2000 multi-membered N-heterocycles

multi-membered N-heterocyclesR 0690

14 - 148Discovery of Orally Active Nonpeptide Vitronectin Receptor An-tagonists Based on a 2-Benzazepine Gly-Asp Mimetic. — Tworepresentatives (I) and (II) of a novel class of potent and orally bioavailableαvβ3 antagonists are synthesized which possess promising inhibiting activity invarious in vitro and in vivo models for osteoporosis. — (MILLER, WILLIAMH.; ET AL.; J. Med. Chem. 43 (2000) 1, 22-26; Res. Dev. Div., SmithKlineBeecham Pharm., Collegeville, PA 19426, USA; EN)

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