1997 rings with 7 or more members

rings with 7 or more membersQ 0050

43 - 089A New Framework for the Cycloaromatization of Enediynes underMild Conditions. — A new functional model (I) for enediyne toxins, e.g.calicheamicin, is designed and synthesized. The cycloaromatization reactionproceeds with a half-time of 13-14 hours under a variety of conditions, e.g., inthe presence of Et3N, TFA or MeOH. — (SEMMELHACK, M. F.; GU, Y.;HO, D. M.; Tetrahedron Lett. 38 (1997) 32, 5583-5586; Dep. Chem., PrincetonUniv., Princeton, NJ 08544, USA; EN)

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