2008

HydrationO 0335 Rh(I)-Catalyzed Hydration of Organonitriles under Ambient Conditions. — The

hydration of organonitriles using the new catalyst system, cf. conditions A, proceeds under mild conditions and tolerates a variety of functional groups as well as a stereo-genic center. This procedure enables the production of industrially and pharmaceutical-ly important substances in a straightforward manner and is complementary to many practical methods which use microorganisms for enzymatic hydration of nitriles utiliz-ing the higher valent metals Fe(III) and Co(III). The functionalization of nitrile-con-taining polymer may be realized using the present strategy. — (GOTO, A.; ENDO, K.; SAITO*, S.; Angew. Chem., Int. Ed. 47 (2008) 19, 3607-3609; Dep. Chem., Grad. Sch. Sci., Nagoya Univ., Chikusa, Nagoya 464, Japan; Eng.) — H. Hoennerscheid

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