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CHEM 7100 (14421): “THEORY OF ANALYTICAL CHEMISTRY” STAFF Instructor: Dr. Mary T. Rodgers Email: mrodgers@chem.wayne.edu Office: 33 Chemistry (313) 577-2431 Office Hour: Monday 1:00 – 2:00 PM; also available other times by appointment SCHEDULE Lectures: Mondays, Wednesdays, and Fridays, 10:40 – 11:35 PM Location: 1111 Old Main REQUIRED MATERIALS 1. Because the materials covered in this course will be derived from a variety of sources, I have

developed a custom course pack for CHM 7100 that is available on-line from University Readers at https://students.universityreaders.com/store/ . The course pack price is $130.34, and includes materials that we will use in class daily, so you should purchase your own copy.

To purchase the course pack, please follow the instructions below:

Step 1: Log on to https://students.universityreaders.com/store/. Step 2: Create an account or log in if you have an existing account to purchase. Step 3: Easy-to-follow instructions will guide you through the rest of the ordering process. Payment can be made by all major credit cards or with an electronic check. Orders are typically processed within 24 hours and the shipping time will depend on the selected shipping method and day it is shipped (orders are not shipped on Sundays or holidays). If you experience any difficulties, please email orders@universityreaders.com or call (800) 200-3908 x503.

2. Additional readings from the literature will be assigned during the course. Dr. Rodgers will

expect you to retrieve your own copy of journal articles available in house or on-line through the WSU library, occasionally make use of textbooks on reserve at the library, and explore the internet.

Course content will be derived from a variety of sources including but not limited to . . . 1. The Internet 2. Various research publications, and in particular, analytical chemistry journals and topical

journals of relevance to instrumentation and applications employed in the practice of analytical chemistry

• American Laboratory

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• The Analyst • Analytical and Bioanalytical Chemistry • Analytical Biochemistry • Analytical Chemistry • Analytical Chimica Acta • Analytical Letters • Applied Spectroscopy • Clinical Chemistry • International Journal of Mass Spectrometry • Instrumentation Science and Technology • Journal of the American Chemical Society • Journal of the American Society for Mass Spectrometry • Journal of the Association of Official Analytical Chemists • Journal of Chromatographic Science • Journal of Chromatography • Journal of Electroanalytical Chemistry • Journal of Liquid Chromatography and Related Techniques • Journal of Microcolumn Separations • Microchemical Journal • Microchimica Acta • Separation Science • Spectrochimica Acta • Talanta

Note: WSU faculty and students have electronic access to many of the above mentioned journals as well as a wide variety of other journals at . . .

http://www.lib.wayne.edu

3. Various Analytical Chemistry, Instrumental Analysis, and Chemical Analysis Text and Reference Books (materials from texts underlined lined below are included in the CHM7100 course pack available from University Readers).

• “Fundamentals of Analytical Chemistry”, D. A. Skoog, D. M. West, F. J. Holler, and S. R. Crouch, 8th edition, Brooks/Cole, 2004.

• “Handbook of Instrumental Techniques for Analytical Chemistry”, F. A. Settle, Ed., Prentice-Hall, 1997.

• “Analytical Chemistry: A Modern Approach to Analytical Science”, R. Kellner, J.-M. Mermet, M. Otto, M. Valcarcel, H. M. Widmer, 2nd edition, Wiley-VCH Verlag, 2004.

• “The Art and Science of Chemical Analysis”, C. G. Enke, Wiley, 2001. • “Chemical Instrumentation: A Systematic Approach”, H. Strobel and W. R.

Heineman, 3rd edition, Addison-Wesley, 1989. • “Instrumental Analysis”, G. D. Christian and J. D. O’Reilly, 2nd edition, Allyn and

Bacon, 1986.

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• “Principles of Instrumental Analysis”, Douglas A. Skoog, F. James Holler, Stanley R. Crouch, 6th edition, Thomson Brooks/Cole, 2007.

• “Quantitative Chemical Analysis”, D. C. Harris, W.H. Freeman and Co., 2007. • “Handbook of Basic Tables for Chemical Analysis”, T. J. Bruno, P. D. N.

Svoronos, CRC Press, 2004. • “Vogel's Textbook of Quantitative Chemical Analysis”, Harlow : Longman, 1999. • “Chemical Analysis”, H. A. Laitinen and W. E. Harris, 2nd edition, McGraw-Hill,

1975. • “Ionic Equilibrium: A Mathematical Approach”, J. N. Butler, Addison-Wesley,

1964. • “Ionic Equilibrium: Solubility and pH Calculations”, J. N. Butler, Wiley, 1998. • “Unified Equilibrium Calculations”, W. B. Guenther, Wiley, 1991.

4. Various Topical Chemistry Text and Reference Books

• “Chromatography: Concepts and Contrasts”, J. M. Miller, 2nd edition, John Wiley & Sons, Inc., 2005.

• “The Essence of Chromatography”, C. F. Poole, Elsevier, 2003. • “Introduction to Modern Liquid Chromatography”, L. R. Snyder, J. J. Kirkland,

Wiley, 1979, 1996. • “Capillary Electrophoresis: Theory and Practice”, P. Camilleri, ed., CRC Press,

1993. • “Practical Capillary Electrophoresis”, R. Weinberger, Academic Press, 1993, 2000. • “Introduction to Mass Spectrometry: Instrumentation, Applications, and Strategies

for Data Interpretation”, J. T. Watson and O. D. Sparkman, 4th edition, Wiley. • “Interpretation of Mass Spectra”, Fred W. McLafferty and Frantisek Turecek, 4th

edition, University Science Books, 1993. • “Mass Spectrometry: A Foundation Course”, E. Downard, Royal Society of

Chemistry, 2007. • “Mass Spectrometry: A Textbook”, Jürgen H. Gross, Springer, 2004.

http://www.ms-textbook.com/ • “Mass Spectrometry Principles and Applications”, E. de Hoffmann and V.

Stroobant, 2nd edition, John Wiley & Sons Ltd., 2007. • “Mass Spectrometry Basics”, Christopher G. Herbert and Robert A. W. Johnstone,

CRC Press, 2003. • “Fundamentals of Contemporary Mass Spectrometry”, C. Dass, D. M. Desiderio &

N. M. Nibbering, eds., Wiley-Interscience Series on Mass Spectrometry, 2007. • “Mass Spectrometry”, E. Constantin and A. Schnell, Ellis Horwood Limited, 1990. • “Fourier Transforms in NMR, Optical and Mass Spectrometry, A User’s

Handbook”, Alan G. Marshall and Francis R. Verdun, Elsevier Science Publishers, 1990.

• “Time of Flight Mass Spectrometry”, Robert J. Cotter ed., ACS Symposium Series 549, 1994.

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• “Principles and Practice of Biological Mass Spectrometry”, C. Dass, D. M. Desiderio & N. M. Nibbering, eds., Wiley-Interscience Series on Mass Spectrometry, 2000.

• “The Encyclopedia of Mass Spectrometry, M. L. Gross & R. Caprioli, eds. in chief, Elsevier, 2003.

• “Principles of Fluorescence Spectroscopy”, J. R. Lakowicz, 3rd edition, Springer, New York, 2006.

• “Fundamental Concepts of Analytical Electrochemistry”, P. T. Kissinger, W. R. Heineman, 2nd edition, Marcel Dekker, Inc., 1996.

Many of the books listed above are available in the Science & Engineering library and have been put on reserve for this course. I have requested that the library buy the other books. However, it is only a request and subject to budgetary constraints.

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GRADING CRITERIA Homework Assignments (20%) There will be homework assignments approximately every one to two weeks. They will be handed out in class and will be due one week later. Late homework will be subject to a 20% penalty and will be accepted no more than one week late. All homework is to represent an individual effort. You may discuss the assignments and problems with others, but you must carry out the assignment / solve all problems on your own. Feel free to consult with Dr. Rodgers when you have problems. The nature of the homework assignments will vary during the course and will involve problem solving, descriptive explanations, and reading and evaluation of research publications relevant to analytical chemistry published in the literature, etc. In Class Exams (Tentative exam dates 10/8, 11/10, and 12/13) (3 @ 20% each) There will be three in class exams. These exams will be comprehensive and include all of the material covered in the relevant section of the course. The exams are likely to be highly descriptive, but will probably also involve some problem solving as well. The exam dates listed above are only tentative. Dr. Rodgers reserves the right to alter the exam dates should she decide Final Project Will be scheduled during the week of December 6-10 (20%) Each student will be required to prepare and present an oral presentation that will be educational / tutorial in nature and deal with some aspect of analytical chemistry. Appropriate topics for the final project might include but are not limited to: the specific topics covered in this course, but could also involve the historical evolution of various analytical methods, or applications and techniques employed in the practice of advanced analytical chemistry. The presentations will be expected to be 15-20 minutes in length, well organized, cite the appropriate literature references used for preparation, and be presented in a professional manner. Each student will be required to pick a unique topic. Each student will be expected to turn in both a hard and soft copy of their presentation. Professor Rodgers will need to travel a few times during the term and expects to miss several lectures. If possible we will schedule make up classes. However if scheduling make up classes becomes problematic, we will schedule an extended time period for the presentation of the final projects near the end of the term in lieu of make up clases. Final Exam There will be NO final exam at the end of the term.

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COURSE OUTLINE “The Theory of Analytical Chemistry” is truly a very broad field and cannot be comprehensively covered in a single course. This course is meant to provide general background relevant to the field of analytical chemistry and a survey of a limited number of the techniques employed in the practice of advanced analytical chemistry. Listed below are the topics that we will cover in CHM7100. I do not plan to cover the topics highlighted in grey as it is expected that they will have been adequately covered in your undergraduate coursework and that all students will have already mastered the relevant material. If this is not true of your background, please let me know (either in class or anonymously via email). There are many other topics that are relevant to “The Theory of Analytical Chemistry”, but will not be covered in this course due to time limitations. If there is a topic of particular interest to you that will not be covered in CHM7100, you will have the opportunity to learn about the technique of interest by choosing that topic for your final project. I. INTRODUCTION TO ANALYTICAL CHEMISTRY II. STATISTICS

• Errors in Chemical Analysis • Random Errors in Chemical Analysis • Statistical Data Treatment and Evaluation • Sampling, Standardization, and Calibration

CHEMICAL EQUILIBRIA CLASSICAL METHODS OF ANALYSIS II. CHROMATOGRAPHY

• Introduction to Chromatography • Band Broadening and Kinetics • Physical Forces and Interactions • Optimizing Separation • Gas Chromatography • Liquid Chromatography in Columns • Quantitation: Detectors and Methods • Chromatography with Mass Spectral Detection (GC/MS and LC/MS) • Capillary Electrophoresis and Capillary Electrochromatography

III. MICROFLUIDICS

• Miniaturized Analytical Systems

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IV. MASS SPECTROMETRY • Introduction to Mass Spectrometry • The Mass Spectrometer (Types and Principles of Operation) • Tandem Mass Spectrometry SPECTROCHEMICAL METHODS

V. FLUORESCENCE

• Introduction to Fluorescence • Instrumentation for Fluorescence Spectroscopy • Fluorophores • Quenching Fluorescence • Fluorescence Sensing

VI. BIOSENSORS

• Principles of Detection

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COURSE POLICIES 1. ATTENDANCE: Attendance at all lectures and exams is expected in CHM7100. Because the course is intensive and fast-paced, it is important to attend all lectures because they will be the primary mode of communication between Professor Rodgers and the students. In addition, course information and most handouts will be given at the beginning of the lecture. PLEASE AVOID BEING LATE. 2. UNIVERSITY ACADEMIC HONESTY POLICY: Cheating on exams, homework assignments, final projects, and all other forms of dishonest behavior represents a violation of the University Honor Code. All forms of academic dishonesty will be prosecuted to the fullest extent as outlined in the Student Due Process Policy of the University. Any student that commits academic dishonesty will receive a grade of F for the course. 3. HOMEWORK: Late homework will be subject to a 20% penalty and will be accepted no more than one week after the time it was due. Extensions MAY be granted without penalty in some cases and will be decided upon by Dr. Rodgers on a case by case basis. 4. EXAMS: Excused absences from examinations MAY be granted by Dr. Rodgers, but must be granted BEFORE the starting time of the exam. In cases where Dr. Rodgers approves an absence from an exam, an alternative time for the make-up exam will be chosen by Dr. Rodgers and the student. 5. Please be considerate and respectful of Dr. Rodgers and other students in the course by ensuring that your CELL PHONE IS TURNED OFF PRIOR TO ENTERING THE CLASSROOM FOR LECTURES AND EXAMS. 6. STUDENT DISSABILITY SERVICES: “If you have a documented disability that requires accommodations, you will need to register with Student Disability Services (SDS) for coordination of your academic accommodations. The SDS office is located at 1600 David Adamany Undergraduate Library in the Student Academic Success Services department. SDS telephone number is (313) 577-1851 or (313) 577-3365 (TDD only). Once you have your accommodations in place, I will be glad to meet with you privately during my office hours to discuss your special needs. SDSs’ mission is to assist the university in creating an accessible community where students with disabilities have an equal opportunity to fully participate in their educational experience at Wayne State University.” Please refer to the SDS website for further information and the services that can be provided: http://studentdisability.wayne.edu/