• Home

  • Documents

  • ChemInform Abstract: Efficient One-Pot Synthesis of Polysubstituted...
1
ChemInform 2011, 42, issue 49 © 2011 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Uracil derivatives R 0520 DOI: 10.1002/chin.201149161 Efficient One-Pot Synthesis of Polysubstituted 6-[(1H-1,2,3-Triazol-1-yl)meth- yl]uracils Through the "Click" Protocol. — A variety of acyclic triazolo nucleoside analogues is synthesized utilizing Cu(I)-catalyzed azide—alkyne Huisgen "click" cy- cloaddition reactions. None of the prepared compounds exhibits any significant antivi- ral, antiproliferative or thymidine phosphorylase inhibitory activities. — (JANSA*, P.; SPACEK, P.; VOTRUBA, I.; BREHOVA, P.; DRACINSKY, M.; KLEPETAROVA, B.; JANEBA, Z.; Collect. Czech. Chem. Commun. 76 (2011) 9, 1121-1131, http://dx.doi.org/10.1135/cccc2011074 ; Inst. Org. Chem. Biochem., Acad. Sci. Czech Rep., CZ-166 10 Prague 6, Czech Republic; Eng.) — H. Toeppel 49- 161

ChemInform Abstract: Efficient One-Pot Synthesis of Polysubstituted 6-[(1H-1,2,3-Triazol-1-yl)methyl]uracils Through the “Click” Protocol

Embed Size (px)

Citation preview

Page 1: ChemInform Abstract: Efficient One-Pot Synthesis of Polysubstituted 6-[(1H-1,2,3-Triazol-1-yl)methyl]uracils Through the “Click” Protocol

Uracil derivativesR 0520 DOI: 10.1002/chin.201149161

Efficient One-Pot Synthesis of Polysubstituted 6-[(1H-1,2,3-Triazol-1-yl)meth-yl]uracils Through the "Click" Protocol. — A variety of acyclic triazolo nucleoside analogues is synthesized utilizing Cu(I)-catalyzed azide—alkyne Huisgen "click" cy-cloaddition reactions. None of the prepared compounds exhibits any significant antivi-ral, antiproliferative or thymidine phosphorylase inhibitory activities. — (JANSA*, P.; SPACEK, P.; VOTRUBA, I.; BREHOVA, P.; DRACINSKY, M.; KLEPETAROVA, B.; JANEBA, Z.; Collect. Czech. Chem. Commun. 76 (2011) 9, 1121-1131, http://dx.doi.org/10.1135/cccc2011074 ; Inst. Org. Chem. Biochem., Acad. Sci. Czech Rep., CZ-166 10 Prague 6, Czech Republic; Eng.) — H. Toeppel

49- 161

ChemInform 2011, 42, issue 49 © 2011 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

METHODOLOGY Molecularstructuresenumeration and ......Koch et al. J Cheminform Page5of17 changing4bonds,sinceweaimtondminimaltransfor - mations.Letuscall a 13 and a 24 thetwofixedbonds,with

METHODOLOGY Molecularstructuresenumeration and ......Koch et al. J Cheminform Page5of17 changing4bonds,sinceweaimtondminimaltransfor - mations.Letuscall a 13 and a 24 thetwofixedbonds,with

Documents
The role of polysubstituted heterocycles in the synthesis ... phosphorous trichloride. With acetic anhydride they can be rearranged into the corresponding 2-acetoxy derivatives 10

The role of polysubstituted heterocycles in the synthesis ... phosphorous trichloride. With acetic anhydride they can be rearranged into the corresponding 2-acetoxy derivatives 10

Documents
Open Access CSgator:kanjintegratedkwebkplatformk forjcompoundksetkanalysis · 2019. 3. 4. · Parkjet al. J Cheminform Pagek6kofk8 currentlackofenoughcompound-targetdataevenafter

Open Access CSgator:kanjintegratedkwebkplatformk forjcompoundksetkanalysis · 2019. 3. 4. · Parkjet al. J Cheminform Pagek6kofk8 currentlackofenoughcompound-targetdataevenafter

Documents
Síntese de peptídeo modificado contendo grupo 1, 2, 3-triazol 1, 4

Síntese de peptídeo modificado contendo grupo 1, 2, 3-triazol 1, 4

Documents
SÍNTESE E CARACTERIZAÇÃO FOTOFÍSICA DE TRIAZOL

SÍNTESE E CARACTERIZAÇÃO FOTOFÍSICA DE TRIAZOL

Documents
SYNTHESIS AND CHARACTERIZATION OF POLYSUBSTITUTED

SYNTHESIS AND CHARACTERIZATION OF POLYSUBSTITUTED

Documents
Classification System for Solid Supports Used ... - FIZ CHEMIE › fileadmin › user_upload › Cheminform › Spore › _… · FIZ CHEMIE BERLIN - 5 (23) - The remainder of the

Classification System for Solid Supports Used ... - FIZ CHEMIE › fileadmin › user_upload › Cheminform › Spore › _… · FIZ CHEMIE BERLIN - 5 (23) - The remainder of the

Documents
Statistical principle-based approach for gene and protein ... · Lai et al. J Cheminform Page 2 of 9 tobiologicaldatabaserecords.Intheabovecases,“A2A” isasubtypeof“adenosinereceptor”.erefore“A2A

Statistical principle-based approach for gene and protein ... · Lai et al. J Cheminform Page 2 of 9 tobiologicaldatabaserecords.Intheabovecases,“A2A” isasubtypeof“adenosinereceptor”.erefore“A2A

Documents
ChemInform Sheet A4on chemo-, regio-, and stereo-selective reactions. The RefLib database is included with CIRX and provides reactions abstracted from Theilheimer’s Synthetic Methods

ChemInform Sheet A4on chemo-, regio-, and stereo-selective reactions. The RefLib database is included with CIRX and provides reactions abstracted from Theilheimer’s Synthetic Methods

Documents
One-Pot Methodology for the Synthesis of Polysubstituted ... · 2.2 - DEVELOPMENT OF NEW METHODOLOGY FOR 3-CYANOPYRIDINE SYNTHESIS 2.2.0-Aims 91 2.2.1 - Two-Component Method Development

One-Pot Methodology for the Synthesis of Polysubstituted ... · 2.2 - DEVELOPMENT OF NEW METHODOLOGY FOR 3-CYANOPYRIDINE SYNTHESIS 2.2.0-Aims 91 2.2.1 - Two-Component Method Development

Documents
Durham Research Online - COnnecting REpositories · 2017. 12. 14. · T D ACCEPTED MANUSCRIPT 1 Polysubstituted and ring-fused pyridazine systems from tetrafluoropyridazine Graham

Durham Research Online - COnnecting REpositories · 2017. 12. 14. · T D ACCEPTED MANUSCRIPT 1 Polysubstituted and ring-fused pyridazine systems from tetrafluoropyridazine Graham

Documents
MER: a shell script and annotation server for minimal named ......Couto and Lamurias J Cheminform Page 5 of 10 common,sandswesempiricallysfoundsthatsmostsofsthestwo-charactersmatchesswereserrors

MER: a shell script and annotation server for minimal named ......Couto and Lamurias J Cheminform Page 5 of 10 common,sandswesempiricallysfoundsthatsmostsofsthestwo-charactersmatchesswereserrors

Documents
METHODOLOGY Ecientiterativevirtualscreening with … · 2018. 3. 1. · Ahmed et al. J Cheminform Page4of8 10contain‘high-scoring’ligands.eunassignedbin3is excludedfromtraining.Figure

METHODOLOGY Ecientiterativevirtualscreening with … · 2018. 3. 1. · Ahmed et al. J Cheminform Page4of8 10contain‘high-scoring’ligands.eunassignedbin3is excludedfromtraining.Figure

Documents
Természetes vegyületek és szintetikus szteroid analógok …real-d.mtak.hu/973/1/dc_1140_15_tezisek.pdf · 2017-05-29 · mutattak jelentős hatást, a triazol gyűrű meghatározó

Természetes vegyületek és szintetikus szteroid analógok …real-d.mtak.hu/973/1/dc_1140_15_tezisek.pdf · 2017-05-29 · mutattak jelentős hatást, a triazol gyűrű meghatározó

Documents
ChemInform RxnFinder

ChemInform RxnFinder

Self Improvement
Vollhardt 6e Lecture PowerPoints - Chapter 4.ppt [Read-Only]jwhitesell.ucsd.edu/documents/Chapter4.pdf · Use the lowest possible numbering sequence for polysubstituted cycloalkanes

Vollhardt 6e Lecture PowerPoints - Chapter 4.ppt [Read-Only]jwhitesell.ucsd.edu/documents/Chapter4.pdf · Use the lowest possible numbering sequence for polysubstituted cycloalkanes

Documents
Open Access Programming langage in chemiy: a eie of HTML5 ... · Theien J Cheminform Page 3 of 19 HTML5 econtentweviewontheInternetismadepossiblebya unionofseveraltechnologies,mainlyHypertextMarkup

Open Access Programming langage in chemiy: a eie of HTML5 ... · Theien J Cheminform Page 3 of 19 HTML5 econtentweviewontheInternetismadepossiblebya unionofseveraltechnologies,mainlyHypertextMarkup

Documents
Polysubstituted ferrocenes as tunable redox mediators · well as their solubility and the availability of spectroscopic probes to monitor reaction progress and stability are important

Polysubstituted ferrocenes as tunable redox mediators · well as their solubility and the availability of spectroscopic probes to monitor reaction progress and stability are important

Documents
Database fingerprint (DFP): an approach to represent ... · Fernández‑de Gortari et al. J Cheminform DOI 10.1186/s13321‑017‑0195‑1 PRELIMINARY COMMUNICATION Database fingerprint

Database fingerprint (DFP): an approach to represent ... · Fernández‑de Gortari et al. J Cheminform DOI 10.1186/s13321‑017‑0195‑1 PRELIMINARY COMMUNICATION Database fingerprint

Documents
RESEARCHARTICLE OpAccess ......Jiangiet al. J Cheminform Pagej2jofj26 playerindrugabsorption,distribution,metabolism, excretion,andtoxicity(ADMET)[5, 6],andhasalsobeen

RESEARCHARTICLE OpAccess ......Jiangiet al. J Cheminform Pagej2jofj26 playerindrugabsorption,distribution,metabolism, excretion,andtoxicity(ADMET)[5, 6],andhasalsobeen

Documents
Supporting Information A Domino Pericyclic Route to … · S1 Supporting Information A Domino Pericyclic Route to Polysubstituted Salicylic Acid Derivatives: Four Sequential Processes

Supporting Information A Domino Pericyclic Route to … · S1 Supporting Information A Domino Pericyclic Route to Polysubstituted Salicylic Acid Derivatives: Four Sequential Processes

Documents
ChemDoodle Web Components: HTML5 toolkit for chemical graphics, interfaces… · 2017-04-10 · Burger. J Cheminform DOI 10.1186/s13321-015-0085-3 REVIEW ChemDoodle Web Components:

ChemDoodle Web Components: HTML5 toolkit for chemical graphics, interfaces… · 2017-04-10 · Burger. J Cheminform DOI 10.1186/s13321-015-0085-3 REVIEW ChemDoodle Web Components:

Documents
BIOINFORMATICS Review …“.Jónsdóttir et al. Fig. 1. Number of papers in PubMed 1992–2004 containing the keywords ‘bioinformatics’ (top left), ‘chemoinformatics’ or ‘cheminform-atics’,

BIOINFORMATICS Review …“.Jónsdóttir et al. Fig. 1. Number of papers in PubMed 1992–2004 containing the keywords ‘bioinformatics’ (top left), ‘chemoinformatics’ or ‘cheminform-atics’,

Documents
voriject-200-mg-iv-infuzyon-cozeltisi-icin-liyofi-f199 ... · VORİJECT, geniş spektrumlu, triazol grubuna dahil antifungal bir ajandır ve aşağıda belirtilen mantar enfeksiyonlarının

voriject-200-mg-iv-infuzyon-cozeltisi-icin-liyofi-f199 ... · VORİJECT, geniş spektrumlu, triazol grubuna dahil antifungal bir ajandır ve aşağıda belirtilen mantar enfeksiyonlarının

Documents
anie.199510211 Preparation, Structure, and Reactivity of 1,3,4- Triphenyl-4,5-dihydro-lH-l,2,4-triazol-5-ylidene, a New Stable Carbene

anie.199510211 Preparation, Structure, and Reactivity of 1,3,4- Triphenyl-4,5-dihydro-lH-l,2,4-triazol-5-ylidene, a New Stable Carbene

Documents
Novel hydroxamic acids incorporating 1-((1H-1,2,3-Triazol

Novel hydroxamic acids incorporating 1-((1H-1,2,3-Triazol

Documents
2013 Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory synd

2013 Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory synd

Documents
One-pot Multi-component Synthesis of Some ... · PDF filesynthesis of polysubstituted imidazoles via one-pot multi-component reaction of various aldehydes, benzil, aliphatic/aromatic

One-pot Multi-component Synthesis of Some ... · PDF filesynthesis of polysubstituted imidazoles via one-pot multi-component reaction of various aldehydes, benzil, aliphatic/aromatic

Documents
Durham Universityetheses.dur.ac.uk/2861/1/2861_946.pdfABSTRACT Stereocontralled Synthesis of Highly Functionalized Heterocycles John G. Mina MSc, November 2005 Polysubstituted heterocycles

Durham Universityetheses.dur.ac.uk/2861/1/2861_946.pdfABSTRACT Stereocontralled Synthesis of Highly Functionalized Heterocycles John G. Mina MSc, November 2005 Polysubstituted heterocycles

Documents
RESEARCHARTICLE LargescalecomparisonofQSAR … · 2020. 3. 19. · Boscet al. J Cheminform Page3of16 Dta preparation Compoundstructureswereextractedfromthedatabase inSMILESformatandusingRDKit(version2017_09_01)

RESEARCHARTICLE LargescalecomparisonofQSAR … · 2020. 3. 19. · Boscet al. J Cheminform Page3of16 Dta preparation Compoundstructureswereextractedfromthedatabase inSMILESformatandusingRDKit(version2017_09_01)

Documents