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Chapter 18: The Chemistry of Heredity Molecular Genetics © 2003 John Wiley and Sons Publish Courtesy Alfred Pasieka/Peter Arnold, Inc.

Chapter 18: The Chemistry of HeredityThe Chemistry of Heredity Molecular Genetics © 2003 John Wiley and Sons Publishers Courtesy Alfred Pasieka/Peter Arnold,

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Page 1: Chapter 18: The Chemistry of HeredityThe Chemistry of Heredity Molecular Genetics © 2003 John Wiley and Sons Publishers Courtesy Alfred Pasieka/Peter Arnold,

Chapter 18: The Chemistry of Heredity

Molecular Genetics

© 2003 John Wiley and Sons Publishers

Courtesy Alfred Pasieka/Peter Arnold, Inc.

Page 2: Chapter 18: The Chemistry of HeredityThe Chemistry of Heredity Molecular Genetics © 2003 John Wiley and Sons Publishers Courtesy Alfred Pasieka/Peter Arnold,

Figure 18.1: (1) Preparing the gelatin. (2) Adding canned pineapple to the liquid gelatin. (3) Adding fresh pineapple to the liquid gelatin. (4) The gelatin mixture does not solidify in the presence of fresh pineapple.

© 2003 John Wiley and Sons Publishers

Courtesy Andy Washnik

Page 3: Chapter 18: The Chemistry of HeredityThe Chemistry of Heredity Molecular Genetics © 2003 John Wiley and Sons Publishers Courtesy Alfred Pasieka/Peter Arnold,

Figure 18.2: The geometry of a single, double (DNA), and triple (gelatin) helix.

© 2003 John Wiley and Sons Publishers

Page 4: Chapter 18: The Chemistry of HeredityThe Chemistry of Heredity Molecular Genetics © 2003 John Wiley and Sons Publishers Courtesy Alfred Pasieka/Peter Arnold,

Figure 18.3: Gregor Mendel laid the foundation for our understanding of how individual characteristics are passed from parents to offspring.

© 2003 John Wiley and Sons Publishers

Courtesy Leslie Holzer/Photo Researchers

Page 5: Chapter 18: The Chemistry of HeredityThe Chemistry of Heredity Molecular Genetics © 2003 John Wiley and Sons Publishers Courtesy Alfred Pasieka/Peter Arnold,

Figure 18.4: A typical animal cell.

© 2003 John Wiley and Sons Publishers

Courtesy David M. Phillips/Visuals Unlimited

Page 6: Chapter 18: The Chemistry of HeredityThe Chemistry of Heredity Molecular Genetics © 2003 John Wiley and Sons Publishers Courtesy Alfred Pasieka/Peter Arnold,

Figure 18.5: Chromosomes and DNA (Section 18.6).

© 2003 John Wiley and Sons Publishers

Courtesy BioPhoto Asoc/Science Source/Photo Researchers

Page 7: Chapter 18: The Chemistry of HeredityThe Chemistry of Heredity Molecular Genetics © 2003 John Wiley and Sons Publishers Courtesy Alfred Pasieka/Peter Arnold,

Figure 18.6: Stages in the mitosis of a human cell.

© 2003 John Wiley and Sons Publishers

Courtesy J. C. Revy/Copyright ISM/Phototake

Page 8: Chapter 18: The Chemistry of HeredityThe Chemistry of Heredity Molecular Genetics © 2003 John Wiley and Sons Publishers Courtesy Alfred Pasieka/Peter Arnold,

Figure 18.7: An early (1953) model of a portion of a DNA molecule, designed and built by James Watson, left, and Francis Crick, right (Section 18.10).

© 2003 John Wiley and Sons Publishers

Courtesy A. Barrington/Science Source/Photo Researchers

Page 9: Chapter 18: The Chemistry of HeredityThe Chemistry of Heredity Molecular Genetics © 2003 John Wiley and Sons Publishers Courtesy Alfred Pasieka/Peter Arnold,

Figure 18.8: Ribose, 2-deoxyribose, and phosphoric acid.

© 2003 John Wiley and Sons Publishers

Page 10: Chapter 18: The Chemistry of HeredityThe Chemistry of Heredity Molecular Genetics © 2003 John Wiley and Sons Publishers Courtesy Alfred Pasieka/Peter Arnold,

Figure 18.9: The amine bases of DNA.

© 2003 John Wiley and Sons Publishers

Page 11: Chapter 18: The Chemistry of HeredityThe Chemistry of Heredity Molecular Genetics © 2003 John Wiley and Sons Publishers Courtesy Alfred Pasieka/Peter Arnold,

Figure 18.10: The combination of 2-deoxyribose, cytosine, and phosphoric acid produces a typical nucleotide.

© 2003 John Wiley and Sons Publishers

Page 12: Chapter 18: The Chemistry of HeredityThe Chemistry of Heredity Molecular Genetics © 2003 John Wiley and Sons Publishers Courtesy Alfred Pasieka/Peter Arnold,

Figure 18.11: A typical segment of the DNA chain.

© 2003 John Wiley and Sons Publishers

Page 13: Chapter 18: The Chemistry of HeredityThe Chemistry of Heredity Molecular Genetics © 2003 John Wiley and Sons Publishers Courtesy Alfred Pasieka/Peter Arnold,

Figure 18.12: Thymine and uracil.

© 2003 John Wiley and Sons Publishers

Page 14: Chapter 18: The Chemistry of HeredityThe Chemistry of Heredity Molecular Genetics © 2003 John Wiley and Sons Publishers Courtesy Alfred Pasieka/Peter Arnold,

Figure 18.13: Hydrogen bonding and the double helix of DNA.

© 2003 John Wiley and Sons Publishers

Page 15: Chapter 18: The Chemistry of HeredityThe Chemistry of Heredity Molecular Genetics © 2003 John Wiley and Sons Publishers Courtesy Alfred Pasieka/Peter Arnold,

Figure 18.14: DNA replication.

© 2003 John Wiley and Sons Publishers

Page 16: Chapter 18: The Chemistry of HeredityThe Chemistry of Heredity Molecular Genetics © 2003 John Wiley and Sons Publishers Courtesy Alfred Pasieka/Peter Arnold,

Dolly, the first successful clone of an adult mammal.

© 2003 John Wiley and Sons Publishers

Courtesy AP/Wide World Photos

Page 17: Chapter 18: The Chemistry of HeredityThe Chemistry of Heredity Molecular Genetics © 2003 John Wiley and Sons Publishers Courtesy Alfred Pasieka/Peter Arnold,

Rainbow (left), the cat, and CC (right), the cloned kitten.

© 2003 John Wiley and Sons Publishers

Courtesy Texas A&M University, College of Veterinary Medicine

Page 18: Chapter 18: The Chemistry of HeredityThe Chemistry of Heredity Molecular Genetics © 2003 John Wiley and Sons Publishers Courtesy Alfred Pasieka/Peter Arnold,

© 2003 John Wiley and Sons Publishers

Classify as reversible or irreversible the effects of (a) hot water on the proteins of gelatin, (b) the high temperature canning process on the proteins of bromelin, and (c) the high temperatures of frying on the proteins of egg white.

QUESTION

Page 19: Chapter 18: The Chemistry of HeredityThe Chemistry of Heredity Molecular Genetics © 2003 John Wiley and Sons Publishers Courtesy Alfred Pasieka/Peter Arnold,

© 2003 John Wiley and Sons Publishers

Identify a polypeptide produced by the human body that helps ensure the effective nourishment of newly born children.

QUESTION

Page 20: Chapter 18: The Chemistry of HeredityThe Chemistry of Heredity Molecular Genetics © 2003 John Wiley and Sons Publishers Courtesy Alfred Pasieka/Peter Arnold,

© 2003 John Wiley and Sons Publishers

Name another chemical, in addition to vitamin C, that is found in much higher concentrations in oranges (and lemons, as well as other citrus fruit) than in apples (See Chapter 10)

QUESTION

Page 21: Chapter 18: The Chemistry of HeredityThe Chemistry of Heredity Molecular Genetics © 2003 John Wiley and Sons Publishers Courtesy Alfred Pasieka/Peter Arnold,

© 2003 John Wiley and Sons Publishers

Is red hair classified as a phenotype or a genotype? What term do we give to the carrier of the genetic information that transmits the characteristic of red hair from parent to child?

QUESTION

Page 22: Chapter 18: The Chemistry of HeredityThe Chemistry of Heredity Molecular Genetics © 2003 John Wiley and Sons Publishers Courtesy Alfred Pasieka/Peter Arnold,

© 2003 John Wiley and Sons Publishers

Based on the limited data of this section, what correlation, if any, appears to exist between the number of chromosomes in the cells of mammals and nonmammals? Of plants and animals?

QUESTION

Page 23: Chapter 18: The Chemistry of HeredityThe Chemistry of Heredity Molecular Genetics © 2003 John Wiley and Sons Publishers Courtesy Alfred Pasieka/Peter Arnold,

© 2003 John Wiley and Sons Publishers

What is the full chemical term represented by the letters of DNA?

QUESTION

Page 24: Chapter 18: The Chemistry of HeredityThe Chemistry of Heredity Molecular Genetics © 2003 John Wiley and Sons Publishers Courtesy Alfred Pasieka/Peter Arnold,

© 2003 John Wiley and Sons Publishers

How would you define a gene in biological terms? In chemical terms?

QUESTION

Page 25: Chapter 18: The Chemistry of HeredityThe Chemistry of Heredity Molecular Genetics © 2003 John Wiley and Sons Publishers Courtesy Alfred Pasieka/Peter Arnold,

© 2003 John Wiley and Sons Publishers

In what way(s) are mRNA and tRNA similar? How do they differ?

QUESTION

Page 26: Chapter 18: The Chemistry of HeredityThe Chemistry of Heredity Molecular Genetics © 2003 John Wiley and Sons Publishers Courtesy Alfred Pasieka/Peter Arnold,

© 2003 John Wiley and Sons Publishers

What amino acid does the codon GGC correspond to?

QUESTION

Page 27: Chapter 18: The Chemistry of HeredityThe Chemistry of Heredity Molecular Genetics © 2003 John Wiley and Sons Publishers Courtesy Alfred Pasieka/Peter Arnold,

© 2003 John Wiley and Sons Publishers

Why are the two DNA strands of a double helix regarded as complementary rather than identical?

QUESTION

Page 28: Chapter 18: The Chemistry of HeredityThe Chemistry of Heredity Molecular Genetics © 2003 John Wiley and Sons Publishers Courtesy Alfred Pasieka/Peter Arnold,

© 2003 John Wiley and Sons Publishers

What is the difference between a gene and a genome?

QUESTION

Page 29: Chapter 18: The Chemistry of HeredityThe Chemistry of Heredity Molecular Genetics © 2003 John Wiley and Sons Publishers Courtesy Alfred Pasieka/Peter Arnold,

© 2003 John Wiley and Sons Publishers

What was the first adult mammal to be cloned successfully? When and where did this occur, and how many unsuccessful attempts preceded the first success?

QUESTION