Chem 3550

Chapter 16:Production of NADH and NADPH: The Citric Acid Cycle, the Glyoxylate Cycle

(Skip), and the Pentose Phosphate Pathway

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These are all very important! Know names and cofactors, as well as reactants and products.

Rearrange to facilitate later oxidation (cannot oxidize 3° carbon)

4 Carbons6 Carbons

Loss of CO2

Oxidation of alcohol to ketone (note use of NAD+)

5 Carbons

Similar to PDC reactions for Acetyl-CoA formation

High Energy Compound

GTP (or ATP) production

Oxidation of alkane to alkene (note use of FAD); Succ. Deh. Is a membrane-bound enzyme

Hydration Reaction is stereospecific

Oxidation of alcohol to ketone (note use of NAD+)

4 Carbons

This is something you should be very comfortable with

Know this!Regulation is very important!

Summary

Also known as E1

Second level of control of PDC in eukaryotes

Kinase: enzyme to puts on a phosphatePhosphatase: enzyme that takes of a phosphate

Amphibolic nature of CAC

X

Pentose Phosphate Pathway

NADPH produced! Used for lipid biosynthesis