Nucleic acidsU 0700 DOI: 10.1002/chin.201204184

Efficient Synthesis and Biological Properties of the 2'-Trifluoromethyl Analogues of Acyclic Nucleosides and Acyclic Nucleoside Phosphonates. — Title compounds (VII), (X) and (XIII), CF3-analogues of tenofovir, are synthesized efficiently using tri-fluoromethyloxirane (II) as the key reagent. None of the products are found to exhibit any anti-HIV, anti-RSV, anti-HCV or antiproliferative activities. — (JANSA*, P.; KOLMAN, V.; KOSTINOVA, A.; DRACINSKY, M.; MERTLIKOVA-KAISEROVA, H.; JANEBA, Z.; Collect. Czech. Chem. Commun. 76 (2011) 10, 1187-1198, http://dx.doi.org/10.1135/cccc2011105 ; Inst. Org. Chem. Biochem., Acad. Sci. Czech Rep., CZ-166 10 Prague 6, Czech Republic; Eng.) — R. Langenstrassen

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ChemInform 2012, 43, issue 04 © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

ChemInform 2012, 43, issue 04 © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim