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Pyrazine derivativesR 0550 Efficient N-Arylation/Dealkylation of Electron Deficient Heteroaryl Chlorides

and Bicyclic Tertiary Amines under Microwave Irradiation. — A highly efficient microwave procedure is developed for the synthesis of the N-heteroaryl chloroethyl piperazines (III) and piperidines (V), which are valuable scaffolds for the generation of drug-like small molecule libraries. The unisolated chlorides may be further converted into esters (VII) and (VIII). — (WANG*, H.-J.; WANG, Y.; CSAKAI, A. J.; EARLEY, W. G.; HERR, R. J.; J. Comb. Chem. 11 (2009) 3, 355-363; Dep. Med. Chem., Albany Mol. Res., Inc., Albany, NY 12212, USA; Eng.) — Kieslich

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