendly attitude to us. His laboratory is devoted to the study of early immunological response against cancer, nanomedicine and, generally, modulation of innate immunity responses in pathological conditions. The goal of their studies is to understand reciprocal interactions between immunological and cancer mechanisms to develop more
effective immunotherapies and they are successfully developing that research area because of their valued experiences.
Since 2012, they are using a biosafety cabinet, Class II Labculture® Low Noise, and a CelCulture® CO2 incubator. They use these instruments for cultivation and manipulation of animal and human cell lines originated from normal or cancer tissues. They are satisfied with the quality and reliability of the instruments. There was no service needed. They are not experiencing contamination in the incubator that shows an extraordinary cleanness in the chamber, thanks to the ULPA filter, all other protection features (line-in filters, intelligent heating preventing condensations, built-in decontamination system, etc.) and the ISOCIDE? coating that both instruments have. The instruments are placed in a very small room so the low noise level of the cabinet is an excellent feature helping people to work in comfort and thus, safely as well.
Institute of Microbiology, Academy of SciencesSource: http://mbucas.cz/
Labculture® Low Noise BSC at the Academy of Sciences
University of Maryland relies on Labculture® Reliant
University of Maryland is a public research university; one of the 62 members of the Association of American Universities, comprising the leading research universities in the US and Canada. It is committed to being a preeminent national center for research and for graduate education, and the institutions of choice for Maryland?s undergraduates of exceptional ability and promise.University of Maryland
Being in the research field, the University relies on the safety of their laboratory equipment. These equipment must make sure that their researchers, most especially their students are safe from lab hazards; they should be an advocate of lab safety.
With the strict requirements to consider, the University opted to purchase 2 units of Labculture® Reliant Biological Safety Cabinets (BSCs) used for Cell Biology Research. These BSCs are equipped with easy-to-use switches and UV timer; energy and space-saving; low noise; ergonomic, which makes it an ideal equipment for research facilities.
Labculture® Reliant BSC at the University of Maryland
Esco News
Premium hospital in the US chose to use Esco BSCs
Mercy Medical Center, with its doctors and nurses, is committed to provide patients and their families with quality, comprehensive patient care. The hospital has been awarded several times; ranked #1 Community Hospital in Maryland by US News & World Report for 2015-2016; Best Regional Hospital in Gynecology, Orthopedics, Neurology & Neurosurgery, Geriatrics and Nephrology; among the 100 Great Hospitals in America (according to Becker?s Hospital Review); among the 100 Best Hospitals for Patients Experience by Women?s Choice Awards; and many others.
An excellent hospital needs excellent equipment. That is why they chose Labculture® Biological Safety Cabinets to help them during preparation of patient?s samples before culturing and analysis. They have started using Esco BSC on 2007. The real-time airflow monitor, which gives confidence to the users that working in their BSC is safe, is one of the main reasons why they prefer to purchase another unit this year.
Mercy Medical Center at Baltimore, Maryland, USA
Laboratory | 11
Mercy Medical Center Labculture® BSC at Mercy Medical Center
All about StandardsInternational Standards for Biological Safety Cabinets
The need for standards for Biological Safety Cabinets
Biological safety cabinets, also known as microbiological safety cabinets, have been widely recognized as primary containment devices in dealing with biohazards. In general, these biosafety cabinets are used to provide personnel, environment and product protection. The terms should only be applied to those devices that meet the requirements based on their construction, airflow velocities and patterns, and their exhaust systems.
The evolution of these containment devices prompted the need for consistency in its construction and performance. Moreover, the cabinet industry continues to grow so it is imperative to develop uniformity of these products throughout the world. As a result, various not-for-profit organizations created standards for biological safety cabinets.
The standards for biological safety cabinets are used to set the minimum requirements for manufacturers to comply with in terms of the products? construction and performance criteria. In general, the major international standards in use today put emphasis on the biosafety cabinet?s performance in terms of providing protection to the worker and environment, and product if applicable.
12 | Laboratory Esco News
EN 12469
EN 12469 is the harmonized European standard for microbiological safety cabinets, replacing the former German DIN 12950, British BS5726 and French NF X44-291:1984 standards in 2000. Similar to the NSF/ANSI 49, it specifies the requirements for both the cabinet?s construction and performance criteria. Though EN 12469 standard is based from NSF/ANSI 49, there are several differences between the two.
Underwriters Laboratories Inc. (UL)
UL is an independent, not-for-profit product safety testing and certification organization and is one of the most recognized conformity assessment providers in the world. In order for a biosafety cabinet to be certified by NSF, it should conform to UL Standard 61010A-1 which covers electrical equipment for laboratory use.
JIS K3800
JIS K3800 is also known as the Japan Industrial Standard. The certification is performed by Japan Air Cleaning Association (JACA). This standard specifies performance, structure, and material and test method of Class II biological safety cabinets. The Class II biological safety cabinets specified in this standard are Type A, Type B1, Type B2 and Type B3. The cabinets should satisfy the requirements established by Minister of Health, Labor and Welfare based on the Ministerial Ordinance No. 99 of the Ministry of Health and Welfare in 1998.
AS 2252
AS 2252, also known as the Australian standard, was prepared by the Australian members of the Joint Standards Australia/Standards New Zealand Committee ME-060. It supersedes AS/NZS 2647:2000. This standard specifies requirements for biological safety cabinets including installation and use. For Class I biological safety cabinet, emphasis is given to personnel and environment protection. For Class II biological safety cabinet, its design should provide personnel, environment and product protection.
SFDA YY 0569
SFDA YY 0569 or the State Food and Drug Administration YY 0569 is the Chinese Standard for biological safety cabinets. It is modeled on both the EN 12469:2000 and NSF49:2002. This standard adopted the KI-Discus test from the European standard. Even though YY 0569 is based on the two major international standards, there are some notable improvements, i.e. instant display for air exchange rate and air intake, audio and visual warning system, to alert workers of performance malfunction. Similar to NSF, it recognizes four types of Class II BSCs. In summary, there are aspects unique to NSF and EN standards that are used as basis for YY 0569.
International Standards for Biological Safety Cabinets
The following are the major international standards for Biological Safety Cabinets:
NSF/ ANSI 49
The NSF International Biological Safety Cabinetry Program was initiated during the 1970s. This standard gained official recognition from American National Standards Institute (ANSI) in 2002. It specifies the requirements for both the biosafety cabinet construction and performance criteria. In addition, reliable operation, durability, cleanability, noise level, and illumination control, vibration control, and electrical safety of the cabinet are checked as well.
Esco News
Comparison of NSF/ANSI 49 and EN 12469
There are several differences between NSF/ANSI 49 and EN 12469. However, despite the below-mentioned differences, both are the two major international standards in use today. Predominantly, Europeans use EN certified cabinets while Americans use NSF certified cabinets.
Laboratory | 13
Categories NSF EN
Application The standard only applies to Class II biological safety cabinets.
The standard is relevant to Class I, II and III biological safety cabinets.
Subcategories of Class II BSCs
The standard defines Class II subtypes, i.e. A1, A2, B1, and B2.
The standard defines only a general Class II cabinet; EN cabinet is nearly equivalent of the NSF Class II Type A2 BSC.
Microbiological Challenge Testing for operator protection
The standard uses microbiological challenge test to assess operator, product and cross-contamination protection.
- Adopted by EN for both testing and acceptance - Recognizes KI-Discus test ~ the only way to validate the containment of the cabinet.
Downflow Velocity No requirement; yet NSF requires a larger test sample size and requires traceable test equipment for more verifiable testing results ~ more reliable, precise and accurate.
Required; yet does not specify the test instrument accuracy and type.
Inflow velocity Very specific inflow requirements ~ distinguishes subcategories of Class II BSC; uses a Direct Inflow Measurement as the primary standard ~ provides repeatable and accurate inflow measurements.
Inflow test is conducted by measuring the airflow above the exhaust HEPA filter and back calculating the inflow ~ allows for calculation error, multiple sets of data provide different velocity values.
For A2, 0.5m/s 0.4m/s
Performance envelope* NSF requires that Class II cabinets must function +/- 0.025 m/s of the inflow and downflow setpoints.
None, requires the cabinet airflows to be within the generic velocity ranges.
Secondary tests for worker comfort: noise, light, vibration
Noise Distance used is just an approximate operator head position (12 inches in front of the cabinet and 15 inches above the plane of the work surface at the vertical centerline of the cabinet).
Distance is 1 meter from the center of the work opening.
Maximum limit for Noise Level 67 dBA 65 dBA
Light level 650 lux 750 lux; EN standard is not completely precise about background lighting levels, accuracy of the measurement instrument, and test point grid.
Filter leak test Uses a generated aerosol challenge Allows alternative test using natural aerosol challenge test.
Pressurizing Testing Every unit manufactured should undergo ?soap bubble pressure leak test? ~ verifies that the cabinet is airtight.
EN requires a ?type-test? performed by an independent laboratory.
Other miscellaneous tests Requires chemical and abrasion resistance of the cabinet external paintwork and motor/ blower performance test.
Not required
Construction - Detailed construction requirements. - Does not allow noise insulation materials inside the contaminated areas in the cabinet - Emphasis on cleanability of contaminated surfaces
Requires airflow alarm system
References:
Brian Garret. 2014. 6 major differences between North American and European BSC design standards. [Online] Available from: http://www.labconco.com/news/6-differences-in-american-and-european-bscs [Accessed September 2, 2015].
Centers for Disease Control and Prevention. Appendix A ? Primary Containment for Biohazards: Selection, Installation and Use of Biological Safety Cabinets. USA. Centers for Disease Control and Prevention. Available from: http://www.cdc.gov/biosafety/publications/bmbl5/BMBL5_appendixA.pdf [Accessed September 2, 2015].
Hu Longfei, et. al. Chinese Biosafety Laws and Regulations, Including Matters of Biosecurity and Oversight of Genetic Engineering Activities. China. Available from http://cns.miis.edu/stories/pdf_support/070917_hu.pdf [Accessed September 4, 2015].
IHS Engineering 360. 2015. Standard: JSA ? JIS K 3800, Class II Biological Safety Cabinets. New York, USA. IHS Engineering 360. Available from http://standards.globalspec.com/std/1296600/jsa-jis-k-3800 [Accessed September 4, 2015].
Lin Xiang Qian. 2012. Comparison between EN 12469:2000 and ANSI/ NSF 49:2002 Standards. Singapore. Esco Micro Pte. Ltd. [Accessed September 3, 2015].
NSF International. 2015. NSF/ANSI 49: Biosafety Cabinetry Certification. USA. NSF. Available from http://www.nsf.org/services/by-industry/pharma-biotech/biosafety-cabinetry/nsf-ansi-49-biosafety-cabinetry-certification/ [Accessed September 2, 2015].
Standards Australia. 2009. Controlled environments Part 2: Biological safety cabinets Class II ? Design. Australia. Standards Australia.
In Esco, we make sure that all our biosafety cabinets comply with at least one of these international standards. Some models were certified by NSF/ANSI 49, while others were certified by EN 12469. We have the most certified biosafety cabinet, Labculture® Class II Type A2. Our very own Labculture® has been certified by NSF/ANSI 49, EN 12469, JIS K 3800, SFDA YY 0569, a first in the biosafety cabinet industry!
14 | Medical Esco News
Smart IVF Daya Medika, Indonesia, currently has 2 Miri® Benchtop Multiroom Incubator. The first unit was installed in September 2014 while the second in October of the same year. Again, Miri has proven its worth with the first baby
Success stories with the Esco Miri®
boy born on 13th July while the second and third (Twins) born on 15th July of this year.
One of our missions is to help in fulfilling every couple?s dream of having a baby of their own. Hence, it is our pride and joy to know that we have been an instrument in achieving the dreams of these couples, now parents of these cuties.
Esco Medical products are now being used by leading IVF Clinics and are recommended by top embryologists in the world.
A note from Prof. Hakan of Anatolia IVF and Women?s Health Center
"Being a clinician, what I believe is that 80% of success or failure of an IVF treatment cycles is from the lab! Optimum in-vitro culture condition is indispensable to achieve highest live birth rates in an IVF Lab. We recently purchased 2 Miri® Benchtop Multiroom Incubators and we are very happy using them. Having monitored the cleavage and blastulation rates of the 6 lids, they appear to be consistent. We also recently commenced to offer liberal PGS (trophoectoderm biopsy) for advanced maternal age cases and very happy with the first results; in this context provision of good in vitro culture conditions with these incubators have greatly contributed. The last point is that MedikalTim, the Turkish distributor, has designed a cheap but very useful stand with a drawer system to put 3 Miri® incubators on top of each other to save from the space; very good job!"
Professor Hakan Yaral?, MDAnatolia IVF and Women?s Health CenterAnkara, Turkey
Thank you Professor Hakan for appreciating our Team?s effort in providing excellent product and service to you and your team. We look forward to more successful births in your care.
Smart IVF Daya Medika 1st Miri Baby born on July 13, 2015
Smart IVF Daya Medika Twins (2nd and 3rd babies) born on July 15, 2015
Anatolia IVF and Women's Health Center Source: http://www.ivfinturkey.co.uk/
Satisfied user of Miri Multiroom Incubator at Anatolia IVF and Women's Health Center
Esco New s
IVF is becoming more popular worldwide, thus the necessity for advanced and reliable equipment is essentially increasing. Embryologists need to take more control and monitor their procedures, from the collection of gametes to embryo implantation, for a higher pregnancy success rate.
To address these recent needs, Esco invests substantial amount of time and effort in Research and Development and came up with new IVF tools.
Technology | 15
A new level of Quality Control in IVF
Semi Closed Environment (IVF/ICSI)Maximum performance and Quality Control of your procedures
Semi Closed Environment (SCE) takes the controlled environment from your incubators to previous procedures in the laboratory workflow. We believe that maximum control of the environment throughout the entire ART procedure is beneficial and will lead to better outcome.
With the SCE product line, you can now perform microscopy and ICSI with a stable, controlled and monitored CO2 and temperature, inside the working area.
SCE ICSI (Semi Closed Environment ? Intra-Cytoplasmic Sperm Injection)- Digital inverted microscope (Zeiss objectives). 4x, 20x and 40x. Manual motorized focus/zoom.
SCE IVF (Semi Closed Environment ? In-vitro Fertilization)- Digital inverted microscope (Zeiss objective). 4x. Manual motorized focus/zoom.
Key benefits of both systems:
- 3 incubator compartments with access from the front (inside the working area) and from the back (outside the working area).
- Pre-installed stereo microscope or micromanipulator (based on your requirements).
- Heated zones on the work area.- CO2 controlled environment separately monitored in the working area
and the 3 incubator compartments.- VOC filtering of the air in the incubators and the large working area.- Data logger software with full insight of temperature and gas
conditions.
Miri® GA Mini Gas Validation Unit
Miri® GA Mini is a handheld device intended to do spot measurements of CO2 and O2. The Miri® GA Mini can connect to any brand of incubator and is a perfect accessory for spot monitoring on Miri® TL and Miri® Multiroom Incubators.
Key Features:
- Fast spot measurement of gas concentrations.- Gas suction rate is gentle and adjustable in the range from 0-8L/h.- For one incubator/chamber at the time.
Semi Closed Environment (IVF / ICSI)
MIri GA Mini Gas Validation Unit
16 | Technology Esco News
Working procedures are to be as smooth as possible with the new culture dishes from Esco. We have targeted optimal work routines and smooth procedures in the lab. With the 4 different types of dishes, we are able to support and make various procedures and demands easier.
All dishes are Gamma-sterilized and Oxygen plasma-treated for high wet-ability (hydroscopic).
CultureCoin for Miri® TL- Holds up to 14 embryos with individual numbered wells (1-14).- For single and separated culture where each embryo are cultured in its
own environment.- Ergonomic design for easy handling and location of embryos.- Separate well for pH measurements.- Packed in 1 dish pouches and delivered in boxes of 25 pcs.
Communal Reservoir CultureCoin for Miri® TL- Well of the well position for each embryo but culture medium and oil
overlay is shared for all positions.- Same ergonomic advantages as the regular CultureCoin, so embryo
placement and location is very easy and allows the pipette to be held in a comfortable angle.
- Holds up to 14 embryos. The wells are numbered (1-14).- Same footprint as the regular CultureCoin, so the user can choose which
type to use in the Miri TL.- Packed in 1 dish pouches and delivered in boxes of 25 pcs.
Fertilization and culturing dish for standard procedures- 8 separate wells (separation on both medium and oil layer).- Each well holds a maximum of 0.6 mL. Medium volumes can be
adjusted by the user. Microdroplet culture and larger volume culture possible.
- Well slopes down towards the center of the dishmaking oocyte or embryo; placement predictable and easy to locate.
- Central work area saves time when moving the dish during microscopy.- Ergonomic pipette access angle.- Flat bottom for good thermal contact.- Lid is smaller than the dish (fits inside outer rim).Makes handling safe.
No more dishes dropped due to gripping the lid only and dropping the dish.
- Good gas exchange inside the dish due to sufficient opening between lid and dish.
- Each well is clearly numbered (1-8).- Packed in 5 dish pouch.
ICSI Dish- The dish has 8 separate positions for oocytes.- Oocytes from one patient is loaded into these before the ICSI start.- The wells are individually numbered.- One oocyte is then moved to the working area.- A sperm cell is loaded from the sperm area and injected into the oocyte.- Then, the oocyte is moved to the other side to the culturing wells. That
side also has 8 wells. These wells are for the finished cells.- A row of 8 washing wells are located in between.- Packed in 1 dish pouches and delivered in boxes of 25 pcs.- The Esco ICSI dish features working areas.
- One for the injection of the oocyte.- One for holding sperm.
CultureCoin for Miri TL
Communal Reservoir CultureCoin for Miri TL
Fertilization and Culturing Dish
ICSI Dish
Culture and Fertilization Dishes
Esco News
Over 40 distributors and partners across the globe attended the Distributor?s Meeting in Le Méridien Parkhotel, Frankfurt, Germany last June 17, 2015.
Alvin Heah, Esco?s Director for Business Development & Projects, opened the program with a warm welcome and appreciation. The program was then highlighted by XQ Lin, Esco Group President and CEO, with the latest updates from the company on geographic expansion, new partnerships and ventures, marketing initiatives and new products.
A scrumptious dinner buffet in a French-inspired restaurant at the same hotel followed. With jest in everyone's heart, a surprise birthday cake was given to Lim Yae Foong, COO, as an appreciation for her love for the company and its people.
This event strengthens our bonds as partners and heightens our abilities to respond to the increasing demands of products and services in the industry. We thank all our distributors in helping us fulfill our mission of delivering state-of-the-art laboratory equipment in every part of the world.
Training and Seminars | 17
Esco meets Distributors during ACHEMA 2015
Esco with Distributors from around the world
Esco South Africa, pushing forward
Biobanking Forum
Held on June 10, Industry leaders across the country presented the following topics in this forum;
- Essential Biobanking Operation: Specimen Receipt, Storage and Distribution- Quality Control and Information management in Biobanking - Biobanks and Human Subjects Research - The University of Witwatersrand approach
During this event, Esco Technologies launched the revolutionary Lexicon® Ultra-low Temperature freezer with Aalto Controller.
VacciXcell Product Launch
The TideCell & BelloCellTM Bioreactor systems were officially launched on June 22-25. The launch was witnessed by key people, ranging from cell culture R&D to Production Managers and Quality control officials from across the Industry. XL Lin, CEO of VacciXcell, and King Chang were the keynote speakers.
Participants during Biobanking Forum XL Lin, VacciXcell CEO, giving speech during launch
18 | Training and Seminars Esco News
Esco China held its Annual Distributors' Engineers TrainingEsco China organized its annual distributor engineering training at Esco China Product Training Center on July 20-21, 2015. The training was attended by 40 participants.
Esco Group Service Manager, Kenny Chee, conducted hands-on training covering our newest products which include Gen 3 Laminar Flow Cabinets and Centrifuges. Some of the participants shared their experiences on installation and troubleshooting of our biological safety cabinets, laminar flow cabinets, CO2 incubators, and some other products, which made the discussion more dynamic and interesting. The expertise, competence and professionalism of the Esco engineers have been the inspiration of the participants and may those guide them in their everyday journey of servicing their customers.
We are very grateful for the efforts exerted by our Distributors? Engineers in partnering with Esco in saving lives.
The participants during the discussions Esco with Distributors' Engineers
Hands on training Kenny Chee, Esco Service Manager, during discussions
Esco Medical held its annual technical training in Singapore As part of our commitment in providing quality products and services, Esco has successfully conducted its annual Advanced Technical Training in its headquarters in Singapore.
Once again we would like to thank all distributors across Asia and staff who have made this event possible. Hand in hand, we aim to provide only the best in embryo incubation.
Esco New s Training and Seminars | 19
Biosafety seminars in Bangladesh, held in series
Esco Biosafety Institute (EBI), headed by Petrus Carbonell, is honored to be part of ?Biosafety Awareness: A Pathway to Improved Public Health?. The seminar was organized by Military Institute of Science and Technology (MIST) and was held on August 05, 2015 in Dhaka, Bangladesh. The aim of the seminar is to raise biosafety awareness in laboratories and hospitals.
The rising number of pathogens and hazardous chemicals affecting human is alarming. Working hand in hand with international organizations, government agencies, and every
Petrus Carbonell, Pres.- Biosafety Institute, on Principles of Biosafety
Zharmaine Solivet,Product Specialist, on Hazardous Drugs Handling
Safe practices in protecting against occupational hazards
Esco Lifesciences ? Bangladesh invited professionals from various pharmaceutical industries in the country to participate in a biosafety seminar, which was held on August 06, 2015 in Dhaka, Bangladesh. The seminar focused on safe practices with laboratory ventilation equipment, aseptic processing, occupational exposures and sterility testing.
A comprehensive range of pharmaceutical isolators was also presented in the seminar to provide engineering controls and measures in protecting the health of workers against occupational hazards. A key point raised in the seminar was that a successful safety program would have contributions from different sectors including engineering, toxicology, industrial hygiene, and operations.
Excellent feedback was received after the seminar. One-on-one discussions with selected companies were done to provide specific solutions to each need.
Esco is looking forward to more collaborations with the pharmaceutical industry in Bangladesh.
Petrus Carbonell discussing biosafety and biological safety cabinets
Zharmaine Solivet discussing Sterility Testing
Biosafety Awareness: A Pathway to Improved Public Health
person in the healthcare field is one of the most effective ways in educating the public and reducing occupational hazards in the medical field.
Petrus ended his speech with the note, ?If Bangladesh is safe, and then the world is safe as well.? Esco Biosafety Institute is looking forward to working with MIST in safeguarding the health of the public.
20 | Training and Seminars Esco News
As part of Esco promise, biological safety seminars are conducted through the efforts of our colleagues all over the world. This aims to promote biosafety awareness, which will in turn reduce or better yet eliminate the risks of contaminating the environment with biological hazards and prevent the spread of infectious diseases.
Esco China held a series of seminars with the same goal. Seminars were held in Institute of Microbiology in Chinese Academy of Sciences, China National Research Institute of Food & Fermentation Industries, Nankai University, Mars China, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Rongchang Pharma, and Peking Union Medical College Hospital.
We hope that we have imparted the true essence of biosafety, and may those guide each of us as we fulfill our obligation to our environment and to the society.
Biological safety seminars held in China
Bangladesh?s medical laboratories and hospitals have been urged to focus on bio-safety, given the emergence of new diseases.
?If Bangladesh is safe, then the world is safe as well,? Petrus Paolo Carbonell, President of the Esco Biosafety Institute, Singapore, said at a seminar on Wednesday.
Carbonell was delivering the keynote paper at the Military Institute of Science and Technology (MIST) in Dhaka.
Its new ?biomedical engineering? department has organised the seminar to make students aware of the critical need of bio-safety, particularly in laboratories and hospitals.
Maj Gen Dr HR Harun, consultant surgeon general of the Bangladesh Armed Forces, said bio-safety was not a new issue, but ?we are looking at it from a different point of view?.
Here are some excerpts from bdnews24.com, the Bangladesh?s First Internet Newspaper;
?When they are in the ICU, they are 20 percent more likely to get hospital-acquired infections,? he said. ?This can prolong hospital stay by 2.5 times.?
Health Secretary Syed Monjurul Islam, the seminar?s chief guest, said that it was ?critical? to maintain bio-safety because of the emergence of new diseases.
?We must all be partners in this effort,? Esco Institute?s President said, stressing that one institute or country cannot fight off the challenges alone in the current age of globalisation when diseases are spreading faster than before.
Maj Gen Md Siddiqur Rahman Sarker, commandant of the MIST, was present, among others, at the seminar.
Read the full article here >>> http://m.bdnews24.com/en/detail/health/1007043
Esco News Events | 21
Esco on the moveEsco is committed in delivering innovative tools to uphold its promise of meeting every customer's needs and even exceeding their expectations by continuous research and development. Esco wants to ensure that every need is met and each laboratory all over the world would benefit from the safe and reliable features that our products offer. Hence, we actively participated in various conferences and trade shows to bring you solutions.
ACHEMA was a great success, thanks to our visitors. We have received excellent feedback for our latest innovative technologies and product developments in Biosafety, Thermostatics, Isolators and Bioprocessing (Bioreactors) Technology.
Among them were our new CelSafe® Incubator with High Heat Sterilization Cycle, which allows easy, quick and safe sterilization.
Eagerly awaited is also the product launch of our Avona Stability Chamber, the Versati? Benchtop/Micro Centrifuges and OrbiCult? Ambient/Incubator Shakers, which were on display first time and exclusively at ACHEMA.
Our Pharma experts were sought after and the latest product development made in Britain - a Sterility Testing Isolator - as well as our Ventilated Balance Enclosure with a bag-in bag-out system, received the greatest interest alongside the Downflow Booth and the TideCell® Biorector for big batch applications.
On behalf of the entire Esco Lab and Pharma Team, we hope that you enjoyed the Exhibition as much as we did. Experience further innovative research solutions with Esco.
ACHEMA
Esco meeting with customers during ACHEMA
Esco booth with visitors at ACHEMA 2015
ESHRE 2015 was a very special experience for Esco Medical. We are grateful to the existing users, our loyal customers, who helped by bringing their colleagues over to see our Miri® TL and Miri® Multiroom Incubators. We have received overwhelming positive response especially on the image quality and automatic cleavage detection software of Miri® TL. We are grateful also for giving us great inputs on our new products, the Semi Closed Enviroment (SCE) for IVF and ICSI. We will surely incorporate those in the final units.
On behalf of the entire Esco Medical Team, we hope that you enjoyed the Congress as much as we had. We wish that our products have given new hopes and we promise to continuously deliver top-of-the-line products that address IVF concerns and in turn help increase pregnancy success rates.
ESHRE
Esco meeting with customers at ESHRE 2015 Esco booth with visitors at ESHRE 2015
22 | Events Esco News
R3 Nordic is a nonprofit organization and an established strong Nordic networks in the purity of technology, controlled and clean environments. R3 Nordic apply on industries and activities with the environments and systems where authorities purity requirements defined ?low and controlled level of contamination? is required for both personnel and product protection with associated maintenance and technology.
The R3 Nordic symposium this year was held at Lillestrom, Norway on May 10-12. Esco participated with a table booth and presented Containment Barrier Isolator (CBI) together with our distributor, Alere, carrying NordicSafe® Biological Safety Cabinet (BSC). The attendees became interested with CBI and Airstream® Class III BSC specifically because of their ergonomic design, in addition to maximum protection and containment features. During the event, Esco gave a lecture and presentation on BSC and Pharma Product Line.
Esco participated in LabWorld 2015 Exhibition held on 24 - 26th of June at Shanghai New International Expo Centre (SNIEC), Shanghai, China.
A wide variety of life sciences laboratory equipment such as biological safety cabinet, CO2 incubator, laboratory incubator and freeze dryer were displayed. This also has been a good venue to launch new products such as Versati? Centrifuge and OrbiCult? Laboratory Shakers, These products successfully attracted a great number of visitors, end users, and dealers due to their design and features that demonstrate advantages over their competitors.
On the side, a ?WeChat Lucky Draw? session was held as gratitude to our visitors who registered in our WeChat application. Travel bags, red wines and Esco Goodies were given as prize for the lucky winners. This mini event amplified the excitement in the booth.
LabWorld
Esco booth with visitors at LabWorld 2015
Products displayed at LabWorld 2015Winners of Esco Goodies at LabWorld 2015
R3 Nordic Symposium
R3 Nordic Symposium Esco table booth with visitors
Esco News Events | 23
Esco South Africa exhibited at the largest Laboratory showcase in Africa, Lab Africa 2015, hosted at the Coca- Cola Dome in Johannesburg on 4-6 of August. Lexicon® II ULT Freezer, Frontier® Acela Fume Hood, CelCulture® CO2 Incubator, HP Series Lab Refrigerator, ProvocelTMl Microplate Shaker and Airstream® Biological Safety Cabinet were exhibited in the event. Dr. Einesco, Esco?s mascot, became the most popular attraction of the Esco booth.
With almost two decades of Lab Africa, the event has become an icon in the South African Laboratory calendar. Thousands of brands from around the globe exhibit products via South African distributors and recently Kenya. Visitors may easily source products and suppliers for the laboratory industry, whilst gathering information about the latest trends and technologies. This year, Lab Africa attracted more than 3000 visitors across 3 days.
Lab Africa 2015
Esco booth at Lab Africa 2015
On July 24-26, IVF Experts Meeting, the most prestigious annual conference on Assisted Reproduction in Vietnam, was held solemnly at the Imperial Hotel, Vung Tau City.
Having the same mission and as a support to the conference?s goals, Esco Vietnam presented the experts with the Miri® Benchtop Multiroom Incubator and Miri® TL Time Lapse Embryo Incubator. Miri® TL attracted and received overwhelming compliments from IVF specialists because of its excellent design and advanced incubation and time lapse technology.
As the conference ended, everybody went home with a new hope, inspiration and a new perspective in their profession. Expect that Esco will always be here to support and look for answers to uphold our common goals of giving hopes to those who want to have little ones.
IVF Experts
Esco Vietnam Team at Esco stand during IVF Experts Meeting 2015
Conference during IVF Experts Meeting 2015
Meet us at following eventsABSA 2015October 9-14, 2015Rhode Island Convention CenterProvidence, Rhode Island, USA
Lab Asia 2015October 6-8, 2015Putra World Trade Centre (PWTC)Kuala Lumpur, Malaysia
2015 CPhI WorldwideOctober 13-15, 2015IFEMA, Feria de MadridMadrid, Spain
ASRM 2015October 17-21, 2015Baltimore Convention CenterBaltimore, Maryland, USA
BioJapan 2015October 14-16, 2015Pacifico YokohamaYokohama, Japan
Khimia 2015October 27-30, 2015Expocentre FairgroundsMoscow, Russia
MEDICA 2015November 16-19, 2015Düsseldorf FairgroundsDüsseldorf, Germany
The 17th Chongqing ART ConferenceNovember 12-14, 2015Chongqin Shenji Sofitel Hotel Chongqing, China
25 | Product Guide Esco News
Biological Safety Cabinets Laminar Flow Cabinets CO2 Incubators
Laboratory ShakersCold StorageLaboratory Centrifuges
Ducted Fume Hoods Ductless Fume Hoods
Benchtop Multl-room Incubators Time Lapse Incubators
IVF Workstations Anti Vibration Tables Gas Analyzers
General Processing Platform Isolators (GPPI)
Aseptic Containment Isolators (ACTI)
Weighing and Dispensing Containment Isolators (WDCI)
Downflow Booths Containment Barrier Isolators
Esco News Global Network |
Esco News is the online publication of Esco Micro for its customers, partners, suppliers and friends.
Published byEsco Micro Pte. Ltd.21 Changi South Street 1Singapore 486777
Phone: +65 6542 0833Fax: +65 6542 6920Email: [email protected]: www.escoglobal.com
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Photo EditorLenbert [email protected]
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SOUTH AFRICA
Esco Technologies Pty Ltd.Tel: +27(0)82 8539 655Email: [email protected]: http://za.escoglobal.com
