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Medicinal chemistryV 1100 Discovery of R-142086 as a Factor Xa (FXa) Inhibitor: Syntheses and Structure—
-Activity Relationships of Cinnamyl Derivatives. — Among various derivatives of type (I) compound (Ie) (R-142086) exhibits potent anticoagulant activity in vitro and in vivo and no mutagenic potential. — (TANAKA*, N.; et al.; Chem. Pharm. Bull. 57 (2009) 1, 22-33; Shinagawa R&D Cent., Daiichi Sankyo Co., Ltd., Shinagawa, Tokyo 134, Japan; Eng.) — K. Schneider
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ChemInform 2009, 40, issue 35 © 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim