Amino acidsU 0400 DOI: 10.1002/chin.201116204

A Practical Synthesis of trans-3-Substituted Proline Derivatives Through 1,4-Addition. — A short synthesis of trans-3-substituted proline derivatives such as (VII) is accomplished by Cu-catalyzed addition of Grignard reagents to dehydroproline esters (III). The nonracemic vinylproline (VIIa) is prepared using Evans oxazolidinone as chiral auxiliary. — (HUY, P.; NEUDOERFL, J.-M.; SCHMALZ*, H.-G.; Org. Lett. 13 (2011) 2, 216-219, http://dx.doi.org/10.1021/ol102613z ; Fachber. Chem., Univ. Koeln, D-50939 Koeln, Germany; Eng.) — Kieslich

16- 204

ChemInform 2011, 42, issue 16 © 2011 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim