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Chapter 12 Patterns of Patterns of Inheritance Inheritance

Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

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Page 1: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

Chapter 12

Patterns of Patterns of InheritanceInheritance

Page 2: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

2Chapter 12

GeneticsGeneticsField founded by Field founded by Gregor MendelGregor Mendel

Worked with Worked with sweet peasweet pea

Knew nothing of cells, Knew nothing of cells, chromosomes, etc.; also chromosomes, etc.; also interested in math.interested in math.

Was unappreciated by peersWas unappreciated by peers

Work was rediscovered after Work was rediscovered after DarwinDarwin

Page 3: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

3Chapter 12

MendelMendel

Page 4: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

4Chapter 12Seeds & Flowers of Edible Seeds & Flowers of Edible PeaPea

Intact pea flowerIntact pea flower Flower dissected to showFlower dissected to showreproductive structuresreproductive structures

StamensStamens(male)(male)

produceproducepollenpollen

StamensStamens(male)(male)

produceproducepollenpollen

CarpelCarpel(female)(female)producesproduces

eggseggs

CarpelCarpel(female)(female)producesproduces

eggseggs

Page 5: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

5Chapter 12Definitions 1Definitions 1

Must know these!!!Must know these!!!

TraitTrait—A variable characteristic of —A variable characteristic of organismorganism

GeneGene—A segment of chromosomal —A segment of chromosomal DNA controlling a specific traitDNA controlling a specific trait

LocusLocus—Chromosomal position —Chromosomal position where DNA for a specific gene liveswhere DNA for a specific gene lives

GenomeGenome—Refers to all standard loci —Refers to all standard loci for a speciesfor a species

Page 6: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

6Chapter 12

Definitions 2Definitions 2Must know these!!!Must know these!!!AllelesAlleles—Different forms of a —Different forms of a genegene

• ““Flower color” is a gene;Flower color” is a gene;• ““Purple” is one flower-color allelePurple” is one flower-color allele• ““White” is another flower-color White” is another flower-color alleleallele

GenotypeGenotype—List of alleles for an —List of alleles for an individual at specific genesindividual at specific genes

• Familiar organisms are diploidFamiliar organisms are diploid• One or two alleles per individualOne or two alleles per individual

Page 7: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

7Chapter 12

Definitions 3Definitions 3

HomozygousHomozygous—Maternal & paternal —Maternal & paternal alleles samealleles same

• Father donates purple-flower alleleFather donates purple-flower allele• Mother donates purple-flower alleleMother donates purple-flower allele

HeterozygousHeterozygous—Maternal & —Maternal & paternal alleles differpaternal alleles differ

• Father donates purple-flower alleleFather donates purple-flower allele• Mom donates white-flower alleleMom donates white-flower allele

Page 8: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

8Chapter 12

Definitions 4Definitions 4PhenotypePhenotype::

• List of traits exhibited by individualList of traits exhibited by individual• Doesn’t always represent genotypeDoesn’t always represent genotype

DominantDominant—Allele that is —Allele that is expressed 100% in heterozygoteexpressed 100% in heterozygote

RecessiveRecessive—Allele is not expressed —Allele is not expressed in heterozygotein heterozygote

Incomplete dominanceIncomplete dominance——heterozygote displays heterozygote displays intermediate trait intermediate trait

Page 9: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

9Chapter 12

11 22 33 44 55 66 77 88 99 10101111121213131414151516161717181819192020212122222323242425252626Loci:Loci:

Genes, Alleles,Genes, Alleles,Loci, and ChromosomesLoci, and Chromosomes

Chromosome from One ParentChromosome from One Parent

Homologous Chromosome from Other ParentHomologous Chromosome from Other Parent

11 22 33 44 55 66 77 88 99 10101111121213131414151516161717181819192020212122222323242425252626Loci:Loci:

M locus has gene

that controls

leaf color. Plant

homozygous for this

gene

D locus has gene

that controls

plant height. Plant

homozygous for this

gene

Bk locus has gene

that controls

fruit shape. Plant

heterozygous for this

gene

Page 10: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

10

Chapter 12

Genetic SymbolismGenetic SymbolismOften use initial letter of dominant Often use initial letter of dominant alleleallele

• CapitalCapital letter represents dominant letter represents dominant

• Lower caseLower case of of same lettersame letter represents recessiverepresents recessive

If purple flower dominant to If purple flower dominant to white…white…

• ““P” represents allele for purpleP” represents allele for purple

• ““p” represents allele for whitep” represents allele for white

Page 11: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

11

Chapter 12

Foundation GeneticsFoundation Genetics

Mendel’s LawsMendel’s Laws

1.1. Law of DominanceLaw of Dominancea.a.Interaction of the two resultingInteraction of the two resulting

in expression of only onein expression of only one

AaAaDominantDominant RecessiveRecessive

Page 12: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

12

Chapter 12II. The foundation of II. The foundation of geneticsgenetics

A - aA - a AA aa

2. Law of Segregation2. Law of Segregation

a. Paired alleles of a gene separate a. Paired alleles of a gene separate

during meiosis resulting in a gameteduring meiosis resulting in a gametethat contains only a single allelethat contains only a single allele

for each gene presentfor each gene present

Page 13: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

13

Chapter 12II. The foundation of II. The foundation of geneticsgenetics

3. Law of Independent Assortment3. Law of Independent Assortment

Pairs of alleles (genes) that control Pairs of alleles (genes) that control

different traits segregate independentlydifferent traits segregate independentlyof each other during meiosis of each other during meiosis

(genes) (genes) if the alleles are on separateif the alleles are on separate

chromosomeschromosomes

Page 14: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

14

Chapter 12

Independent AssortmentIndependent Assortment

1a - 1b1a - 1b

2a - 2b2a - 2b

3a - 3b3a - 3b

1a1a1b1b2b2b3a3a

2a2a3b3b

Page 15: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

15

Chapter 12

Linear order - LinkageLinear order - Linkage

RedAllele, p

RoundAllele, l

PurpleAllele, P

LongAllele, L

Flower colorFlower colorgenegene

Pollen shapePollen shapegenegene

Page 16: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

16

Chapter 12

Cross Fertilization of Parents Cross Fertilization of Parents

True-breedingTrue-breedingPurple-floweredPurple-flowered

ParentParent

True-True-breedingbreedingWhite-White-

floweredfloweredParentParent

Cross-FertilizeCross-Fertilize

All Purple-floweredAll Purple-floweredOffspringOffspring

Pollen

Pollen

P P

F1

Page 17: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

17

Chapter 12

Self-fertilization of FSelf-fertilization of F22

F1

Self-FertilizeSelf-Fertilize

F2 F2 F2 F2

75% Purple75% Purple25% White25% White

Page 18: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

18

Chapter 12

Genotype vs PhenotypeGenotype vs Phenotype

Phenotype is how we look/behavePhenotype is how we look/behave• PurplePurple flowers flowers• WhiteWhite flowers flowers

Genotype is what our genes sayGenotype is what our genes say• White FlowersWhite Flowers / / White FlowersWhite Flowers • White FlowersWhite Flowers / / Purple FlowersPurple Flowers • Purple FlowersPurple Flowers / / Purple FlowersPurple Flowers

Page 19: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

19

Chapter 12

Genotype vs Phenotype 2Genotype vs Phenotype 2

GenotypesGenotypes• PP = homozygous for PP = homozygous for purplepurple flower flower• pp = homozygous for pp = homozygous for whitewhite flower flower• Pp = heterozygous for flower colorPp = heterozygous for flower color

Phenotype from genotype:Phenotype from genotype:• PP = PP = purplepurple flower flower• Pp = Pp = purplepurple flower flower• pP = pP = purplepurple flower flower• pp = pp = WhiteWhite flower flower

Page 20: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

20

Chapter 12

Genotype - PhenotypeGenotype - Phenotype

Page 21: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

21

Chapter 12

Gametes of HomozygotesGametes of Homozygotes

A A A A

Homozygous ParentHomozygous Parent GametesGametes

All gametes identicalAll gametes identicalregarding this generegarding this gene

Page 22: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

22

Chapter 12

Gametes of HeterozygotesGametes of Heterozygotes

A a A a

Heterozygous ParentHeterozygous Parent GametesGametes

Gametes 50/50Gametes 50/50regarding this generegarding this gene

Page 23: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

23

Chapter 12

pphomozygo

usrecessive

Homozygous DominantHomozygous DominantX Homozygous RecessiveX Homozygous Recessive

P

p

P

p

Purp

le P

are

nt

Purp

le P

are

nt

PPhomozygo

usdominant

Whit

e P

are

nt

Whit

e P

are

nt

spermspermnucleinuclei

eggeggnucleinuclei

spermspermnucleinuclei

eggeggnucleinuclei

Page 24: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

24

Chapter 12

Pp

pP

P Sperm + p EggsP Sperm + p Eggssame as p Sperm + P Eggssame as p Sperm + P Eggs

Purp

le F

Purp

le F

11Purp

le F

Purp

le F

11

P p

spermspermnucleusnucleus

eggeggnucleusnucleus

++

p P

eggeggnucleusnucleus

spermspermnucleusnucleus

++

Page 25: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

25

Chapter 12

PurplePurplehomozygouhomozygou

ssdominant dominant

(PP)(PP)PurplePurpleheterozygoheterozygo

usus (Pp) (Pp)PurplePurple

heterozygoheterozygousus

(pP) (pP)WhiteWhitehomozygouhomozygou

ssrecessive recessive

(pp)(pp)

Pp X Pp CrossPp X Pp Cross

P

p

p

P

p

P

P

p

++

++

++

++

FF11 Sperm SpermFF11 Eggs Eggs FF22 Offspring Offspring

Page 26: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

26

Chapter 12Using Punnett SquaresUsing Punnett Squaresin Genetic Crossesin Genetic Crosses

Named after geneticist Reginald Named after geneticist Reginald PunnettPunnett

Figured using Figured using Punnett squaresPunnett squares• Considers only genes of interestConsiders only genes of interest

• List sperm genotypes across topList sperm genotypes across top

• List egg genotypes down sideList egg genotypes down side

• Fill in boxes with zygote genotypesFill in boxes with zygote genotypes

Page 27: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

27

Chapter 12

P p

1(25%)White

3 (75%)3 (75%)PurplePurple

FrequenciesFrequenciesPhenotypesPhenotypes

GenotypesGenotypes

FrequenciesFrequencies

Making a Punnett Square:Making a Punnett Square:Heterozygous X HeterozygousHeterozygous X Heterozygous

Eggs of Heterozygous Eggs of Heterozygous PlantPlant

Pollen ofPollen ofHeterozygous Heterozygous

Plant Plant

1111 22

P

p pP

PpPP

pp

PP pppP Pp

Page 28: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

28

Chapter 12

ProbabilityProbability

Page 29: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

29

Chapter 12

ProbabilityProbabilityProbabilityProbability

Coin TossCoin Toss Probability of Probability of heads =heads = 1/2 or 50%1/2 or 50%

Probability of tails =Probability of tails =1/2 or 50%1/2 or 50%

10 tosses - 7th toss = heads10 tosses - 7th toss = heads

10 tosses - 4th toss = heads10 tosses - 4th toss = heads

10 tosses - 3rd toss = tails10 tosses - 3rd toss = tails

1/21/2

1/21/2

1/21/2

3 tosses in a row = heads3 tosses in a row = heads 1/81/8

1/2 (1st toss) X 1/2 (2nd toss) X 1/2 (3rd toss)1/2 (1st toss) X 1/2 (2nd toss) X 1/2 (3rd toss)

Page 30: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

30

Chapter 12

Consider Flower ColorConsider Flower ColorPretend flower color affected by Pretend flower color affected by only one gene (only one gene (monohybrid monohybrid crosscross))

Assume all alleles are purple or Assume all alleles are purple or whitewhite

Purple (P) is dominant to white (p)Purple (P) is dominant to white (p)

HeterozygotesHeterozygotes will have flowers as will have flowers as purple as homozygous dominantspurple as homozygous dominants

Page 31: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

31

Chapter 12

p p

(50%)White

(50%)(50%)PurplePurple

FrequenciesFrequenciesPhenotypesPhenotypes

GenotypesGenotypes

FrequenciesFrequencies

Test Cross:Test Cross:Heterozygous X Homozygous Heterozygous X Homozygous RecessiveRecessiveEggs of Homozygous Eggs of Homozygous

RecessiveRecessive

Pollen of unknownPollen of unknownplant with dominant plant with dominant

phenotypephenotype(Heterozygous)(Heterozygous)

22

P

p pp

PpPp

pp

Pp pppP pp22

Page 32: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

32

Chapter 12

p p

(100%)(100%)PurplePurple

FrequenciesFrequenciesPhenotypesPhenotypes

GenotypesGenotypes

FrequenciesFrequencies

Test Cross:Test Cross:Homozygous X Homozygous Homozygous X Homozygous RecessiveRecessive

Eggs of Homozygous Eggs of Homozygous RecessiveRecessive

Pollen of unknownPollen of unknownplant with dominant plant with dominant

phenotypephenotype(Homozygous)(Homozygous)

P

Pp

PpPp

Pp

Pp PpPp Pp

P

44

Page 33: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

33

Chapter 12Traits of PeasTraits of PeasStudied by MendelStudied by Mendel

Plant size

Flower location

Flower color

Pod color

Pod shape

Seed shape

Seed color

Page 34: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

34

Chapter 12Dihybrid Cross:Dihybrid Cross:SSssYYyy X S X SssYYyy

SYSY

SSyy

ssYY

sysy

SsYy ParentSsYy ParentSelf-fertilizesSelf-fertilizes

14

14

14

14

SYSY SSyy ssYY sysy14

14

14

14

Eggs

Sperm

116

116

116

116

116

116

116

116

116

116

116

116

116

116

116

116

SSYYSSYY SSYSSYyy SSssYYYY SSssYYyy

SSSSyyYY SSSSyyyy SSsysyYY SSsyysyy

ssSYYSYY ssSYSYyy ssssYYYY ssssYYyy

ssSSyyYY ssSSyyyy ssyssyYY ssyyssyy

Page 35: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

35

Chapter 12

Dihybrid Cross - ProbabilityDihybrid Cross - Probability

B = Brown EyesB = Brown Eyesb = Blue Eyesb = Blue Eyes

A = Black HairA = Black Hair

a = Blond Haira = Blond Hair

P GenerationP Generation

BbAa BbAa BbAaBbAa

Possible GametesPossible Gametes

MaleMaleFemaleFemale

malemaleBA,Ba,bA,BA,Ba,bA,

babaFemaleFemale

BA, Ba, bA, baBA, Ba, bA, ba

Page 36: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

36

Chapter 12

Dihybrid ProbabilityDihybrid Probability

ABAB AbAb aBaB abab

ABAB

AbAb

aBaB

abab

ABAABABB AABbAABb AaBAaB

BB AaBbAaBb

AABbAABb AAbbAAbb AaBbAaBb AabbAabb

AaBBAaBB AaBbAaBb aaBBaaBB aaBbaaBb

AaBbAaBb AabbAabb aaBbaaBb aabbaabbBlack Hair - Brown eyesBlack Hair - Brown eyesBlack Hair - Blue EyesBlack Hair - Blue Eyes

9933Blond Hair - Brown Eyes Blond Hair - Brown Eyes Blond Hair - Blue EyesBlond Hair - Blue Eyes

3311

Page 37: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

37

Chapter 12Dihybrid Probability - Math Dihybrid Probability - Math SolvedSolved

Brown Eyes = BBrown Eyes = B

Blue Eyes = bBlue Eyes = b

Black Hair = ABlack Hair = A

Blond Hair = aBlond Hair = a

Male BbAaMale BbAa

Female BbAaFemale BbAa

Probability = 3/4Probability = 3/4

Probability = 1/4Probability = 1/4

Probability = 3/4Probability = 3/4

Probability = 1/4Probability = 1/4

Page 38: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

38

Chapter 12Dihybrid Probability - Math Dihybrid Probability - Math SolvedSolved

3/4 B-3/4 B-1/4 bb1/4 bb

3/4 A -3/4 A -1/4 aa1/4 aaXX

9/16 B-A-9/16 B-A-3/16 bbA-3/16 bbA-3/16 B-aa3/16 B-aa1/16 bbaa1/16 bbaa

Page 39: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

39

Chapter 12

LinkageLinkage

RedAllele, p

RoundAllele, l

PurpleAllele, P

LongAllele, L

Flower colorFlower colorgenegene

Pollen shapePollen shapegenegene

Page 40: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

40

Chapter 12

Incomplete DominanceIncomplete Dominance

Page 41: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

41

Chapter 12

Incomplete DominanceIncomplete Dominance

Page 42: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

42

Chapter 12

RR RR

(100%)(100%)Pink (intermediate)Pink (intermediate)

FrequenciesFrequenciesPhenotypesPhenotypes

GenotypesGenotypes

FrequenciesFrequencies

Incomplete Dominance:Incomplete Dominance:Homozygous-X Homo RecessiveHomozygous-X Homo RecessiveEggs of HomozygousEggs of Homozygous

RR Red Parent Red Parent

Pollen ofPollen ofHomozygous Homozygous

R'R' White White ParentParent

R'

R'R'R

R'RR'R

R'R

R'R R'RR'R R'R

Pink Pink

Pink Pink

11

Page 43: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

43

Chapter 12

(25%)(25%)(25%)(25%)RedRed WhiteWhite

RR R'R'

(50%)(50%)PinkPink

FrequenciesFrequenciesPhenotypesPhenotypes

GenotypesGenotypes

FrequenciesFrequencies

Incomplete Dominance:Incomplete Dominance:FF11 X F X F11

Eggs of HeterozygousEggs of HeterozygousRR' Pink FPink F11 Parent Parent

Pollen ofPollen ofHeterozygous Heterozygous

RR' Pink F Pink F11 ParentParent

RR

R'R'R'R

RR'RR

R'R'

RR R'R'RR' R'R1111 22

Red Pink

Pink White

Page 44: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

44

Chapter 12Normal Red Blood Cells - Normal Red Blood Cells - PleiotropyPleiotropy

Page 45: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

45

Chapter 12

Sickled Cells - PleiotropySickled Cells - Pleiotropy

Page 46: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

46

Chapter 12

PleiotropyPleiotropy

Page 47: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

47

Chapter 12Epistasis two sets of genes Epistasis two sets of genes working togetherworking together

Page 48: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

48

Chapter 12Polygenic Inhertance - Polygenic Inhertance - multiple genesmultiple genes

Three Sets of GenesThree Sets of Genes

Working in tandemWorking in tandem

AABBCCAABBCC

AaBbCcAaBbCc

aabbccaabbcc

Skin ColorSkin Color

HeightHeight

Eye ColorEye Color

Page 49: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

49

Chapter 12Polygenic Inhertance - Polygenic Inhertance - multiple genesmultiple genes

Page 50: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

50

Chapter 12

ABAB

AbAb

aBaB

abab

ABAB AbAb aBaB abab

HumaHuman Eye n Eye ColorColor

EGGSEGGS

SPER

MS

PER

M

MotherMother

AaBbAaBb

FatherFather

AaBbAaBb

AABBAABB AABbAABb AaBBAaBB AaBbAaBb

blackblack dark browndark brown dark browndark brown light brownlight brown

AAbBAAbB

dark browndark brown

AAbbAAbb

light brownlight brown

AabBAabB

light brownlight brown

AabbAabb

blueblue

aABBaABB aABbaABb aaBBaaBB aaBbaaBb

dark browndark brown light brownlight brown light brownlight brown blueblue

aABbaABb aAbbaAbb aaBbaaBb aabbaabb

light brownlight brown blueblue blueblue light bluelight blue

Page 51: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

51

Chapter 12

Multiple AllelesMultiple Alleles

Blood TypeBlood Type A - B - AB - OA - B - AB - O

A A AA - AoAA - Ao

BB BB - BoBB - Bo

ABAB ABAB

OO oooo

GenotypeGenotype

Page 52: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

52

Chapter 12

10%10%

34%34%

37%37%

4%4%

B or ABB or AB

A or ABA or AB

O,AB,O,AB,A,BA,B

(universal(universal))

ABAB

B or OB or O

A or OA or O

OO

AB, A,AB, A,B, OB, O

(universal)(universal)

AA

BB

A & BA & B

NeitherNeither

BB or BOBB or BO

AA or AOAA or AO

OOOO

ABAB

OO

ABAB

BB

AA

FreqFreqDonatesDonatesRe-Re-ceivesceives

Anti-Anti-bodiesbodiesRBCsRBCsGenotypeGenotypeTypTyp

ee

Human ABO Blood GroupHuman ABO Blood Group

Page 53: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

53

Chapter 12

RH Blood FactorRH Blood Factor

RH - another Blood ProteinRH - another Blood Protein

Rh + you have the proteinRh + you have the protein

Rh -- you donot have the proteinRh -- you donot have the protein85% of the population are Rh +85% of the population are Rh +

15% of the population are Rh 15% of the population are Rh −−

4% of the population are AB4% of the population are AB

What % of the population are AB What % of the population are AB −−

Page 54: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

54

Chapter 12

Rh Blood FactorRh Blood Factor

Female Rh + Female Rh + Male Rh Male Rh −−

Child Rh +Child Rh +

Female Rh Female Rh −− Male Rh Male Rh

Child Rh Child Rh Mother will start to build upMother will start to build up

anti Rh antibodiesanti Rh antibodies

Page 55: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

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Chapter 12

XX11 XX22

Sex DeterminationSex Determinationin Mammalsin Mammals

EGGSEGGS

Male ParentMale ParentYYXXmm

SSPPEERRMM

Female OffspringFemale Offspring

Male OffspringMale OffspringYY

XXmmXXmmXX11 XX22XXmm

YY YYXX11 XX22

XX11 XX22Female ParentFemale Parent

Page 56: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

56

Chapter 12Sex Determination Sex Determination in Mammalsin Mammals

QuickTime™ and aYUV420 codec decompressor

are needed to see this picture.

Page 57: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

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Chapter 12

Sex Linked Sex Linked

The gene is found on the X chromosomeThe gene is found on the X chromosomeColor Blindness - recessive Color Blindness - recessive

traittraitFemale possible genotypesFemale possible genotypes

CCCC CcCc cccc

Male possible genotypesMale possible genotypes

CyCy cycy

Page 58: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

58

Chapter 12

Color BlindnessColor Blindness

Page 59: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

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Chapter 12

Sex LinkedSex Linked

GenotypesGenotypes Cc - CyCc - Cy

CC cc

CC

yy

CcCc CcCc

CyCy ccyy

25% colorblind25% colorblind50% of the males colorblind50% of the males colorblind

Page 60: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

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Chapter 12

Sex InfluencedSex Influenced

Dominant in one sexDominant in one sex

Recessive in the otherRecessive in the other

Reason: Reason:

The presence or absenceThe presence or absence

TestosteroneTestosteroneEstrogenEstrogen

of the sex hormonesof the sex hormones

Page 61: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

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Chapter 12Sex InfluencedSex InfluencedMale Pattern BaldnessMale Pattern Baldness

Page 62: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

62

Chapter 12Sex Influenced Sex Influenced Male Pattern BaldnessMale Pattern Baldness

Dominant in MalesDominant in MalesRecessive in FemalesRecessive in Females

BBBB

BbBb

bbbb

BaldBaldBalBaldd

NonbaldNonbald

BaldBald

NonbaldNonbald

NonbaldNonbald

Page 63: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

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Chapter 12

Sex Limited TraitSex Limited Trait

Trait is limited to one sexTrait is limited to one sex

All secondary sex characteristics All secondary sex characteristics

are sex limitedare sex limited

Page 64: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

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Chapter 12

Sex Limited TraitSex Limited Trait

Cabbage ButterflyCabbage Butterfly

YellowYellow

Cabbage ButterflyCabbage Butterfly

whitewhite

Page 65: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

65

Chapter 12

Sex Limited TraitSex Limited Trait

Page 66: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

66

Chapter 12

Sex Limited TraitSex Limited Trait

Page 67: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

67

Chapter 12

Sex Limited TraitSex Limited Trait

Page 68: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

68

Chapter 12

How to Read PedigreesHow to Read Pedigrees

= male= male = female= female

= parents= parents

oror = individual who shows the trait = individual who shows the trait

oror = heterozygous carrier of= heterozygous carrier ofautosomal trait autosomal trait

= offspring = offspring

11 22 33I, II, III, IV, or VI, II, III, IV, or V = generation = generation

Page 69: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

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Chapter 12

A Recessive PedigreeA Recessive Pedigree

Page 70: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

70

Chapter 12Pedigrees:Pedigrees:Legacy of Queen VictoriaLegacy of Queen Victoria

Page 71: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

71

Chapter 12Incidence of Down Incidence of Down SyndromeSyndrome

1010 2020 3030 4040 505000

100100

200200

300300

400400

Age of Mother (years)Age of Mother (years)

Num

ber

per

100

0 B

irth

sN

um

ber

per

100

0 B

irth

s

Page 72: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

Chapter 12

The endThe end

Page 73: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

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Chapter 12

Meiosis IIMeiosis I

YYSS

SS YY

yyss

ss yy

yySS

SS yy

YYss

YYss

SS yy yySS

YY YYssss

Independent AssortmentIndependent Assortment

SSss

YYyy

SS

ss

YY

yy

YY

yy

SS

ss

YY YY

SS

ss

yy yySS

ss

Randomly one or the

other

SS YY YYSS

ss yy yyss

ChromosomeReplication

Page 74: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

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Chapter 12

red

red

Purple

Purple

round

round

Long

Long

PP

PP

pp

pp

LL

LL

ll

ll

PP

pp

pp

LL

LL

ll

ll

PP

LL

pp LL

ll

ll

PP

pp

PP

LL

pp LL

ll

ll

PP

pp

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LL

ll

ll

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PP

pp

pp

PP

PP

pp

pp

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LL

ll

ll

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pp

pp

LL

LL

ll

ll

Crossing OverCrossing Over

SisterSisterChromatidsChromatids

DuplicatedDuplicatedChromosomeChromosome

DuplicatedDuplicatedChromosomeChromosome

LL

LL

ll

ll

PP

PP

pp

pp

SisterSisterChromatidsChromatids

Hom

olo

gous

Hom

olo

gous

Chro

moso

mes

Chro

moso

mes

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pp

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old combinationold combination

new combinationnew combination

new combinationnew combination

old combinationold combination

FlowerColor

PollenShape

Page 75: Chapter 12 Patterns of Inheritance. 2 Chapter 12Genetics Field founded by Gregor Mendel Worked with sweet pea Knew nothing of cells, chromosomes, etc.;

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Chapter 12

25%25%Normal fNormal f Carrier fCarrier fNormal mNormal m

25%25% 25%25% 25%White-e m

FrequenciesFrequenciesPhenotypesPhenotypes

GenotypesGenotypes

FrequenciesFrequencies

Sex Linkage:Sex Linkage:Eye Color in Fruit FliesEye Color in Fruit Flies

Eggs of Eggs of XR Xr FemaleFemale

Sperm ofSperm ofXXRRY Male Y Male

1111

YXR

XRXrXRXR

YXr

XRXR XrYXRXr XRY

R r

R

Female Female

Male Male

11 11