Chapter 1 - sbdi.co.kr€¦Chapter 1 INTRODUCTION MICROSCOPY: THE GLOBAL MARKET IAS017E July 2013 Andrew McWilliams Project Analyst ISBN: 1-56965-492-1 …

Chapter 1INTRODUCTION

MICROSCOPY: THE GLOBAL MARKET

IAS017EJuly 2013

Andrew McWilliamsProject Analyst

ISBN: 1-56965-492-1

BCC Research49 Walnut Park, Building 2Wellesley, MA 02481866-285-7215, 781-489-7301www.bccresearch.comCustom Reports:[email protected]

IAS017E - Microscopy: The Global Market

Copyright © BCC Research, Wellesley MA USA, Website: www.bccresearch.com 2

CHAPTER 1INTRODUCTION

STUDY BACKGROUND

The field of microscopy has undergone an enormous evolution since the earliest opticalmicroscopes were developed in the 1600s. The optical microscope has been refinedcontinuously since its introduction, resulting in today’s superb scientific instruments. However, the optical microscope is ultimately limited in the minimum size and nature ofthe features that it can resolve by manufacturability constraints and, ultimately, thephysics of light itself.

New microscopy technologies have been developed to overcome these limitations, such aselectron, scanning probe and focused ion beam microscopy. The field of microscopycontinues to evolve rapidly as new requirements and imaging technologies aredeveloped. While optical microscopes once accounted for the bulk of all microscopes soldaround the world today, they are in the minority today.

While microscopes today are a multi-billion-dollar industry, their true importance lies inthe activities they make possible, such as life sciences research, microelectronics andadvanced-materials science. Microscopy is particularly important to the expanding field ofnanotechnology.

STUDY GOALS AND OBJECTIVES

This report is an updated version of an earlier BCC study published in 2011. The goal ofthis study is to provide the reader with an understanding of recent developments inmicroscopy technologies and applications and their impact on the future size and structureof the market for various types of microscopes and microscope accessories. Specific studyobjectives include identifying segments of the microscopy market with the greatestcommercial potential in the near- to mid-term (2013 to 2018), identifying and, wherepossible, quantifying the key demand drivers, projecting future demand for different typesof microscopes, and evaluating the technical and other challenges that must be overcomefor the market to realize its full potential.

INTENDED AUDIENCE

The report is intended especially for manufacturers and vendors of microscopes andrelated accessories. Other readers who should find it particularly useful includeentrepreneurs, investors, venture capitalists and other readers with a need to know wherethe microscopy market is headed over the next five years.

The report should also be of interest to end users such as nanotechnology companieswhose technology road maps may make critical assumptions about the availability andperformance of different materials characterization technologies, including microscopes. Other potential readers include members of technical and professional organizations suchas ASM International and the American Society for Nondestructive Testing.



SCOPE AND FORMAT

The report addresses the global market for microscopes and microscope accessories overthe period from 2012 through 2018, including:

Optical (light) microscopes.●

Electron microscopes.●

Scanning probe microscopes.●

Other types of microscope (e.g., focused ion beam, confocal).●

Microscope accessories.●

The report includes the following major elements:

Executive summary.●

Definitions.●

Brief history of microscopy.●

Microscope technologies.●

Patent analysis.●

Major end uses and applications.●

Global market trends by type of instrument, end-user segment and●

geographical region.Technology trends, limits and challenges.●

Industry structure (e.g., firm size and financial performance, ownership,●

market shares).

METHODOLOGY AND INFORMATION SOURCES

The findings and conclusions of this report are based on information gathered fromindustry sources, including microscope manufacturers and users. Interview data werecombined with information gathered through an extensive review of secondary sources,such as trade publications, trade associations, company literature and online databases, toproduce the projections contained in this report.

The base year for analysis and projection is 2012. With 2012 as a baseline, marketprojections were developed for 2013 to 2018. These projections are based on acombination of a consensus among the primary contacts combined with our understandingof the key market drivers and their impact from a historical and an analytical perspective. The analytical methodologies used to generate the market estimates are described indetail in the section on Detailed Market Projections.

All dollar projections presented in this report are in 2012 constant U.S. dollars.

ANALYST CREDENTIALS

Andrew McWilliams, the author of this report, is a partner in the Boston-basedinternational technology and marketing consulting firm, 43rd Parallel LLC. He is theauthor of the previous edition of this report as well as other BCC Research studies of



microscopy-related technologies, such as MFG016F – Nondestructive Testing, IAS027BMicrosensors – MEMS: Biosensors and Nanosensors, NAN041A – Nanopatterning, NAN031E– Nanotechnology: A Realistic Market Assessment, NAN036B – Nanotechnology forPhotonics, NAN038A – Nanotechnology in Life Science Applications, IAS015A – MaterialsCharacterization Instruments; AVM067B Metamaterials – Technologies and Global Markets;andAVM066C Superconductors: Technologies and Global Market.

RELATED BCC REPORTS

Readers of this study may find the following BCC Research studies also relevant.

AVM067B Metamaterials – Technologies and Global Markets●

AVM066C Superconductors: Technologies and Global Market●

IAS015A Materials Characterization Instruments●

IAS027B Microsensors – MEMS, Biosensors and Nanosensors●

MFG016F Nondestructive Testing●

NAN029A Tools and Instrumentation for Nanotechnology●

NAN041A Nanopatterning●

NAN038A Nanotechnology in Life Science Applications●

NAN036B Nanotechnology for Photonics●

NAN029A Tools and Instrumentation for Nanotechnology●

NAN035A Nanosensors●

NAN031E Nanotechnology: A Realistic Market Assessment●

NAN046A Molecular, Nanoscale and Atomic Imaging●

SAS003D Forensic Technologies: New and Growing Markets●

BCC ONLINE SERVICES

BCC offers an online information retrieval service. BCC’s home page, located atwww.bccresearch.com, enables readers to:

Examine BCC’s complete catalog of Market Research Reports and place●

direct orders.Subscribe to any of BCC’s many industry newsletters.●

Read announcements of recently published reports and newly launched●

newsletters.Register for BCC’s well-known conferences.●

Request additional information on any BCC product.●

Take advantage of special offers.●



DISCLAIMER

The information developed in this report is intended to be as reliable as possible at thetime of publication and is of a professional nature. This information does not constitutemanagerial, legal or accounting advice;, nor should it serve as a corporate policy guide,laboratory manual or an endorsement of any product, as much of the information isspeculative in nature. The author assumes no responsibility for any loss or damage thatmight result from reliance on the reported information or its use.

Chapter 2SUMMARY


IAS017EJuly 2013


ISBN: 1-56965-492-1




CHAPTER 2SUMMARY

The global market for microscopes and accessories was worth about $3.8 billion in 2012. After weathering the recent global economic dislocations, the microscopy market enjoysfavorable near- to mid-term prospects. Sales are projected to exceed $4.0 billion in 2013and approach $5.4 billion by 2018, a compound annual growth rate (CAGR) of 6% between2013 and 2018.

SUMMARY TABLE

MARKET FOR MICROSCOPES, ACCESSORIES AND SUPPLIES, THROUGH 2018($ MILLIONS)

Segment 2012 2013 2018CAGR%

2013-2018Microscopes 3,325.0 3,483.3 4,687.3 6.1Accessories and supplies 515.0 542.3 692.1 5.0Total 3,840.0 4,025.6 5,379.4 6.0

Source: BCC Research

The fastest-growing segment of the market is scanning probe microscopes, with a CAGR of10% between 2013 and 2018. Charged particle microscopes have a projected CAGR of6.8%, and optical microscopes 4.7%.

As a result, charged particle microscopes are projected to increase their market sharefrom 41.7% in 2012 to 43.4% in 2018. Optical microscopes are projected to lose marketshare, from 39.1% in 2012 to 36.6% in 2018, while scanning probe microscopes’ share isprojected to grow from 5.9% to 7.1%.

In 2012, the life sciences were the dominant end-user market for microscopes, with 31%of the total market, followed by materials science (26%), semiconductor manufacturing(24%), education (12%) and nanotechnology (7%). Between 2012 and 2018,semiconductor manufacturing’s share of the market is projected to slip from 24% to 19%. Meanwhile, materials science, education and nanotechnology should gain market share,while life sciences’ share remains constant.



SUMMARY FIGURE

MARKET FOR MICROSCOPES, ACCESSORIES AND SUPPLIES, 2012-2018($ MILLIONS)

Source: BCC Research

The United States accounted for the largest share of the overall global microscope marketin 2012 with nearly one-third of the market for all types of microscopes. Japan had thesecond-largest market share, with 20% of the global market, followed by other Asiancountries with 19% and the EU with 18%.

Japan and other Asian markets are expected to experience the most rapid growth over thenext five years, with CAGRs of 7.0% and 7.4%, respectively, between 2013 and 2018. TheU.S. and the EU are expected to lag behind with average annual growth rates of 5.2% and6%, respectively.


IAS017EJuly 2013


ISBN: 1-56965-492-1


http://www.bccresearch.com/market-research/instrumentation-and-sensors/microscopes-market-ias017e.html


Copyright © BCC Research, Wellesley MA USA, Website: www.bccresearch.com

TABLE OF CONTENTSTOPIC PAGE NO.

CHAPTER 1 INTRODUCTION 2

STUDY BACKGROUND 2 STUDY GOALS AND OBJECTIVES 2 INTENDED AUDIENCE 2 SCOPE AND FORMAT 3 METHODOLOGY AND INFORMATION SOURCES 3 ANALYST CREDENTIALS 3 RELATED BCC REPORTS 4 BCC ONLINE SERVICES 4 DISCLAIMER 5

CHAPTER 2 SUMMARY 7

SUMMARY TABLE MARKET FOR MICROSCOPES, ACCESSORIES AND SUPPLIES,THROUGH 2018 ($ MILLIONS) 7

SUMMARY FIGURE MARKET FOR MICROSCOPES, ACCESSORIES AND SUPPLIES,2012-2018 ($ MILLIONS) 7

CHAPTER 3 MICROSCOPY OVERVIEW 10

GENERAL DESCRIPTION 10 DEFINITIONS 10

Charged Particle 10 Compound Microscope 10 Confocal Microscope 10 Depth of Field 10 Dispersion 10 Eyepiece 11 Inverted Microscope 11 Immersion Media 11 Lens 11

FIGURE 1 MAGNIFYING LENS PRINCIPLES 12 Magnification 12 Nanoscale 12 Near-Field 12 Numerical Aperture (NA) 13 Objective 13 Phase Shift 13

FIGURE 2 LIGHT WAVE PHASES 13 Polarization 14

FIGURE 3 POLARIZATION 14 Reflected Light Microscopes 14 Reflecting Microscopes 14 Refraction 15

FIGURE 4 REFRACTION 15 Resolution 16 Scanning Probe 16 Superconducting Quantum Interference Device (SQUID) 16



TOPIC PAGE NO. Stereoscopic 16 Tunneling Current 17 Wavelength 17

FIGURE 5 LIGHT WAVE 17 FIGURE 6 WAVELENGTHS USED IN OPTICAL MICROSCOPY (NM) 17

BRIEF HISTORY OF MICROSCOPY 18 TYPES OF MICROSCOPES 20

OPTICAL MICROSCOPES 20 Description and Applications 20

TABLE 1 TYPES AND MAIN APPLICATIONS OF OPTICAL MICROSCOPES 20 Upright (Compound) Microscopes 21 Binocular Stereomicroscopes 21 Polarizing Microscopes 21 Metallographic Microscopes 22 Reflecting Microscopes 22

FIGURE 7 REFLECTING MICROSCOPE 22 Phase Contrast Microscopes 23

FIGURE 8 BASIC PRINCIPLE OF A PHASE CONTRAST MICROSCOPE 24 Fluorescence Microscope 24

FIGURE 9 FLUORESCENCE MICROSCOPY PRINCIPLES 25 FIGURE 10 FLUORESCENCE MICROSCOPE LAYOUT 26

Confocal Microscopes 27 FIGURE 11 PRINCIPLES OF CONFOCAL MICROSCOPY 28

Scanning Near-Field Optical Microscopes (SNOM) 30 FIGURE 12 SCANNING NEAR-FIELD OPTICAL MICROSCOPE PRINCIPLES 30

Inverted Microscopes 31 Other Types of Optical Microscope 31

Advanced Confocal Microscopy 32 Phase-Sensitive Scatter-Field Optical Imaging 32 Stochastic Optical Reconstruction Microscopy (STORM) 32 Stimulated Emission Depletion Microscopy (STED) 32 Structured Illumination Microscopy (SIM) 33 Second Harmonic Generation (SHG) Microscopy 33 Super-Resolution Fluorescence Microscopy 33 Coherent Anti-Stokes Raman Scattering (CARS) Microscopy 33 Simultaneous Light Scattering Microscopy (LSM) 34 4Pi Microscopy 34 Microsphere Nanoscope 34 Metamaterial-Lens Microscopes 34

Patent Analysis 35 Technologies 35

FIGURE 13 OPTICAL MICROSCOPY PATENTS BY TYPE OF TECHNOLOGY, AS OF JUNE15, 2013 (PERCENT OF TOTAL PATENTS) 36

TABLE 2 U.S. OPTICAL MICROSCOPY PATENTS AS OF JUNE 15, 2013 (NUMBER OFPATENTS BY TYPE OF TECHNOLOGY) 36

Trends Over Time 37 FIGURE 14 OPTICAL MICROSCOPY PATENTS ISSUED ANNUALLY BY TYPE OFTECHNOLOGY, 2005-2012 (NUMBER OF PATENTS) 37



TOPIC PAGE NO. TABLE 3 OPTICAL MICROSCOPY PATENTS ISSUED ANNUALLY BY TYPE OFTECHNOLOGY, 2005-2012 (NUMBER OF PATENTS) 38

Patent Holders 38 FIGURE 15 MAJOR OPTICAL MICROSCOPY PATENT HOLDERS (%) 38 TABLE 4 MAJOR OPTICAL MICROSCOPY PATENT HOLDERS (NUMBER/%) 39 FIGURE 16 MAJOR OPTICAL MICROSCOPY PATENT HOLDERS BY TECHNOLOGY TYPE(PERCENTAGES OF TOTAL PATENTS) 39

TABLE 5 OPTICAL MICROSCOPY PATENT HOLDERS BY TECHNOLOGY TYPE (NUMBEROF PATENTS) 40

Manufacturers 40 TABLE 6 OPTICAL MICROSCOPE MANUFACTURERS 41

CHARGED PARTICLE MICROSCOPES 42 Description and Applications 42

TABLE 7 TYPES AND PRIMARY APPLICATIONS OF CHARGED PARTICLEMICROSCOPES 42

Transmission Electron Microscopes 43 FIGURE 17 TRANSMISSION ELECTRON MICROSCOPE 45

Scanning Electron Microscopes (SEMs) 46 FIGURE 18 SCANNING ELECTRON MICROSCOPE 47 FIGURE 19 SCANNING ELECTRON MICROSCOPE - SAMPLE INTERACTION 47

Environmental Scanning Electron Microscope (ESEM) 48 Field Emission Scanning Electron Microscopes (FESEMs) 49 Field Ion Microscopes (FIM) 49

Other Types of Electron Microscopes 50 Electron Probe Microanalyzer (EPMA) 50 Scanning Transmission Electron Microscopes (STEMs) 50 High-Voltage Electron Microscopes 50 Focused Ion Beam (FIB) Microscopes 51 Reflection Electron Microscope (REM) 52 Low-Energy Electron Microscopy (LEEM) 52 Photoelectron Emission Microscope (PEEM) 52


FIGURE 20 U.S. CHARGED PARTICLE MICROSCOPY PATENTS BY TYPE OFTECHNOLOGY, THROUGH JUNE 15, 2013 (PERCENT OF U.S. PATENTS ISSUED) 53

TABLE 8 U.S. CHARGED PARTICLE MICROSCOPY PATENTS, THROUGH JUNE 15,2013 (NUMBER AND PERCENT OF U.S. PATENTS) 54

FIGURE 21 CHARGED PARTICLE MICROSCOPY PATENTS ISSUED ANNUALLY BY TYPEOF TECHNOLOGY, 2005–2012 (NUMBER OF PATENTS) 55

TABLE 9 CHARGED PARTICLE MICROSCOPY PATENTS ISSUED ANNUALLY BY TYPEOF TECHNOLOGY, THROUGH 2012 (NUMBER OF PATENTS) 56

Patent Holders 56 FIGURE 22 CHARGED PARTICLE MICROSCOPE PATENT HOLDERS, THROUGH JUNE15, 2013 (% OF TOTAL PATENTS ISSUED) 56

TABLE 10 CHARGED PARTICLE MICROSCOPY PATENT HOLDERS, THROUGH JUNE 15,2013 (NUMBER OF PATENTS ISSUED) 56

FIGURE 23 MAJOR CHARGED PARTICLE MICROSCOPY PATENT HOLDERS BYTECHNOLOGY TYPE (PERCENT OF TOTAL PATENTS) 57

TABLE 11 MAJOR CHARGED PARTICLE MICROSCOPY PATENT HOLDERS, BYTECHNOLOGY TYPE (NUMBER OF PATENTS) 58



TOPIC PAGE NO. Manufacturers 58

TABLE 12 CHARGED PARTICLE MICROSCOPE MANUFACTURERS 59 SCANNING-PROBE MICROSCOPES 59

Description and Applications 59 FIGURE 24 SCANNING PROBE MICROSCOPE 59 TABLE 13 TYPES AND PRIMARY APPLICATIONS OF SCANNING PROBE MICROSCOPES 61

Scanning Tunneling Microscopes (STM) 61 Atomic Force Microscopes (AFM) 62

FIGURE 25 ATOMIC FORCE MICROSCOPE PROBE 62 Other Types of Scanning Probe Microscopes 64

Magnetic Force Microscopes (MFMs) 64 Electric Force Microscopes (EFMs) 64 Scanning Thermal Microscopy (SThM) 65


FIGURE 26 SCANNING PROBE MICROSCOPY PATENTS BY TYPE OF TECHNOLOGY,AS OF JUNE 15, 2013 (PERCENT OF TOTAL PATENTS) 66

TABLE 14 U.S. SCANNING PROBE MICROSCOPY PATENTS (NUMBER/%) 66 Trends Over Time 66

FIGURE 27 SCANNING PROBE MICROSCOPY PATENTS ISSUED ANNUALLY BY TYPEOF TECHNOLOGY, 2005-2012 (NUMBER OF PATENTS ISSUED ANNUALLY) 66

TABLE 15 SCANNING PROBE MICROSCOPY PATENTS ISSUED ANNUALLY BY TYPE OFTECHNOLOGY, 2005-2012 (NUMBER OF PATENTS) 67

Patent Holders 68 FIGURE 28 SCANNING PROBE MICROSCOPE PATENT HOLDERS, THROUGH JUNE 15,2013 (PERCENT OF TOTAL U.S. PATENTS ISSUED) 68

TABLE 16 SCANNING PROBE MICROSCOPY PATENT HOLDERS (NUMBER/%) 69 FIGURE 29 MAJOR SPM PATENT HOLDERS, BY TECHNOLOGY TYPE (PERCENT OFTOTAL PATENTS) 69

TABLE 17 SCANNING PROBE MICROSCOPY PATENT HOLDERS, BY TECHNOLOGYTYPE (NUMBER OF PATENTS) 71

Manufacturers 71 TABLE 18 SCANNING PROBE MICROSCOPE MANUFACTURERS 71

ACCESSORIES AND SUPPLIES 72 Description and Applications 72

TABLE 19 MICROSCOPE ACCESSORIES AND THEIR MAIN FUNCTIONS 72 Photomicroscopy Equipment 72 Illumination Systems 73 Microscope Stages and Accessories 73 Eyepieces 74 Objectives 74 Scanning Probes 74 Consumables 75

Patent Analysis 75 Accessory Types 75

FIGURE 30 U.S. MICROSCOPE ACCESSORY PATENTS BY ACCESSORY TYPE, AS OFJUNE 15, 2013 (PERCENT OF TOTAL PATENTS ISSUED) 76

TABLE 20 U.S. MICROSCOPE ACCESSORY PATENTS (NUMBER/%) 76 Patent Holders 77



TOPIC PAGE NO. FIGURE 31 MICROSCOPE ACCESSORY PATENT HOLDERS, THROUGH JUNE 15, 2013(PERCENT OF PATENTS ISSUED) 77

TABLE 21 MICROSCOPE ACCESSORY PATENT HOLDERS AND APPLICANTS,THROUGH JUNE 15, 2013 (%) 77

Manufacturers 78 TABLE 22 MICROSCOPE ACCESSORY MANUFACTURERS 78

END USERS 78 TABLE 23 MICROSCOPE END-USER INDUSTRIES 79

SEMICONDUCTORS 79 Optical Microscopes 80 Charged Particle Microscopes 80 Scanning Probe Microscopes 81

PHOTOVOLTAICS (PV) 81 LIFE SCIENCES 81

TABLE 24 GLOBAL LIFE SCIENCES SALES, 2012 ($ BILLIONS) 82 Optical Microscopes 82 Charged Particle Microscopes 83

MATERIALS SCIENCE 84 FIGURE 32 MATERIALS SCIENCE INSTRUMENTS MAJOR MARKET SEGMENTS, 2012(PERCENT OF TOTAL SALES) 84

Optical Microscopes 85 Charged Particle Microscopes 85 Scanning Probe Microscopes 86

NANOTECHNOLOGY 87 Charged Particle Microscopes 87 Scanning Probe Microscopes 87

OTHER END USERS 87 Education 88

Optical Microscopes 88 Other Types of Microscopes 88

Environmental Science 88 Optical Microscopes 88 Charged Particle Microscopes 88

Forensics 88 Optical Microscopes 89 Charged Particle Microscopes 89

Food Processing 89 Optical Microscopes 90 Charged Particle Microscopes 90

CHAPTER 4 GLOBAL MARKET FOR MICROSCOPES AND ACCESSORIES 2012THROUGH 2018 92

OVERALL MARKET SIZE AND SEGMENTATION 92 FIGURE 33 TRENDS IN GLOBAL SALES OF MICROSCOPES AND ACCESSORIES/SUPPLIES, 2012-2018 ($ MILLIONS) 92

DETAILED MARKET ANALYSIS AND PROJECTIONS 92 MARKET BY TYPE OF INSTRUMENT 92

TABLE 25 PROJECTED GLOBAL MICROSCOPE SALES BY PRODUCT TYPE, THROUGH2018 ($ MILLIONS) 93



TOPIC PAGE NO. FIGURE 34 MICROSCOPY MAJOR MARKET SEGMENTS, 2012 VERSUS 2018 (%) 94

Optical Microscopes 95 Optical Microscope Market Size and Segmentation 95

FIGURE 35 OPTICAL MICROSCOPE MARKET SEGMENTATION, 2012 (% OF TOTALOPTICAL MICROSCOPE SALES) 95

TABLE 26 OPTICAL MICROSCOPE SALES, 2012 ($ MILLIONS/%) 96 Market Drivers 97

Spending on Educational Equipment 97 FIGURE 36 TRENDS IN U.S. EDUCATIONAL EXPENDITURES, 2002–2018 ($ BILLIONS) 97 TABLE 27 U.S. EDUCATIONAL EXPENDITURES, THROUGH 2018 ($ BILLIONS) 98

Trends in Infrared Spectroscopy 99 TABLE 28 GLOBAL MOLECULAR SPECTROMETRY SALES, THROUGH 2018 ($BILLIONS) 99

Life Sciences R&D and Healthcare Spending 99 FIGURE 37 TRENDS IN LIFE SCIENCES R&D SPENDING, 2012–2018 ($ BILLIONS) 99 TABLE 29 LIFE SCIENCES R&D SPENDING, THROUGH 2018 ($ BILLIONS) 100

Materials Science Instrument Spending 100 FIGURE 38 MATERIALS CHARACTERIZATION INSTRUMENT SALES TRENDS,2012-2018 ($ BILLIONS) 100

TABLE 30 GLOBAL SPENDING ON MATERIALS CHARACTERIZATION INSTRUMENTS,THROUGH 2018 ($ BILLIONS) 101

Technology Shift Away From Compound Optical Microscopy 101 Future Market for Optical Microscopes 102

TABLE 31 PROJECTED SALES OF OPTICAL MICROSCOPES, THROUGH 2018 ($MILLIONS) 102

TABLE 32 PROJECTED GROWTH RATE OF MARKET FOR STEREOSCOPICMICROSCOPES, THROUGH 2018 (PERCENT CAGR) 103

TABLE 33 PROJECTED GROWTH RATE OF MARKET FOR SCANNING NEAR-FIELDOPTICAL MICROSCOPES, THROUGH 2018 (PERCENT CAGR) 103

FIGURE 39 OPTICAL MICROSCOPE MARKET SEGMENTATION, 2018 (%) 104 Charged Particle Microscopes 104

Charged Particle Microscope Market Size and Segmentation 105 FIGURE 40 CHARGED PARTICLE MICROSCOPE MARKET SEGMENTS, 2012 (%) 105 TABLE 34 CHARGED PARTICLE MICROSCOPE SALES, 2012 ($ MILLIONS) 106

Market Drivers 106 Semiconductor Industry Investment Trends 106

FIGURE 41 MARKETS FOR SCANNING ELECTRON MICROSCOPES, 2012 (PERCENTOF TOTAL SEM SALES) 106

FIGURE 42 PROJECTED GROWTH IN SEMICONDUCTOR CAPITAL EQUIPMENTSPENDING, 2012-2018 ($ BILLIONS) 107

TABLE 35 SEMICONDUCTOR INDUSTRY CAPITAL EQUIPMENT SPENDINGPROJECTIONS, THROUGH 2018 ($ BILLIONS/CAGR PERCENTAGE) 108

Technology Shifts 108 FIGURE 43 CHARGED PARTICLE MICROSCOPE SALES GROWTH VERSUS GROWTH INMAJOR UNDERLYING MARKETS, 2003-2008 (CAGR%) 108

Future Market for Charged Particle Microscopes 110 TABLE 36 PROJECTED SALES OF CHARGED PARTICLE MICROSCOPES, THROUGH2018 ($ MILLIONS) 110

TABLE 37 PROJECTED GROWTH RATE OF SEM SALES TO THE LIFE AND MATERIALSSCIENCES, THROUGH 2018 ($ MILLIONS) 111



TOPIC PAGE NO. FIGURE 44 CHARGED PARTICLE MICROSCOPE MARKET SEGMENTS, 2018 (PERCENTOF TOTAL SALES) 112

Scanning Probe Microscopes 112 Scanning Probe Microscope Market Size and Segmentation 113

FIGURE 45 SPM MARKET PRODUCT SEGMENTS, 2012 (%) 113 Market Drivers 114

Trends in Nanoscale Applications 114 Technology Shifts 114

Future Market for Scanning Probe Microscopes 115 TABLE 38 PROJECTED SALES OF SCANNING PROBE MICROSCOPES, THROUGH 2018($ MILLIONS) 115

FIGURE 46 SCANNING PROBE MICROSCOPE MARKET SEGMENTS, 2018 (PERCENTOF TOTAL SALES) 116

Accessories and Supplies 116 Market Size and Segmentation 116

FIGURE 47 MICROSCOPE ACCESSORIES AND SUPPLIES MARKET SEGMENTATION,2012 (%) 117

TABLE 39 SALES OF MICROSCOPE ACCESSORIES AND CONSUMABLES, 2012 ($MILLIONS/%) 117

Market Drivers 117 Number of Microscopes in Use Worldwide 117

FIGURE 48 TRENDS IN NUMBER OF MICROSCOPES IN USE WORLDWIDE, 2011-2018(MILLION UNITS) 118

TABLE 40 NUMBER OF MICROSCOPES IN USE WORLDWIDE, THROUGH 2018(MILLION UNITS) 118

Future Markets for Microscope Accessories and Supplies 118 TABLE 41 PROJECTED SALES OF MICROSCOPE ACCESSORIES AND SUPPLIES,THROUGH 2018 ($ MILLIONS) 119

MARKETS BY END-USER SEGMENT 119 Optical Microscopes 119

FIGURE 49 OPTICAL MICROSCOPE MARKET SHARES BY END-USER SEGMENT, 2012VERSUS 2018 (%) 120

TABLE 42 END-USER MARKETS FOR OPTICAL MICROSCOPES, THROUGH 2018 ($MILLIONS) 121

Charged Particle Microscopes 121 FIGURE 50 CHARGED PARTICLE MICROSCOPE MARKET SHARES BY END-USERSEGMENT, 2012 VERSUS 2018 (%) 122

TABLE 43 END-USER MARKETS FOR CHARGED PARTICLE MICROSCOPES, THROUGH2018 ($ MILLIONS) 123

Scanning Probe Microscopes 123 All Types of Microscopes 123

FIGURE 51 MICROSCOPE MARKET SHARES BY END-USER SEGMENT, 2012 VERSUS2018 (%) 123

TABLE 44 END-USER MARKETS FOR ALL TYPES OF MICROSCOPES*, THROUGH 2018($ MILLIONS) 125

GEOGRAPHICAL MARKETS 125 Optical Microscopes 125

FIGURE 52 OPTICAL MICROSCOPE GEOGRAPHICAL MARKET SHARES, 2012 VERSUS2018 (%) 125



TOPIC PAGE NO. TABLE 45 GEOGRAPHICAL MARKETS FOR OPTICAL MICROSCOPES, THROUGH 2018($ MILLIONS) 127

Charged Particle Microscopes 127 FIGURE 53 CHARGED PARTICLE MICROSCOPE GEOGRAPHICAL MARKET SHARES,2012 VERSUS 2018 (%) 127

TABLE 46 GEOGRAPHICAL MARKETS FOR CHARGED PARTICLE MICROSCOPES,THROUGH 2018 ($ MILLIONS) 129

Scanning Probe Microscopes 129 FIGURE 54 SCANNING PROBE MICROSCOPE GEOGRAPHICAL MARKET SHARES,2012 VERSUS 2018 (%) 130

TABLE 47 GEOGRAPHICAL MARKETS FOR SCANNING PROBE MICROSCOPES,THROUGH 2018 ($ MILLIONS) 131

Types of Microscopes 131 FIGURE 55 MICROSCOPE MARKET SHARES BY END-USER SEGMENT, 2012 VERSUS2018 (%) 131

TABLE 48 GEOGRAPHICAL MARKETS FOR ALL TYPES OF MICROSCOPES,* THROUGH2018 ($ MILLIONS) 133

CHAPTER 5 INDUSTRY STRUCTURE 135

MARKET SHARES 135 OPTICAL MICROSCOPES 135

FIGURE 56 OPTICAL MICROSCOPY MARKET SHARES, 2012 (%) 135 CHARGED PARTICLE MICROSCOPES 136

Electron Microscopes 136 FIGURE 57 ELECTRON MICROSCOPE MARKET SHARES, 2012 (%) 136

Focused Ion Beam Microscopes 137 FIGURE 58 FOCUSED ION BEAM MICROSCOPE MARKET SHARES, 2012 (%) 137

SCANNING PROBE MICROSCOPES 138 FIGURE 59 SCANNING PROBE MICROSCOPE MARKET SHARES, 2012 (%) 138

OWNERSHIP TRENDS 138 CHAPTER 6 COMPANY PROFILES 142

APPLIED MATERIALS, INC. 142 BRUKER AXS 142 BRUKER OPTICS INC. 142 BUEHLER INC. 142 CAMECA SA 143 DANISH MICRO ENGINEERING A/S 143 FEI COMPANY 143 GATAN, INC. 144 HITACHI HIGH TECHNOLOGIES CORP. 144 JASCO INTERNATIONAL CO. LTD. 144 JEOL LTD. 145 LEICA MICROSYSTEMS AG 145 MIS INC. 145 NANONICS IMAGING LTD. 146 NANOSURF AG 146 NIKON CORP. 146 NT-MDT CO. 147



TOPIC PAGE NO. OBDUCAT-CAMSCAN LTD. 147 OLYMPUS CORPORATION 147 OMICRON NANOTECHNOLOGY GMBH 147 PARK SYSTEMS CORP. 148 PERKIN ELMER, INC. 148 QUESTAR CORP. 148 SCHOTT NORTH AMERICA INC. 148 SHIMADZU CORP. 149 SII NANOTECHNOLOGY INC. 149 THERMO FISHER SCIENTIFIC INC. 149 VEECO INSTRUMENTS INC. 149 WITEC WISSENSCHAFTLICHE INSTRUMENTE UND TECHNOLOGIE GMBH 150 ZEISS (CARL) NTS GMBH 150



LIST OF TABLESTABLE HEADING PAGE NO.

SUMMARY TABLE MARKET FOR MICROSCOPES, ACCESSORIES AND SUPPLIES,THROUGH 2018 ($ MILLIONS) 7

TABLE 1 TYPES AND MAIN APPLICATIONS OF OPTICAL MICROSCOPES 20 TABLE 2 U.S. OPTICAL MICROSCOPY PATENTS AS OF JUNE 15, 2013 (NUMBER OFPATENTS BY TYPE OF TECHNOLOGY) 36

TABLE 3 OPTICAL MICROSCOPY PATENTS ISSUED ANNUALLY BY TYPE OFTECHNOLOGY, 2005-2012 (NUMBER OF PATENTS) 38

TABLE 4 MAJOR OPTICAL MICROSCOPY PATENT HOLDERS (NUMBER/%) 39 TABLE 5 OPTICAL MICROSCOPY PATENT HOLDERS BY TECHNOLOGY TYPE (NUMBEROF PATENTS) 40

TABLE 6 OPTICAL MICROSCOPE MANUFACTURERS 41 TABLE 7 TYPES AND PRIMARY APPLICATIONS OF CHARGED PARTICLE MICROSCOPES 42 TABLE 8 U.S. CHARGED PARTICLE MICROSCOPY PATENTS, THROUGH JUNE 15, 2013(NUMBER AND PERCENT OF U.S. PATENTS) 54

TABLE 9 CHARGED PARTICLE MICROSCOPY PATENTS ISSUED ANNUALLY BY TYPE OFTECHNOLOGY, THROUGH 2012 (NUMBER OF PATENTS) 56

TABLE 10 CHARGED PARTICLE MICROSCOPY PATENT HOLDERS, THROUGH JUNE 15,2013 (NUMBER OF PATENTS ISSUED) 56

TABLE 11 MAJOR CHARGED PARTICLE MICROSCOPY PATENT HOLDERS, BYTECHNOLOGY TYPE (NUMBER OF PATENTS) 58

TABLE 12 CHARGED PARTICLE MICROSCOPE MANUFACTURERS 59 TABLE 13 TYPES AND PRIMARY APPLICATIONS OF SCANNING PROBE MICROSCOPES 61 TABLE 14 U.S. SCANNING PROBE MICROSCOPY PATENTS (NUMBER/%) 66 TABLE 15 SCANNING PROBE MICROSCOPY PATENTS ISSUED ANNUALLY BY TYPE OFTECHNOLOGY, 2005-2012 (NUMBER OF PATENTS) 67

TABLE 16 SCANNING PROBE MICROSCOPY PATENT HOLDERS (NUMBER/%) 69 TABLE 17 SCANNING PROBE MICROSCOPY PATENT HOLDERS, BY TECHNOLOGY TYPE(NUMBER OF PATENTS) 71

TABLE 18 SCANNING PROBE MICROSCOPE MANUFACTURERS 71 TABLE 19 MICROSCOPE ACCESSORIES AND THEIR MAIN FUNCTIONS 72 TABLE 20 U.S. MICROSCOPE ACCESSORY PATENTS (NUMBER/%) 76 TABLE 21 MICROSCOPE ACCESSORY PATENT HOLDERS AND APPLICANTS, THROUGHJUNE 15, 2013 (%) 77

TABLE 22 MICROSCOPE ACCESSORY MANUFACTURERS 78 TABLE 23 MICROSCOPE END-USER INDUSTRIES 79 TABLE 24 GLOBAL LIFE SCIENCES SALES, 2012 ($ BILLIONS) 82 TABLE 25 PROJECTED GLOBAL MICROSCOPE SALES BY PRODUCT TYPE, THROUGH2018 ($ MILLIONS) 93

TABLE 26 OPTICAL MICROSCOPE SALES, 2012 ($ MILLIONS/%) 96 TABLE 27 U.S. EDUCATIONAL EXPENDITURES, THROUGH 2018 ($ BILLIONS) 98 TABLE 28 GLOBAL MOLECULAR SPECTROMETRY SALES, THROUGH 2018 ($ BILLIONS) 99 TABLE 29 LIFE SCIENCES R&D SPENDING, THROUGH 2018 ($ BILLIONS) 100 TABLE 30 GLOBAL SPENDING ON MATERIALS CHARACTERIZATION INSTRUMENTS,THROUGH 2018 ($ BILLIONS) 101

TABLE 31 PROJECTED SALES OF OPTICAL MICROSCOPES, THROUGH 2018 ($MILLIONS) 102

TABLE 32 PROJECTED GROWTH RATE OF MARKET FOR STEREOSCOPICMICROSCOPES, THROUGH 2018 (PERCENT CAGR) 103

TABLE 33 PROJECTED GROWTH RATE OF MARKET FOR SCANNING NEAR-FIELDOPTICAL MICROSCOPES, THROUGH 2018 (PERCENT CAGR) 103



TABLE HEADING PAGE NO. TABLE 34 CHARGED PARTICLE MICROSCOPE SALES, 2012 ($ MILLIONS) 106 TABLE 35 SEMICONDUCTOR INDUSTRY CAPITAL EQUIPMENT SPENDINGPROJECTIONS, THROUGH 2018 ($ BILLIONS/CAGR PERCENTAGE) 108

TABLE 36 PROJECTED SALES OF CHARGED PARTICLE MICROSCOPES, THROUGH2018 ($ MILLIONS) 110

TABLE 37 PROJECTED GROWTH RATE OF SEM SALES TO THE LIFE AND MATERIALSSCIENCES, THROUGH 2018 ($ MILLIONS) 111

TABLE 38 PROJECTED SALES OF SCANNING PROBE MICROSCOPES, THROUGH 2018($ MILLIONS) 115

TABLE 39 SALES OF MICROSCOPE ACCESSORIES AND CONSUMABLES, 2012 ($MILLIONS/%) 117

TABLE 40 NUMBER OF MICROSCOPES IN USE WORLDWIDE, THROUGH 2018(MILLION UNITS) 118

TABLE 41 PROJECTED SALES OF MICROSCOPE ACCESSORIES AND SUPPLIES,THROUGH 2018 ($ MILLIONS) 119

TABLE 42 END-USER MARKETS FOR OPTICAL MICROSCOPES, THROUGH 2018 ($MILLIONS) 121

TABLE 43 END-USER MARKETS FOR CHARGED PARTICLE MICROSCOPES, THROUGH2018 ($ MILLIONS) 123

TABLE 44 END-USER MARKETS FOR ALL TYPES OF MICROSCOPES*, THROUGH 2018($ MILLIONS) 125

TABLE 45 GEOGRAPHICAL MARKETS FOR OPTICAL MICROSCOPES, THROUGH 2018($ MILLIONS) 127

TABLE 46 GEOGRAPHICAL MARKETS FOR CHARGED PARTICLE MICROSCOPES,THROUGH 2018 ($ MILLIONS) 129

TABLE 47 GEOGRAPHICAL MARKETS FOR SCANNING PROBE MICROSCOPES,THROUGH 2018 ($ MILLIONS) 131

TABLE 48 GEOGRAPHICAL MARKETS FOR ALL TYPES OF MICROSCOPES,* THROUGH2018 ($ MILLIONS) 133



LIST OF FIGURESFIGURE TITLE PAGE NO.

SUMMARY FIGURE MARKET FOR MICROSCOPES, ACCESSORIES AND SUPPLIES,2012-2018 ($ MILLIONS) 7

FIGURE 1 MAGNIFYING LENS PRINCIPLES 12 FIGURE 2 LIGHT WAVE PHASES 13 FIGURE 3 POLARIZATION 14 FIGURE 4 REFRACTION 15 FIGURE 5 LIGHT WAVE 17 FIGURE 6 WAVELENGTHS USED IN OPTICAL MICROSCOPY (NM) 17 FIGURE 7 REFLECTING MICROSCOPE 22 FIGURE 8 BASIC PRINCIPLE OF A PHASE CONTRAST MICROSCOPE 24 FIGURE 9 FLUORESCENCE MICROSCOPY PRINCIPLES 25 FIGURE 10 FLUORESCENCE MICROSCOPE LAYOUT 26 FIGURE 11 PRINCIPLES OF CONFOCAL MICROSCOPY 28 FIGURE 12 SCANNING NEAR-FIELD OPTICAL MICROSCOPE PRINCIPLES 30 FIGURE 13 OPTICAL MICROSCOPY PATENTS BY TYPE OF TECHNOLOGY, AS OF JUNE15, 2013 (PERCENT OF TOTAL PATENTS) 36

FIGURE 14 OPTICAL MICROSCOPY PATENTS ISSUED ANNUALLY BY TYPE OFTECHNOLOGY, 2005-2012 (NUMBER OF PATENTS) 37

FIGURE 15 MAJOR OPTICAL MICROSCOPY PATENT HOLDERS (%) 38 FIGURE 16 MAJOR OPTICAL MICROSCOPY PATENT HOLDERS BY TECHNOLOGY TYPE(PERCENTAGES OF TOTAL PATENTS) 39

FIGURE 17 TRANSMISSION ELECTRON MICROSCOPE 45 FIGURE 18 SCANNING ELECTRON MICROSCOPE 47 FIGURE 19 SCANNING ELECTRON MICROSCOPE - SAMPLE INTERACTION 47 FIGURE 20 U.S. CHARGED PARTICLE MICROSCOPY PATENTS BY TYPE OFTECHNOLOGY, THROUGH JUNE 15, 2013 (PERCENT OF U.S. PATENTS ISSUED) 53

FIGURE 21 CHARGED PARTICLE MICROSCOPY PATENTS ISSUED ANNUALLY BY TYPEOF TECHNOLOGY, 2005–2012 (NUMBER OF PATENTS) 55

FIGURE 22 CHARGED PARTICLE MICROSCOPE PATENT HOLDERS, THROUGH JUNE 15,2013 (% OF TOTAL PATENTS ISSUED) 56

FIGURE 23 MAJOR CHARGED PARTICLE MICROSCOPY PATENT HOLDERS BYTECHNOLOGY TYPE (PERCENT OF TOTAL PATENTS) 57

FIGURE 24 SCANNING PROBE MICROSCOPE 59 FIGURE 25 ATOMIC FORCE MICROSCOPE PROBE 62 FIGURE 26 SCANNING PROBE MICROSCOPY PATENTS BY TYPE OF TECHNOLOGY, ASOF JUNE 15, 2013 (PERCENT OF TOTAL PATENTS) 66

FIGURE 27 SCANNING PROBE MICROSCOPY PATENTS ISSUED ANNUALLY BY TYPE OFTECHNOLOGY, 2005-2012 (NUMBER OF PATENTS ISSUED ANNUALLY) 66

FIGURE 28 SCANNING PROBE MICROSCOPE PATENT HOLDERS, THROUGH JUNE 15,2013 (PERCENT OF TOTAL U.S. PATENTS ISSUED) 68

FIGURE 29 MAJOR SPM PATENT HOLDERS, BY TECHNOLOGY TYPE (PERCENT OFTOTAL PATENTS) 69

FIGURE 30 U.S. MICROSCOPE ACCESSORY PATENTS BY ACCESSORY TYPE, AS OFJUNE 15, 2013 (PERCENT OF TOTAL PATENTS ISSUED) 76

FIGURE 31 MICROSCOPE ACCESSORY PATENT HOLDERS, THROUGH JUNE 15, 2013(PERCENT OF PATENTS ISSUED) 77

FIGURE 32 MATERIALS SCIENCE INSTRUMENTS MAJOR MARKET SEGMENTS, 2012(PERCENT OF TOTAL SALES) 84

FIGURE 33 TRENDS IN GLOBAL SALES OF MICROSCOPES AND ACCESSORIES/SUPPLIES, 2012-2018 ($ MILLIONS) 92



FIGURE TITLE PAGE NO. FIGURE 34 MICROSCOPY MAJOR MARKET SEGMENTS, 2012 VERSUS 2018 (%) 94 FIGURE 35 OPTICAL MICROSCOPE MARKET SEGMENTATION, 2012 (% OF TOTALOPTICAL MICROSCOPE SALES) 95

FIGURE 36 TRENDS IN U.S. EDUCATIONAL EXPENDITURES, 2002–2018 ($ BILLIONS) 97 FIGURE 37 TRENDS IN LIFE SCIENCES R&D SPENDING, 2012–2018 ($ BILLIONS) 99 FIGURE 38 MATERIALS CHARACTERIZATION INSTRUMENT SALES TRENDS,2012-2018 ($ BILLIONS) 100

FIGURE 39 OPTICAL MICROSCOPE MARKET SEGMENTATION, 2018 (%) 104 FIGURE 40 CHARGED PARTICLE MICROSCOPE MARKET SEGMENTS, 2012 (%) 105 FIGURE 41 MARKETS FOR SCANNING ELECTRON MICROSCOPES, 2012 (PERCENT OFTOTAL SEM SALES) 106

FIGURE 42 PROJECTED GROWTH IN SEMICONDUCTOR CAPITAL EQUIPMENTSPENDING, 2012-2018 ($ BILLIONS) 107

FIGURE 43 CHARGED PARTICLE MICROSCOPE SALES GROWTH VERSUS GROWTH INMAJOR UNDERLYING MARKETS, 2003-2008 (CAGR%) 108

FIGURE 44 CHARGED PARTICLE MICROSCOPE MARKET SEGMENTS, 2018 (PERCENTOF TOTAL SALES) 112

FIGURE 45 SPM MARKET PRODUCT SEGMENTS, 2012 (%) 113 FIGURE 46 SCANNING PROBE MICROSCOPE MARKET SEGMENTS, 2018 (PERCENT OFTOTAL SALES) 116

FIGURE 47 MICROSCOPE ACCESSORIES AND SUPPLIES MARKET SEGMENTATION,2012 (%) 117

FIGURE 48 TRENDS IN NUMBER OF MICROSCOPES IN USE WORLDWIDE, 2011-2018(MILLION UNITS) 118

FIGURE 49 OPTICAL MICROSCOPE MARKET SHARES BY END-USER SEGMENT, 2012VERSUS 2018 (%) 120

FIGURE 50 CHARGED PARTICLE MICROSCOPE MARKET SHARES BY END-USERSEGMENT, 2012 VERSUS 2018 (%) 122


FIGURE 52 OPTICAL MICROSCOPE GEOGRAPHICAL MARKET SHARES, 2012 VERSUS2018 (%) 125

FIGURE 53 CHARGED PARTICLE MICROSCOPE GEOGRAPHICAL MARKET SHARES,2012 VERSUS 2018 (%) 127

FIGURE 54 SCANNING PROBE MICROSCOPE GEOGRAPHICAL MARKET SHARES, 2012VERSUS 2018 (%) 130


FIGURE 56 OPTICAL MICROSCOPY MARKET SHARES, 2012 (%) 135 FIGURE 57 ELECTRON MICROSCOPE MARKET SHARES, 2012 (%) 136 FIGURE 58 FOCUSED ION BEAM MICROSCOPE MARKET SHARES, 2012 (%) 137 FIGURE 59 SCANNING PROBE MICROSCOPE MARKET SHARES, 2012 (%) 138

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Chapter 1 - sbdi.co.kr€¦Chapter 1 INTRODUCTION MICROSCOPY: THE GLOBAL MARKET IAS017E July 2013 Andrew McWilliams Project Analyst ISBN: 1-56965-492-1 …