2000 multi-membered N-heterocycles

multi-membered N-heterocyclesR 0690

33 - 1577-Methyl-6,7,8,9,14,15-hexahydro-5H-benz[d]indolo[2,3-g]azecine: ANew Heterocyclic System and a New Lead Compound for DopamineReceptor Antagonists. — Derivative (IVa) represents one of the mostpotent D1 antagonists at the rat striatal receptor identified to date. Compound(IVa) and its analogues are synthesized by quaternization of the correspondingquinolizidines [cf. (I)] and opening of the central C–N bond of the ammoniumsalts (III) and (V) by reaction with sodium amide. — (WITT, THOMAS;HOCK, FRANZ J.; LEHMANN, JOCHEN; J. Med. Chem. 43 (2000) 10,2079-2081; Inst. Pharm., Rhein. Friedrich-Wilhelms-Univ., D-53121 Bonn,Germany; EN)

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