View this journal online at

wileyonlinelibrary.com

CyanationO 0273 DOI: 10.1002/chin.201052036

A New Combined Source of "CN" from N,N-Dimethylformamide and Ammonia in the Palladium-Catalyzed Cyanation of Aryl C—H Bonds. — Isotopic incorpo-ration experiments reveal that the carbon and nitrogen of the "CN" originate from the N,N-dimethyl moiety of DMF and ammonia, respectively. The present method exhibits an excellent degree of regioselectivity, generating only monosubstituted nitriles at the less hindered C—H position. Doubly labeled 13C- and 15N-nitrile compounds are pre-pared for the first time. — (KIM, J.; CHANG*, S.; J. Am. Chem. Soc. 132 (2010) 30, 10272-10274, DOI:10.1021/ja104917t ; Dep. Chem., Korea Adv. Inst. Sci. Technol., Daejeon 305-701, S. Korea; Eng.) — Klein

52- 036

ChemInform 2010, 41, issue 52 © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim